Abstract
Using knockout and transgenic technology, genetically modified animal models allowed us to understand the role of glucagon signalling in metabolism. Mice with a global deletion of the glucagon receptor gene (Gcgr) were designed using gene targeting. The phenotype of Gcgr(-/-) mouse provided important...
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PMID: 21824268
PDF is available here.
Abstract
We investigated whether preoperative ingestion of a glucose solution interferes with fasting-induced protection against renal I/R injury. METHODS.: Mice were randomized into the following groups: fasted for 3 days with access to water (fasted) or a glucose solution (fasted+glc) and fed ad libitum wi...
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PMID: 21926943
PDF is available here.
Angeliki Asimaki,
Harikrishna Tandri,
Elizabeth R Duffy,
Jeffrey R Winterfield,
Shannon Mackey-Bojack,
Maria M Picken,
Leslie T Cooper,
David J Wilber,
Frank I Marcus,
Cristina Basso,
Gaetano Thiene,
Adalena Tsatsopoulou,
Nikos Protonotarios,
William G Stevenson,
William J McKenna,
Shiva Gautam,
Daniel G Remick,
Hugh Calkins and
Jeffrey E Saffitz
Abstract
We observed a false-positive case in which plakoglobin signal was reduced in a patient initially believed to have ARVC but who actually had cardiac sarcoidosis. Sarcoidosis can masquerade clinically as ARVC but has not been previously associated with altered desmosomal proteins.
We o...
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PMID: 21859801
PDF is available here.
Abstract
We tested the hypothesis that rottlerin mitigates deleterious effects associated with CP/CPB....
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PMID: 21911819
PDF is available here.
Abstract
Stress (exposure to hyperkalemic cardioplegia, metabolic inhibition, or osmotic) results in significant myocyte swelling and reduced contractility. In contrast to wild-type mice, these detrimental consequences are not observed in mice lacking the Kir6.2 subunit of the sarcolemmal ATP-sensitive potass...
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PMID: 21911821
PDF is available here.
Abstract
We hypothesized that rigid rings with nonphysiological three-dimensional shapes, but not saddle-shaped rigid rings or flexible bands, increase AML strains....
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PMID: 21911823
PDF is available here.
Abstract
Although localized delivery of biocomposite materials, such as calcium hydroxyapatite (CHAM), have been demonstrated to potentially attenuate adverse left ventricular (LV) remodeling after myocardial infarction (MI), the underlying biological mechanisms for this effect remain unclear. This study test...
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PMID: 21911817
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We previously showed that adenoviral-delivered overexpression of an endogenous inhibitor, the tissue inhibitor of metalloproteinases-3 (TIMP-3), significantly retarded intimal thickening in short-term autologous porcine arteriovenous interposition grafts (28 days). However, it is essential to determ...
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PMID: 21911803
PDF is available here.
Circulation (124)11 Suppl 2011
Mei Huang,
Patricia Nguyen,
Fangjun Jia,
Shijun Hu,
Yongquan Gong,
Patricia E de Almeida,
Li Wang,
Divya Nag,
Mark A Kay,
Amato J Giaccia,
Robert C Robbins and
Joseph C Wu
Abstract
We performed a cell trafficking experiment, which demonstrated significantly greater recruitment of bone marrow cells to the ischemic myocardium in the double-knockdown group. Fluorescence-activated cell sorting showed significantly higher activation of endogenous c-kit(+) cardiac progenitor cells....
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PMID: 21911818
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We used bioinformatics analysis and experimental validation assays to show that Bim, a critical apoptotic activator, is an important target gene of the microRNA cocktail, which collectively can bind to the 3'UTR region of Bim and suppress its expression.
We have demonstrated that a m...
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PMID: 21911815
PDF is available here.
Circulation (124)11 Suppl 2011
Tobias Deuse,
Martina Seifert,
Neil Phillips,
Andrew Fire,
Dolly Tyan,
Mark Kay,
Philip S Tsao,
Xiaoqin Hua,
Joachim Velden,
Thomas Eiermann,
Hans-Dieter Volk,
Hermann Reichenspurner,
Robert C Robbins and
Sonja Schrepfer
Abstract
We therefore aimed to generate a hypoantigeneic hESC line with improved survival characteristics.
Using various in vivo, nonischemic, hindlimb xenotransplant models (immunocompetent and defined immunodefective mouse strains) as well as human in vitro T-cell and natural killer (NK)-ce...
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PMID: 21911816
PDF is available here.
Abstract
The biopolymer matrigel loaded with cytokine can be used for the recruitment in vivo of specific cell populations and as a vector for the preparation of cell cultures. Data demonstrate that the injection of the matrigel biopolymer supplemented with interleukin-8 (IL-8) in the leech H...
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PMID: 21400659
PDF is available here.