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Electron Spin Resonance Spectroscopy (0):
Recent article
Electron Spin Resonance Spectroscopy
Abstract
We investigate the possible linkage between ROS, β-catenin and arsenic induced transformation and tumorigenesis in human colorectal adenocarcinoma cell line, DLD1 cells. Our results show that arsenic was able to activate p47(phox) and p67(phox), two key proteins for activation of NADPH oxidase. Ars...
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PMID: 21854796
PDF is available here.
PDF is available here.
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Fungal Biology (115)10 2011
Abstract
Our aim was to investigate the response of selected yeasts and yeast-like fungi from extreme environments to various temperatures at the level of their plasma membranes, in order to elucidate the connections between their plasma-membrane fluidity (measured by electron paramagnetic resonance spectro...
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PMID: 21944207
PDF is available here.
PDF is available here.
Molecular BioSystems (7)9 2011
Abstract
PELDOR (pulsed electron-electron double resonance) spectroscopy was applied to determine spin-spin distances in spin-labeled DNA duplexes (13-mer and 17-mer) containing the damaged sites 8-oxoguanine or uncleavable abasic site analogue tetrahydrofuran. The lesions were located in one...
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PMID: 21731955
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)10 2011
Abstract
We perform an EPR study on the role played by the membrane composition in tuning the interaction between lipid bilayers and two peptides, gH626-644 and gB632-650, that are highly fusogenic fragments of the gH and gB glycoproteins of herpes simplex virus. Our results show that both peptides interact...
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PMID: 21798233
PDF is available here.
PDF is available here.
Abstract
We show that studying biomolecular structures in nano-confinements improves the accuracy of cryostructures and provides better insight into the relationship between hydration water and biomolecules. Synthetic prion protein peptides are studied in two experimental conditions: (i) in confined nanochan...
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PMID: 21844377
PDF is available here.
PDF is available here.
Abstract
To date, there are only a few, non-evidence based, cerebroprotective therapeutic strategies for treatment and, accordingly, for prevention of secondary brain injuries following severe closed head trauma. In order to develop new therapy strategies, existing realistic animal models nee...
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PMID: 21739409
PDF is available here.
PDF is available here.
Abstract
We report a solid-state photochemical rearrangement reaction by which aromatic N-chloroamides exposed to UV light or sunlight are rapidly and efficiently converted to chloroaromatic amides. The course, the intermediate (nascent chlorine vs dichlorine) and the outcome of the reaction depend on the exc...
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PMID: 21612242
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)11 2011
Abstract
[Fe(4)S(4)]- and [Fe(3)S(4)]-clusters are ubiquitous iron-sulfur motifs in biological systems. The [Fe(3)S(4)] composition is, however, of much lower natural abundance than the more typical [Fe(4)S(4)]-clusters. In the present study formation of [Fe(3)S(4)]-clusters has been examined using chemically...
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PMID: 21756871
PDF is available here.
PDF is available here.
Abstract
We have specifically assigned the hyperfine interactions in a reaction intermediate. These results help clarify the nature of the reaction intermediate, supporting a direct interaction between the unique fourth Fe in the cluster and C2 and O3 of the ligand....
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PMID: 21574560
PDF is available here.
PDF is available here.
Abstract
We show that the mechanism revealed for activation of the wild-type complex, namely an outward tilt motion of the cytoplasmic part of the receptor helix F and a concomitant rotation of the transmembrane transducer helix TM2, is also valid for the D75N variant. Apparently, the D75N mutation shifts th...
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PMID: 21539797
PDF is available here.
PDF is available here.
Abstract
We found unstable microscopic domains (compositional/phase fluctuations) in the absence of ceramide, and macroscopically separated fluid and gel phases upon addition of ceramide. We also observed phase fluctuations in the presence of ceramide within the broad phase transition regions. We compare our...
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PMID: 21539783
PDF is available here.
PDF is available here.
Abstract
We report a simplified analysis for the orientation-selective DEER data which can be applied when the orientation selection of one spin in the spin pair dominates the orientation selection of the other spin. The dipolar spectra reveal a dominant distance of 3.85 nm and a dominant orientation of the...
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PMID: 21539799
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)5 2011
Abstract
The primary aim of this study is the elucidation of the mechanism of disulfide induced alteration of ligand binding in human tear lipocalin (TL). Disulfide bonds may act as dynamic scaffolds to regulate conformational changes that alter protein function including receptor-ligand interactions. A singl...
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PMID: 21466861
PDF is available here.
PDF is available here.
Abstract
These results are consistent with a C3 α-hydroxyalkyl radical in which the p-orbital harboring the unpaired electron spin at C3 is periplanar with the C-H bonds at both C2 and C4....
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PMID: 21513273
PDF is available here.
PDF is available here.
Abstract
Two proteins involved in nitrogen fixation contain ferredoxin-type [4Fe4S] clusters that exist in paramagnetic ground state upon oxidation, a property never observed since the discovery of ferredoxins 50 years ago. This unique characteristic suggests a specific coupling in these clusters necessary fo...
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PMID: 21488637
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
We used mutants of horse heart cyt c in which each of the four Tyr residues was substituted for Phe and assessed their contribution to the peroxidase catalysis. Tyr67Phe mutation was associated with a partial loss of the oxygenase function of the cyt c/CL complex and the lowest concentration of H(2)...
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PMID: 21550335
PDF is available here.
PDF is available here.
Abstract
We have applied X-band HYSCORE, a 2D pulsed EPR technique, to characterize the exchangeable protons around the semiquinone (SQ) in the Q(A) and Q(B) sites, using samples of (15)N-labeled reaction centers, with the native high spin Fe(2+) exchanged for diamagnetic Zn(2+), prepared in (1)H(2)O and (2)...
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PMID: 21417328
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)7 2011
Abstract
The 6xHis-tag-pscA gene, which was genetically engineered to express N-terminally histidine (His)-tagged PscA, was inserted into a coding region of the recA gene in the green sulfur bacterium Chlorobaculum tepidum (C. tepidum). Although the inactivation of the recA gene strongly suppressed a homologo...
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PMID: 21420930
PDF is available here.
PDF is available here.
Abstract
To investigate the enantioselective oxidative damage of the pesticide dichlorprop (DCPP) to maize, young seedlings were exposed to solutions of DCPP enantiomers and racemate at different concentrations. Early root development was more influenced by (R)-DCPP than racemic (rac)- and (S)-DCPP. Inhibitio...
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PMID: 21401104
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)7 2011
Abstract
The electronic properties of the Mn(4)O(x)Ca cluster in the S(2) state of the oxygen-evolving complex (OEC) were studied using X- and Q-band EPR and Q-band (55)Mn-ENDOR using photosystem II preparations isolated from the thermophilic cyanobacterium T. elongatus and higher plants (spinach). The data p...
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PMID: 21406177
PDF is available here.
PDF is available here.
Abstract
The objective of this work was to study Fe distribution, and oxidative and nitrosative metabolism in Laternula elliptica for physiological analysis and interspecific comparisons. Lipid peroxidation, superoxide dismutase and catalase activity and total Fe content were estimated in the...
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PMID: 21094695
PDF is available here.
PDF is available here.
Abstract
Our data analysis also provides strong support for the notion that in the S(2) state the coordination of the Mn(III) ion is square-pyramidal (5-coordinate) or octahedral (6-coordinate) with tetragonal elongation. In addition, it is shown that only one of the currently published OEC models, the Siegb...
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PMID: 21341708
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (22)2 2011
Abstract
Doxorubicin belongs to anthracycline cytotoxic drugs and it is widely used as a major therapeutic agent in the treatment of various types of tumors. However,its therapeutic use is limited by the development of myelosuppression and cardiotoxicity after a specific cumulative dose is reached. The aim o...
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PMID: 21218605
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)4 2011
Abstract
We studied the reactions of wild type (WT) methMb and its alanine mutant at Cys110 (C110A) with H(2)O(2), particularly in the presence of reduced glutathione (GSH) which is well known as a reducing agent. The formation rates of the ferryloxo (Fe(IV)=O) species by H(2)O(2) under air were about the sa...
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PMID: 21256983
PDF is available here.
PDF is available here.
Abstract
We report (40)Ar/(39)Ar incremental heating analyses and new ESR/U-series age estimates from the "20 m terrace" at Ngandong and Jigar. Both data sets are internally consistent and provide no evidence for reworking, yet they are inconsistent with one another. The (40)Ar/(39)Ar analyses give an averag...
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PMID: 21738710
PDF is available here.
PDF is available here.
Abstract
Our results implicate that, when equipped with targeting ligands, liposomes are most suitable for the imaging of plaque-associated endothelial markers due to low background enhancement, whereas micelles, which accumulate extravascularly on a long timescale, are suited for imaging of less abundant ma...
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PMID: 20882509
PDF is available here.
PDF is available here.
Abstract
In plants, reactive oxygen species (ROS), also known as active oxygen species (AOS), are associated with normal, physiologic processes as well as with responses to adverse conditions. ROS are connected to stress in many ways: as primary elicitors, as products and propagators of oxidative damage, or...
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PMID: 20960131
PDF is available here.
PDF is available here.
Abstract
We have focused on the development of tumor pO(2) as a surrogate marker to identify the therapeutic window during metronomic chemotherapy.We report the effect of four weekly administrations of cyclophosphamide (140 mg/Kg, i.p), a chemo drug, on tumor pO(2) and growth of subcutaneous 9L tumors in SCI...
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PMID: 21445776
PDF is available here.
PDF is available here.
Abstract
We have investigated a non-invasive method to enhance tissue pO(2) of peripheral tumors using topical application of formulations with BN (Benzyl Nicotinate), a vasodilator, and have used EPR (Electron Paramagnetic Resonance) oximetry to follow its effect on tumor oxygenation.We incorporated 2.5% BN...
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PMID: 21445772
PDF is available here.
PDF is available here.
Abstract
The new poly-imidazole N(8) ligand (S)-2-piperazinemethanamine-1,4-bis[2-((N-(1-acetoxy-3-(1-methyl-1H-imidazol-4-yl))-2-(S)-propyl)-(N-(1-methyl-1H-imidazol-2-ylmethyl)))ethyl]-N-(phenylmethyl)-N-(acetoxy), also named (S)-Pz-(C2-(HisIm))(2) (L), containing three chiral (S) centers, was obtained by a...
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PMID: 21298193
PDF is available here.
PDF is available here.
Abstract
Gum of Chios mastic (Pistacia lentiscus var. chia) is a natural antimicrobial agent that has found extensive use in pharmaceutical products and as a nutritional supplement. The molecular mechanisms of its anti-inflammatory activity, however, are not clear. In this work, the potential role of antioxid...
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PMID: 21645369
PDF is available here.
PDF is available here.
Abstract
A novel interpretation of EPR spectra of the TEMPO radical in water-lipid media in terms of the model of two independent movements of nitroxil is presented. A program of the theoretical modeling of EPR spectra has been developed, and the results of its operation have been demonstrated by an example o...
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PMID: 21786695
PDF is available here.
PDF is available here.
Abstract
EPR characteristics of transient paramagnetic states photoinduced in isolated reaction centers of Rhodobacter sphaeroides R26 with intact electron transfer have been studied. It was demonstrated that the detected weak triplet state EPR signal belongs to the primary donor molecule and is populated via...
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PMID: 21786698
PDF is available here.
PDF is available here.
Abstract
Paramagnetic centers in the blood of patients with prostate adenocarcinoma have been studied prior to and after plastic orchectomy by EPR. It has been shown that significant alterations in blood paramagnetic centers occur after the surgery. These alterations point to an improvement of antioxidant pro...
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PMID: 21950079
PDF is available here.
PDF is available here.
Abstract
We have batch-fabricated cantilevers with ∼100 nm diameter nickel nanorod tips and force sensitivities of a few attonewtons at 4.2 K. The magnetic nanorods were engineered to overhang the leading edge of the cantilever, and consequently the cantilevers experience what we believe is the lowest surf...
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PMID: 21082863
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)4 2011
Abstract
These results present strong evidence that the CBD forms an integral part of the phospholipid bilayer when formed from a Chol/POPS mixture up to a mixing ratio of ~2. Interestingly, CSL in cholesterol alone (without phospholipids) when suspended in buffer does not detect formation of bilayer-like st...
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PMID: 21192917
PDF is available here.
PDF is available here.
Abstract
We present a family of trigonal pyramidal iron(II) complexes supported by tris(pyrrolyl-α-methyl)amine ligands of the general formula [M(solv)(n)][(tpa(R))Fe] (M = Na, R = tert-butyl (1), phenyl (4); M = K, R = mesityl (2), 2,4,6-triisopropylphenyl (3), 2,6-difluorophenyl (5)) and their characteriza...
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PMID: 21141856
PDF is available here.
PDF is available here.
Abstract
We investigated the high affinity binding mode of truncated aS (1-99) (aS99) with Cu(II), in a stoichiometric ratio, to elucidate the residues involved in the binding site and the role of copper ions in the protein oligomerization. We used Electron Paramagnetic Resonance spectroscopy on the Cu(II)-a...
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PMID: 21141829
PDF is available here.
PDF is available here.
Abstract
We designed a stable Cu(2+) coordination scaffold composed of a four-stranded α-helical coiled-coil structure. Two His residues and one Cys residue were situated to form the trigonal planar geometry and to coordinate the Cu(2+) in the hydrophobic core of the scaffold. The protein bound Cu(2+), disp...
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PMID: 21126081
PDF is available here.
PDF is available here.
Abstract
Abstract
Angiogenin is one of the more potent angiogenic factors known, whose activity may be affected by the presence of copper ions. Copper(II) complexes with the peptides encompassing the putative endothelial cell binding domain of angiogenin, Ac-KNGNPHREN-NH(2) and Ac-PHREN-NH(2), have been characterized...
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PMID: 20941439
PDF is available here.
PDF is available here.
Abstract
We show that exogenously added macular carotenoids can quench RPE/choroid singlet oxygen. When the singlet oxygen quenching ability of the macular carotenoids was investigated in solution, it was shown that a mixture of meso-zeaxanthin, zeaxanthin, and lutein in a ratio of 1:1:1 can quench more sing...
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PMID: 20678467
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1801)12 2010
Abstract
Adipokines have been reported to contribute to glomerular injury during obesity or diabetes mellitus. However, the mechanisms mediating the actions of various adipokines on the kidney remained elusive. The present study was performed to determine whether acid sphingomyelinase (ASM)-ceramide associat...
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PMID: 20858552
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)1 2011
Abstract
These results are explained as follows: i) bromoxynil has a lower affinity for PSII with the non-heme iron oxidized than DCMU therefore, ii) the midpoint potential of the Fe(II)/Fe(III) couple is lower with DCMU bound than with bromoxynil bound in PsbA3-PSII; and iii) the midpoint potential of the F...
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PMID: 20937242
PDF is available here.
PDF is available here.
Abstract
The Pd(3)(dppm*)(3)(CO)(n+) enantiomers (n = 2 (2), 1 (3)) were prepared either from (R,R)- or (S,S)-P-chirogenic bis(phenyl-m-xylylphosphino)methane (dppm*; 1) and Pd(OAc)(2) in the presence of CF(3)CO(2)H, CO and water (n = 2), and then by reductive electrolysis (n = 1). The stable enantiomeric [P...
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PMID: 20683535
PDF is available here.
PDF is available here.
Abstract
Four bis-phenolate complexes [Zn(II)L], [Ni(II)L], [Cu(II)L] and [Co(II)L] (where [H(2)L = 2,2'-[2,2']bipyridinyl-6-yl-bis-4,6-di-tert-butylphenol] have been synthesized. The copper(II) and nickel(II) complexes have been characterized by X-ray diffraction, showing a metal ion within a square planar...
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PMID: 20820605
PDF is available here.
PDF is available here.
Abstract
The microstructure of liposomes formed by the lipopolysaccharides (LPS) derived from Burkholderia cenocepacia ET-12 type strain LMG 16656, Burkholderia multivorans strain C1576 and Agrobacterium tumefaciens strain TT111 has been investigated by a combined experimental strategy, including dynamic lig...
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PMID: 20852798
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
We have designed a molecular system consisting of a heteroleptic [Ru(bpy)(2)L](2+) chromophore covalently linked to a Mn(III)-Salen unit. We demonstrate the light induced oxidation of the Mn(III) center in this putative photo-catalyst assembly to a Mn(IV) high spin intermediate. Both oxidation state...
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PMID: 20835470
PDF is available here.
PDF is available here.
Abstract
The hexaazamacrocycles [28](DBF)(2)N(6) {cyclo[bis(4,6-dimethyldibenzo[b,d]furaniminoethyleneiminoethylene]} and [32](DBF)(2)N(6) {cyclo[bis(4,6-dimethyldibenzo[b,d]furaniminopropyleneiminopropylene]} form stable dinuclear copper(ii) complexes suitable to behave as receptors for several anionic subs...
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PMID: 20820604
PDF is available here.
PDF is available here.
Abstract
The chemical reaction of Pt(II)(L(1))Cl(2) [L(1) = N-4-tolylpyridine-2-aldimine] with a bidentate N,S-donor atom ligand, 2-methylthioaniline, (HL(2)) in alkaline methanolic medium yielded a mixed ligand donor-acceptor complex, [Pt(II)(L(1))(L(2))]Cl, [1]Cl. The complex has been characterized by diff...
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PMID: 20733997
PDF is available here.
PDF is available here.
Abstract
We estimate the negative excess entropy (DeltaS(E)) of aqueous methanol at low temperature and high pressure using experimentally-derived structural data and a recently introduced cluster model. On cooling to 190 K the cluster sizes increase, but the change in DeltaS(E), which according to this meth...
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PMID: 20539889
PDF is available here.
PDF is available here.
Inorganic Chemistry (49)18 2010
Abstract
We have characterized two high-valent complexes [LFe(IV)(μ-O)(2)Fe(III)L], 1, and [LFe(IV)(O)(μ-O)(OH) Fe(IV)L], 4. Addition of hydroxide or fluoride to 1 produces two new complexes, 1-OH and 1-F. Electron paramagnetic resonance (EPR) and Mössbauer studies show that both complexes have an S = 1/...
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PMID: 20795646
PDF is available here.
PDF is available here.
Abstract
We used Q-cycle inhibitors of the coenzyme QH(2)-cytochrome c reductase complex to assess the electron transfer properties of coq10 cells. Our results show that coq10 mutants respond to antimycin A, indicating an active Q-cycle in these mutants, even though they are unable to transport electrons thr...
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PMID: 20875086
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
When calibrated in 60Co or MV photon beams, corrections for the photon energy dependence of detector response are needed to achieve the highest accuracy when using lithium formate EPR dosimeters for measuring absorbed doses around brachytherapy sources emitting photons in the energy range of 20-150...
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PMID: 20964214
PDF is available here.
PDF is available here.
Abstract
Penetration of the liposome membranes formed in the gel phase from DPPC (DPPC liposomes) and in the liquid-crystalline phase from egg yolk lecithin (EYL liposomes) by the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) and 16 DOXYL (2-ethyl-2-(15-methoxy-oxopentadecyl)-4,4-dimethyl-3-oxazolidinyloxy) s...
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PMID: 19857052
PDF is available here.
PDF is available here.
Abstract
We recently developed a technique for free radical and oxidative stress monitoring using the ex vivo electron spin resonance (ESR) spin trapping method in patients with neuroemergency. Blood samples were collected by catheterization of the internal jugular bulb. The alkoxyl radical level was measure...
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PMID: 19812971
PDF is available here.
PDF is available here.
Abstract
Using periodic DFT calculations, it is concluded that the stable radiation-induced alanine radical most probably is the result of reductive deamination and protonation of the detached amino group, yielding an NH(4)(+) ammonium ion and a negatively charged radical.
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PMID: 20559598
PDF is available here.
PDF is available here.
Abstract
These results showed that EPR spectroscopy can be a useful method for determining the properties of high spin oxoiron(IV) complexes. The oxoiron(IV) complex was crystallized at -35 degrees C, and its structure was determined by X-ray diffraction methods. The complex has a trigonal bipyramidal coordi...
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PMID: 20704272
PDF is available here.
PDF is available here.
Abstract
We used the relaxation-induced dipolar modulation enhancement (RIDME) technique to measure the electron spin echo envelope modulation caused by the dipole interactions between paramagnetic FMN and heme iron centers in the [Fe(III)][FMNH(*)] (FMNH(*): FMN semiquinone) form of a human inducible NOS (i...
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PMID: 20695464
PDF is available here.
PDF is available here.
Abstract
We describe integration of PRE and DEER data with conventional solution-state nuclear magnetic resonance (NMR) methods for structure determination of Dsy0195, a homodimer (62 amino acids per monomer) from Desulfitobacterium hafniense. Our results indicate that combination of conventional NMR restrai...
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PMID: 20698532
PDF is available here.
PDF is available here.