Abstract
We first formulated the simultaneous dual-isotope MPS reconstruction problem as a joint estimation problem. A cross-tracer prior that couples voxel values on both images was then proposed. We developed an iterative algorithm to reconstruct the MPS images that converges to the maximum a posteriori so...
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PMID: 20952334
PDF is available here.
Abstract
We demonstrate the proposed approach that reduces false TWA detections while maintaining a lower missed TWA detection, compared with all the other methods tested. A simple averaging-based TWA estimation algorithm was coupled with the surrogate significance testing and was evaluated on three public d...
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PMID: 20409986
PDF is available here.
Abstract
The echogenicity of whole blood is known to vary during the flow cycle under pulsatile flow both in vitro and in vivo. However, the fundamental underlying mechanisms remain uncertain. The combined effects of flow acceleration and the shear rate were recently used to explain the cyclic variations of s...
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PMID: 21134805
PDF is available here.
Abstract
To devise a noninvasive imaging method for resolving the relative contribution of splenic and splanchnic blood flow to portal venous flow and derive quantitative estimates for parameters pertaining to splenic and portal hemodynamics.
Tracer concentration-time curves o...
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PMID: 21776814
PDF is available here.
Abstract
This concept of filling the aneurysm sac with PDMS may lead to a percutaneous treatment for endoleaks. While the results of this study show that PDMS may be used to treat endoleaks in vitro, further tests are required to determine if this approach is suitable in vivo....
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PMID: 21521061
PDF is available here.
Abstract
This paper presents a novel, magnetic resonance imaging (MRI)-compatible, force sensor suitable for cardiac catheterization procedures. The miniature, fiber-optic sensor is integrated with the tip of a catheter to allow the detection of interaction forces with the cardiac walls. The optical fiber lig...
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PMID: 21118758
PDF is available here.
Abstract
We name three-band diagrams (TBDs), are introduced, as a sensible generalization of the two standard indicators, i.e., the time-averaged WSS and the oscillatory shear index. TBDs provide a handy access to additional information contained in the dynamic structure of the WSS signal as a function of th...
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PMID: 21517520
PDF is available here.
Abstract
Arterial elasticity has been proposed as an independent predictor of cardiovascular diseases and mortality. Identification of the different propagating modes in thin shells can be used to characterize the elastic properties. Ultrasound radiation force was used to generate local mecha...
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PMID: 21428498
PDF is available here.
Abstract
Discrepancies in mean transvalvular gradient have been observed between Doppler echocardiography and catheter-based techniques in the assessment of aortic stenosis (AS). The Reynolds number (RE) has been shown to influence Doppler-derived gradients, and may be useful in resolving Doppler- and cathete...
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PMID: 21560814
PDF is available here.
Abstract
Reduced training times, increasing complexity of endovascular and open vascular interventions and concerns for patient's safety have necessitated a modernisation in surgical training. A more strategic approach is required to facilitate the acquisition of surgical skills outside the operating room and...
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PMID: 21224807
PDF is available here.
Marijn P MP Rolf,
Mark B M MB Hofman,
Peter D PD Gatehouse,
Karin K Markenroth-Bloch,
Martijn W MW Heymans,
Tino T Ebbers,
Martin J MJ Graves,
John J JJ Totman,
Beat B Werner,
Albert C AC van Rossum,
Philip J PJ Kilner and
Rob M RM Heethaar
Abstract
This study showed that with current systems there was no generic protocol which resulted into acceptable flow offset values. Protocol optimization would have to be performed on a per scanner and per protocol basis. Proper optimization might make accurate (transverse) aortic flow quantification possi...
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PMID: 21388521
PDF is available here.
Abstract
Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice condi...
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PMID: 21606600
PDF is available here.
Abstract
We show that the ubiquitous Ising-model approaches (e.g., Graph Cuts, Random Walker) are not appropriate for tackling this problem and propose a novel method based on recursive minimal paths for doing so. To motivate our method, we focus on the intertwined portal and hepatic venous systems in the li...
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PMID: 21761657
PDF is available here.
Abstract
Cardiac arrest occurs when organized cardiac contractility ceases and circulation stops. During cardiac arrest, electrical activity may be abnormal or absent, and the rhythm documented can be ventricular fibrillation, pulseless ventricular tachycardia, pulseless electrical activity, or asystole. It...
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PMID: 21068526
PDF is available here.
Abstract
A three-dimensional finite element analysis based canine heart model is introduced that would enable the assessment of cardiac function.
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PMID: 21158300
PDF is available here.
Abstract
We show that the latter approach reveals exquisite control of angiogenesis that determines the location of new vessels with astonishing accuracy, motivating a reappraisal of the physiological remodelling process and a new approach to computational investigations into peripheral O(2) transport....
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PMID: 20660019
PDF is available here.
Abstract
In this Commentary, the roles of uridine adenosine tetraphosphate as an endothelium-derived contracting or relaxing factor described in the paper by Tölle et al. are considered and put into the wider context of the mechanisms of control of vascular tone by purinergic signalling via receptors loca...
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PMID: 20880393
PDF is available here.
Abstract
Background- Multiple echocardiographic parameters have been identified to predict the severity of aortic regurgitation (AR) with variable reliability. This study was performed to identify which echocardiographic parameters best predict the severity of AR in a cohort of patients with congenital heart...
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PMID: 20581048
PDF is available here.
Abstract
We review and compare the existing methods of studying cardiac dynamics, including restitution protocol (S1-S2), dynamic restitution protocol and multistability test protocol (S1-CI-S2). We focus on cardiac cell dynamics to elucidate regularities of heart rhythm. We demonstrate the advantages of our...
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PMID: 20153355
PDF is available here.
Abstract
Our computational results for alterations in flow and pressure, using reasonable physiological values for rates of constituent growth and turnover, concur with findings in the literature. For example, for flow-induced remodeling, our simulations predict that, although the wall shear stress is restor...
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PMID: 20039091
PDF is available here.
Abstract
We will also review the available clinical, autopsy and experimental data linking MDMA with cardiac toxicity. Most available data indicate that oxidative stress plays an important role in the cardiotoxic actions of MDMA. Moreover, new data indicates that redox active metabolites of MDMA may play esp...
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PMID: 20420571
PDF is available here.
Abstract
Of the 556 operations, the Aristotle basic complexity score could be assigned to 553 operations and the risk adjustment in congenital cardiac surgery-1 method to 536 operations. Procedures were performed in two institutions in Croatia and seven institutions abroad. The average complexity for cardiac...
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PMID: 20307335
PDF is available here.
Abstract
Interest in developing durable mitral valve repair methods is growing, underscoring the need to better understand the native mitral valve mechanics. In this study, the authors investigate the dynamic deformation of the mitral valve strut chordae-to-anterior leaflet transition zone using a novel stre...
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PMID: 20670053
PDF is available here.
Abstract
These results may help explain plaque stability, as cells in shoulder regions near an atherosclerotic plaque had a cobblestone morphology indicating that they may be more permeable to subendothelial transport and express prothrombotic factors, which would increase the risk of atherothrombosis....
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PMID: 20670062
PDF is available here.
Abstract
We also explore how relatively small increases in large pore numbers dramatically increase J(v) during acute inflammation....
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PMID: 20200043
PDF is available here.
Abstract
We focus on current problems that limit the integration of our knowledge of mechanisms investigated in detail at the cellular level into a more complete understanding of modulation of blood-to-tissue exchange in whole organs when the endothelial barrier is exposed to acute and more long-term inflamm...
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PMID: 20418473
PDF is available here.
Abstract
This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P(if)) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regula...
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PMID: 20472565
PDF is available here.
Abstract
We investigated the association between HR response to exercise testing and age with prognosis in 5437 asymptomatic women.
Participants underwent a symptom-limited maximal stress test in 1992. HR reserve (change in HR from rest to peak), chronotropic index, and age-predicted peak HR were calculated....
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PMID: 20585008
PDF is available here.
Abstract
We study under which circumstances a region of depolarized tissue can re-excite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. For this purpose, we use a simplified ionic model that reproduces well the ventricular action potential. With the help o...
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PMID: 20866648
PDF is available here.
Abstract
In patients, V(root) was 6.4% +/- 4.8% of the intraaortic balloon volume during 1:1 assistance and 10.0% +/- 5.0% during 1:2 assistance. In vitro and with an artificial heart simulating the native heart, V(cor) was smaller, 3.7% and 3.8%, respectively. The distribution of V(tip) in vitro varied, wit...
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PMID: 20080266
PDF is available here.
Abstract
We analyze how the characteristics of spontaneous and triggered calcium sparks are related to cardiac ryanodine receptor (RYR) gating. We show that the frequency of spontaneous sparks and the probability distribution of calcium release flux quanta of triggered sparks correspond quantitatively to pre...
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PMID: 20548054
PDF is available here.
Abstract
Augmentation index (AIx), a marker of the number of aortic wave reflections (AWRs), is influenced not only by the magnitude of incident and reflected pressure waves but also by the time of return. A new triangulation method has been developed, enabling us to better quantify AWRs and to determine the...
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PMID: 20418478
PDF is available here.
Abstract
We introduce an integrative three-dimensional electromechanical model of the left ventricle of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, and mechanical activity is represented by the Niederer-Hunter-Smith active contractile tension model and...
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PMID: 20400690
PDF is available here.
Abstract
A segmented k-space acquisition technique using noninterleaved velocity encodings is presented to reduce spatial and temporal blur in phase-contrast cardiovascular magnetic resonance imaging. A translating phantom with pulsatile flow was used to simulate imaging of coronary arteries on a 1.5-T GE Ec...
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PMID: 20657227
PDF is available here.
Abstract
Pathways and densities of descending vasa recta (DVR) and ascending vasa recta (AVR) in the outer zone of the inner medulla (IM) were evaluated to better understand medullary countercurrent exchange. Nearly all urea transporter B (UT-B)-positive DVR, those vessels exhibiting a continuous endothelium...
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PMID: 20392798
PDF is available here.
Abstract
The outer zone of the renal inner medulla (IM) is spatially partitioned into two distinct interstitial compartments in the transverse dimension. In one compartment (the intercluster region), collecting ducts (CDs) are absent and vascular bundles are present. Ascending vasa recta (AVR) that lie withi...
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PMID: 20392799
PDF is available here.
Abstract
We investigated to what extent maximal ventricular elastance (E(max)) is dynamically controlled by the arterial baroreflex and force-frequency relation in conscious dogs and to what extent these mechanisms are attenuated after the induction of heart failure (HF). We mathematically analyzed spontaneo...
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PMID: 20435845
PDF is available here.
Abstract
Deep hypothermic circulatory arrest is necessary for some types of cardiac and aortic surgery. Perfusion of the brain can be maintained using a heart-lung machine and unilateral antegrade cerebral perfusion. Cooling rates during extracorporeal circulation depend on local perfusion. A...
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PMID: 20442040
PDF is available here.
Abstract
This study proposes a finite-impulse-response (FIR) prediction model to analyze the unpredictable intra-QRS potentials (UIQP) for identifying ventricular tachycardia patients with high-risk ventricular arrhythmias. The simulation study shows that a QRS complex including abnormal intra-QRS potentials...
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PMID: 20605138
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
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PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
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PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
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PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.
Abstract
Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in th...
|
PMID: 20576941
PDF is available here.