Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Models, Genetic (0):
Recent article
Models, Genetic
Abstract
We present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker informatio...
|
PMID: 21812099
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We examined the spatial configuration of Hox clusters in embryonic mouse tissues where different Hox genes are active. When the cluster is transcriptionally inactive, Hox genes associate into a single 3D structure delimited from flanking regions. Once transcription starts, Hox clusters switch to a b...
|
PMID: 21998387
PDF is available here.
PDF is available here.
Abstract
We developed a luciferase-based assay system for measuring the frequency of chromosomal homologous recombination and SSA. An I-SceI-induced DSB, within a nonfunctional luciferase gene, could be efficiently repaired by HR. Additionally, the continuous expression of the I-SceI endonuclease in the HR r...
|
PMID: 21842267
PDF is available here.
PDF is available here.
Biochemistry (Washington) (50)37 2011
Abstract
We benchmark the method using six molecules for which crystallographic data are available: tRNA(phe) and 5S rRNA from Escherichia coli, the P4-P6 domain of the Tetrahymena group I ribozyme, and ligand-bound domains from riboswitches for adenine, cyclic di-GMP, and glycine. SHAPE-directed modeling of...
|
PMID: 21842868
PDF is available here.
PDF is available here.
Abstract
We have examined possible roles of these genes in mycobacterial cell wall biosynthesis through inactivation of their respective orthologs in Mycobacterium smegmatis mc(2)155, phenotypic characterization of the mutant strains via metabolic labeling with [U-(14)C]-glucose, cell-free reactions with UDP...
|
PMID: 21952433
PDF is available here.
PDF is available here.
Abstract
Modeling transit bus emissions and fuel economy requires a large amount of experimental data over wide ranges of operational conditions. Chassis dynamometer tests are typically performed using representative driving cycles defined based on vehicle instantaneous speed as sequences of...
|
PMID: 22010377
PDF is available here.
PDF is available here.
Abstract
We introduce a similarity-based regression method for assessing the main genetic and interaction effects of a group of markers on quantitative traits. The method uses genetic similarity to aggregate information from multiple polymorphic sites and integrates adaptive weights that depend on allele fre...
|
PMID: 21835306
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Epigenetic mechanisms in the endosperm and their consequences for the evolution of flowering plants.
Abstract
We will discuss possible mechanisms underlying this phenomenon. Polyploidization raises an immediate reproductive barrier in the endosperm, pointing towards an important but greatly underestimated role of the endosperm in preventing interploidy hybridizations. Parent-of-origin-specific gene expressi...
|
PMID: 21549229
PDF is available here.
PDF is available here.
Abstract
We show using a kinetic model that Hfq can efficiently and robustly achieve this difficult task by minimizing the sequestration of sRNAs and target mRNAs in Hfq complexes. This sequestration can be reduced by two non-mutually exclusive kinetic mechanisms. The first mechanism involves heterotropic co...
|
PMID: 21876666
PDF is available here.
PDF is available here.
Abstract
Abstract
We propose the sequence kernel association test (SKAT), a supervised, flexible, computationally efficient regression method to test for association between genetic variants (common and rare) in a region and a continuous or dichotomous trait while easily adjusting for covariates. As a score-based var...
|
PMID: 21737059
PDF is available here.
PDF is available here.
Abstract
We find that transcriptional resources are initially limiting during recovery and that recovering animals are highly sensitive to any additional decrease in transcriptional resources. We provide evidence that operons become advantageous because, by clustering growth genes into operons, fewer promote...
|
PMID: 21663799
PDF is available here.
PDF is available here.
Abstract
We investigate the DNA ligase requirement of chromosomal translocation formation in mouse cells. Mammals have two other DNA ligases, Lig1 and Lig3, in addition to Lig4. As deletion of Lig3 results in cellular lethality due to its requirement in mitochondria, we used recently developed cell lines def...
|
PMID: 21655080
PDF is available here.
PDF is available here.
Abstract
Abstract
We review the cellular signaling networks that regulate the activity of transcription factors during brain development and discuss the functional roles of specific activity-regulated transcription factors in specific stages of synapse formation, refinement, and maturation. Interestingly, a number of...
|
PMID: 21555405
PDF is available here.
PDF is available here.
Abstract
We review the cellular signaling networks that regulate the activity of transcription factors during brain development and discuss the functional roles of specific activity-regulated transcription factors in specific stages of synapse formation, refinement, and maturation. Interestingly, a number of...
|
PMID: 21555405
PDF is available here.
PDF is available here.
Abstract
We have found evidences that genome-wide changes in nucleosome occupancy play a critical role in controlling the rigorous parasite replication in infected red blood cells. However, the role of nucleosome positioning at remarkable locations such as transcriptional start sites (TSS) was not investigat...
|
PMID: 20708104
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We show through chromatin immunoprecipitation (ChIP) that SPT5L/KTF1, a silencing factor and a homolog of SPT5 elongation factors, binds chromatin at loci subject to transcriptional silencing. Chromatin binding of SPT5L/KTF1 occurs downstream of RNA Polymerase V, but independently from the presence...
|
PMID: 21738482
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We map Sirt6 occupancy on mouse promoters genome-wide and show that Sirt6 occupancy is highly dynamic in response to TNF-α. More than half of Sirt6 target genes are only revealed upon stress-signaling. The majority of genes bound by NF-κB subunit RelA recruit Sirt6, and dynamic Sirt6 relocalizatio...
|
PMID: 21738489
PDF is available here.
PDF is available here.
PLoS Biology (9)6 2011
Abstract
We employ population genomics data from Escherichia coli, Saccharomyces paradoxus, and Drosophila to provide evidence suggesting that it is not the indels per se but the sequence in which indels occur that causes the accumulation of nucleotide substitutions. We found that about two-thirds of indels...
|
PMID: 21697975
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We show that Saccharomyces cerevisiae NMD mutants accumulate 5'-extended RNAs (CD-CUTs) of many subtelomeric genes. Using the subtelomeric ZRT1 and FIT3 genes activated in response to zinc and iron deficiency, respectively, we show that transcription of these CD-CUTs mediates repression at the bona...
|
PMID: 21738494
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Abstract
We summarize the roles of siRNA-mediated chromatin modification in various biological processes of A. thaliana, and present some speculation on the functions and interactions of silencing factors that, while not yet assigned to defined biochemical activities, have been loosely assigned to specific e...
|
PMID: 21605714
PDF is available here.
PDF is available here.
Abstract
We simultaneously measured absolute mRNA and protein abundance and turnover by parallel metabolic pulse labelling for more than 5,000 genes in mammalian cells. Whereas mRNA and protein levels correlated better than previously thought, corresponding half-lives showed no correlation. Using a quantitat...
|
PMID: 21593866
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1813)5 2011
Abstract
We sought to identify proteins that interact with ataxin-1 through yeast two-hybrid screening. In this study, transcriptional corepressor CtBP2 was identified as a protein that interacted with ataxin-1. CtBP2 and ataxin-1 colocalized in the nucleus of mammalian cells. Since the E-cadherin promoter i...
|
PMID: 21315774
PDF is available here.
PDF is available here.
Abstract
Nature Genetics (43)5 2011
Abstract
Nature Genetics (43)5 2011
Abstract
We identify an association between variants in GPC5, encoding glypican-5, and acquired nephrotic syndrome through a genome-wide association study and replication analysis (P value under a recessive model (P(rec)) = 6.0 × 10(-11), odds ratio = 2.54). We show that GPC5 is expressed in podocytes and t...
|
PMID: 21441931
PDF is available here.
PDF is available here.
Genetika (Moskva) (47)5 2011
Abstract
The mechanisms of displacements of quantitative trait dominance in spring wheat are discussed in terms of the theory of the ecological genetic organization of quantitative traits. A conventional interpretation of displacements ofgenotype points on Hayman's graphs in terms of classical diallelic cross...
|
PMID: 21786675
PDF is available here.
PDF is available here.
Abstract
Liver metastasis is a fatal step in the progression of colorectal cancer (CRC); however, the epigenetic evolution of this process is largely unknown. To decipher the epigenetic alterations during the development of liver metastasis, the DNA methylation status of 12 genes, including 5...
|
PMID: 21406167
PDF is available here.
PDF is available here.
médecine/sciences (27)4 2011
Abstract
Abstract
Familial hypobetalipoproteinemia (FHBL) is an autosomal dominant disease characterized by abnormally low levels of apolipoprotein-B (apoB) containing lipoproteins. FHBL is caused by APOB, PCSK9 or ANGPTL3 mutations or is associated with loci located in chromosomes 10 and 3p21. However, other genes sh...
|
PMID: 21502677
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Abstract
We have analysed two major biological systems involving epigenetic control of gene activity. In the first system we demonstrate the interplay between genetic and epigenetic controls over the transcriptional activity of FLC, a major repressor of flowering in Arabidopsis. FLC is down-regulated by low...
|
PMID: 21459171
PDF is available here.
PDF is available here.
A genome-wide comparison of the functional properties of rare and common genetic variants in humans.
Abstract
We address this question for humans specifically from the perspective of population allele frequency of variants across the complete genome, including both coding and noncoding regions. We establish simple criteria to assess the likelihood that variants are functional based on their genomic location...
|
PMID: 21457907
PDF is available here.
PDF is available here.
Abstract
We conclude that Foxp3(+) cells are needed to maintain acceptance of major histocompatibility complex-incompatible renal allografts in the first 3 months after transplantation and may act by inhibiting DC maturation.
Copyright © 2011 American Society for Investigative Pathology. Pub...
|
PMID: 21435448
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Gene therapy is an exciting field that has attracted much interest since the first submission of clinical trials. Preliminary results were very encouraging and prompted many investigators and researchers. However, the ability of stem cells to differentiate into specific cell types holds immense poten...
|
PMID: 21431572
PDF is available here.
PDF is available here.
Abstract
We review recent data and theory that support gene duplication as a theoretically predicted and experimentally supported means of resolving intralocus sexual antagonism. We believe that this role is probably the consequence of sexual conflict for housekeeping genes that are required in males and fem...
|
PMID: 21397976
PDF is available here.
PDF is available here.
Trends in Genetics (27)5 2011
Abstract
Since the first animal genomes were completely sequenced ten years ago, evolutionary biologists have attempted to use the encoded information to reconstruct different aspects of the earliest stages of animal evolution. One of the most important uses of genome sequences is to understand relationships...
|
PMID: 21414681
PDF is available here.
PDF is available here.
Abstract
When the ribosome machinery reaches a stop codon in the mRNA, protein synthesis stops, and nascent polypeptide release is catalysed by class-I release factors (RFs); class-II RFs then promote the release of class-I RFs. Cryo electron microscopy structures of termination complexes and crystal structur...
|
PMID: 21420300
PDF is available here.
PDF is available here.
Abstract
Basic tenets of Mendelian inheritance are violated by paramutations in which trans-homolog interactions lead to heritable changes in gene regulation and phenotype. First described in plants, similar behaviors have now been noted in diverse eukaryotes. Genetic and molecular studies of paramutations oc...
|
PMID: 21420347
PDF is available here.
PDF is available here.
Current Biology (21)5 2011
Abstract
We carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulation of a target that is not subject to Ago2-mediated catalytic cleavage. By quantitating the number of molecules of the miRNA and its target in steady state and in the course of its decay,...
|
PMID: 21353554
PDF is available here.
PDF is available here.
Abstract
We evaluate the statistical performance of Msvar, a full-likelihood Bayesian method that infers past demographic change from microsatellite data. Our simulation tests show that Msvar is very efficient at detecting population declines and expansions, provided the event is neither too weak nor too rec...
|
PMID: 21385729
PDF is available here.
PDF is available here.
Abstract
We examined the etiology of stability and change in religious values and religious attendance in males and females during adolescence and early adulthood. The heritability of both religious values and religious attendance increased from adolescence to early adulthood, although the increase was great...
|
PMID: 20711848
PDF is available here.
PDF is available here.
Abstract
Abstract
We provide new approaches to calculate the parameters used in the frequency surveying method: a maximum likelihood estimation of the regression parameters (r(1), r(2), s(1) and s(2)) and a revised Frequency Surveying framework with variable binning and a database preprocessing to take the population...
|
PMID: 21094108
PDF is available here.
PDF is available here.
Behavior Genetics (41)2 2011
Abstract
Our results confirm previous findings of an interaction between the MAOA-VNTR polymorphism and self-reported maltreatment. Results for boys and girls differ according to MAOA-VNTR genotype and direction of phenotypic expression....
|
PMID: 20734127
PDF is available here.
PDF is available here.
Abstract
Abstract
We develop a genetic algorithm (GA)-based multiple regression with fuzzy inference system (FIS) to classify the presence of hypoglycemic episodes. GA is used to find the optimal fuzzy rules and membership functions of FIS and the model parameters of regression method. From a clinical study of 16 chi...
|
PMID: 21349796
PDF is available here.
PDF is available here.
Systems Biology, IET (5)2 2011
Abstract
Many methods had been developed on inferring transcriptional network from gene expression. However, it is still necessary to design new method that discloses more detailed and exact network information. Using network-assisted regression, the authors combined the averaged three-way mu...
|
PMID: 21405197
PDF is available here.
PDF is available here.
Abstract
We highlight the distinction between the two by placing this discussion within the broader context of evolution in structured populations. In this review we show that the current debate overlooks important aspects of the interplay between genetic and demographic structuring, and argue that a continu...
|
PMID: 21353325
PDF is available here.
PDF is available here.
Abstract
We isolated and analyzed 100 new mutant alleles derived from two parental alleles that both contain an intact Ac and a fractured Ac (fAc) structure at the maize p1 locus. Mutants were characterized by PCR and sequencing; the results show that nearly 90% (89/100) of the mutant alleles represent struc...
|
PMID: 21339479
PDF is available here.
PDF is available here.
Abstract
We show here that two discrete ~150-kb regions, both located early in the right replichore, exhibit prolonged juxtaposition of sister loci, for 20 and 30 min, respectively, after replication. Flanking regions, meanwhile, separate. Thus, the two identified regions comprise specialized late-splitting...
|
PMID: 21282646
PDF is available here.
PDF is available here.
Abstract
We present the available literature. Studying the associations between genetic variations and the risk of arterial thrombosis may help elucidating the role of VWF in the pathogenesis of arterial thrombosis. However, as current studies differed in study design, study population, and study endpoint, a...
|
PMID: 21342431
PDF is available here.
PDF is available here.
Trends in Genetics (27)4 2011
Abstract
The emerging field of epigenomics has the potential to bridge the gap between static genomic sequences and complex phenotypes that arise from multigenic, nonlinear and often context-dependent interactions. However, this goal can only be achieved if easily manageable experimental systems are available...
|
PMID: 21288591
PDF is available here.
PDF is available here.
Mutation Research (721)2 2011
Abstract
Our results show a dose-dependent increase in the migration of DNA in cells of the exposed organisms. A comparison among DNA lesions per mole number of the test chemical in the exposed groups showed that both BLM and CPT induce more DSBs than CP. Interestingly, Cr(VI) at 20.0μg/ml was found to indu...
|
PMID: 21281740
PDF is available here.
PDF is available here.
Abstract
We analyzed the association between combinations of SNPs and Graves' disease by investigating 108 SNPs in 384 cases and 652 controls. We evaluated our method by differentiating between cases and controls in a five-fold cross validation test, and it achieved a 72.9% prediction accuracy with a combina...
|
PMID: 21318483
PDF is available here.
PDF is available here.
Cell Cycle (10)3 2011
Abstract
We have recently found that targeting is regulated through the cell cycle. Immediately following the initiation of DNA replication, active genes lose peripheral localization for ~30 minutes. This regulation is mediated by cyclic phosphorylation of a nucleoporin by Cdk1. Some genes that are targeted...
|
PMID: 21228627
PDF is available here.
PDF is available here.
Abstract
We have therefore developed a different combination approach for the treatment of HIV infection in which an RNA aptamer, with high binding affinity to the HIV-1 envelope (gp120) protein and virus neutralization properties, is attached to and delivers a small interfering RNA (siRNA) that triggers seq...
|
PMID: 21248316
PDF is available here.
PDF is available here.
Abstract
We investigated the molecular mechanisms of the smoking cessation drug varenicline, a nicotinic acetylcholine receptor (nAChR) partial agonist, in its ability to decrease voluntary ethanol intake in mice. Previous to our study, other labs had shown that this drug can decrease ethanol consumption and...
|
PMID: 21239887
PDF is available here.
PDF is available here.