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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Models, Biological (5):
Recent article
Models, Biological
Abstract
Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two establi...
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PMID: 21808243
PDF is available here.
PDF is available here.
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Abstract
The introduction of predictive molecular markers has radically enhanced the identification of which patients may benefit from a given treatment. Despite recent controversies, KRAS mutation is currently the most recognized molecular predictive marker in colorectal cancer (CRC), predicting efficacy of...
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PMID: 21810517
PDF is available here.
PDF is available here.
Abstract
We summarized the results of 29 grassland plant experiments where both the phylogeny of plant species used in the experiments is well described and where extensive trait data are available. Functional trait variation was only partially related to phylogenetic distances between species, and the resul...
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PMID: 21905424
PDF is available here.
PDF is available here.
Abstract
We use penalized splines within a Bayesian state-space modeling framework to estimate and visualize survival probability in two dimensions. The approach is flexible in that no parametric form for the relationship between survival and coordinates need be specified a priori. To illustrate our method,...
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PMID: 21905433
PDF is available here.
PDF is available here.
Abstract
We applied capture-mark-recapture analysis to 25 years of monthly trapping data from a fluctuating prairie vole Microtus ochrogaster population in Illinois, USA, to estimate realized population growth rates and associated vital rates (survival and recruitment) and modeled them as a function of vole...
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PMID: 21905434
PDF is available here.
PDF is available here.
Nature Medicine (17)8 2011
Abstract
Abstract
We observed that the muscle force/GF ratios of major flexor muscles remain particularly stable with respect to the width whereas other muscle ratios differed largely. This may argue for a control strategy in which the actions of flexors were preserved in spite of change in joint postures. The estima...
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PMID: 21844605
PDF is available here.
PDF is available here.
Nature Cell Biology (13)8 2011
Abstract
How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Sta...
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PMID: 21808242
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We generated mice (termed "Nes-Met") in which met is inactivated from midembryonic stages onward in the CNS only. Adult animals showed motor behavioral defects suggestive of impaired innervation of pectoral muscles. Correspondingly, in neonatal spinal cords of Nes-Met mutants, we observed death of a...
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PMID: 21813676
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)8 2011
Abstract
We review the recent development of these algorithms and models; then list the related software and data sources; and finally discuss the existence problems and perspectives in this field....
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PMID: 21831798
PDF is available here.
PDF is available here.
Abstract
Our results also show that this replacement may change the strain energy distribution within the bone. Based on a semi-mechanistic bone remodeling theory, it is speculated that this alteration in strain energy distribution in artificial bone can destabilize normal bone remodeling process, and theref...
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PMID: 21870458
PDF is available here.
PDF is available here.
Abstract
Loss of pulp due to caries and pulpitis leads to loss of teeth and reduced quality of life. Thus, there is an unmet need for regeneration of pulp. A promising approach is stem cell therapy. Autologous pulp stem/progenitor (CD105(+)) cells were transplanted into a root canal with stro...
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PMID: 21417716
PDF is available here.
PDF is available here.
Abstract
We begin with a brief history of tau, then provide an overview of pathological forms of tau, followed by a discussion of the differential degradation of tau by either the proteasome or autophagy and possible mechanisms by which pathological forms of tau may exert their toxicity. We conclude by discu...
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PMID: 21348938
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1811)10 2011
Abstract
We focused on the formation of N-acylethanolamines from pNAPEs. While recombinant NAPE-PLD catalyzed direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the same reaction occurred in the brain homogenate of NAPE-PLD-deficient mice, suggesting that this reaction occurs...
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PMID: 21801852
PDF is available here.
PDF is available here.
Abstract
We beginning to understand how individual cells transduce mechanical force into biochemical signals. In turn, this knowledge of mechanotransduction at the cellular level is beginning to clarify the role of mechanics in patterning processes during embryonic development. In this perspective, we will d...
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PMID: 21763607
PDF is available here.
PDF is available here.
Abstract
Developmental biologists understand how different cells contribute to organ function and how cellular components work together to produce a phenotype. These insights need to be more widely applied to systems biology. Another challenge is to incorporate real-time imaging and develop computational appr...
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PMID: 21763604
PDF is available here.
PDF is available here.
Abstract
The development of facile forward and reverse genetic approaches has propelled the deconvolution of gene function in biology. While the origins of these techniques reside in the study of single-cell or invertebrate organisms, in many cases these approaches have been applied to vertebrate model system...
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PMID: 21763608
PDF is available here.
PDF is available here.
Abstract
We summarized available plasma pharmacokinetic data derived from neonates or children following intravenous administration of fosfomycin. Subsequently, we used this information for recalculation of different dosing strategies and simulated a variety of clinically applied dosing regimens. The percent...
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PMID: 21740073
PDF is available here.
PDF is available here.
Abstract
Efavirenz plasma concentration-time data obtained from 29 HIV-1-infected, treatment-naïve patients were merged with previously reported data from 32 adult healthy subjects. The model identified sex and HIV/AIDS disease as statistically significant categorical predictors of efavirenz pharmacokinetic...
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PMID: 21740076
PDF is available here.
PDF is available here.
Abstract
We demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the an...
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PMID: 21741598
PDF is available here.
PDF is available here.
Cell Stem Cell (9)1 2011
Abstract
The cell therapy branch of the regenerative medicine field has been innovative in developing new models of delivery and development and identifying alternative sources of funding. We discuss the implications of these changes for pharmaceutical companies and the opportunities they off...
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PMID: 21726828
PDF is available here.
PDF is available here.
Abstract
We have developed an approach that enhances the power of clustering techniques to infer functional and regulatory meaning of protein states in cell signaling networks. We have created a new computational framework for applying clustering to biological data in order to overcome the typical dependence...
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PMID: 21799663
PDF is available here.
PDF is available here.
Abstract
We focused on a small number of well-characterized, interacting molecules involved in actin-dependent filopodia formation: the actin remodeler Eps8, whose capping and bundling activities are a function of its ligands, Abi-1 and IRSp53, respectively; VASP and Capping Protein (CP), which exert antagon...
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PMID: 21814501
PDF is available here.
PDF is available here.
Abstract
We have developed a sparse Bayesian factor analysis model in which the observed expression diversity of among a large set of high-dimensional images is modeled by a small number of hidden common factors. We apply this approach on embryonic expression patterns from a Drosophila RNA in situ image data...
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PMID: 21814502
PDF is available here.
PDF is available here.
Abstract
We examined candidate functional variants of a haplotype block at 8q24 encompassing the two independent risk alleles for prostate and breast cancer, rs620861 and rs13281615. We used the mapping of DNase I hypersensitive sites as a tool to prioritise regions for further functional analysis. This appr...
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PMID: 21814516
PDF is available here.
PDF is available here.