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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Spectrometry, Mass, Electrospray Ionization (0):
Recent article
Spectrometry, Mass, Electrospray Ionization
Biomedical Chromatography (24)12 2010
Abstract
Maraviroc is a first-in-class CCR5 antagonist that shows potent anti-HIV-1 activity in vitro and in vivo and is well tolerated in both healthy volunteers and HIV-1-infected patients. The method for determination of maraviroc (UK-427,857) and its major metabolite (UK-408,027) in human plasma consists...
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PMID: 21077250
PDF is available here.
PDF is available here.
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Abstract
I = 0.20 M (KCl)) and the metal ion binding strengths of the ligands are discussed. It was found that ligands with two low basicity O donors (oxalic and cyclobutane-1,1-dicarboxylic acid) bind the metal ion at acidic conditions but are not able to prevent the hydrolysis at physiologically relevant c...
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PMID: 20922244
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
An efficient method for highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids was developed via indium mediated allylation of (R)-phenylglycinol methyl ether based imines of trifluoropyruvate in good yields with high diastereoselectivities at room temperature; to illust...
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PMID: 20856962
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (~2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.
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PMID: 20865197
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
The first ratiometric fluorescent probe for hydroxyl radical ratiometric imaging in living cells was rationally designed based on a hybrid coumarin-cyanine platform.
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PMID: 20856981
PDF is available here.
PDF is available here.
Abstract
We have shown that the presence of 3-nitrotyrosine within a peptide sequence severely depletes the peptide backbone fragments typically observed following electron capture dissociation (ECD) mass spectrometry. Instead, ECD of nitrated peptides is characterised by abundant losses of small neutrals (h...
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PMID: 20830387
PDF is available here.
PDF is available here.
Abstract
We used IRMPD spectroscopy and ion mobility spectrometry to assess whether i-motif structures were preserved in the gas phase. We first investigated the IRMPD spectral signature of the tetramer [dC(6)](4), which can only be formed via C-H(+)-C base pairing, compared to the single strand dC(6). The I...
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PMID: 20838693
PDF is available here.
PDF is available here.
Abstract
We investigate whether "supercharging" reagents able to shift the charge state distributions (CSDs) of electrosprayed protein ions upward also influence gas-phase protein structure. A differential mobility analyzer and a mass spectrometer are combined in series (DMA-MS) to measure the mass and mobil...
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PMID: 20877871
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that ESI-MS is unique amongst other techniques in capturing intermediary metallospecies that evolve during the course of metal transfer to the chelator EDTA, as a model reaction to mimic the biological function of the protein as a zinc donor. Zinc release from the two-domain protein E(C) app...
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PMID: 20877787
PDF is available here.
PDF is available here.
Abstract
Negative ion electrospray mass spectra of the peptides produced by tryptic and chymotrypsin digests of bovine insulin, and from the tryptic digest of lysozyme identify at least 80% of the sequences of these proteins. In particular, negative ion mass spectrometry identifies and positions disulfide mo...
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PMID: 20835491
PDF is available here.
PDF is available here.
Abstract
A rapid, simple and sensitive multi-residue method was developed and validated for the simultaneous quantification and confirmation of 69 pesticides in fruit and vegetables using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The samples were extracted following the quick, easy, cheap, e...
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PMID: 20730643
PDF is available here.
PDF is available here.
Abstract
We have examined the antimalarial structure-activity relationship of a series of methoxylated chalcones (A-CHCH-CO-B) against Plasmodium falciparum (3D7 strain) using fluorescence-based SYBR Green assay. Our study has revealed that electron releasing methoxy groups on ring A and electron withdrawing...
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PMID: 20863599
PDF is available here.
PDF is available here.
Abstract
New binuclear double-stranded helicates were formed between manganese(ii) perchlorate and chiral phenyl- and polyphenyl-bridged oligopyridines; they are active catalysts for alkene epoxidation.
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PMID: 20830406
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
Serum samples from kidney cancer patients and healthy controls were analyzed by both direct infusion mass spectrometry (DIMS) and liquid chromatography-mass spectrometry (LC-MS) with a high resolution ESI-Q-TOFMS. The classification and biomarker discovery capacities of the two methods were compared...
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PMID: 20856980
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
We describe profiling of human plasma with liquid chromatography (LC) coupled to Fourier-transform mass spectrometry (FTMS). FTMS is a high-resolution mass spectrometer providing mass accuracy and resolution to discriminate thousands of m/z features, which are peaks defined by m/z, retention time an...
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PMID: 20838665
PDF is available here.
PDF is available here.
Abstract
We demonstrate that effective identification and characterization of both peptides and glycopeptides mixtures, and their constituent glycan structures, can be achieved from a single sample injection event....
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PMID: 19882125
PDF is available here.
PDF is available here.
Abstract
Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification. Moreover, the differential activation potency of bile acids on FXR, which is du...
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PMID: 20869337
PDF is available here.
PDF is available here.
Abstract
As³+ bound to the two-domain, recombinant human metallothionein (isoform 1a) is stable at pH 7 and translocates via protein-protein interactions to other metallothionein proteins. The data show As³+ transfer from the two-domain β-α-hMT to binding sites in the isolated apo-β-hMT and apo-α-hMT....
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PMID: 20833145
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
Our present results suggested that 1-BB could cause hepatotoxicity as well as depletion of GSH content, due to the formation of GSH conjugates with 1-BB in mice.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20600521
PDF is available here.
PDF is available here.
Abstract
Fitoterapia (81)6 2010
Rapid profiling and target analysis of principal components in Fuling Decoctions by UFLC-DAD-ESI-MS.
Abstract
The traditional Chinese medicine formula Fuling Decoction (FD) has been clinically used for eczema treatment, but the unclear chemical distribution and the lack of quality control have strongly restricted its application. In this study, an analytical method incorporating ultra-fast liquid chromatogr...
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PMID: 20362035
PDF is available here.
PDF is available here.
Abstract
Quantitative phytochelatin (PC) analysis is, due to oxidation sensitivity of the PCs, matrix effects, and time consuming sample preparation, still a challenging analytical task. In this study, a rapid, simple, and sensitive method for precise determination of native PCs in crude extracts of the gree...
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PMID: 20632163
PDF is available here.
PDF is available here.
Abstract
We have studied an embryo-specific, zinc-binding metallothionein (E(C)) from wheat by nuclear magnetic resonance, electrospray mass spectrometry, site-directed mutagenesis, and molecular modelling. Wheat E(C) exploits differences in affinities of Cys(4) and Cys(2)His(2) sites for Cd(2+) and Zn(2+) t...
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PMID: 20467686
PDF is available here.
PDF is available here.
Abstract
A simple, sensitive, selective and reproducible method based on high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (LC/MS) was developed for the determination of a macrolide antibiotic azithromycin in human plasma. The internal standard (roxithromycin) was separa...
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PMID: 21073024
PDF is available here.
PDF is available here.