Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Mohammad R Ebrahimkhani,
Fiona Oakley,
Lindsay B Murphy,
Jelena Mann,
Anna Moles,
Maria J Perugorria,
Elizabeth Ellis,
Anne F Lakey,
Alastair D Burt,
Angela Douglass,
Matthew C Wright,
Steven A White,
Fabrice Jaffré,
Luc Maroteaux and
Derek A Mann
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
Abstract
We therefore developed an efficient bacterial expression system to produce a panel of π-TRTX-Pc1a mutants for probing structure-activity relationships as well as isotopically labeled toxin for determination of its solution structure and dynamics. We demonstrate that the toxin pharmacophore resides...
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PMID: 21825095
PDF is available here.
Abstract
In the 1990s, a technique was developed to transfer proteins from electrophoresis gels onto poly(vinylidene difluoride) (PVDF) membranes, digest the proteins on the membranes with proteases such as trypsin and analyze the resulting peptides on the membranes directly by mass spectrometry to identify t...
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PMID: 21848805
PDF is available here.
Abstract
We used mathematical modeling and quantitative in vivo experiments to define the contributions of individual components of the G₁-S network downstream of Hog1 to this stress-induced delay in the cell cycle. The length of the arrest depended on the degree of stress and the temporal proximity of the...
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PMID: 21954289
PDF is available here.
Abstract
Aqueous two-phase systems (ATPS) are considered as efficient downstream processing techniques in the production and purification of enzymes, since they can be considered harmless to biomolecules due to their high water content and due to the possibility of maintaining a neutral pH value in the medium...
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PMID: 21852207
PDF is available here.
Abstract
In this paper, a pH-inductive protein-scaffold biosynthesis of shape-tunable crystalline gold nanoparticles at room temperature has been developed. By simple manipulation of the reaction solution's pH, anisotropic gold nanoparticles including spheres, triangles and cubes could be produced by incubati...
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PMID: 21828895
PDF is available here.
Abstract
We directly observed the melting behavior of different conformers in a single experiment. Our results agree with other calorimetric and spectroscopic data and data obtained by single-molecule studies, atomic force microscopy, and mechanical unfolding by optical tweezers. We propose that the end of t...
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PMID: 21819151
PDF is available here.
Abstract
We resolved cytoplasmic and membrane-associated complexes from hESCs and characterised their composition, stoichiometry, and dynamics by denaturing SDS-PAGE. The reliability of the fractionation was examined by western blot analysis of membrane and cytosolic markers. MALDI TOF/TOF mass spectrometry...
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PMID: 21727978
PDF is available here.
Abstract
This review covers progress in proteome research on Mycoplasma pneumoniae made over the last 5 years. This bacterium is one of the smallest known self-replicating bacteria. With fewer than 700 proposed proteins, it is well suited to a comprehensive proteome analysis. While all of the...
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PMID: 21751371
PDF is available here.
Abstract
Sea star coelomic fluid is in contact with all internal organs, carrying signaling molecules and a large population of circulating cells, the coelomocytes. These cells, also known as echinoderm blood cells, are responsible for the innate immune responses and are also known to have an...
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PMID: 21751360
PDF is available here.
Abstract
We developed an integrated proteomic platform with the combination of 2-D native/SDS-PAGE-based proteomics with co-immunoprecipitation, far-Western blotting, His-tag affinity purification and functional analysis, and used it to investigate the E. coli cytosolic complexome. A total of 24 distinct het...
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PMID: 21717022
PDF is available here.
Abstract
Expressing proteins of interest as fusion to proteins of bacterial envelope is a powerful technique for biotechnological and medical applications. The synthetic gene (VacII) encoding for T-cell epitopes of selected genes of Mycobacterium tuberculosis namely, ESAT6, MTP40, 38 kDa, and...
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PMID: 21941936
PDF is available here.