Abstract
Functional mitral regurgitation (FMR) is a common finding in patients with heart failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies sample sizes were relatively small and semiquantitative methods for FMR grading were used.
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PMID: 21807656
PDF is available here.
Rodrigo R Bagur,
Juan Maria JM Manazzoni,
Éric É Dumont,
Daniel D Doyle,
Jean J Perron,
François F Dagenais,
Patrick P Mathieu,
Richard R Baillot,
Éric É Charbonneau,
Jacques J Metrás,
Siamak S Mohammadi,
Mélanie M Côté,
François F Philippon,
Pierre P Voisine and
Josep J Rodés-Cabau
Abstract
To assess the incidence of conduction disturbances leading to permanent pacemaker implantation (PPI) following isolated aortic valve replacement (AVR) in a large cohort of elderly patients with severe symptomatic aortic stenosis, and to determine the predictive factors and prognostic value of PPI fol...
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PMID: 21828221
PDF is available here.
Abstract
We determined that infection with CM3.1 resulted in a significantly reduced frequency and absolute number of neutrophils in the oviducts during acute infection. This reduction in neutrophils was associated with significantly lower levels of neutrophil chemokines in the oviducts and decreased product...
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PMID: 21825059
PDF is available here.
Abstract
We present our early experience with an attempt to optimize extracorporeal membrane oxygenation, emphasizing reduced adjunctive mechanical ventilatory support and aggressive rehabilitation, with a goal of ambulation. This strategy has been enabled by the introduction of a dual-lumen draw and return...
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PMID: 21924145
PDF is available here.
Abstract
The evaluation of peritoneal CT attenuation values in patients with peritonitis is simple and can be used for objective assessment of the severity of peritonitis.
Copyright © 2011 Elsevier Inc. All rights reserved....
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PMID: 21943948
PDF is available here.
Abstract
To our knowledge, our findings provide novel evidence to support the hypothesis of a mild iron overload in patients with prediabetes and T2D. A cohort study concerned with the effect of the attenuation of excess iron on glucose metabolism in a prediabetic population is warranted....
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PMID: 21880847
PDF is available here.
Abstract
Approximately 5% of Canadians are vitamin B-12 deficient. One percent of adult Canadians have metabolic vitamin B-12 deficiency, as evidenced by combined vitamin B-12 deficiency and high tHcy status. In a folate-replete population, vitamin B-12 is a major determinant of tHcy....
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PMID: 21900461
PDF is available here.
Abstract
The reported prevalence of hepatopulmonary syndrome (HPS) in cirrhotic patients is heterogeneous. Although the prevalence of chronic liver diseases is high in Egypt, however, scanty data is available about HPS.
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PMID: 21922852
PDF is available here.
Abstract
Multiple lines of evidence from a total of six sets of safety data, with treatment for up to 5 years, including results from all adalimumab-treated patients, and a subset of patients treated with 40 mg eow dosing, did not show evidence of cumulative toxicity, and showed adverse event rates that we...
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PMID: 21834597
PDF is available here.
Abstract
In 1989, there were 19,000 patients on the UNOS (United Network of Organ Sharing) wait list for organs compared to 110,000 today. Without an equivalent increase in donors, the patients awaiting these organs for transplant face increasing severity of illness and risk of dying without receiving a trans...
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PMID: 21905444
PDF is available here.
Abstract
We summarize data on the economic consequences of liver and renal allograft quality in contemporary practice. Policy makers and providers must work together to ensure that financial disincentives do not lead to wastage of lifesaving organs....
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PMID: 21905445
PDF is available here.
David J Thurman,
Ettore Beghi,
Charles E Begley,
Anne T Berg,
Jeffrey R Buchhalter,
Ding Ding,
Dale C Hesdorffer,
W Allen Hauser,
Lewis Kazis,
Rosemarie Kobau,
Barbara Kroner,
David Labiner,
Kore Liow,
Giancarlo Logroscino,
Marco T Medina,
Charles R Newton,
Karen Parko,
Angelia Paschal,
Pierre-Marie Preux,
Josemir W Sander,
Anbesaw Selassie,
William Theodore,
Torbjörn Tomson and
Samuel Wiebe
Abstract
We discuss: (1) conceptual and operational definitions of epilepsy, (2) data resources and recommended data elements, and (3) methods and analyses appropriate for epidemiologic studies or the surveillance of epilepsy. Variations in these are considered, taking into account differing resource availab...
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PMID: 21899536
PDF is available here.
Abstract
This article summarises the key points from the 2011 British Thoracic Society (BTS) recommendations on managing passengers with respiratory disease planning air travel. The guidance aims to provide practical advice for respiratory specialists in secondary care and serves as a valuable reference for o...
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PMID: 21807654
PDF is available here.
Abstract
Background. Efficient host defense mechanisms are crucial for survival in sepsis and septic arthritis. S100 proteins are reported to have proinflammatory and bactericidal properties. The aim of this study was to investigate the role of S100A4 in staphylococcal arthritis. Methods. S100A4 knockout...
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PMID: 21844298
PDF is available here.
Abstract
Hilar cholangiocarcinoma (HC) is invariably fatal without surgical intervention. The primary aim of the current study was to report overall survival and recurrence-free survival outcomes after surgical resection of HC.
Between December 1992 and December 2009, 85 patie...
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PMID: 21871986
PDF is available here.
Abstract
A previous multicenter randomized trial demonstrated that mechanical bowel preparation (MBP) does not guard against anastomotic leakage in elective colorectal surgery. The aim of this complementary study was to evaluate the effects of MBP on morbidity and mortality after anastomotic...
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PMID: 21871987
PDF is available here.
Abstract
Chronic obstructive pulmonary disease (COPD) is often associated with changes of the structure and the function of the right ventricle (RV). Therefore, the assessment of right ventricular function and myocardial mass (MM) is clinically important for the evaluation of the severity of COPD, which may p...
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PMID: 21852436
PDF is available here.
Abstract
Predictors of quality of life can define potentially modifiable factors to increase favorable outcomes after pediatric stroke. Quality of life was measured using the Centre for Health Promotion's Quality of Life Profile (CHP-QOL) in 112 children surviving arterial ischemic stroke or cerebral sinoveno...
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PMID: 21836124
PDF is available here.
Abstract
We conducted this study to examine the reproductive health status and depression levels of women who live in sanctuary houses after being subjected to domestic violence. The total number of women in the study is 65. Data were collected via descriptive, violence, and women's reproductive health proble...
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PMID: 21834719
PDF is available here.
Cristina C Sala,
Maria M Grau,
Rafel R Masia,
Joan J Vila,
Isaac I Subirana,
Rafel R Ramos,
Jaime J Aboal,
Ariadna A Sureda,
Ramon R Brugada,
Jaume J Marrugat,
Joan J Sala and
Roberto R Elosua
Abstract
We sought to analyze the trends in first Q-wave acute myocardial infarction (AMI) case fatality from 1978 to 2007 in a population-based hospital register, to determine the variables related to these changes, and to assess the effectiveness of current AMI management.
Population-based...
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PMID: 21884859
PDF is available here.
Abstract
We hypothesized that the increased prevalence of CVD among Indian Asians would be reflected by their having a greater burden of subclinical carotid artery atherosclerosis compared with European whites.
We studied 2,288 healthy subjects and 148 patients with known CVD from the London...
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PMID: 21884861
PDF is available here.
Abstract
We compared symptoms, function, and QOL in SA and European Canadians with CAD using the Seattle Angina Questionnaire (SAQ).
Using the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease, an outcomes registry that captures patients undergoing cardiac catheteri...
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PMID: 21884867
PDF is available here.
Abstract
High-degree atrioventricular block (HAVB) is a frequent complication in the acute stages of a myocardial infarction associated with an increased rate of mortality. However, the incidence and clinical significance of HAVB in late convalescent phases of an AMI is largely unknown. The a...
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PMID: 21884874
PDF is available here.
Abstract
Objectives. To evaluate the effectiveness of a two session guided self-help (GSH) intervention provided by primary care graduate mental health workers (PCGMHWs) in a primary care mental health service. Design. Pragmatic randomized trial, with a wait list control design. Method. Patients present...
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PMID: 21810108
PDF is available here.
Abstract
This observational study aimed to identify simple electroencephalogram indices of inadequate intraoperative opioid-mediated nociceptive blockade and to compare these indices with routinely used clinical predictors of severe postoperative pain in adults. Intraoperative trend and waveform data (electro...
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PMID: 21970132
PDF is available here.
Abstract
The aim of this study was to address whether NP might be a predictive factor for severity of CF. The authors collected data from the literature on NP as a unique or associated sign in CF and reviewed the clinical and molecular aspects of CF associated with NP. CF genotypes and clinical severity in NP...
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PMID: 21858268
PDF is available here.
Abstract
Experimental evidences have shown that tumor necrosis factor (TNF)-α may play a role in the pathogenesis of nonsegmental vitiligo, and successful cases of vitiligo treated with TNF-α inhibitors have been recently reported.
Two cases of refractory generalized vitilig...
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PMID: 21388239
PDF is available here.
Abstract
These results show that the IC reduction is associated with higher serum levels of CRP in stable COPD patients, suggesting a potential role of dynamic pulmonary hyperinflation on development and maintenance of low grade systemic inflammation in COPD....
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PMID: 22013730
PDF is available here.
Abstract
To track cognitive change over time in dementia-free older adults and to examine terminal cognitive decline.
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PMID: 21832224
PDF is available here.
Iacopo I Olivotto,
Francesca F Girolami,
Roberto R Sciagrà,
Michael J MJ Ackerman,
Barbara B Sotgia,
J Martijn JM Bos,
Stefano S Nistri,
Aurelio A Sgalambro,
Camilla C Grifoni,
Francesca F Torricelli,
Paolo G PG Camici and
Franco F Cecchi
Abstract
The purpose of this study was to assess myocardial blood flow (MBF) using positron emission tomography in patients with hypertrophic cardiomyopathy (HCM) according to genetic status.
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PMID: 21835320
PDF is available here.
Abstract
To assess the features of pain and its impact on the health-related quality of life (HRQOL) in neuromyelitis optica (NMO).
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PMID: 21813781
PDF is available here.
Abstract
There is a clinical association between asthma and chronic rhinosinusitis (CRS). This study was designed to determine whether severity of coexistent asthma affects the clinical presentation of CRS.
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PMID: 21819754
PDF is available here.
Abstract
The objective of this study is to assess cost-effectiveness of different biologic strategies in patients with moderate-to-severe active RA after an insufficient response to anti-TNF agents within the context of the Italian healthcare system.
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PMID: 21813056
PDF is available here.
Abstract
Transcatheter aortic valve implantation (TAVI) has emerged as an alternative technique in patients with severe symptomatic aortic valve stenosis. However, a number of patients have no benefit after implantation. This prospective study attempted to identify predictors of poor treatment response.
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PMID: 21835283
PDF is available here.
Abstract
Our goal is to examine novel echocardiographic characteristics of phenotype-negative carriers for a known sarcomeric gene mutation for HCM....
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PMID: 21835286
PDF is available here.
Abstract
Increased aortic stiffness and reduced baroreceptor reflex sensitivity have been described independently after coarctation of the aorta (CoA) repair. This study sought to determine the relationship between these variables and blood pressure control in adolescents after early CoA repa...
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PMID: 21835303
PDF is available here.
Abstract
To evaluate tear levels of neuromediators in patients with dry eye disease and to identify statistical correlations with the clinical findings.
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PMID: 21825181
PDF is available here.
Abstract
Depressive symptoms are known to compromise health status in cardiac disease, but this relationship has not been described in peripheral artery disease (PAD). Depressive symptoms (PHQ-9) and disease-specific health status (Peripheral Artery Questionnaire, PAQ) were assessed in 242 PAD patients underg...
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PMID: 21828173
PDF is available here.
Ingrid I Bacher,
Sylvain S Houle,
Xin X Xu,
Laurie L Zawertailo,
Alexandra A Soliman,
Alan A AA Wilson,
Peter P Selby,
Tony P TP George,
Julia J Sacher,
Laura L Miler,
Stephen J SJ Kish,
Pablo P Rusjan and
Jeffrey H JH Meyer
Abstract
Greater prefrontal cortex and anterior cingulate cortex monoamine oxidase A (MAO-A) binding is associated with depressed mood. Substances in cigarette smoke, such as harman, inhibit MAO-A, and cigarette withdrawal is associated with depressed mood. Dysphoria during cigarette withdrawal predicts relap...
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PMID: 21810646
PDF is available here.
Pierre N PN Tariot,
Lon S LS Schneider,
Jeffrey J Cummings,
Ronald G RG Thomas,
Rema R Raman,
Laura J LJ Jakimovich,
Rebekah R Loy,
Barbara B Bartocci,
Adam A Fleisher,
M Saleem MS Ismail,
Anton A Porsteinsson,
Michael M Weiner,
Clifford R CR Jack,
Leon L Thal,
Paul S PS Aisen and
Abstract
Agitation and psychosis are common in Alzheimer disease and cause considerable morbidity. We attempted to delay or to prevent agitation and psychosis with the use of divalproex sodium (valproate).
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PMID: 21810649
PDF is available here.
Abstract
Dairy products have been perceived as having the potential to cause adverse effects in individuals with Crohn's disease (CD) and are often avoided, potentially increasing the risk of osteoporosis and related morbidity associated with inadequate dietary calcium intake....
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PMID: 21802562
PDF is available here.
Abstract
Azelaic acid (AzA) gel 15% is approved by the US Food and Drug Administration (FDA) for the treatment of papulopustular rosacea (PPR). Its efficacy and safety as monotherapy have been demonstrated. Release of active drug from the gel formulation is superior to the cream. The combination of AzA gel 15...
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PMID: 21916272
PDF is available here.
Abstract
Primary central nervous system vasculitis (PCNSV) is a rare primary vasculitis limited to the brain and spinal cord. It can affect any age group, but has a predilection for subjects aged 40 to 60 years without clear gender predominance. Clinical manifestations are nonspecific, including headache, non...
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PMID: 21586204
PDF is available here.
Abstract
Many factors in tracheal intubation lead to postoperative sore throat from mucosal injury. Mometasone furoate spray is a moderate potency corticosteroid that prevents influx of inflammatory cells into the mucosa. The present study assessed the efficacy of this drug for reducing posto...
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PMID: 21863678
PDF is available here.
Abstract
To determine the incidence, prescribing risk factors of alcohol withdrawal delirium (AWD), and factors complicating AWD, in alcohol dependent patients hospitalized for alcohol detoxification.
Patients attending the detoxification program at Chiang Mai University Hospi...
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PMID: 21863683
PDF is available here.
Abstract
Cutaneous lupus erythematosus (CLE) is an autoimmune inflammatory skin disease seen in patients with or without systemic lupus erythematosus. The management of CLE includes treatment and prevention of lesions as well as routine assessment for systemic disease. Treatment options inclu...
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PMID: 21503694
PDF is available here.
Abstract
We examined disease activity, use of medication, need for surgery, and hospitalization before and after cannabis use in 30 patients (26 males) with CD. Disease activity was assessed by the Harvey Bradshaw index for Crohn's disease.
Of the 30 patients 21 improved significantly after t...
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PMID: 21910367
PDF is available here.
Abstract
Transarterial chemoembolization (TACE) is the mainstay of management for patients with hepatocellular carcinoma who are not suitable for curative treatments.
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PMID: 21912767
PDF is available here.
Abstract
We investigated the role of angiotensin-converting enzyme (ACE) I/D and -240A>T, angiotensinogen (AGT) M235T, and angiotensin type 1 receptor (AGTR1) 1166A > C polymorphisms in modulating the susceptibility to the disease.
Eight hundred twenty-one consecutive patients with severe car...
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PMID: 21819925
PDF is available here.
Abstract
To evaluate open-label adalimumab therapy for clinical effectiveness, fistula healing, patient-reported outcomes and safety in Canadian patients with moderate to severe Crohn's disease (CD) who were either naive to or previously exposed to antitumour necrosis factor (anti-TNF) therapy.
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PMID: 21912766
PDF is available here.
Abstract
quality of life was reduced in both behavioural groups compared with participants without either condition. Disability was greater in the group with apathy. Variation in disability score (56%, P < 0.001) was explained by greater levels of apathy, depression, motor impairment and longer disease dur...
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PMID: 21788252
PDF is available here.