Abstract
One of the procedures used most recently with longitudinal data is linear mixed models. In the context of health research the increasing number of studies that now use these models bears witness to the growing interest in this type of analysis. This paper describes the application of...
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PMID: 22059318
PDF is available here.
Abstract
We present an application of in silico quantitative structure-activity relationship (QSAR) models to establish a new ligand-based computational approach for generating virtual libraries. The Free-Wilson methodology was applied to extract rules from two data sets containing compounds which were scree...
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PMID: 20981520
PDF is available here.
Abstract
We conducted a nationwide, population-based prospective cohort study of all female residents in Denmark diagnosed with stage I-III invasive breast carcinoma who were reported to the Danish Breast Cancer Cooperative Group registry between 1996 and 2003 (n = 18 769). Women were followed for a median...
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PMID: 21813413
PDF is available here.
Abstract
In the study described in this article, the authors' objective was to measure particles < or = 2.5 microm in aerodynamic diameter (PM2.5) and carbon monoxide (CO) in outdoor waiting areas and patios of restaurants and bars in downtown Athens, Georgia, where indoor smoking is banned....
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PMID: 22010328
PDF is available here.
Abstract
Spaceflight and simulated microgravity often associate with pain and prediabetes. Streptozotocin (STZ)-induced moderate insulinopenia rat models of prediabetes result in pressure hyperalgesia. The current study was designed to determine whether or not simulated microgravity induced b...
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PMID: 21961404
PDF is available here.
Abstract
We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p = 0.008), lower ACR (p = 0.001) and NT-proBNP (p = 0.001) and increased GFR (p<0.001).
We conclude that diurnal BP v...
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PMID: 21546328
PDF is available here.
Abstract
Researchers have suggested that maternal hypertensive disorders during pregnancy affect fetal growth. The authors examined the associations between systolic and diastolic blood pressures in different trimesters of pregnancy and both repeatedly measured fetal growth characteristics an...
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PMID: 21859836
PDF is available here.
Abstract
Theoretical and experimental quantitative structure-retention relationships (QSRR) models are useful for characterizing solvent properties and column selectivity in reversed phase liquid chromatography (RPLC). The chromatographic behavior of a model analyte, the herbicide atrazine, in a system derive...
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PMID: 21819857
PDF is available here.
Abstract
We assessed the performance of syndromic indicators based on Google Flu Trends (GFT) and emergency department (ED) data for the early detection and monitoring of the 2009 H1N1 pandemic waves in Manitoba.
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PMID: 21913587
PDF is available here.
Abstract
We evaluated a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method, which utilizes aTRAQ reagents, for amino acid analysis in urine. aTRAQ reagents tag the primary and secondary amino groups of amino acids. Internal standards for each amino acid are also labeled with a modified aT...
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PMID: 21852206
PDF is available here.
Abstract
We hypothesized that early EUS-CPN would reduce pain and morphine consumption, increase quality of life (QOL), and prolong survival....
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PMID: 21844506
PDF is available here.
Abstract
We proposed a comparative protocol which considers both the active area available for transduction following nanomaterial deposition and the sensitivity. Based on the protocol, when no nanomaterials were involved, TEOS/GOx biosensors exhibited the highest efficacy, followed by BSA/GA/GOx and TMOS/GO...
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PMID: 21828892
PDF is available here.
Abstract
We characterized the pharmacokinetics of fentanyl in 15 patients (American Society of Anesthesiologists Physical Status Classification 2 or 3) undergoing living-donor liver transplantation (LDLT). Fentanyl was continuously infused at the rate of 200-400 µg/h throughout the operation. The time cour...
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PMID: 21814196
PDF is available here.
Abstract
To investigate associations between serum bisphenol A (BPA) concentrations and follicular response to exogenous ovary stimulation.
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PMID: 21813122
PDF is available here.
Abstract
We conclude that HPs and SSA/Ps in Korean patients share some, but not all, clinical and molecular characteristics to those that occur in Americans. The data support the theory that the right and left colon are biologically different with regard to susceptibility to serrated cancer, and that anatomi...
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PMID: 21836485
PDF is available here.
Abstract
When cycling on level ground at a speed greater than 14 m/s, aerodynamic drag is the most important resistive force. About 90% of the total mechanical power output is necessary to overcome it. Aerodynamic drag is mainly affected by the effective frontal area which is the product of the projected fron...
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PMID: 21936289
PDF is available here.
Abstract
These results show that the IC reduction is associated with higher serum levels of CRP in stable COPD patients, suggesting a potential role of dynamic pulmonary hyperinflation on development and maintenance of low grade systemic inflammation in COPD....
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PMID: 22013730
PDF is available here.
Abstract
We conducted a cross-sectional study to identify reference values of PNIF among healthy school children and adolescents aged from eight to fifteen years old, selected from 14 randomly selected public schools. Participants performed measurements of PNIF using the In-check-inspiratory flow meter (Clem...
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PMID: 21858260
PDF is available here.
Abstract
Accurate time measurement is essential to temporal analysis in sport. This study aimed to (a) develop a new method for time computation from surveyed trajectories using a high-end global navigation satellite system (GNSS), (b) validate its precision by comparing GNSS with photocells,...
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PMID: 21957698
PDF is available here.
Abstract
We investigated the effects of self-controlled practice on learning multiple motor skills. Thirty participants were randomly assigned to self-control or yoked conditions. Participants learned a three-keystroke pattern with three different relative time structures. Those in the self-control group cho...
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PMID: 21957703
PDF is available here.
Abstract
The purposes of this study were to generate correction equations for self-reported height and weight quartiles and to test the accuracy of the body mass index (BMI) classification based on corrected self-reported height and weight among 739 male and 434 female college students. The B...
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PMID: 21957697
PDF is available here.
Abstract
Linear, quadratic, and artificial neural network (ANN)-based metamodels were developed for predicting the extent of anthrax spore inactivation by chlorine dioxide in a ventilated three-dimensional space over time from computational fluid dynamics model (CFD) simulation data. Dimensio...
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PMID: 22010381
PDF is available here.
Abstract
We recently introduced the enhanced aromatic sequon as a family of portable structural motifs that are stabilized upon glycosylation in specific reverse turn contexts: a five-residue type I β-turn harboring a G1 β-bulge (using a Phe-Yyy-Asn-Xxx-Thr sequon) and a type II β-turn within a six-residu...
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PMID: 21825145
PDF is available here.
Najib M NM Rahman,
Nicholas A NA Maskell,
Alex A West,
Richard R Teoh,
Anthony A Arnold,
Carolyn C Mackinlay,
Daniel D Peckham,
Chris W H CW Davies,
Nabeel N Ali,
William W Kinnear,
Andrew A Bentley,
Brennan C BC Kahan,
John M JM Wrightson,
Helen E HE Davies,
Clare E CE Hooper,
Y C Gary YC Lee,
Emma L EL Hedley,
Nicky N Crosthwaite,
Louise L Choo,
Emma J EJ Helm,
Fergus V FV Gleeson,
Andrew J AJ Nunn and
Robert J O RJ Davies
Abstract
More than 30% of patients with pleural infection either die or require surgery. Drainage of infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did not improve outcomes in an earlier, large, randomized trial.
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PMID: 21830966
PDF is available here.
Abstract
This study sought to compare the direct cost of medical care and clinical events during the first year after patients with intermediate risk acute chest pain were randomized to stress cardiac magnetic resonance (CMR) observation unit (OU) testing versus inpatient care.
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PMID: 21835378
PDF is available here.
Abstract
The objective of this study was to assess dental students' attitudes toward underserved populations across their four years of dental school. Students at the Herman Ostrow School of Dentistry of the University of Southern California were invited to take part in the study. Participating students compl...
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PMID: 21828295
PDF is available here.
Abstract
We discovered that curcuminoids were mainly present as glucuronides in plasma, whereas in free form in tumor tissue. A validated LC/MS/MS method was established to determine the three free curcuminoids in tumor homogenate. Samples were separated on a Zorbax SB-C(18) column, eluted with acetonitrile-...
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PMID: 21856253
PDF is available here.
Abstract
We have recently reported that when cholesterol is oxidized with an ozone-like oxidant generated by activated mouse neutrophils, secosterol-A is generated which is then converted to secosterol-B by an aldol reaction. To investigate further pathophysiological roles of secosterols, we have developed a...
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PMID: 21871845
PDF is available here.
Abstract
Iturin A, a powerful antifungal surfactant, is a kind of bacterial lipopeptide produced by Bacillus strains. This study addresses the use of an aqueous two-phase system (ATPS) using ethanol/ammonium sulfate to extract iturin A from Bacillus amyloliquefaciens NJN-6 fermentation broth...
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PMID: 21872538
PDF is available here.
Abstract
We provided healthy subjects and stroke patients with a virtual task during robot-assisted gait training, which allowed modulating cognitive load by adapting the difficulty level of the task. We quantified the cognitive load of stroke patients by using psychophysiological measurements and performanc...
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PMID: 21827971
PDF is available here.
Abstract
Depressive symptoms are known to compromise health status in cardiac disease, but this relationship has not been described in peripheral artery disease (PAD). Depressive symptoms (PHQ-9) and disease-specific health status (Peripheral Artery Questionnaire, PAQ) were assessed in 242 PAD patients underg...
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PMID: 21828173
PDF is available here.
Abstract
We assessed whether demographic, body composition, and ambulatory activity measures were predictive of arterial elasticity within each group. Fifty-one American Indians and 66 Caucasians between the ages of 8 and 30 years were assessed on large artery elasticity index, small artery elasticity index,...
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PMID: 21828174
PDF is available here.
Abstract
Assessing energy requirements is a fundamental activity in clinical dietetics practice. A study was designed to determine whether published linear regression equations were accurate for predicting resting energy expenditure (REE) in fasted Hispanic children with obesity (aged 7 to 15...
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PMID: 21802568
PDF is available here.
Abstract
Recognition of trauma-induced coagulopathy by conventional coagulation testing (CCT) is limited by their slow results, incomplete characterization, and their poor predictive nature. Rapid thrombelastography (r-TEG) delivers a more comprehensive assessment of the coagulation system bu...
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PMID: 21825945
PDF is available here.
Abstract
Underwater treadmill (UTM) exercise is being used with increased frequency for rehabilitation of injured athletes, yet there has been little research conducted on this modality.
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PMID: 21828386
PDF is available here.
Abstract
quality of life was reduced in both behavioural groups compared with participants without either condition. Disability was greater in the group with apathy. Variation in disability score (56%, P < 0.001) was explained by greater levels of apathy, depression, motor impairment and longer disease dur...
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PMID: 21788252
PDF is available here.
Abstract
In this paper, polychlorinated biphenyl (PCB), organochlorine pesticide (OCP) and pyrethroid pesticides in peach was investigated by comparing their residual level in peach juice, pulps and peels using dispersive liquid-liquid microextraction based on solidification of floating organ...
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PMID: 21703950
PDF is available here.
Abstract
the orthostatic HR response and, to a lesser extent, SBP recoverability, appear impaired in frailty. Orthostatic haemodynamics may be useful markers of frailty....
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PMID: 21749997
PDF is available here.
Abstract
The computation time required for modeling the nonlinear response of an axon to an applied electric field is a significant limitation to optimizing a large number of neural interface design parameters through use of advanced computer algorithms. This paper introduces two methods of p...
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PMID: 21750371
PDF is available here.
Abstract
We tested the association between estimated NEAP and serum bicarbonate in patients with CKD. Design, setting, participants, & measurements NEAP was estimated among 462 African American adults with hypertensive CKD using published equations: NEAP (mEq/d) = -10.2 + 54.5 (protein [g/d]/potassium [mEq/d...
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PMID: 21700817
PDF is available here.
Abstract
We aimed to identify factors associated with endogenous EPO levels and investigate their relation to all-cause mortality. Design, setting, participants, & measurements Between 2004 and 2005, 215 patients with type 2 diabetes were enrolled. Exclusion criteria included stage renal disease ESRD and any...
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PMID: 21734083
PDF is available here.
Abstract
We hypothesized that patients with intradialytic hypertension have higher interdialytic ambulatory systolic BP than those without intradialytic hypertension. Design, setting, participants, & measurements We performed a case-control study in adult hemodialysis patients. Cases consisted of subjects wi...
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PMID: 21734087
PDF is available here.
Abstract
A high performance liquid chromatography method with ultraviolet and fluorimetric detection has been developed for the simultaneous determination of urinary creatinine (Cr), tryptophan (Trp) and three Trp-related metabolites including kynurenine (Kyn), kynurenic acid (Kyna) and 5-hyd...
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PMID: 21855425
PDF is available here.
Abstract
A selective, simple and efficient method-ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for determination of two toxic alkaloids, namely strychnine and brucine in mice plasma. The UPLC separation was carried out using a 1.7μm BEH C(18) co...
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PMID: 21855426
PDF is available here.
Abstract
The present study was initiated to develop a sensitive and highly selective method for the simultaneous quantification of the nerve agent VX (O-ethyl S-[2(diisopropylamino)ethyl] methylphosphonothioate) and its toxic metabolite (EA-2192) in blood and plasma samples in vivo and in vit...
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PMID: 21862421
PDF is available here.
Abstract
We investigated the expression of P2Y(12) receptor in coronary atherectomy tissues retrieved from patients with acute myocardial infarction (AMI) or stable angina pectoris (SAP). Tissue specimens were collected from 35 patients with AMI and 19 with SAP who underwent directional coronary atherectomy....
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PMID: 21726836
PDF is available here.
Abstract
We explore the effects of hydrological and meteorological conditions on WNV infection among Culex genus mosquitoes collected during 2001-2009 in Suffolk County, Long Island, NY. We show that WNV infection rates in assayed pools of Culex mosquitoes are associated in both space and time with hydrologi...
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PMID: 21845947
PDF is available here.
Abstract
Our group has proposed the concept of subharmonic aided pressure estimation (SHAPE) utilizing microbubble-based ultrasound contrast agent signals for the noninvasive estimation of hydrostatic blood pressures. An experimental system for in vitro SHAPE was constructed based on two single-element transd...
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PMID: 21842580
PDF is available here.
Abstract
Survival after heart transplant has improved and more attention is focused on developmental outcomes. We aimed to determine the survival, morbidity, and developmental outcomes of young children after heart transplant.
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PMID: 21545999
PDF is available here.
Abstract
We measured the frequency of perceived stigma and discrimination among caregivers of veterans with TBI and examined whether perceived stigma and discrimination are associated with caregiver strain, social isolation, depression, and anxiety.
Seventy caregivers of veterans with TBI com...
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PMID: 21723524
PDF is available here.
Abstract
The number of diabetic patients worldwide was estimated to be approximately 285 million in 2010. Approximately 5% of all diabetic patients have foot ulcers, often preceded by neuropathy and delayed healing resulting from peripheral vascular disease which leads to increased risk of infection. Addition...
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PMID: 21972765
PDF is available here.
Abstract
The well-established relationship between childhood adversity and psychosis is likely to involve other factors such as genetic variants that can help us to understand why not everyone exposed to adverse events develops psychotic symptoms later in life.
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PMID: 21719879
PDF is available here.
Abstract
We investigated 53 healthy individuals aged 18 to 89 years and assessed MEG during a resting condition. Generators of focal magnetic slow waves were localized. Results showed a significant influence of age: dipole density decreases with increasing age. The relationship between cognitive performance...
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PMID: 21698438
PDF is available here.
Abstract
This paper examines the usefulness of psychophysiological measurements in a biocooperative feedback loop that adjusts the difficulty of an upper extremity rehabilitation task. Psychophysiological measurements (heart rate, skin conductance, respiration and skin temperature) were used...
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PMID: 21708507
PDF is available here.
Abstract
Asthma is an obstructive airway disease characterized by airway inflammation.
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PMID: 21679494
PDF is available here.
Abstract
We had previously shown that transplanting bone marrow and hematopoietic stem cells could generate renal cells and lead to the preservation of kidney function in a mouse model for cystinosis (Ctns(-/-)) that develops chronic kidney injury, 4 months post transplantation. Here, we determined the long-...
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PMID: 21248718
PDF is available here.