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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Models, Immunological (0):
Recent article
Models, Immunological
Collegium Antropologicum (35)2 2011
Abstract
Before and after kidney transplantations, in vitro tests that measure the level of reactivity between donor and recipient lymphocytes are performed for better organ selection and as indicator of possible organ rejection. In these tests, donor's and recipient's lymphocytes are stimula...
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PMID: 21755705
PDF is available here.
PDF is available here.
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médecine/sciences (27)5 2011
Abstract
Abstract
Abstract
Abstract
We sought to understand the consequences of neutrophil recruitment during pneumonic plague, and we studied the susceptibility of C3H-HeN mice lacking the CXC chemokine KC or its receptor CXC receptor 2 (CXCR2) to pulmonary Y. pestis infection. We found that without Kc or Cxcr2, disease progression w...
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PMID: 21356370
PDF is available here.
PDF is available here.
Abstract
We quantify the relative importance of CTLs, NK cells, B cells and target cell limitation in controlling acute SIV infection in rhesus macaques. Using three different methods, we find that the availability of target cells and CD8(+) T cells are important predictors of viral load dynamics. If CTL are...
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PMID: 21408213
PDF is available here.
PDF is available here.
Abstract
Caspase 1 activation by inflammasome complexes in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces the maturation and secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Recent reports have...
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PMID: 21350580
PDF is available here.
PDF is available here.
Abstract
We offer a new perspective on how immune responses are regulated. We do not cover how they are turned on and off, but focus instead on the second major aspect of an immune response: the control of effector class. Although it is generally thought that the class of an immune response is tailored to fi...
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PMID: 21350581
PDF is available here.
PDF is available here.
Abstract
We focus on 'crosstalk manipulation' - the microbial strategies that instigate, subvert or disrupt the molecular signalling crosstalk between receptors of the innate immune system. This proactive interference undermines host defences and contributes to microbial adaptive fitness and persistent infec...
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PMID: 21350579
PDF is available here.
PDF is available here.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (146)1 2011
Abstract
Our current appreciation of the role of the immune system is that it plays a necessary and driving role in the disease process. Investigations into the genetics of psoriasis has spurred further examinations into the contributions of immune mediators such as IL-23, IL-17, IL-22, and TNF as well as ce...
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PMID: 21317854
PDF is available here.
PDF is available here.
Abstract
We sought to outline many of the recent advances in uncovering the cell and molecular mechanisms that generate Th2 responses.
It is clear that the Th2 pathway can no longer be considered a 'default pathway' of the lung immune system as multiple cells and cytokines have now been ident...
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PMID: 21150435
PDF is available here.
PDF is available here.
Abstract
Dendritic cells generally play an important role as sentinels in the immune system. They are also very important in protecting the airways from invading pathogens and harmful particles and antigens. This review discusses current knowledge about dendritic cell function and the interac...
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PMID: 21150432
PDF is available here.
PDF is available here.
Journal of Hepatology (54)6 2011
Abstract
We describe here new approaches, for use with therapeutic vaccination, to overcome the inhibitory mechanisms impairing immune responses. We also describe innovative strategies for generating functional immune responses and inducing sustained control of this persistent infection.
Copy...
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PMID: 21238516
PDF is available here.
PDF is available here.
Journal of Hepatology (54)6 2011
Abstract
Hepatitis C virus (HCV) is a blood borne disease estimated to chronically infect 3% of the worlds' population causing significant morbidity and mortality. Current medical therapy is curative in approximately 50% of patients. While recent treatment advances of genotype 1 infection usi...
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PMID: 21236312
PDF is available here.
PDF is available here.
Abstract
We hypothesized that a weak T regulatory cell (Treg) response might contribute to the control of viral replication in HIV controllers, but might also contribute to generalized immune activation, contributing to CD4+ T cell loss. To address these hypotheses, we measured frequencies of activated (CD38...
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PMID: 21305005
PDF is available here.
PDF is available here.
TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.
Abstract
We have analyzed the molecular mechanisms underlying rEA activity in mice, and confirmed that rEA activates multiple immune cell types, including DCs, macrophages, NK, B, and T cells. The rEA adjuvant also elicits the induction of pleiotropic pro-inflammatory cytokines, responses that completely dep...
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PMID: 21760953
PDF is available here.
PDF is available here.
Abstract
Biomedical systems involve a large number of entities and intricate interactions between these. Their direct analysis is, therefore, difficult, and it is often necessary to rely on computational models. These models require significant resources and parallel computing solutions. These approaches are...
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PMID: 21431578
PDF is available here.
PDF is available here.
médecine/sciences (27)6-7 2011
Abstract
médecine/sciences (27)6-7 2011
Abstract
Abstract
We show that repeated stimulation of TLR9 produced an HLH/MAS-like syndrome on a normal genetic background, without exogenous antigen. Like previous HLH models, TLR9-induced MAS was IFN-γ dependent; however, unlike other models, disease did not require lymphocytes. We further showed that IL-10 play...
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PMID: 21576823
PDF is available here.
PDF is available here.
Abstract
We explore the effect of co-existing CCL19 and CCL21 concentration fields on guiding T cell migration. Using microfluidic devices that can configure single and superimposed chemokine fields we show that under physiological gradient conditions, human peripheral blood T cells chemotax to CCL21 but not...
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PMID: 21464944
PDF is available here.
PDF is available here.
Abstract
We critically consider the mechanistic bases for this specificity/degeneracy enigma and also compare and contrast Ag recognition by Abs and TCRs....
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PMID: 21173256
PDF is available here.
PDF is available here.
Abstract
We report that Treg promotes such neuroprotection by an even broader range of mechanisms than previously seen including inhibition of virus release, killing infected MP, and inducing phenotypic cell switches. Changes in individual Treg-induced macrophage proteins were quantified by iTRAQ labeling fo...
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PMID: 20954747
PDF is available here.
PDF is available here.
Abstract
We suggest here that life-threatening infectious diseases in childhood, occurring in the course of primary infection, result mostly from individually rare but collectively diverse single-gene variations of variable clinical penetrance, whereas the genetic component of predisposition to secondary or...
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PMID: 21091717
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Abstract
We show that a West Nile virus (WNV) mutant (E218A) that lacks 2'-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling. 2'-O methylation of viral RNA did not affect IFN induction in WNV-infected fibroblasts but in...
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PMID: 21085181
PDF is available here.
PDF is available here.
Journal of Hepatology (54)4 2011
Abstract
We summarize current knowledge of T cell responses against tumour-associated antigens, as well as the mechanisms underlying the poor quality of these responses in patients with HCC. Insights into these important aspects of HCC immunology are crucial for the further development of novel immunotherapi...
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PMID: 21145836
PDF is available here.
PDF is available here.
FASEB Journal (24)11 2010
Abstract
We have developed a vaccine against the extra domain-B (ED-B) of fibronectin. This 91-aa domain, inserted by alternative splicing, is expressed during vasculogenesis in the embryo, but essentially undetectable under normal conditions in the adult. However, ED-B is highly expressed around angiogenic...
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PMID: 20634349
PDF is available here.
PDF is available here.
Abstract
We hypothesized that B cell-activating agents might alter chemokine responses by affecting downstream signal transducers, and that such effects might differ depending on the activator. We found that activating mouse B cells using either anti-IgM or lipopolysaccharide (LPS) increased the surface expr...
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PMID: 20871625
PDF is available here.
PDF is available here.
Abstract
We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation and are tumor specific. Unexpectedly, added glycans terminate at high mannose, suggesting a potentially important interaction of F...
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PMID: 20937880
PDF is available here.
PDF is available here.
Abstract
We have studied lupus AAbs that bind dsDNA and cross-react with the NR2A and NR2B subunits of the NMDA receptor (NMDAR). In adult mouse models, when the blood-brain barrier is compromised, these NMDAR-reactive AAbs access the brain and elicit neuronal death with ensuing cognitive dysfunction and emo...
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PMID: 20921396
PDF is available here.
PDF is available here.
American Naturalist (176)4 2010
Abstract
We introduce a mechanistic framework for modeling within-host infection dynamics. Our analysis focuses first on a single parasitemia peak and then on the dynamics of multiple peaks that rely on stochastic switching between groups of parasite variants. A major feature of trypanosome infections is the...
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PMID: 20715972
PDF is available here.
PDF is available here.
Abstract
Significant progress in multiple sclerosis (MS) treatment has been made over the last two decades, including the emergence of disease-modifying therapy (DMT). However, substantial unmet medical need persists and has stimulated the search for new therapeutics. Teriflunomide, one of the several oral DM...
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PMID: 20880295
PDF is available here.
PDF is available here.
Abstract
We develop an analytical framework that links the dynamical nature of immunity and viral variation across these scales. Our epidemiological model incorporates within-host viral evolutionary dynamics for a virus that causes acute infections (e.g. influenza and norovirus) with changes in host immunity...
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PMID: 20335194
PDF is available here.
PDF is available here.
Abstract
We have generated and validated a mathematical model of type 1 diabetes pathophysiology in a well-characterized animal model of spontaneous type 1 diabetes, the non-obese diabetic (NOD) mouse. The model is based on an extensive survey of the public literature and input from an independent scientific...
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PMID: 20491795
PDF is available here.
PDF is available here.
Abstract
We observed that the responses to LPS and FCA are similar in that both AGP isoforms are induced whereas they differ in that the FCA exhibits a 6 h lag period. The response to HgCl(2,) however, exhibits the specific biphasic induction only of the 40-43 kDa AGP. The serum 40-43 kDa AGP glycoform gradu...
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PMID: 20363221
PDF is available here.
PDF is available here.
Seminars in Immunology (22)4 2010
Abstract
We discuss how the interplay between intrinsic TCR signals and cell extrinsic signals provided by Notch and TCR ligands help to assign and support a final lineage fate decision.
2010 Elsevier Ltd. All rights reserved....
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PMID: 20466561
PDF is available here.
PDF is available here.
Journal of Internal Medicine (268)2 2010
Abstract
We assessed whether IL-1beta and interferon (IFN)-gamma, cytokines produced during inflammatory conditions, may impact on IL-7 production.
We used human intestinal epithelial cells (DLD-1 cell line) and bone marrow stromal cells (HS27 cell line), known to produce IL-7; IL-7 productio...
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PMID: 20497296
PDF is available here.
PDF is available here.
Nature Reviews: Genetics (11)8 2010
Abstract
Plants are engaged in a continuous co-evolutionary struggle for dominance with their pathogens. The outcomes of these interactions are of particular importance to human activities, as they can have dramatic effects on agricultural systems. The recent convergence of molecular studies of plant immunit...
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PMID: 20585331
PDF is available here.
PDF is available here.
Nature Immunology (11)8 2010
Abstract
We report that the transcription factor MafB thwarts auto-amplification by a metastable switch activity. MafB acted as a weak positive basal regulator of transcription at the IFNB1 promoter through activity at transcription factor AP-1-like sites. Interferon elicitors recruited the transcription fac...
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PMID: 20581830
PDF is available here.
PDF is available here.
Immunological Reviews (236)1 2010
Abstract
Summary: The regulation of lymphocyte homeostasis is critical for the development and formation of productive immune responses. Cell numbers must be maintained to allow sufficient numbers of lymphocytes to combat foreign pathogens but prevent the accumulation of excess lymphocytes that may increase...
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PMID: 20636818
PDF is available here.
PDF is available here.
Journal of Immunology (185)2 2010
Abstract
We show that virulent M. tuberculosis and its cell wall mannose-capped lipoarabinomannan induce PPARgamma expression through a macrophage mannose receptor-dependent pathway. When activated, PPARgamma promotes IL-8 and cyclooxygenase 2 expression, a process modulated by a PPARgamma agonist or antagon...
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PMID: 20554962
PDF is available here.
PDF is available here.
Abstract
We will discuss the specialized properties of mucosal T cells in the context of immune homeostasis and inflammation....
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PMID: 20594129
PDF is available here.
PDF is available here.
Biomaterials (31)19 2010
Abstract
The destruction of bone around joint replacements (periprosthetic osteolysis) is an adverse biological response associated with the generation of excessive wear particles. Wear debris from the materials used for joint replacements stimulate a chronic inflammatory and foreign body reaction that leads...
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PMID: 20398931
PDF is available here.
PDF is available here.
Abstract
The development of type 1 diabetes involves a complex interaction between pancreatic beta-cells and cells of both the innate and adaptive immune systems. Analyses of the interactions between natural killer (NK) cells, NKT cells, different dendritic cell populations and T cells have highlighted how t...
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PMID: 20577267
PDF is available here.
PDF is available here.
Abstract
We discuss recent findings regarding human T(Reg) cells, including the ontogeny and development of T(Reg) cell subsets that have naive or memory phenotypes, the unique mechanisms of suppression mediated by T(Reg) cell subsets and factors that regulate T(Reg) cell lineage commitment. We discuss futur...
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PMID: 20559327
PDF is available here.
PDF is available here.
Abstract
We review recent observations revealing the ability of gammadelta T cells to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress. These studies provide insights into how they acquire these properties, through both developmental...
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PMID: 20539306
PDF is available here.
PDF is available here.
Abstract
We explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antig...
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PMID: 20559326
PDF is available here.
PDF is available here.
Abstract
We focus on host factors that influence the outcome of viral infection, including genetic susceptibility, the age of the host when infected, the dose and route of infection, the induction of anti-inflammatory cells and proteins, as well as the presence of concurrent infections and past exposure to c...
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PMID: 20577268
PDF is available here.
PDF is available here.
Nature Immunology (11)7 2010
Abstract
Abstract
We show that stimulation of innate pathways by microbiota-derived ligands and antigen-specific T cell stimulation are both required for intestinal inflammation. Microbiota-derived ligands promoted spontaneous T cell proliferation by activating dendritic cells (DCs) to produce IL-6 via Myd88, as show...
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PMID: 20498021
PDF is available here.
PDF is available here.
Abstract
The susceptibility of elderly people to infectious diseases is usually associated to increasing risk factors found in young adults. However, the role of immune function ageing is associated with the decline of immune function but this decline is not homogenous. Some functions such as the cellular im...
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PMID: 20092974
PDF is available here.
PDF is available here.
Abstract
We analyze the expression of IGF-1 and IL-4 from a single plasmid vector, where each gene is expressed through an independent promoter and enhancer sequence. Regenerative and anti-inflammatory effects of IGF-1 alone and of both IGF-1 and IL-4 were analyzed in an in vitro chondrocyte inflammatory mod...
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PMID: 20188584
PDF is available here.
PDF is available here.
Biosystems (100)3 2010
Abstract
We present a new theory of how lymphocyte-antigen interaction is governed. We present 'chronicity', a quantitative record of previous lymphocyte-antigen interactions, which is used to regulate lymphocyte behavior. When the chronicity of a lymphocyte increases with the interaction and gets beyond the...
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PMID: 20347007
PDF is available here.
PDF is available here.
Abstract
Early maternal separation and other disruptions of attachment relations are known to increase risk for the later onset of depressive illness in vulnerable individuals. It is suggested here that sensitization involving proinflammatory processes may contribute to this effect. This argument is based on...
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PMID: 20359585
PDF is available here.
PDF is available here.
Abstract
We have developed a mutation-selection model of T-cell epitope evolution that allows the human leukocyte antigen (HLA) genotype of the host to influence the evolutionary process. This is one of the first examples of the incorporation of environmental parameters into a phylogenetic model and has many...
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PMID: 20089717
PDF is available here.
PDF is available here.
Drug Discovery Today (15)9-10 2010
Abstract
We briefly review current understanding of the inflammatory mechanisms involved in the pathogenesis of COPD. This understanding has enabled the identification of several therapeutic targets that might have great potential for the development of novel anti-inflammatory and anti-remodeling biologic th...
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PMID: 20223295
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (221)1-2 2010
Abstract
We characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclear cells (PBMC) of healthy subjects and RRMS patients by gene expression microarrays. We demonstrated that LAQ induced suppression of genes related to antigen presentation and corresponding inflammatory pathways. The...
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PMID: 20347159
PDF is available here.
PDF is available here.
Journal of Immunology (184)8 2010
Abstract
We investigated relationships among chimeric TCR (cTCR) expression density, target Ag density, and cTCR triggering to predict lysis of target cells by cTCR(+) CD8(+) T human cells as a function of Ag density. Triggering of cTCR and canonical TCR by Ag could be quantified by the same mathematical equ...
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PMID: 20220093
PDF is available here.
PDF is available here.
Current Biology (20)7 2010
Abstract
I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to viral detection. Furthermore, new complexiti...
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PMID: 20392426
PDF is available here.
PDF is available here.