Abstract
We present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker informatio...
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PMID: 21812099
PDF is available here.
Abstract
We present the adaptation of the Behavioral Activation for Depression Scale (BADS), developed by Kanter, Mulick, Busch, Berlin, and Martell (2007), in a Spanish sample. The psychometric properties were tested in a sample of 263 participants (124 clinical and 139 non-clinical). The results show that,...
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PMID: 22059343
PDF is available here.
Abstract
The aim of this work was to update the validation of the Social Anxiety Screening Scale (SASS/EDAS) in a sample of Spanish adolescents. To achieve this, one study with a sample of 1489 students in secondary education, of ages 14 to 17 years, were carried out. The psychometric propert...
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PMID: 22059341
PDF is available here.
Abstract
The aim of this study was to examine the factorial validity of the Job Expectations Questionnaire (Cuestionario de Expectativas Laborales CEL) in a sample of Mexican workers. Following a cross validation approach, two samples were used in the study. The first sample consisted of 380...
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PMID: 22059344
PDF is available here.
Abstract
We propose an alternative approach based on omnibus tests of equality of means and variances and in subject-by-subject analyses (where applicable), and we show that these tests have adequate Type I error rates and power. The approach is illustrated with a re-analysis of published data from a signal...
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PMID: 22059346
PDF is available here.
Abstract
The aim of this work is to examine the pentafactorial validity of the AF5 Self-Concept Questionnaire in Spanish and Chilean young adults. From the responses of a total of 4,383 young adults aged 17 to 22 years (1,918 Spanish, 44%, and 2,465 Chilean, 56%) it was analyzed the reliabili...
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PMID: 22059311
PDF is available here.
Abstract
The Affective Neuroscience Personality Scales have been designed to provide a personality assessment tool based on six distinct affective systems. The six neural systems involved were labeled PLAY, SEEK, CARE, FEAR, ANGER and SADNESS. Spirituality has been integrated into the questio...
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PMID: 22059336
PDF is available here.
Abstract
The aim of this study was to adapt to Catalan the parents' and children's global report forms of the Alabama Parenting Questionnaire (APQ), using a community sample of 364 children between 10 and 15 years old and their families. Sociodemographic information (from parents) and the pre...
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PMID: 22059338
PDF is available here.
Abstract
We have explored the psychometric properties and construct validity of the Turkish adaptation of the Mathematics Teacher Efficacy Belief Instrument developed by Enochs, Smith, & Huinker (2000) for in-service mathematics teachers. The instrument distinguishes between two dimensions of efficacy belief...
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PMID: 22059339
PDF is available here.
Abstract
We the adaptation and testing of the psychometric properties of the Running Addiction Scale (RAS) in Spanish. To this end, we conducted two independent studies. The aim of the first was to present the first preliminary psychometric data (pilot sample of 174 marathon runners). Explained the process o...
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PMID: 22059340
PDF is available here.
Abstract
These results provided empirical evidence in favour of the reliability and validity of the Parenting Stress Index-Short Form in Spanish fathers, and can be useful to elucidate the mechanisms through which stress impacts parenting and permitting to develop more targeted interventions for infants and...
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PMID: 22059342
PDF is available here.
Abstract
To date, the statistical software designed for assessing differential item functioning (DIF) with Mantel-Haenszel procedures has employed the following statistics: the Mantel-Haenszel chi-square statistic, the generalized Mantel-Haenszel test and the Mantel test. These statistics per...
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PMID: 22059345
PDF is available here.
Abstract
We present an application of in silico quantitative structure-activity relationship (QSAR) models to establish a new ligand-based computational approach for generating virtual libraries. The Free-Wilson methodology was applied to extract rules from two data sets containing compounds which were scree...
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PMID: 20981520
PDF is available here.
Abstract
We introduce a flow cytometry-based method for quantifying newly generated neurons in the brain based on the counting of cell nuclei from dissected brain regions. Important steps involve density sedimentation of the cell nuclei, and staining for the proliferation marker bromodeoxy uridine and nuclea...
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PMID: 21812782
PDF is available here.
Abstract
We have measured blood concentrations of kynurenines and inflammatory markers in 28 patients undergoing coronary arterial graft surgery and, for comparison, 28 patients undergoing non-bypass thoracic surgery. A battery of cognitive tests was completed before and after the operations. The results sho...
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PMID: 21819405
PDF is available here.
Abstract
Dideoxyosones (DDOs) are intermediates in the synthesis of advanced glycation endproducts (AGEs), such as pentosidine and glucosepane. Although the formation of pentosidine and glucosepane in the human lens has been firmly established, the formation of DDOs has not been demonstrated. The aim of this...
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PMID: 21820400
PDF is available here.
Abstract
We examined the ability of the Verigene CLO assay (Nanosphere, Northbrook, IL) to identify CYP2C19 (*)2 and (*)3 polymorphisms in 1,286 unique whole blood samples. The Verigene CLO assay accurately identified homozygous and heterozygous (*)2 and (*)3 phenotypes with a specificity of 100% and a final...
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PMID: 21917683
PDF is available here.
Abstract
Our aim was to assess the reproducibility of morphologic characteristics and determine their relative importance for histologic diagnoses on selected trephine biopsy sections. For the study, 56 prefibrotic MPN trephine specimens were blindly reviewed by 4 hematopathologists using a scoring list of 1...
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PMID: 21917685
PDF is available here.
Abstract
The results showed that MOTHMO is capable of replicating the seat belt-to-shoulder complex interaction, pelvis impacts, head displacement, neck and shoulder belt loading from inboard mounted belts, and impacts from multiple directions. Overall, the model performed better than Thor-NT and at least as...
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PMID: 21972862
PDF is available here.
Abstract
We hypothesize that cell-scaffold interaction and mechanical deformation results in upregulation of genes related to osteogenic/chondrogenic differentiation and thus changes extracellular matrix (ECM) composition in human bone marrow mesenchymal stem cell (hBMSC)-derived tissue-engineered grafts. hB...
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PMID: 21554191
PDF is available here.
Abstract
Biologic scaffolds composed of extracellular matrix (ECM) have been used successfully in preclinical models and humans for constructive remodeling of functional, site-appropriate tissue after injury. The mechanisms underlying ECM-mediated constructive remodeling are not completely un...
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PMID: 21563860
PDF is available here.
Abstract
Our aim is to develop an instrument to evaluate psychiatrist' experience induced by each patient. This paper describes the development and preliminary validation of this instrument....
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PMID: 21938079
PDF is available here.
Abstract
We cover the principal developments since the original development of the S-K method....
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PMID: 21819856
PDF is available here.
Abstract
We investigated the use of hollow-fiber microdialysis (MD) sampling coupled on-line with high-performance liquid chromatography (HPLC) as an alternative to sample pretreatment for the direct determination of MEL and its analogue cyanuric acid (CYA) in NDC. After MD sampling, the dialysate was inject...
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PMID: 21819860
PDF is available here.
Abstract
Two methods for determination of imidapril hydrochloride (IMD) in the form of tablets were developed and the stability-indicative determination of IMD in solid state formulations by means of the proposed methods was investigated. IMD is not a pharmacopeial raw material, therefore there is no official...
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PMID: 21928708
PDF is available here.
Abstract
The influence of temperature and relative air humidity on the stability of omeprazole (OME) in solid state was studied. Changes in the concentration were monitored by HPLC with UV detection. The method was validated; its selectivity, range of linearity, precision, limit of detection (LOD) and limit o...
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PMID: 21928721
PDF is available here.
Abstract
Sulfurous compounds: sodium sulfite Na2SO3 (E 221), sodium bisulfite NaHSO, (E 222), and sodium metabisulfite Na2S2O5 (E 223) are largely used as antioxidants in many pharmaceutical formulations. A method for determination of sodium metabisulfite in parenteral formulations containing tartrate ions wa...
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PMID: 21928707
PDF is available here.
Abstract
We evaluated a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method, which utilizes aTRAQ reagents, for amino acid analysis in urine. aTRAQ reagents tag the primary and secondary amino groups of amino acids. Internal standards for each amino acid are also labeled with a modified aT...
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PMID: 21852206
PDF is available here.
Abstract
Intervening on social determinants of health requires that public health stakeholders enter into intersectoral partnerships. The lack of valid tools to evaluate the quality of partnerships is a significant constraint to formulating convincing arguments for this kind of action. In light of this shortc...
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PMID: 21913588
PDF is available here.
Abstract
A sensitive enzymeless organophosphate pesticides (OPs) sensor is fabricated by using Au nanoparticles (AuNPs) decorated graphene nanosheets (GNs) modified glassy carbon electrode as solid phase extraction (SPE). Such a nanostructured composite film, combining the advantages of AuNPs...
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PMID: 21807193
PDF is available here.
David J Thurman,
Ettore Beghi,
Charles E Begley,
Anne T Berg,
Jeffrey R Buchhalter,
Ding Ding,
Dale C Hesdorffer,
W Allen Hauser,
Lewis Kazis,
Rosemarie Kobau,
Barbara Kroner,
David Labiner,
Kore Liow,
Giancarlo Logroscino,
Marco T Medina,
Charles R Newton,
Karen Parko,
Angelia Paschal,
Pierre-Marie Preux,
Josemir W Sander,
Anbesaw Selassie,
William Theodore,
Torbjörn Tomson and
Samuel Wiebe
Abstract
We discuss: (1) conceptual and operational definitions of epilepsy, (2) data resources and recommended data elements, and (3) methods and analyses appropriate for epidemiologic studies or the surveillance of epilepsy. Variations in these are considered, taking into account differing resource availab...
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PMID: 21899536
PDF is available here.
Abstract
We proposed a comparative protocol which considers both the active area available for transduction following nanomaterial deposition and the sensitivity. Based on the protocol, when no nanomaterials were involved, TEOS/GOx biosensors exhibited the highest efficacy, followed by BSA/GA/GOx and TMOS/GO...
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PMID: 21828892
PDF is available here.
Abstract
Natural antibodies (NA) create a crucial barrier at the initial steps of the innate humoral immune response. The main role of NA in the defense system is to bind the pathogens at early stages of infection. Different pathogens are recognized by the presence of highly conserved antigen determinant [e.g...
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PMID: 21844254
PDF is available here.
Abstract
This study examined the repeatability of and agreements between central corneal thickness measurements obtained by four different non-contact pachymetry devices.
Seventy-eight eyes of 39 subjects were included. Central corneal thickness of each eye was measured by Vis...
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PMID: 21899245
PDF is available here.
Abstract
To examine the between-grader repeatability of height, depth, and cross-sectional area measurements of the lower tear meniscus, using a Fourier-domain optical coherence tomography (OCT) system.
A total of 16 patients with dry eye had the lower tear meniscus of the rig...
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PMID: 21899246
PDF is available here.
Abstract
Our study shows the clinical application of FISH in formalin-fixed, paraffin-embedded tissue for detection of Xp11.2 translocation RCCs and other tumors with this genetic aberration....
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PMID: 21817901
PDF is available here.
Abstract
We have developed a sensitive mutation assay, wobble-enhanced amplification refractory mutation system, for detecting the 8 most commonly reported mutations of clinical importance in the KRAS and BRAF genes; KRAS g.34GC (p.G12R), g.34GA (p.G12S), g.34GT (p.G12C), g.35GA (p.G12D), g.35GC (p.G12A), g....
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PMID: 21817902
PDF is available here.
Abstract
We developed and validated multiplex ligation-dependent probe amplification (MLPA) for aCGH confirmation. The method performance validation showed linearity through the expected analytical measurement range (0.05 to 2 genome equivalents). The interassay normalized coefficient of variation averaged 3...
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PMID: 21817904
PDF is available here.
Abstract
To determine test-retest and inter-rater reliability of hand-held dynamometry when used to measure knee--extensor strength in patients with advanced cancer.
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PMID: 21826388
PDF is available here.
Abstract
We aimed to assess the incremental prognostic accuracy of eGFR(CKD-EPI) versus eGFR(MDRD) in subjects at increased risk for CV disease.
We performed a post hoc analysis of the VALIANT trial that enrolled 14,527 patients with acute myocardial infarction with signs and symptoms of hear...
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PMID: 21884875
PDF is available here.
Abstract
The use of ultrasound is now widespread within the field of Emergency Medicine. The availability of lightweight and relatively cheap ultrasound devices has enabled clinicians to obtain more detailed information about the condition of acutely ill and injured patients than can be done...
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PMID: 21911912
PDF is available here.
Abstract
I and II exhibited significant differences for most of tooth groups (ranged from 0.02 to 0.22 mm) while no significant difference was found between methods I and III (ranged from 0.03 to 0.11 mm).
Tooth width measurement with on-screen 2-dimensional scanned images of dental casts is...
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PMID: 21894350
PDF is available here.
Abstract
The interaction of the extra-membranous domain of tetrameric inwardly rectifying Kir2.1 ion channels (Kir2.1NC(4)) with the membrane associated guanylate kinase protein PSD-95 has been studied using Transmission Electron Microscopy in negative stain. Three types of complexes were observed in electron...
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PMID: 21756874
PDF is available here.
Abstract
We examined the effect of a graphical indication of the magnitude of Trigg's Tracking Variable, a simple statistically based trend detection algorithm, on the accuracy and latency of the detection of changes in a micro-simulation. Ten anaesthetists each viewed 20 simulations with four variables disp...
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PMID: 21970133
PDF is available here.
Abstract
As the reliability of malignant hyperthermia normal in vitro contracture test results has been questioned, this study set out to determine the reliability of malignant hyperthermia normal results in New Zealand. Three hundred and twenty-nine anaesthetics were administered to malignant hyperthermia no...
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PMID: 21970134
PDF is available here.
Abstract
The purpose of this study was to observe the effects of a submaximal isometric training program on estimation capacity at 25, 50, and 75% of maximal contraction in isometric action and at two angular velocities. The second purpose was to study the variability of isometric action. To...
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PMID: 21957704
PDF is available here.
Abstract
To compare venous pressure and haemoglobin oxygen saturation measured from a catheter in the superior vena cava (SVC) with a catheter inserted via the femoral vein, and to assess the agreement of these measurements. To assess the effect of intra-abdominal pressure and intrathoracic p...
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PMID: 21880001
PDF is available here.
Abstract
Our prespecified plan was to perform a meta-analysis of the clinical accuracy of mean peripheral thermometer temperature difference from core temperature and calculation of limits of agreement.
Systematic review identified three studies that compared infrared tympanic, rectal or oral...
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PMID: 21880009
PDF is available here.
Abstract
These results were confirmed by direct DNA sequencing and by high-resolution melting analysis. The costs and time constraints of each detection method were compared at the same time. In conclusion, our newly designed multiplex SNaPshot assay is a fast, inexpensive, sensitive, and robust technique fo...
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PMID: 21742054
PDF is available here.
Abstract
Modeling transit bus emissions and fuel economy requires a large amount of experimental data over wide ranges of operational conditions. Chassis dynamometer tests are typically performed using representative driving cycles defined based on vehicle instantaneous speed as sequences of...
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PMID: 22010377
PDF is available here.
Abstract
We present a fully integrated microfluidic device capable of performing high-precision RT-qPCR measurements of gene expression from hundreds of single cells per run. Our device executes all steps of single-cell processing, including cell capture, cell lysis, reverse transcription, and quantitative P...
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PMID: 21808033
PDF is available here.
Anders A Carlsson,
Christer C Wingren,
Malin M Kristensson,
Carsten C Rose,
Mårten M Fernö,
Håkan H Olsson,
Helena H Jernström,
Sara S Ek,
Elin E Gustavsson,
Christian C Ingvar,
Mattias M Ohlsson,
Carsten C Peterson and
Carl A K CA Borrebaeck
Abstract
We screened 240 sera from 64 patients with primary breast cancer. This unique longitudinal sample material was collected from each patient between 0 and 36 mo after the primary operation. The velocity for each serum protein was determined by comparing the samples collected at the primary operation a...
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PMID: 21844363
PDF is available here.
Mats M Larsson,
David L DL Duffy,
Gu G Zhu,
Jimmy Z JZ Liu,
Stuart S Macgregor,
Allan F AF McRae,
Margaret J MJ Wright,
Richard A RA Sturm,
David A DA Mackey,
Grant W GW Montgomery,
Nicholas G NG Martin and
Sarah E SE Medland
Abstract
We have performed genome-wide association scans on four iris characteristics (crypt frequency, furrow contractions, presence of peripupillary pigmented ring, and number of nevi) in three Australian samples of European descent. Both the discovery (n = 2121) and replication (n = 499 and 73) samples sh...
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PMID: 21835309
PDF is available here.
Abstract
Previous studies reported that CD10 positive Colorectal Cancer Cells (CRC) characterized by deeply invasive neoplasia.
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PMID: 21834477
PDF is available here.