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Models, Molecular (0):
Recent article
Models, Molecular
Biochimica et Biophysica Acta (1807)11 2011
Abstract
The cytochrome bc(1) complex is a key component in several respiratory pathways. One of the characteristics of the eukaryotic complex is the presence of a small acidic subunit, which is thought to guide the interaction of the complex with its electron acceptor and facilitate electron transfer. Paraco...
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PMID: 21856278
PDF is available here.
PDF is available here.
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Abstract
We report the synthesis and optical characterization of a series of aryl- and diaryl-2(1H)-pyrimidones. The electronic transitions of these chromophores are modulated by the extent of conjugation between the pendant phenyl ring and the pyrimidone core as well as the presence of electron-donating aux...
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PMID: 21790121
PDF is available here.
PDF is available here.
Abstract
A short and highly modular three-step synthesis of a new class of substituted naphthothiophenes has been developed exploiting a Pd-catalyzed tandem direct arylation/Suzuki coupling transformation as the key step.
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PMID: 21793545
PDF is available here.
PDF is available here.
Abstract
A series of conformationally flexible bicyclic N-arylimides were employed as molecular balances to study the weak aliphatic CH-π interaction between alkyl and arene groups. The formation of intramolecular CH-π interactions in the folded conformers was characterized by X-ray crystal...
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PMID: 21797218
PDF is available here.
PDF is available here.
Abstract
Metal-ligand complexes of Cu(OTf)(2) with an appropriate bisphosphine ligand have been shown to effectively catalyze the formation of substituted tetrahydropyrans via a sequential olefin migration and Prins-type cyclization. This methodology provides convenient access to a variety of...
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PMID: 21797234
PDF is available here.
PDF is available here.
Abstract
A palladium-catalyzed (3 + 2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids. The ABCD ring system of the natural product family is prepared in six steps from commercially available materials...
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PMID: 21786746
PDF is available here.
PDF is available here.
Abstract
An efficient palladium(0)-catalyzed, Cu(I)-mediated synthetic route to trisubstituted olefins and conjugate dienes has been developed via oxo directing Liebeskind-Srogl cross-coupling reactions of gem-dihaloolefin-type α-oxo ketene dithioacetals with aryl and alkenylboronic acids. T...
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PMID: 21761823
PDF is available here.
PDF is available here.
Abstract
An efficient synthetic methodology was developed to assemble 1-azaanthraquinones from N-propargylaminoquinones by copper(II)-promoted sequential 6-endo-dig chlorocyclization and oxidative aromatization. The approach can be extended to preprare chlorinated alkaloids such as cleistophi...
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PMID: 21766780
PDF is available here.
PDF is available here.
Abstract
A facile in situ formed primary amine-imine organocatalyst was developed in the asymmetric Michael addition of substituted 4-hydroxycoumarins to cyclic enones. A series of optically active polycyclic coumarin derivatives were obtained in high yields with excellent enantioselectivitie...
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PMID: 21770363
PDF is available here.
PDF is available here.
Abstract
A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels-Alder reaction to construct domain "A", REDOX chemistry to functionalize domain "B", and a palladium-mediated cross-cou...
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PMID: 21770370
PDF is available here.
PDF is available here.
Abstract
Preparation of a chiral, nonracemic 2,5-diketopiperazine diene has enabled the investigation of intermolecular hetero-Diels-Alder cycloadditions. The diketopiperazine diene is reactive with both electron-rich and -deficient alkene substrates. Diastereofacial control in the cycloaddit...
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PMID: 21770431
PDF is available here.
PDF is available here.
Abstract
An effective and facile method for the synthesis of 2-substituted perhydrofuro[2,3-b]pyran derivatives is described. The cyclization of 2-C-aldehydo-2-deoxy-d-thioglucoside in the presence of N-iodosuccinimide (NIS) is highly stereoselective. 2-Substituted cyclization products were o...
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PMID: 21774487
PDF is available here.
PDF is available here.
Abstract
The two isomers of 6-stilbene-amide-α-CD (6-StiNH-α-CD) exhibit different inclusion behaviors upon complexation with an alkyl chain bearing pyridinium end caps. Photoisomerization of the stilbene moiety of the CD derivative affects threading due to complexation between the axle and...
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PMID: 21774508
PDF is available here.
PDF is available here.
Abstract
A neutral ferrocene-appended aryl triazole receptor 1 for phosphate anions has been synthesized and characterized by X-ray crystal analysis. Among various anions, 1 shows a distinct electrochemical recognition of phosphate anions by its multiple H-bonding (C-H···O) with a tetrahed...
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PMID: 21774510
PDF is available here.
PDF is available here.
Abstract
Zeolite A (LTA) is of much interest in zeolite family because of its large-scale industrial applications. Making Zeolite A (a typical 4-connected tetrahedral framework material) at a lower connectivity (3-connected) might lead to new open architecture with expanded rings and enhanced...
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PMID: 21761820
PDF is available here.
PDF is available here.
Abstract
Through the design and synthesis of a new chiral phosphepine, the first catalytic asymmetric method for the [3 + 2] cycloaddition of allenes with olefins has been developed that generates cyclopentenes that bear nitrogen-, phosphorus-, oxygen-, and sulfur-substituted quaternary stere...
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PMID: 21766794
PDF is available here.
PDF is available here.
Abstract
We studied five patients with recessive joint dislocations and congenital heart defects, including bicuspid aortic valve (BAV) and aortic root dilatation. We identified linkage to chromosome 11 and detected a mutation (c.830G>A, p.Arg277Gln) in B3GAT3, the gene coding for glucuronosyltransferase-I (...
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PMID: 21763480
PDF is available here.
PDF is available here.
Organic Letters (13)14 2011
Abstract
A copper-catalyzed aerobic oxidative intramolecular alkene C-H amination has been developed using readily available substituted 3-benzylidene-2-pyridin-2-ylmethyl-2,3-dihydro-isoindol-1-ones as the starting materials, and the corresponding N-heterocycles were obtained in good to exce...
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PMID: 21696194
PDF is available here.
PDF is available here.
Abstract
An asymmetric Michael-type reaction of phosphorus ylides and α,β-unsaturated ketones under the catalysis of a chiral ion pair catalyst has been described. The ion pair catalyst containing a chiral counteranion was prepared by simply mixing 9-amino-(9-deoxy)-epi-quinine with l-N-Boc...
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PMID: 21755912
PDF is available here.
PDF is available here.
Abstract
The fragmentation reaction of bis-nor-seco-CB[10] with 3,5-dimethylphenol (3) delivers methylene bridged glycoluril pentamer 5 in 81% yield. The host-guest recognition properties of the previously known tetramer 4 and those of pentamer 5 and hexamer 6 toward cationic guests in water...
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PMID: 21739945
PDF is available here.
PDF is available here.
Abstract
A new macrocyclization strategy to synthesize 12- to 31-membered 5-iodo-1,2,3-triazole-containing macrocycles is described. The macrocycles have been generated using a simple and efficient copper-catalyzed cycloaddition in flow under environmentally friendly conditions. This methodol...
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PMID: 21739952
PDF is available here.
PDF is available here.
Abstract
Despite their great diversities, 2D-shaped macrocycles that can serve as the organogelators have been surprisingly rare; two planar macrocyclic fluoropentamers designed by us were highly able to gelate organic solvents, largely derived from their strong tendency to form 1D stacked fi...
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PMID: 21744782
PDF is available here.
PDF is available here.
Abstract
We have performed fluorescence polarisation assays to indirectly measure relative binding affinity, and applied computational simulations to interrogate the behaviour of the eight human BRC-RAD51 complexes, as well as a suite of BRC cancer-associated mutations. Our computational approaches encompass...
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PMID: 21789034
PDF is available here.
PDF is available here.
Abstract
Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound...
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PMID: 21728296
PDF is available here.
PDF is available here.
Abstract
A unique approach to asymmetric synthesis of various optically pure multisubstituted 2,3-dihydropyrroles catalyzed by a novel rosin-derived tertiary amine-thiourea via a tandem Michael/cyclization sequence with high yield (up to 97%) and good to excellent enantioselectivities (up to...
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PMID: 21732616
PDF is available here.
PDF is available here.