Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Spectrometry, Mass, Electrospray Ionization (0):
Recent article
Spectrometry, Mass, Electrospray Ionization
Abstract
Type 2 diabetes mellitus (T2DM) and its attendant complications, such as diabetic nephropathy (DN), impose a significant societal and economic burden. The investigation of discovering potential biomarkers for T2DM and DN will facilitate the prediction and prevention of diabetes. Phos...
|
PMID: 21872008
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Biochemistry (Washington) (50)36 2011
Abstract
We previously identified a novel Jak2 inhibitor named G6. We showed that G6 specifically inhibits Jak2 kinase activity and suppresses Jak2-mediated cellular proliferation. To elucidate the molecular and biochemical mechanisms by which G6 inhibits Jak2-mediated cellular proliferation, we treated Jak2...
|
PMID: 21823612
PDF is available here.
PDF is available here.
Abstract
Two approaches to monitor the matrix effect on ionization in study samples were described. One approach is the addition of multiple reaction monitoring transitions to the bioanalytical methods to monitor the presence of known ionization modification-causing components of the matrix,...
|
PMID: 21827271
PDF is available here.
PDF is available here.
Abstract
Evidence is presented that components of fetal calf serum (FCS) can significantly enhance the splicing correction activity of peptide nucleic acids (PNA) in HeLa pLuc 705 cells. The effect proved more pronounced for PNAs bearing fluorescence tags and relies on the ability of specific components of FC...
|
PMID: 21851222
PDF is available here.
PDF is available here.
Abstract
An ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry method for the direct analysis in oral fluid (OF) of several abused drugs and metabolites in a single chromatographic run was set up and validated. Amphetamine, methamphetamine, morphine,...
|
PMID: 21674163
PDF is available here.
PDF is available here.
Abstract
We observe both the dissociation and unfolding transitions for four tetrameric protein complexes bound to populations of 12 different anions using collisional activation. The data presented here quantifies, for the first time, the influence of a large range of counterions on gas-phase protein struct...
|
PMID: 21675748
PDF is available here.
PDF is available here.
Journal of Proteomics (74)7 2011
Abstract
Matrix vesicles (MVs), released by budding from apical microvilli of osteoblasts during bone formation and development, are involved in the initiation of mineralization by promoting the formation of hydroxyapatite in their lumen. To gain additional insights into MV biogenesis and fun...
|
PMID: 21515422
PDF is available here.
PDF is available here.
Abstract
Infrared multiphoton dissociation spectra of protonated p-aminobenzoic acid generated by electrospray ionization (ESI) from aqueous methanol and acetonitrile solutions were recorded in the gas phase from 2800-4000 cm(-1). The O-protonated ion is more stable than the N-protonated structure in the gas...
|
PMID: 21615176
PDF is available here.
PDF is available here.
Abstract
The designed synthesis and structural characterization of two metal cluster-centered metallosupramolecular architectures are reported. In complex [(CF(3)SO(3))Ag(4)((t)BuC≡C)(Py8)](CF(3)SO(3))(2) (1) and [(CF(3)SO(3))Ag(4){C≡C-(m-C(6)H(4))-C≡C-(m-C(6)H(4))-C≡C-(m-C(6)H(4))-C≡C}Ag(4)(CF(3)SO...
|
PMID: 21561074
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Gas-phase fractionation (GPF), defined as iterative mass spectrometric interrogations of a sample over multiple smaller mass-to-charge (m/z) ranges, enables the ions selected for collision-induced dissociation to come from a greater number of unique peptides compared to the ions selected from the wi...
|
PMID: 18370021
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We have demonstrated that human antibodies with specific human N-glycan structures can be produced in glycoengineered lines of Pichia pastoris and that antibody-mediated effector functions can be optimized by generating specific glycoforms. In this chapter we provide detailed protocols for the analy...
|
PMID: 19277549
PDF is available here.
PDF is available here.
Abstract
IDPs in their unbound state can transiently acquire secondary and tertiary structure. Describing such intrinsic structure is important to understand the transition between free and bound state, leading to supramolecular complexes with physiological interactors. IDP structure is highly dynamic and, th...
|
PMID: 21539793
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)5 2011
Abstract
We found that mutation at position Asn(94) reduces the level of protein secretion whereas mutation at the Asn(4) site has no effect on protein secretion. Purified rJHBP and its mutated forms (N4W and N94A) have the same JH binding activities similar to that of hJHBP. However, both mutants devoid of...
|
PMID: 21315851
PDF is available here.
PDF is available here.
Abstract
We examined pharmacological activities of these compounds in vitro (binding studies) and in vivo (MES test). Pharmacological evaluations revealed one of the compounds, 5a, to be a good lead, exhibiting moderate binding at NMDA receptors (IC(50) = 7.86 μM; K(i) = 5.28 μM), MES neuroprotection activ...
|
PMID: 21496213
PDF is available here.
PDF is available here.
Abstract
This work focused on a new technique for the preparation of doxorubicin (DOX) loaded chitosan (CS) nanoparticles (DOX-CS) - formation by electrospray ionization in the presence of tripolyphosphate (TPP) as the stabilizer. The working distance, needle gauge, flow rate, stirring rate, electrospraying v...
|
PMID: 21544723
PDF is available here.
PDF is available here.
Abstract
The homo-Reformatsky reaction, in which a metal homoenolate of an ester is added to an aldehyde, was adapted to produce γ-lactones from unsaturated, enolizable aldehydes. By use of titanium homoenolate, 11 different γ-lactones were synthesized in one step with moderate to good yields from readily a...
|
PMID: 21395335
PDF is available here.
PDF is available here.
Abstract
We developed a colorimetric tool that simultaneously monitors size distribution and population of PPh3-protected clusters as a function of time. The distribution of the clusters is assigned to different bin sizes by chemical conversion with L3 (L3 = 1,3-bis(diphenylp...
|
PMID: 21381761
PDF is available here.
PDF is available here.
Abstract
The press-residue of black currants provides a good source of phenolic antioxidants. The purpose of this study was to optimize the extraction of phenolic compounds from the press-residue by use of extraction conditions compatible with food use. The effects of temperature, extraction duration, and use...
|
PMID: 21401036
PDF is available here.
PDF is available here.
Phenolic profile and hydrophilic antioxidant capacity as chemotaxonomic markers of tomato varieties.
Abstract
We evaluate the differences in the total and individual polyphenol content and hydrophilic antioxidant capacity of seven varieties of tomato cultivated in Vegas Bajas del Guadiana, Badajoz (Spain), which were collected from two consecutive harvests (2008-2009). Hydrophilic antioxidant capacity was e...
|
PMID: 21395257
PDF is available here.
PDF is available here.
Abstract
The present investigation is focused on potential use of banana pseudostem (BPS), which otherwise is disposed off as a waste or incinerated, as a source of polyphenols or antioxidants. The total phenolics (TP) and total flavonoids (TF) in various solvent extracts of pseudostem (PS) of different banan...
|
PMID: 21405133
PDF is available here.
PDF is available here.
Abstract
Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE(2) by LPS. An (18)F-FDG microPET imaging system was used to evaluate the anti-inflammato...
|
PMID: 21391605
PDF is available here.
PDF is available here.
Abstract
The foam of sparkling wines is a key parameter of their quality. However, the compounds that are directly involved in foam formation and stabilization are not yet completely established. In this work, seven sparkling wines were produced in Bairrada appellation (Portugal) under different conditions an...
|
PMID: 21375299
PDF is available here.
PDF is available here.
Abstract
The phenolic composition of heartwood from Robinia pseudoacacia, commonly known as false acacia, before and after toasting in cooperage was studied by HPLC-DAD and HPLC-DAD/ESI-MS/MS. A total of 41 flavonoid and nonflavonoid compounds were identified, some tentatively, and quantified. Seasoned acacia...
|
PMID: 21375301
PDF is available here.
PDF is available here.
Abstract
This study aimed to identify the pigment composition of black carrot (Daucus carota ssp. sativus var. atrorubens Alef.) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze. Cyanidin 3-xylosyl(glucosyl)galactosides acylated with sinapic acid, ferulic acid, and coumaric acid were detected as m...
|
PMID: 21381748
PDF is available here.
PDF is available here.
Abstract
Molecularly imprinted solid phase extraction (MISPE) has been employed to isolate and concentrate bioactive polyphenols from peanut press waste. To this end, a molecularly imprinted polymer (MIP) templated with the phytoalexin (E)-resveratrol has been prepared via self-assembly with the functional mo...
|
PMID: 21391604
PDF is available here.
PDF is available here.
Abstract
Azlactones participate in stereoselective reactions with electron-deficient alkenes and N-sulfonyl aldimines to give products of 1,3-dipolar cycloaddition and Mannich addition reactions, respectively. Both of these reactions proceed with good to excellent diastereo- and enantioselectivity using a sin...
|
PMID: 21341677
PDF is available here.
PDF is available here.
Journal of Antibiotics (64)5 2011
Abstract
The anti-MRSA antibiotic, WAP-8294A, was isolated from the fermentation broth of Lysobacter sp. The major component, WAP-8294A2, is composed of 1 mol of Gly, L-Leu, L-Glu, D-Asn, D-Trp, D-threo-β-hydroxyasparagine, N-Me-D-Phe and N-Me-L-Val, and 2 mol of L-Ser, D-Orn and D-3-hydroxy-7-Me-octanoic...
|
PMID: 21326252
PDF is available here.
PDF is available here.
Abstract
To identify the 23 amino acid profiles in human tear fluids, and to evaluate whether the ocular disease conditions reflect the amino acid profiles.
|
PMID: 21310375
PDF is available here.
PDF is available here.
Abstract
In forensic medicine autopsy material is primarily investigated to find out the cause of death. But the results of corresponding toxicology measurements often involve more information. With screening methods drugs were detected not being related to the cause of death. Liquid/liquid e...
|
PMID: 21434573
PDF is available here.
PDF is available here.
Abstract
This work aims at comparing alterations in the proteomes of human epithelial ovarian cancer xenografts between stressed and non-stressed immunodeficient mice as well as exploring the molecular mechanisms linking chronic psychological stress to ovarian cancer oncogenesis and progressi...
|
PMID: 21318480
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
We mapped the surface-attached proteome of S. Typhimurium SL1344 grown in vitro under SPI-2-inducing conditions and identified 108 proteins; using secretion signal prediction software, 43% of proteins identified contained a signal sequence. Of these proteins, 13 were known secreted effector proteins...
|
PMID: 21268266
PDF is available here.
PDF is available here.
Abstract
As a continuation of our previous work, which resulted in the identification of a new hit compound as an HIV-1 integrase inhibitor, three novel series of salicylic acid derivatives were synthesized using three versatile and practical synthetic strategies and were assayed for their ca...
|
PMID: 21246739
PDF is available here.
PDF is available here.
Abstract
ABSTRACT:
The degree of metal binding specificity in metalloproteins such as metallothioneins (MTs) can be crucial for their functional accuracy. Unlike most other animal species, pulmonate molluscs possess homometallic MT isoforms loaded with Cu+ or Cd2+. They have, so far, been obtained as native...
|
PMID: 21255385
PDF is available here.
PDF is available here.
Abstract
Phytochemical investigation of the ethanolic extract of defatted fruits of Malva sylvestris Linn. (Malvaceae) led to the isolation of six new steroidal lactones and a homomonoterpenic glucoside along with beta-sitosterol-3-beta-D-glucopyranoside. The structures of new phytoconstituents have been eluc...
|
PMID: 21648194
PDF is available here.
PDF is available here.
Abstract
The flavonoids, kaempferol derivatives: 3-O-alpha-arabinofuranoside, 3-O-beta-glucopyranoside, 3-O-alpha-rhamnopyranoside, 3-O-alpha-rhamnopyranosyl (1 --> 6)-O-beta-glucopyranoside and quercetin derivatives: 3-O-alpha-arabinofuranoside, 3-O-beta-glucopyranoside, 3-O-alpha-rhamnopyranosyl (1 --> 6)-O...
|
PMID: 21648195
PDF is available here.
PDF is available here.
Abstract
These results support hypotheses as to why certain Cu(i) binding amino acids are preferred over others in proteins expressed at different pH and exposed to oxidative environments. The results also have implications for interpreting site-directed mutagenesis studies aimed at identifying copper bindin...
|
PMID: 21553704
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)6 2011
Abstract
I was compared with that of clopidogrel bisulfate form II in 12 male Sprague-Dawley rats. The rats, randomly divided into two groups, received a single oral dose of 8 mg/kg clopidogrel (CP) bisulfate form I and form II, respectively, under fasting condition. The plasma concentrations of CP and its i...
|
PMID: 21827046
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)6 2011
Abstract
New 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only esters derived from ferrocenylformic acid were acti...
|
PMID: 21827047
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
A sensitive and specific liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) method was developed and validated for the identification and quantification of voriconazole (VRC, CAS 137234-62-9) in human plasma. Following liquid-liquid extraction, VRC and lorata...
|
PMID: 21428249
PDF is available here.
PDF is available here.
Abstract
Redox-dependent thylakoid protein phosphorylation regulates both the short- and long-term acclimation of the photosynthetic apparatus to changes in environmental conditions. The major thylakoid phosphoproteins belong to photosystem II (D1, D2, CP43, PsbH) and its light-harvesting antenna (Lhcb1, Lhc...
|
PMID: 20960130
PDF is available here.
PDF is available here.
Abstract
Atrial fibrillation (AF) is the most common form of arrhythmia encountered in clinical practice, and contributes to cardiovascular morbidity and mortality. Despite significant advances in the understanding of the mechanisms associated with AF, the number of effective biomarkers and v...
|
PMID: 21468545
PDF is available here.
PDF is available here.
Abstract
We performed two-dimensional polyacrylamide gel electrophoresis to determine differentially expressed proteins. Peptides of interest were further analysed by mass spectrometry and Mascot software was employed to identify protein matches.
Our data showed that ATP synthase D chain, ubi...
|
PMID: 20859605
PDF is available here.
PDF is available here.
Abstract
We use liquid chromatography with electrospray ionization tandem mass spectrometry to show that the C. elegans insulin/FOXO pathway regulates the metabolism of locally acting lipid hormones called prostaglandins. C. elegans prostaglandins are synthesized without prostaglandin G/H synthase homologs,...
|
PMID: 21145501
PDF is available here.
PDF is available here.
Abstract
We have verified that such heterogeneity exists in PCI purified from single individuals, and that individuals of two different ethnicities possess a similar PCI pattern, verifying that the micro-heterogeneity is conserved among humans. Furthermore, we have provided experimental evidence that PCI in...
|
PMID: 21056543
PDF is available here.
PDF is available here.
Abstract
We observe that on titration of ligand there are characteristic 'charge-state shifts' which manifest as changes in the relative intensities of protein peaks that correlate with the degree of protein-ligand complex formation. We suggest that use of this phenomenon will be particularly suitable for th...
|
PMID: 21056549
PDF is available here.
PDF is available here.
Abstract
(Spectro-)electrochemical results demonstrate ligand-centred hydride ion-carrier capacity for a Rh(I) complex of a novel 'non-innocent' N-heterocyclic carbene ligand created by nicotinamide functionalisation.
|
PMID: 20922240
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1801)12 2010
Abstract
Adipokines have been reported to contribute to glomerular injury during obesity or diabetes mellitus. However, the mechanisms mediating the actions of various adipokines on the kidney remained elusive. The present study was performed to determine whether acid sphingomyelinase (ASM)-ceramide associat...
|
PMID: 20858552
PDF is available here.
PDF is available here.
Innate Immunity (16)6 2010
Abstract
Cystic fibrosis is an autosomal recessive disorder and it is characterised by chronic bacterial airway infection which leads to progressive lung deterioration, sometimes with fatal outcome. Burkholderia multivorans and Burkholderia cenocepacia are the species responsible for most of...
|
PMID: 19880661
PDF is available here.
PDF is available here.
AAPS Journal (12)4 2010
Abstract
We have developed a new nanoparticle technology that can, in one step, capture, concentrate, and separate the peptidome from high-abundance blood proteins. Herein, we describe an initial pilot study whereby the peptidome content of ovarian and prostate cancer patients is investigated with this metho...
|
PMID: 20549403
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)12 2010
Abstract
Journal of Antibiotics (63)12 2010
Abstract
Journal of Antibiotics (63)12 2010
Abstract
Journal of Antibiotics (63)12 2010
Abstract
We isolated a small compound from the fermentation broth of Penicillium verruculosum CR37010. This compound, named decalpenic acid, bears a decalin moiety with a tetraenoic acid side chain. Treatment of C3H10T1/2 cells with decalpenic acid alone induced the expression of early osteoblast markers, su...
|
PMID: 20940725
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)12 2010
Abstract
Journal of Antibiotics (63)12 2010
Abstract
Treatment of a variety of tetracyclines (tigecycline, minocycline, tetracycline and doxycycline) with Ag(2)CO(3)/EDTA or Hg(OAc)(2) cleanly gave the 4,11a-bridged derivatives in high yields. The reactions proceeded through a novel, intramolecular Mannich cyclization of an iminium species generated b...
|
PMID: 20978515
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)12 2010
Abstract
Two new alkaloids, dysideanins A (1) and B (2), along with two known diketopiperazines, cyclo-(Pro-Leu) (3) and cyclo-(Pro-Ile) (4), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B (2) exhibited antibacterial activity. The thiom...
|
PMID: 21063424
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
Chondrocytes are the only cell type present in mature articular cartilage (2-5% of total tissue). The biological activities of the chondrocyte population are regulated by genetic, biologic and biochemical factors, as well as environmental factors (stress, flow and electric field). Although compressi...
|
PMID: 21077246
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
A rapid, sensitive and selective liquid chromatography/tandem mass spectrometry method (LC-MS/MS) was developed and validated for simultaneous determination of albiflorin and paeoniflorin in rat plasma using geniposide as an internal standard. Plasma samples were extracted by solid-phase extraction....
|
PMID: 21077251
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
A simple, high-throughput and specific high-performance liquid chromatography tandem mass spectrometry method has been developed and validated according to the FDA guidelines for simultaneous quantification of olmesartan and pioglitazone in rat plasma. The bioanalytical method consists of liquid-liq...
|
PMID: 21077253
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
A high-throughput liquid chromatography-electrospray ionization mass spectrometric (LC-ESI-MS) method for screening of sirolimus on dried blood spots (DBS) was developed and validated. It involves solvent extraction of a punch of DBS followed by reversed-phase LC on a relatively new monolithic colum...
|
PMID: 21077255
PDF is available here.
PDF is available here.