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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Human Experimentation (3):
Recent article
Human Experimentation
Abstract
We describe the cellular immune responses observed in a human challenge model for dengue infection; a model that has the potential to provide efficacy data for potential vaccine candidates in a controlled setting. Serum levels of sIL-2Rα and sTNF-RII were increased in volunteers who developed illne...
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PMID: 21443963
PDF is available here.
PDF is available here.
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Abstract
Some HIV protease inhibitors (PIs), including full-dose ritonavir (800 mg) and ritonavir-boosted lopinavir, acutely induce insulin resistance in the absence of HIV infection and changes in body composition. Boosting dose ritonavir (100-200 mg) is the most commonly prescribed PI, yet...
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PMID: 20595906
PDF is available here.
PDF is available here.
Oral Diseases (16)7 2010
Abstract
Oral Diseases (2010) 16, 586-591 High quality clinical research is necessary to improve oral health and translate research findings to the practice of dentistry. This has led many academic institutions to consider establishing a formal clinical research center. This is not a trivial undertaking and...
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PMID: 20846148
PDF is available here.
PDF is available here.
Abstract
We compared the pharmacokinetics and pharmacodynamics of GLU with those of insulin aspart (ASP).
Twelve healthy subjects, aged 18-65 years, participated in this randomized, double-blind, crossover trial. Subjects received 0.2 U/kg GLU or ASP under euglycaemic glucose-clamp conditions.
GLU showed a s...
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PMID: 20429049
PDF is available here.
PDF is available here.
Abstract
This paper describes results of a qualitative study that explored barriers to research participation among African American adults. A purposive sampling strategy was used to identify African American adults with and without previous research experience. A total of 11 focus groups were conducted. Gro...
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PMID: 20693733
PDF is available here.
PDF is available here.
Abstract
Abstract
This community's utilization of their Medical Reserve Corps (MRC) unit proved to be a valuable resource in their vaccination clinics as part of their response to the novel influenza A (H1N1) virus. Early planning, mock vaccination drills, and use of a strategic analysis process aided in the formulat...
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PMID: 20694874
PDF is available here.
PDF is available here.
Abstract
Abstract
We should be skeptical, I argue, that the actions prescribed by the rules are ethically obligatory, and consequently we should focus our attention on how to craft the rules so as to promote the legitimate goals of human subjects research. Unfortunately, this cannot be done without evidence about the...
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PMID: 20526958
PDF is available here.
PDF is available here.
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We therefore need an account of fair distribution. Procedural accounts of fair bargaining have been popular solutions to this problem, but I argue that they are insufficient to protect against exploitation. I argue instead that a maximin principle of fair distribution provides a more compelling norm...
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PMID: 20526966
PDF is available here.
PDF is available here.
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La Revue du praticien (60)5 2010
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médecine/sciences (26)5 2010
Abstract
Fifty years after Henrietta Lacks died of aggressive glandular cervical cancer, the first cell line - HeLa cell line - is the workhorse of laboratories everywhere. It helped to produce drugs for numerous diseases, including poliomyelitis, Parkinson's, leukemias. But they are so outrageously robust t...
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PMID: 20510154
PDF is available here.
PDF is available here.
Abstract
These results show that V6 is safe and holds a promise as an anti-atherogenic and overweight/obesity immune intervention.
Copyright 2010 Elsevier Ltd. All rights reserved....
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PMID: 20117273
PDF is available here.
PDF is available here.
Abstract
These results need to be replicated by directed studies and verified by epidemiological studies....
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PMID: 19911191
PDF is available here.
PDF is available here.
Research with the doubly vulnerable population of individuals who abuse alcohol: an ethical dilemma.
Abstract
Individuals who have maladaptive patterns of drinking alcohol fall into the category of vulnerable research participants for many reasons, not the least of which includes the stigma often placed on individuals who abuse alcohol. Vulnerable subgroups within the population of people who abuse alcohol...
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PMID: 20128522
PDF is available here.
PDF is available here.
Abstract
Three-quarters of parents would permit use of their children's NBS samples for research - if their permission is obtained. Parents not in favor of storing NBS samples often opposed the use of NBS samples for research.
Copyright 2009 S. Karger AG, Basel....
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PMID: 19602864
PDF is available here.
PDF is available here.
Pain Practice (10)1 2010
Abstract
Occipital nerve stimulation is a modality reserved for refractory headache disorders. Leads (wires) are inserted subcutaneously in the occipital region to stimulate the distal C1-3 nerves; lead migration may result from repeated mechanical forces on the lead associated with patient m...
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PMID: 19863746
PDF is available here.
PDF is available here.
Pain Practice (10)1 2010
Abstract
Occipital nerve stimulation is a modality reserved for refractory headache disorders. Leads (wires) are inserted subcutaneously in the occipital region to stimulate the distal C1-3 nerves; lead migration may result from repeated mechanical forces on the lead associated with patient m...
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PMID: 19863746
PDF is available here.
PDF is available here.
Pain Practice (10)1 2010
Abstract
Occipital nerve stimulation is a modality reserved for refractory headache disorders. Leads (wires) are inserted subcutaneously in the occipital region to stimulate the distal C1-3 nerves; lead migration may result from repeated mechanical forces on the lead associated with patient m...
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PMID: 19863746
PDF is available here.
PDF is available here.
Pain Practice (10)1 2010
Abstract
Occipital nerve stimulation is a modality reserved for refractory headache disorders. Leads (wires) are inserted subcutaneously in the occipital region to stimulate the distal C1-3 nerves; lead migration may result from repeated mechanical forces on the lead associated with patient m...
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PMID: 19863746
PDF is available here.
PDF is available here.
Abstract
Georgian medical news ()184-185 2010
Abstract
Many historical facts, describing exploitation and discrimination of research subjects which have been justified by the importance of research aims, are known. Today the protection of the rights and safety of persons involved in biomedical research (research subjects) is the necessary precondition f...
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PMID: 20834070
PDF is available here.
PDF is available here.
BMC Infectious Diseases (10)1 2010
Abstract
When using 62% ethanol foams, the time required for dryness often exceeds the recommended 30 s. Therefore, only a small volume is likely to be applied in clinical practice. Small amounts, however, failed to meet the efficacy requirements of EN 1500 and were only somewhat more effective than water....
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PMID: 20338067
PDF is available here.
PDF is available here.
Intervirology (53)3 2010
Abstract
When used in combination with DRV/r, dose adjustment of IDV from 800 mg b.i.d. to 600 mg b.i.d. may be warranted in cases of intolerance.
2010 S. Karger AG, Basel....
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PMID: 20197684
PDF is available here.
PDF is available here.
Abstract
We know very little about what prevention services researchers are currently providing to participants or their successes, best practices and challenges. We recommend that current normative guidance be systematically reviewed and actual practice at vaccine sites be documented. Adding new tools to th...
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PMID: 20429488
PDF is available here.
PDF is available here.
Abstract
Should innovative therapy occur only within a research paradigm and under institutional review board oversight? The health risks from current human embryonic stem cell clinical applications have raised again a fundamental question addressed first in papers submitted to inform the writing of the Belm...
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PMID: 20579252
PDF is available here.
PDF is available here.
Abstract
The author describes the role of the research subject advocate (RSA), inaugurated in 2001, which adds a fourth level of protection for human research subjects.
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PMID: 21089991
PDF is available here.
PDF is available here.
Abstract
Federal regulations require that the level of risk posed by pediatric research be classified as "minimal," "greater than minimal," or "a minor increase over minimal" Interpretation of the meaning of the levels has produced a significant literature exploring the ethical basis for making these determi...
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PMID: 21089990
PDF is available here.
PDF is available here.
Ethnicity & Disease (20)1 2010
Abstract
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Contested Medicine examines the experiments done at the University of Cincinnati by Eugene Saenger and his colleagues during the 1960s, a time of great fear that the Cold War between the United States and the Soviet Union would become a hot war using nuclear weapons. These studies were to provide th...
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PMID: 20495265
PDF is available here.
PDF is available here.
Abstract
Clinical research studies, both nursing and medical, occur in many critical care units. As with any clinical study, it is necessary to obtain informed consent from any person participating in the study. Although many patients are able to agree or refuse to participate in the study, many are unable t...
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PMID: 20703134
PDF is available here.
PDF is available here.
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In the United States, interest in bioethics increased significantly during the 1970s, as new technologies and changing social mores combined to focus attention on contentious issues in medical research and treatment. New legal developments, both statutory and case based, also began to address reprodu...
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PMID: 20648937
PDF is available here.
PDF is available here.
Abstract
This paper aims to examine the spread of paragonimiasis and the Japanese colonial government's response to it. To consolidate colonial rule, the Japanese colonial government needed medications to cure paragonimiasis. When Dr. Ikeda Masakata invented acid emetine to cure paragonimiasis in Manchuria i...
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PMID: 20098057
PDF is available here.
PDF is available here.
Abstract
We look into the history of research and investigation, we realize that investigators have not always respected persons' fundamental rights. This article starts with a short introduction which highlights the role played by investigation for the nursing profession. Then the author presents a historic...
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PMID: 20143735
PDF is available here.
PDF is available here.
Military Medicine (174)10 2009
Abstract
I to 1975 produced thousands of veterans with concerns of possible long-term health consequences. Clinical and research evaluation of potential long-term health effects has been difficult because the exposures occurred decades ago, the identity of troops exposed and exposure magnitudes are uncertain...
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PMID: 19891215
PDF is available here.
PDF is available here.
Abstract
Clinical research is absolutely necessary for the development of medical knowledge. However, progress of Medicine has not always been obtained respecting human rights. From 1880 onwards, after Laveran's discovery of the protozoan nature of malaria, the increase in knowledge on paludism has been rema...
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PMID: 19915760
PDF is available here.
PDF is available here.
Abstract
We investigated the NK cell status in eight healthy volunteers after vaccination with YF 17DD virus. Shortly after vaccination, we observed increased expression of TLR-3 and TLR-9 in NK cells and markers such as CD69, HLA-DP-DQ-DR, CD38 and CD16. The up-regulation of CD69 was positively correlated w...
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PMID: 19647065
PDF is available here.
PDF is available here.
Critical Care Medicine (37)9 2009
Abstract
Abstract
Scenarios where the results of well-intentioned scientific research can be used for both good and harmful purposes give rise to what is now widely known as the 'dual-use dilemma'. There has been growing debate about the dual-use nature of life science research with implications for making biological...
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PMID: 19784453
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 1) 2009
Abstract
Today's drug discovery and development paradigm is not working, and something needs to be done about it. There is good reason to believe that a move away from reliance on animal surrogates for human subjects in the Pharma Industry's R&D programmes could provide an important step forward. However, no...
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PMID: 19807197
PDF is available here.
PDF is available here.