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Karnofsky Performance Status (0):
Recent article
Karnofsky Performance Status
Abstract
The results suggest that remote telehealth technology can play an important role in improving health outcomes and the cost of care of patients with end-stage renal disease who have complex healthcare needs....
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PMID: 21480788
PDF is available here.
PDF is available here.
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Abstract
Glioblastoma has a poor prognosis, with few therapeutic options if it recurs. We report a case in which we were able to inhibit the growth of a recurrent glioblastoma by weekly single-dose administration of interferon-beta.
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PMID: 21528675
PDF is available here.
PDF is available here.
Abstract
The goal of this study was to determine the effect of hyperbaric oxygen therapy on the clinical outcome of patients after resection of meningiomas with conspicuous peritumoral brain edema (PTBE).
232 patients with intracranial meningiomas and conspicuous PTBE were all...
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PMID: 21510270
PDF is available here.
PDF is available here.
Medicinski arhiv (65)2 2011
Abstract
There was no statistically significant difference in values of Karnofsky score between patients in CHOP and CHOP+R groups before the therapy (U=133; Z = -1.87; p = 0.06), although this difference was on the border of statistical significance. The values of Karnofsky score before and after the therap...
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PMID: 21585177
PDF is available here.
PDF is available here.
Journal of Neurosurgery (113 Suppl) 2010
Abstract
We identified 27 patients (39.7%) with recurrent tumor located either local or distant to the site of treatment. The median time from primary treatment of metastasis to recurrence was 10.6 months. The patients' median length of survival (interval between first treatment of cerebral metastasis and la...
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PMID: 21121791
PDF is available here.
PDF is available here.
Journal of Neurosurgery (113 Suppl) 2010
Abstract
Oligometastatic brain metastases may be treated with stereotactic radiosurgery (SRS) alone, but no consensus exists as to when SRS alone would be appropriate. A survey was conducted at 2 radiosurgery meetings to determine which factors SRS practitioners emphasize in recommending SRS alone, and what...
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PMID: 21121790
PDF is available here.
PDF is available here.
Abstract
Performance status (PS) is a good prognostic factor in lung cancer and is used to assess chemotherapy appropriateness. Researchers studying chemotherapy use are often hindered by the unavailability of PS in automated data sources. To the authors' knowledge, no attempts have been made to estimate PS u...
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PMID: 20957722
PDF is available here.
PDF is available here.
Abstract
These results suggest that RPA classification should determine whether or not WBRT is added to SRS. WBRT may be recommended to be added to SRS for patients in whom long-term survival is expected on the basis of RPA classification.
2010 Elsevier Inc. All rights reserved....
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PMID: 20097485
PDF is available here.
PDF is available here.
Abstract
Short-course WBRT with 5 × 4 Gy should be seriously considered for most patients with multiple brain metastases from bladder cancer, as it resulted in improved LC.
2010 Elsevier Inc. All rights reserved....
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PMID: 20171794
PDF is available here.
PDF is available here.
Abstract
The findings suggest that escalation of the WBRT dose beyond 10 × 3 Gy improves outcomes in patients with brain metastases from RCC. The results should be confirmed in a randomized trial stratifying for significant prognostic factors.
2010 Elsevier Inc. All rights reserved....
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PMID: 20488627
PDF is available here.
PDF is available here.
Abstract
To create and validate scoring systems for intracerebral control (IC) and overall survival (OS) of patients irradiated for brain metastases.
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PMID: 20638188
PDF is available here.
PDF is available here.
Abstract
A further decrease in the radiation dose to 30 Gy with whole-ventricle irradiation is sufficient to treat selected patients with intracranial germinoma. Wide-field irradiation or chemotherapy should be avoided as these methods are unnecessary. Thus, reduction of the radiation dose to 30 Gy may be fe...
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PMID: 19864081
PDF is available here.
PDF is available here.
Abstract
The median age was 49 years (27-80 yrs). 62 patients were having per vagina bleeding for more than 6 months before commencement of chemotherapy (range 1-60 months). 49 patients had blood transfusion before chemotherapy, average of 2.7 pints of blood transfused per patient. 84 had at least FIGO stage...
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PMID: 20539327
PDF is available here.
PDF is available here.
Supportive Care Cancer (18)5 2010
Abstract
Although inter-rater agreement was good for all three scales, physicians tended to rate patients as healthier for the PPS and ECOG. The KPS may provide greater consistency of PS ratings by different oncology professionals in clinical and research settings....
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PMID: 19629537
PDF is available here.
PDF is available here.
Bulletin du cancer (97)4 2010
Abstract
We distinguish four groups: group 1 (0 factor and age < 70 years), group 2 (1-3 factors and age < or = 60 years), group 3 (1-3 factors and age between 61 and 70 years) and group 4 (1-3 factors and age > 70 years). The patients of group 1 (N = 47) received 3 courses of CHOP regimen followed by irradi...
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PMID: 20374978
PDF is available here.
PDF is available here.
Turkish Neurosurgery (20)2 2010
Abstract
The mean survival time was 7.5 months (range, 1-18 months). We confirmed the patients' age, gender, Karnofsky Performance Scale score at discharge, postoperative radiotherapy and reoperation as decisive prognostic factors after multivariate analyses. CONCLUSION: We could show that some clinical para...
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PMID: 20401838
PDF is available here.
PDF is available here.
Abstract
After cardiovascular disease, cancer is the most common cause of death. HESA-A is a natural product of herbal and marine origin. The aim of this study was to investigate the beneficial effects of HESA-A in patients with end-stage metastatic cancers.
In this clinical t...
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PMID: 20150223
PDF is available here.
PDF is available here.
Abstract
We analyze the outcomes of 289 patients receiving allogeneic transplantation for primary myelofibrosis between 1989 and 2002, from the database of the Center for International Bone Marrow Transplant Research (CIBMTR). The median age was 47 years (range: 18-73 years). Donors were HLA identical siblin...
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PMID: 19879949
PDF is available here.
PDF is available here.
Abstract
Palliative care, which seeks to alleviate suffering and optimize quality of life, is an increasingly recognized and valued medical subspecialty. With its focus on identifying and managing symptoms and problems encountered in expected functional decline, the domain of palliative care overlaps signifi...
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PMID: 20890140
PDF is available here.
PDF is available here.
Abstract
Our experience of kalumide (bikalutamide) administration in patients with prostatic cancer agrees with the data of other investigators on a good effect of the drug on quality of life of patients with prostatic cancer.
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PMID: 20891045
PDF is available here.
PDF is available here.
Abstract
Dural sinus thrombosis after closed head injury is seen very rarely and its pathophysiological mechanisms are not yet understood. An 18-year-old man who had been crushed in an automobile had closed head injury with Glasgow Coma Score 4. Computerized tomography showed diffuse cerebral edema and right...
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PMID: 20209407
PDF is available here.
PDF is available here.
Voprosy onkologii (56)5 2010
Abstract
Data on the treatment of 278 patients with brain tumors grade III-IV were evaluated, end-results compared and relevant prognostic factors identified. In our view, average fractionated radiotherapy is not inferior to standard fractionation modalities. It offers an advantage of using different single...
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PMID: 21137236
PDF is available here.
PDF is available here.
Abstract
The addition of temozolomide to short-term radiotherapy resulted in a statistically significant survival benefit with minimal additional toxicity in poor-prognosis patients with newly diagnosed glioblastoma. Future studies need to define the best combined regimens of radiotherapy and temozolomide on...
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PMID: 20437859
PDF is available here.
PDF is available here.
Oncology Nursing Forum (37)1 2010
Abstract
To examine the influence of the proposed symptom cluster of fatigue, nausea and vomiting, and sleep disturbances on clinical outcomes defined as behavior changes, depression, and performance status in children and adolescents before and after receiving cisplatin, doxorubicin, or ifos...
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PMID: 20044328
PDF is available here.
PDF is available here.
Abstract
Three patients (11%) reached a partial response; 5 (18%) patients showed stable disease, and 20 (71%) patients progressed upon BVT therapy. Median overall survival of all 28 patients was 6 months (6-month survival rate, 52%). Patients with partial remission or stable disease (n = 8) exhibited a medi...
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PMID: 19229537
PDF is available here.
PDF is available here.
Abstract
We studied their longer term functional outcomes and recovery patterns which have not been well described. All patients admitted to the 18-bed ICU of a university-affiliated teaching hospital following drug overdoses between 1 January 2004 and 31 December 2006 were identified. With ethical approval,...
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PMID: 19775045
PDF is available here.
PDF is available here.
Supportive Care Cancer (17)6 2009
Abstract
Excellent correlation was found between the scores rated by the MD and RA (r = 0.86); good correlation was observed between scores rated by the MD and RT (r = 0.69) and the RT and RA (r = 0.77). Scores between all three raters, as well as between rater pairs, were also found to have good reliability...
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PMID: 18946683
PDF is available here.
PDF is available here.
Abstract
Controlling for income, education, gender, age, physician-assessed medical burden and physical functioning, and interviewer-assessed impairments in basic activities of daily living and physical self-maintenance, and depression, lower agreeableness and higher extroversion were each associated with in...
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PMID: 19461261
PDF is available here.
PDF is available here.
Abstract
It revealed that there was significant effect of treatment with 20 Gy radiotherapy as 76% of the patients during and 80% on the last day of therapy showed > 50% response (p < 0.05). Secondly, median survival of the patients after radiotherapy was two months (p < 0.05). No serious toxicity was noted...
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PMID: 19438128
PDF is available here.
PDF is available here.
Abstract
Oesophageal carcinoma is a frequent disease, which incidence is high and stable (6,000 new cases per year in France). Its epidemiology has changed over the last three decades, adenocarcinoma becoming the most frequent histologic subtype. It is an aggressive disease with an early lymphatic spread. Th...
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PMID: 19357013
PDF is available here.
PDF is available here.
Bulletin du cancer (96)4 2009
Abstract
Our study show that simply distributing CUP CPGs did not change practice and underline the necessity to disseminate and implement CPGs, both to oncologists and organ-specialist physicians....
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PMID: 19435692
PDF is available here.
PDF is available here.
Recursive partitioning analysis of prognostic factors for survival in patients with advanced cancer.
Abstract
The model was able to separate patients into three groups with different durations of survival that were defined by (1) KPS >60; (2) KPS
PDF is available here.
PDF is available here.
Abstract
Brain metastases are quite common during the management of lung carcinomas. Most are solid masses with necrosis and surrounding edema, whereas purely cystic lesions are uncommon and malignant cells creating the wall are usually resistant to radiotherapy, sometimes requiring neurosurgical strategies....
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PMID: 19204557
PDF is available here.
PDF is available here.
Neurosurgery (64)3 Suppl 2009
Abstract
The initial success rate of CT-guided percutaneous cordotomy was 92.5%. The success rate was higher in the malignancy group. In the cancer group, selective cordotomy (pain sensation denervated only in the painful region of the body) was achieved in 83%. In 12 cases, bilateral selective percutaneous...
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PMID: 19240568
PDF is available here.
PDF is available here.
Psychiatria Danubina (21)1 2009
Abstract
There is statistically significant correlation between anxiety and quality of life, that is, with decrease of anxiety quality of life level increases....
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PMID: 19270621
PDF is available here.
PDF is available here.
Revista Medica de Chile (137)2 2009
Abstract
HRQOL in patients on hemodialysis had values below the referential score in subjects with diabetes and coronary artery disease, poor nutritional status and a low educational and socioeconomic level. The incorporation of support professionals, such as social workers, psychologists, dieticians, coveri...
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PMID: 19543641
PDF is available here.
PDF is available here.
Archives of Neurology (66)1 2009
Abstract
A low Karnofsky performance status score predicts poor survival in patients with NM. Patients with a low Karnofsky performance status score may be best served by offering supportive care....
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PMID: 19139302
PDF is available here.
PDF is available here.
Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukrainy, Naukove tovarystvo khirurhiv Ukrainy ()7-8 2009
Abstract
Journal of Neurosurgery (110)1 2009
Abstract
The results of the present study suggest that the ANGPT1/ANGPT2 balance has prognostic value in patients with primary GBMs. The authors' findings support the need for further studies of the feasibility of antiangiogenic therapy in primary GBMs, with a special focus on the normalization of tumor vasc...
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PMID: 18991494
PDF is available here.
PDF is available here.
CANCER NURSING&trade (32)6 2009
Abstract
The purposes of this study were to identify the number and types of symptom clusters using yes/no responses from the Memorial Symptom Assessment Scale, identify the number and types of symptom clusters using severity scores from the Memorial Symptom Assessment Scale, compare the identified symptom c...
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PMID: 19816162
PDF is available here.
PDF is available here.
BMC Cancer (9)1 2009
Abstract
Overall, 20% of patients responded to treatment, for a disease control rate (DCR, responses plus stabilizations) of 47.5%. Groups A and B experienced a response rate of 40% and 26.5% respectively, while the corresponding value for group C was 10%. Out of 19 patients, MGMT promoter was found methylat...
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PMID: 19335893
PDF is available here.
PDF is available here.
Abstract
We administered a satisfaction questionnaire to patients 55 years and older with advanced medical disease and their family caregivers (FCGs). We re-interviewed approximately every two months for a maximum of four visits. Overall, 97 patients and 68 FCGs completed a baseline interview; 57 and 40 comp...
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PMID: 20131581
PDF is available here.
PDF is available here.
Voprosy onkologii (55)2 2009
[Effectiveness of treatment of single cerebral metastasis depending on prognostic groups (RPA RTOG)]
Abstract
Our investigation was aimed at establishing a relationship between single metastases in the brain and a set of prognostic factors. It involved 278 patients treated at the Center in 1983-2003. The whole brain was irradiated in 273 while 159 of them (58.2%) received additional local irradiation of the...
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PMID: 19514377
PDF is available here.
PDF is available here.
Abstract
We evaluated whether the HCT-CI and other readily available pre-transplant variables predicted NRM and OS at a Canadian transplant center. Using a prospective cohort design, we analyzed consecutive adult allogeneic HCT recipients. Of 187 patients, HCT-CI risk was low in 22 (12%), intermediate in 50...
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PMID: 18762762
PDF is available here.
PDF is available here.
Abstract
The introduction of bone cement as an adjunct to fixation of pathologic fracture improved clinical results and reduced the rate of fixation failure....
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PMID: 19773619
PDF is available here.
PDF is available here.
Abstract
Microsurgical removal of cavernous angiomas and surrounding hemosiderin plate tends to significant reduction or elimination of epileptic seizures and improved postoperative neurological status....
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PMID: 19223702
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (26)36 2008
Abstract
A training set of 395 patients, a temporal validation set of 445 patients, and an external validation set of 467 patients were used. The ability of the three- and six-variable models to separate patients into three prognostic groups and to predict their survival was similar using both SPS and NRF me...
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PMID: 19018082
PDF is available here.
PDF is available here.
Abstract
Predictors of and trajectories for evening and morning fatigue were evaluated in family caregivers of oncology patients using hierarchical linear modeling. Evening fatigue trajectory fit a quadratic model. Predictors included baseline sleep disturbances in family caregivers and baseline evening fatig...
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PMID: 19072846
PDF is available here.
PDF is available here.
Neuro-Oncology (10)6 2008
Abstract
We evaluated whether the Radiation Therapy Oncology Group recursive partitioning analysis (RTOG-RPA) would predict survival of these patients and whether there was any benefit from extensive resections depending on RPA class. A total of 243 per-protocol patients with newly diagnosed GBM were operate...
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PMID: 18667747
PDF is available here.
PDF is available here.
Abstract
In our dataset, we found that tumor size had a significant effect on postoperative blood volume. In contrast, no serious bleeding complications occurred in the patients receiving VPA. Therefore, the present study does not provide any evidence for the need to discontinue VPA medication prior to and d...
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PMID: 18937170
PDF is available here.
PDF is available here.
Abstract
Abstract
Total scores for overall QOL are equal in both treatment groups (P = 0.69). Scores for individual components are similar in both treatment groups. However, dryness of mouth is significantly worse in the chemoradiotherapy group (P = 0.01) and ability to communicate with others is poorer in the laryng...
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PMID: 18984267
PDF is available here.
PDF is available here.
Lung Cancer (62)2 2008
Abstract
Despite shorter survival, treatment toxicity was acceptable and PS 2 patients achieved better improvement of pain and dyspnea and tended to better global QOL when compared to PS 0/1 patients....
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PMID: 18417246
PDF is available here.
PDF is available here.
Abstract
We reported on the case of a patient with lung cancer presenting with mildly abundant haemoptysis, who was hospitalised in intensive care. After multidisciplinary discussion, the patient was intubated following recurrent haemorrhage that resulted in respiratory failure. The outcome was favourable. F...
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PMID: 18995155
PDF is available here.
PDF is available here.
Abstract
Fatigue is a common chronic problem for older cancer patients and may represent a major cause of functional dependence....
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PMID: 18838877
PDF is available here.
PDF is available here.
Turkish Neurosurgery (18)4 2008
Abstract
Median cumulative survival time for all the patients with LGG was 141+/-14.83 months. Median survival time was 216+/-78.52 months for astrocytoma Grade I; 115+/-8.22 months for astrocytoma Grade II, and 242+/-76.36 months for oligodendroglioma. Young age, histology subtype (oligodendroglioma) and pr...
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PMID: 19107679
PDF is available here.
PDF is available here.
Abstract
Targeting the epidermal growth factor receptor (EGFR) may be effective in a subset of glioblastoma patients. This phase II study assessed the clinical activity of erlotinib plus carboplatin and to determine molecular predictors of response. The primary endpoint was progression free survival (PFS). P...
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PMID: 18581057
PDF is available here.
PDF is available here.
Abstract
The "surprise" question is effective in identifying sicker dialysis patients who have a high risk for early mortality and should receive priority for palliative care interventions....
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PMID: 18596118
PDF is available here.
PDF is available here.
Panminerva Medica (50)3 2008
Abstract
Twenty five radiotherapy patients receiving Pycnogenol showed a decreased frequency of essentially all investigated side-effects as compared to 21 patients receiving placebo, though in many categories the difference was limited. The most apparent improvements of acute side effects related to decreas...
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PMID: 18927527
PDF is available here.
PDF is available here.
Lancet Oncology (9)9 2008
Abstract