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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Circular Dichroism (0):
Recent article
Circular Dichroism
Abstract
The new poly-imidazole N(8) ligand (S)-2-piperazinemethanamine-1,4-bis[2-((N-(1-acetoxy-3-(1-methyl-1H-imidazol-4-yl))-2-(S)-propyl)-(N-(1-methyl-1H-imidazol-2-ylmethyl)))ethyl]-N-(phenylmethyl)-N-(acetoxy), also named (S)-Pz-(C2-(HisIm))(2) (L), containing three chiral (S) centers, was obtained by a...
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PMID: 21298193
PDF is available here.
PDF is available here.
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Abstract
We report our studies carried out on the interaction between IMP and gelatin in aqueous medium at 25°C using conductimetry, surface tensiometry and circular dichroism (CD) techniques. Both surface tensiometry and conductimetry results indicate that the drug interacts with the gelatin in a surfactan...
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PMID: 20870394
PDF is available here.
PDF is available here.
Abstract
Biochimica et Biophysica Acta (1808)4 2011
Abstract
A pronounced membrane selectivity is demonstrated for short, hydrophilic, and highly charged antimicrobial peptides, end-tagged with aromatic amino acid stretches. The mechanisms underlying this were investigated by a method combination of fluorescence and CD spectroscopy, ellipsometry, and Langmuir...
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PMID: 21192916
PDF is available here.
PDF is available here.
Abstract
We examined the conformational transitions in a multimeric and high molecular weight class II α-mannosidase from Canavalia ensiformis (Jack Bean) (Jbα-man) utilizing intrinsic fluorescence, solute quenching, hydrophobic dye binding, size exclusion chromatography and circular dichroism (CD) spectro...
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PMID: 21087596
PDF is available here.
PDF is available here.
Abstract
Supramolecular aggregates obtained by self-aggregation of five new cationic amphiphilic CCK8 peptides have been obtained in water solution and characterized for: (i) aggregate structure and stability; (ii) CCK8 peptide conformation and bioavailability on the external aggregate surfac...
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PMID: 21157624
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
Abstract
We present the three-dimensional structure of the complex between a cytosolic domain of Pex3p and the binding-region peptide of Pex19p. The overall shape of Pex3p is a prolate spheroid with a novel fold, the 'twisted six-helix bundle.' The Pex19p-binding site is at an apex of the Pex3p spheroid. A 1...
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PMID: 21102411
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)3 2011
Abstract
We report the solubilization of caleosin and of two oleosins in aqueous solution, using various detergents or original amphiphilic polymers, amphipols. All three proteins, insoluble in water buffers, were maintained soluble either by anionic detergents or amphipols. Neutral detergents were ineffecti...
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PMID: 21146495
PDF is available here.
PDF is available here.
Abstract
We briefly describe the general self-assembly of the rod amphiphiles based on a rigid-flexible molecular architecture in aqueous solution. We then highlight the structural changes and the optical/macroscopic switching that occurs in the aqueous assemblies in response to the external signals. For exa...
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PMID: 21128602
PDF is available here.
PDF is available here.
Abstract
We have compared antibacterial activities, outer and inner membrane permeabilizations, LPS binding affinity, perturbation of LPS micelles structures by MSI-594 and MSI-594F5A peptides. Our results demonstrated that the MSI-594F5A has lower activities against Gram-negative bacteria, due to limited pe...
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PMID: 21128620
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)3 2011
Abstract
We examine how the structure and membrane interaction of aurein 2.2 and some of its variants depend on the choice of lipids, and how these models correlate with activity data in intact bacteria (MICs, membrane depolarization). Specifically, we investigated the structure and membrane interaction of a...
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PMID: 21144817
PDF is available here.
PDF is available here.
Abstract
We have designed several peptidomimetics to inhibit HER2-mediated signaling for cell growth. One of the compounds (HERP5, Arg-beta Naph-Phe) exhibited antiproliferative activity with IC(50) values in the micromolar-to-nanomolar range in breast cancer cell lines. Binding of fluorescently labeled HERP...
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PMID: 20919746
PDF is available here.
PDF is available here.
Abstract
Angiogenin is one of the more potent angiogenic factors known, whose activity may be affected by the presence of copper ions. Copper(II) complexes with the peptides encompassing the putative endothelial cell binding domain of angiogenin, Ac-KNGNPHREN-NH(2) and Ac-PHREN-NH(2), have been characterized...
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PMID: 20941439
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)4 2011
Abstract
These results suggest that the PLM cytoplasmic domain populates NKA-associated and membrane-associated states in dynamic equilibrium and that phosphorylation may alter the position of the equilibrium. Interestingly, peptides representing the cytoplasmic domains of two other FXYD proteins, Mat-8 (FXY...
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PMID: 21130070
PDF is available here.
PDF is available here.
Abstract
We report a structural and functional study of cold shock protein A from Mycobacterium tuberculosis, MTB-CspA. Structural investigations by CD and NMR reveal that MTB-CspA is less ordered than expected and is the least thermal stable cold shock protein so far characterized. However, electrophoretic...
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PMID: 20977881
PDF is available here.
PDF is available here.
Abstract
We studied the effect of Mg(2+) on G-quadruplex DNA with CD, FRET, EMSA, and PCR-stop assay. We found that various G-quadruplexes could be differentiated through simultaneous addition of both K(+) and Mg(2+), which could be used for selective identification of G-quadruplexes in promoter oncogene but...
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PMID: 20971074
PDF is available here.
PDF is available here.
Abstract
Building on our previous results that revealed a sized based mechanism for dendrimer/protein binding, the mechanism of complexation is further probed using CD spectroscopy; the results demonstrate that dendrimer/protein binding is not accompanied by changes in the protein's structure and that bindin...
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PMID: 20862438
PDF is available here.
PDF is available here.
Abstract
High-affinity human serum albumin (HSA) binding of the C3-substituted antimalarial 2-hydroxy-1,4-naphthoquinone derivative atovaquone (ATQ) has been demonstrated and studied by circular dichroism (CD), UV/VIS absorption, fluorescence spectroscopy and affinity chromatography methods. The analysis of...
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PMID: 20737064
PDF is available here.
PDF is available here.
Abstract
In order to test the pseudo-γ-turn forming capability of β-homo-proline (β(3)-HPro) 2-[(2S)-1-acetylpyrrolidin-2-yl]-N-methylacetamide (Ac-β(3)-HPro-NHMe) was synthesized and its potential energy landscape was investigated by infrared (IR) and vibrational circular dichroism (VCD) spectroscopy co...
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PMID: 20852799
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)11 2010
Abstract
The aim of the present study was to fabricate polycaprolactone-based nanofibrous scaffolds with incorporated protein via either the blend or coaxial electrospinning technique. Both techniques were compared with respect to processing set-up and scaffold characteristics as well as the...
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PMID: 20594971
PDF is available here.
PDF is available here.
Abstract
A straightforward strategy is reported for chiral discrimination in a specified carotenoid using a CD band, which is insensitive to conformational changes, computed by quantum chemical calculation.
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PMID: 21213969
PDF is available here.
PDF is available here.
Abstract
New binuclear double-stranded helicates were formed between manganese(ii) perchlorate and chiral phenyl- and polyphenyl-bridged oligopyridines; they are active catalysts for alkene epoxidation.
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PMID: 20830406
PDF is available here.
PDF is available here.
Abstract
We extend such work to flexible, multidomain proteins and one of the most widespread membrane transporter families, the major facilitator superfamily, thus showing that more complex membrane proteins can be successfully refolded to recover native substrate binding. We determine the unfolding free en...
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PMID: 20937906
PDF is available here.
PDF is available here.
Abstract
The base specificity and energetics of DNA binding of the phenazinium dyes phenosafranine and safranine-O have been studied using various biophysical tools. The guanine-cytosine base specificity of both compounds was established from binding affinity values and competition dialysis results and also...
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PMID: 20730145
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We engineered a series of mutant CaMs designed to individually increase the Ca²(+) affinity of each of CaM's EF-hands by increasing the number of acidic residues in Ca²(+)-chelating positions. Domain-specific Ca²(+) affinities of each CaM variant were determined by equilibrium fluorescence titrat...
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PMID: 20815817
PDF is available here.
PDF is available here.