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Sensitivity and Specificity (1):
Recent article
Sensitivity and Specificity
Abstract
Smoking is a major risk factor for both cancer and chronic obstructive pulmonary disease (COPD). Computed tomography (CT)-based lung cancer screening may provide an opportunity to detect additional individuals with COPD at an early stage.
To determine whether low-dose...
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PMID: 22028353
PDF is available here.
PDF is available here.
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Abstract
We used the loop-mediated isothermal amplification (LAMP) method developed by our group for malaria diagnosis with genus-specific and species-specific primers for the four human malaria parasites at a field clinic in comparison with standard microscopy. Among 110 blood samples collected from the mal...
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PMID: 21976556
PDF is available here.
PDF is available here.
Abstract
Abstract
Computed tomography angiography (CTA) is increasingly used for non-invasive imaging of the cerebrovascular diseases.
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PMID: 21828003
PDF is available here.
PDF is available here.
Abstract
We conducted a systematic literature review to identify studies published between January 1, 1985, and March 15, 2011. Summary estimates of sensitivity and specificity were obtained by using a summary receiver-operating characteristic (SROC) curve. Study quality was assessed by using the QUADAS surv...
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PMID: 21917673
PDF is available here.
PDF is available here.
Abstract
We examined the ability of the Verigene CLO assay (Nanosphere, Northbrook, IL) to identify CYP2C19 (*)2 and (*)3 polymorphisms in 1,286 unique whole blood samples. The Verigene CLO assay accurately identified homozygous and heterozygous (*)2 and (*)3 phenotypes with a specificity of 100% and a final...
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PMID: 21917683
PDF is available here.
PDF is available here.
Abstract
Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of nosocomial pneumonia remain a global burden. Currently, physicians rely on their experience to discriminate patients with good and poor outcome. However, stand...
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PMID: 21835904
PDF is available here.
PDF is available here.
Abstract
We assessed in-hospital prognostic value of admission plasma B-type natriuretic peptide (BNP) levels in patients undergoing primary percutaneous coronary intervention (p-PCI) for acute ST-elevation myocardial infarction (STEMI).
In a retrospective design, we evaluated 992 patients (8...
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PMID: 21983763
PDF is available here.
PDF is available here.
Abstract
Standard operating procedures (SOPs) are of paramount importance in the analytical field to ensure the reproducibility of the results obtained among laboratories. SOPs gain special interest when the aim is the analysis of potentially unstable compounds. An SOP for analysis of lipid hydroperoxides (Hp...
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PMID: 21851945
PDF is available here.
PDF is available here.
Abstract
A novel and sensitive method was developed for the simultaneous determination of fenbuconazole and its main metabolites enantioselectively using chiral liquid chromatography coupled with tandem mass spectrometry. The separation and determination were performed using reversed-phase chromatography on a...
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PMID: 21816403
PDF is available here.
PDF is available here.
Abstract
A novel and low solvent consumption method for the sensitive determination of fungicide residues in wine samples is proposed. Analytes were extracted by dispersive liquid-liquid microextraction (DLLME) and further determined by gas chromatography-mass spectrometry (GC-MS). Under optimized conditions,...
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PMID: 21820662
PDF is available here.
PDF is available here.
Abstract
C-reactive protein (CRP) was determined in the concentration range 0.01-10 mg L(-1) using hot electron induced electrochemiluminescence (HECL) with devices combining both working and counter electrodes and sample confinement on a single chip. The sample area on the electrodes was defined by a hydroph...
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PMID: 21819858
PDF is available here.
PDF is available here.
Abstract
We investigated the use of hollow-fiber microdialysis (MD) sampling coupled on-line with high-performance liquid chromatography (HPLC) as an alternative to sample pretreatment for the direct determination of MEL and its analogue cyanuric acid (CYA) in NDC. After MD sampling, the dialysate was inject...
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PMID: 21819860
PDF is available here.
PDF is available here.
Abstract
We have developed a sensitive method for detection and quantification of eight N-nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomorpholine (NMor), N-nitrosomethylethylamine (NMEA), N-nitrosopirrolidine (NPyr), N-nitrosodiethylamine (NDEA), N-nitrosopiperidine (NPip), N-nitroso-n-dipropylamine...
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PMID: 21819861
PDF is available here.
PDF is available here.
Abstract
Availability of highly sensitive assays for metal ions can help monitor and manage the environmental and food contamination. In the present study, a monoclonal antibody against Copper(II)-ethylenediaminetetraacetic acid was used to develop two sensitive ELISAs for Cu(II) analysis. Cobalt(II)-EDTA-BSA...
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PMID: 21819866
PDF is available here.
PDF is available here.
Abstract
A rapid and effective method for enantioselective determination of simeconazole enantiomers in food products (cucumber, tomato, apple, pear, wheat and rice) has been developed. The enantiomers were resolved by capillary gas chromatography (GC) using a commercial chiral column (BGB-172) and a temperat...
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PMID: 21819870
PDF is available here.
PDF is available here.
Abstract
Abstract
We conducted a large population-based study involving asymptomatic adults in Taiwan, a population with prevalent upper gastrointestinal lesions, to confirm this claim....
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PMID: 21810951
PDF is available here.
PDF is available here.
Abstract
The reported prevalence of hepatopulmonary syndrome (HPS) in cirrhotic patients is heterogeneous. Although the prevalence of chronic liver diseases is high in Egypt, however, scanty data is available about HPS.
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PMID: 21922852
PDF is available here.
PDF is available here.
Abstract
We evaluated a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method, which utilizes aTRAQ reagents, for amino acid analysis in urine. aTRAQ reagents tag the primary and secondary amino groups of amino acids. Internal standards for each amino acid are also labeled with a modified aT...
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PMID: 21852206
PDF is available here.
PDF is available here.
Abstract
We compared the results of BMBs and FDG-PET for the diagnosis of BM involvement in a large pediatric group with HL....
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PMID: 21825262
PDF is available here.
PDF is available here.
Abstract
The usefulness of fine needle aspiration technique for cytology diagnosis of lymph node lesions has been a subject of controversy over years.
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PMID: 21913543
PDF is available here.
PDF is available here.
Veterinary Record (169)10 2011
Abstract
Abstract
We report a novel, nanosphere-enabled approach to fabricating highly sensitive gas sensors based on ordered arrays of vertically aligned silicon nanowires topped with a periodically porous top electrode. The vertical array configuration helps to greatly increase the sensitivity of the sensor while t...
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PMID: 21817785
PDF is available here.
PDF is available here.
Abstract
We proposed a comparative protocol which considers both the active area available for transduction following nanomaterial deposition and the sensitivity. Based on the protocol, when no nanomaterials were involved, TEOS/GOx biosensors exhibited the highest efficacy, followed by BSA/GA/GOx and TMOS/GO...
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PMID: 21828892
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)36 2011
Abstract
Presse Medicale (40)11 2011
Abstract
End-stage renal disease affects more than 70,000 persons in France, i.e., 1,1 per 1000 people, of whom 53% are on dialysis and 47% are living with a functioning graft. This prevalence increases about 4% per year. Overall, end-stage renal disease incidence tends to stabilize, excep...
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PMID: 21906908
PDF is available here.
PDF is available here.
Abstract
We tested 10 diagnostic assays, including 1 commercial real-time polymerase chain reaction (qPCR) test for the laboratory detection of toxigenic C difficile on 1,000 stool samples. Sensitive culture for toxigenic C difficile using 2 types of media with broth enrichment defined the reference standard...
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PMID: 21846912
PDF is available here.
PDF is available here.
Abstract
Our objective was to assess the sensitivity and specificity of a panel of immunohistochemical stains in distinguishing HCL from other B-cell neoplasms, particularly splenic and extranodal marginal zone lymphomas (SMZL and ENMZL, respectively). The study included 234 bone marrow biopsy specimens: 101...
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PMID: 21846914
PDF is available here.
PDF is available here.
Abstract
We demonstrate that in 222 B-CLPD cases, CD1d expression of less than 45% is strongly predictive of CLL (likelihood ratio, 32.3; specificity, 97.4%; sensitivity, 84.1%). In addition, CD1d showed significantly higher staining intensity in splenic marginal zone lymphoma compared with atypical hairy ce...
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PMID: 21846915
PDF is available here.
PDF is available here.
Abstract
We conducted a prospective cohort study of people tested for ATP release defects to assess bleeding symptoms. Reduced release, with 1 or more agonists, was more common among patients with bleeding disorders than among healthy control subjects (P...
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PMID: 21846909
PDF is available here.
PDF is available here.
Abstract
In this study, 2 patient populations, using different elution strategies, were compared to evaluate eluate yields under more and less restrictive conditions. An informative eluate was defined as one in which an antibody that could be clinically significant was detected in the eluate but was not detec...
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PMID: 21846910
PDF is available here.
PDF is available here.
Abstract
We retrospectively evaluated 16 cytologic criteria on Papanicolaou-stained slides. We assumed that the presence of polysomic cells by FISH indicated successful tumor sampling in specimens from patients with pathologic evidence of malignancy on follow-up. We compared cytologic criteria of malignant b...
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PMID: 21846921
PDF is available here.
PDF is available here.
Abstract
We advocate a strategy of simultaneous testing to optimize diagnostic sensitivity....
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PMID: 21851871
PDF is available here.
PDF is available here.
Abstract
We developed and validated multiplex ligation-dependent probe amplification (MLPA) for aCGH confirmation. The method performance validation showed linearity through the expected analytical measurement range (0.05 to 2 genome equivalents). The interassay normalized coefficient of variation averaged 3...
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PMID: 21817904
PDF is available here.
PDF is available here.
Abstract
We aimed to assess how urine C-peptide creatinine ratio compared with serum C-peptide measurement during a mixed-meal tolerance test in individuals with late-onset, insulin-treated diabetes....
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PMID: 21843301
PDF is available here.
PDF is available here.
Abstract
Recent epidemiological and immunological studies provide evidence for an association between Epstein-Barr virus infection and multiple sclerosis, suggesting a role of Epstein-Barr virus infection in disease induction and pathogenesis. A key question in this context is whether Epstein-Barr virus-infec...
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PMID: 21846731
PDF is available here.
PDF is available here.
Avian Diseases (55)3 2011
Abstract
Riemerella anatipestifer (RA) infections cause major economic losses in the duck industry. Detection of RA using conventional assays is time-consuming and laborious. In this study, a simple and rapid assay for the detection of RA was established based on the GroEL gene sequence of RA...
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PMID: 22017034
PDF is available here.
PDF is available here.
Avian Diseases (55)3 2011
Abstract
Marek's disease (MD) remains a serious problem in the production of poultry. The disease is caused by Marek's disease virus (MDV), and despite the ubiquitous use of vaccination to control losses, MD still affects poultry farming worldwide. The aim of this study was to develop a loop-...
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PMID: 22017048
PDF is available here.
PDF is available here.
Abstract
Our systematic review shows that while the early C-reactive protein concentration is not a good predictor of survival in critically ill patients, the late C-reactive protein concentration may help to identify patients who are at risk of death....
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PMID: 21970129
PDF is available here.
PDF is available here.
Abstract
The purposes of this study were to generate correction equations for self-reported height and weight quartiles and to test the accuracy of the body mass index (BMI) classification based on corrected self-reported height and weight among 739 male and 434 female college students. The B...
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PMID: 21957697
PDF is available here.
PDF is available here.
Abstract
These results were confirmed by direct DNA sequencing and by high-resolution melting analysis. The costs and time constraints of each detection method were compared at the same time. In conclusion, our newly designed multiplex SNaPshot assay is a fast, inexpensive, sensitive, and robust technique fo...
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PMID: 21742054
PDF is available here.
PDF is available here.
Abstract
The V600E mutation in the BRAF oncogene is associated with colorectal carcinomas, with mismatch-repair deficiency and, recently, with nonresponse to epidermal growth factor receptor inhibitor therapy. The use of reliable techniques for its detection is important. The aim of our study...
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PMID: 21708284
PDF is available here.
PDF is available here.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine (13)3 2011
Abstract
The systemic inflammatory response syndrome (SIRS) concept lacks sensitivity and specificity for guiding clinical practice and sepsis research.
To assess the performance of a weighted SIRS score, with emphasis on white cell count and temperature criteria in predicting...
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PMID: 21880000
PDF is available here.
PDF is available here.
Abstract
It was concluded that mTLI and mSDL can complete each other in the detection of abnormalities of sensory and motor fibres in the diagnosis of CTS....
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PMID: 22013732
PDF is available here.
PDF is available here.
Abstract
Homocysteine is a bioactive compound involved in many impotant processes of clinical significance. High sensitivity methods associated with preparation of oxidation-resistant derivatives are of demand for determination of different homocysteine fractions. In this work a derivatization agent N-ethylma...
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PMID: 21846063
PDF is available here.
PDF is available here.
British Journal of Cancer (105)5 2011
Abstract
We reviewed 861 episodes of FN in outpatients with solid tumours, including 692 (80%) episodes with apparent clinical stability. We aimed to investigate the prognosis of this latter group and explore the possibility of stratifying it according to the presenting features. A case-control study was per...
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PMID: 21811253
PDF is available here.
PDF is available here.
Abstract
Abstract
The purpose of this study was to evaluate whether electrocardiographic characteristics of ventricular arrhythmias distinguish patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) from those with right ventricular outflow tract tachycardia (RVOT-VT).
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PMID: 21835319
PDF is available here.
PDF is available here.
Abstract
The MAST-CLA system (Hitachi Chemical Diagnostics, Inc., Mountain View, CA) is an in vitro diagnostic test for the simultaneous determination of specific IgE to different allergens. Recently, a new generation of MAST-CLA was developed (OPTIGEN; Hitachi Chemical Diagnostics). The purpose of this study...
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PMID: 21819752
PDF is available here.
PDF is available here.
Abstract
Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides an alternative to invasive techniques for some heritable disorders. In some countries this testing has transitioned to clinical care, despite the absence of a formal assessment of performance....
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PMID: 21828326
PDF is available here.
PDF is available here.
The Lancet (378)9790 2011
Abstract
The Lancet (378)9790 2011
Abstract
MMW Fortschritte der Medizin (153)32-34 2011
Abstract
Abstract
We compared the performance of the PT2 scheme on the two title molecules using SCF, MP2 and DFT (BLYP, B3LYP, PBE and B3PW91 functionals) methods combined with polarization consistent pc-n (n = 0, 1, 2, 3, 4) basis sets, Dunning's basis sets (aug)-cc-pVXZ where X = D, T, Q, 5, 6 and Pople's...
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PMID: 21153906
PDF is available here.
PDF is available here.
Abstract
The mean MPV in 88 cases of megaloblastic group (7.97 fl) was although statistically significantly higher than mean MPV in 180 cases of non-megaloblastic group (7.04 fl) with P value <0.05 but had limited sensitivity and specificity to discriminate megaloblastic and non-megaloblastic pancytop...
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PMID: 21310007
PDF is available here.
PDF is available here.
Abstract
The Canadian cervical spine rule (CCS) has been found to be an effective tool to determine the need for radiographic evaluation of the cervical spine (c-spine) incorporating both clinical findings and mechanism. Previously, it has been validated only through clinical follow-up or selective use of X-r...
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PMID: 21825938
PDF is available here.
PDF is available here.
Acta Cardiologica (66)4 2011
Abstract
The aims of this study were to determine the characteristics of the apex beat in the full left lateral position in healthy adults, and to assess its value in the diagnosis of left ventricular dilatation.
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PMID: 21894802
PDF is available here.
PDF is available here.
Abstract
Celiac disease (CD) is as frequent in Turkey as in Western countries. This finding challenges old theories hypothesizing a selective effect of agriculture spreading on the predisposition to develop CD. Despite the availability of reliable serological tests, e.g., the anti-transglutaminase and antiend...
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PMID: 21811276
PDF is available here.
PDF is available here.