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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Nonlinear Dynamics (0):
Recent article
Nonlinear Dynamics
Abstract
Efavirenz plasma concentration-time data obtained from 29 HIV-1-infected, treatment-naïve patients were merged with previously reported data from 32 adult healthy subjects. The model identified sex and HIV/AIDS disease as statistically significant categorical predictors of efavirenz pharmacokinetic...
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PMID: 21740076
PDF is available here.
PDF is available here.
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Abstract
We investigated this apparent discrepancy by studying the effects of in vivo conditions on VN neuron activity in vitro using a simple, physiologically based, model of cellular dynamics. We found that membrane potential oscillations were evoked both in response to step and zap current injection for a...
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PMID: 21814508
PDF is available here.
PDF is available here.
Abstract
We characterised, via a synthetic biology approach, a transcriptional positive feedback loop (PFL) by generating a clonal population of mammalian cells (CHO) carrying a stable integration of the construct. The PFL network consists of the Tetracycline-controlled transactivator (tTA), whose expression...
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PMID: 21765813
PDF is available here.
PDF is available here.
Abstract
We propose a deterministic data mining approach for a distribution of a data set (input/output data) into two representative and balanced sets of roughly equal size taking the variability of the data set into consideration with the purpose of allowing both a fair evaluation of learning's accuracy an...
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PMID: 21656926
PDF is available here.
PDF is available here.
Abstract
We use the recorded EEG signals in Recurrence Plots (RP), and extract Recurrence Quantification Analysis (RQA) parameters from the RP in order to classify the EEG signals into normal, ictal, and interictal classes. Recurrence Plot (RP) is a graph that shows all the times at which a state of the dyna...
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PMID: 21656923
PDF is available here.
PDF is available here.
Abstract
Quantitative mapping of structural and functional connectivities in the human brain via non-invasive neuroimaging offers an exciting and unique opportunity to understand brain architecture. Because connectivity alterations are widely reported in a variety of brain diseases, assessmen...
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PMID: 21556745
PDF is available here.
PDF is available here.
Abstract
A previous letter by Gee et al. [J. Acoust. Soc. Am. 121, EL1-EL7 (2007)] revealed likely shortcomings in using common, stationary (long-term) spectrum-based measures to quantify the perception of nonlinearly propagated noise. Here, the Glasberg and Moore [J. Audio Eng. Soc. 50, 331-342 (2002)] algor...
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PMID: 21568378
PDF is available here.
PDF is available here.
Abstract
This study explores the phenomenology of distortion products in nonlinear cochlear models, predicting their amplitude and phase along the basilar membrane. The existence of a backward-traveling wave at the distortion-product frequency, which has been recently questioned by experiments measuring the p...
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PMID: 21568417
PDF is available here.
PDF is available here.
Abstract
We concluded that tissue elasticity and tissue damping are coupled at the level of the stress bearing element, and to the mechanisms underlying dynamic nonlinearity of lung tissue....
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PMID: 21565986
PDF is available here.
PDF is available here.
Abstract
Distortion-product otoacoustic emissions (DPOAEs) were measured as level/phase (L/P) maps in humans, rabbits, chinchillas, and rats with and without an interference tone (IT) placed either near the 2f(1)-f(2) DPOAE frequency place (f(dp)) or at one-third of an octave above the f(2) primary tone (1/3-...
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PMID: 21568412
PDF is available here.
PDF is available here.
Physical Chemistry (62)1 2011
Abstract
We review the underlying principles and excitation and detection schemes, as well as exemplary biomedical applications of this emerging class of molecular imaging techniques....
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PMID: 21453061
PDF is available here.
PDF is available here.
Abstract
The present study demonstrates the targeting of ultrasound contrast agents to human xenograft tumors by exploiting the overexpression of the glycolipid Gb3 in neovasculature. To this end, microbubbles were functionalized with a natural Gb3 ligand, the B subunit of the Shiga toxin (ST...
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PMID: 21439258
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)8 2011
Abstract
We incorporate the electrostatic-hydrogen bond switch mechanism into the Gouy-Chapman model for a membrane that is composed of PA and a hydrogen bond-donating zwitterionic lipid. To this end, our model integrates into the Gouy-Chapman approach a recently suggested electrostatic model for zwitterioni...
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PMID: 21406179
PDF is available here.
PDF is available here.
Abstract
We aimed to evaluate what levels of inhibition of integrin expression are needed to achieve tumor stasis in mice, and to compare this to the level of inhibition achieved in humans. Tumor growth inhibition was measured in mice bearing a pancreatic KP-1 tumor, dosed at 12.5-200 mg/kg over 21 days. I...
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PMID: 21387147
PDF is available here.
PDF is available here.
Abstract
These results showed evidence of nonlinear dynamics in the decentralization of innovation, the emergence of group phenomena from complex interactions of individual efforts, stigmergy in the use of social information, and dynamic tradeoffs between exploration and exploitation of solutions. These resu...
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PMID: 21382262
PDF is available here.
PDF is available here.
Abstract
We quantify the complexity embedded within the paintings of the Jackson Pollock and the musical works of Johann Sebastian Bach. We discuss the challenges inherent in comparisons of the spatial patterns created by Pollock and the sonic patterns created by Bach, including the differing roles that time...
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PMID: 21382264
PDF is available here.
PDF is available here.
Abstract
We developed a new translator tool (SADAPT-TRAN) based on Perl scripts. These scripts (a) automatically translate the core model components into robust Fortran code, (b) perform extensive mutual error checks across all input files and the raw dataset, (c) extend the options of the Monte Carlo Parame...
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PMID: 21369876
PDF is available here.
PDF is available here.
Abstract
We construct a simple but biologically reasonable model based on the experimental results of two frogs, extend the model to a system of three frogs, and theoretically predict the occurrence of rich synchronization phenomena, such as triphase synchronization and 1:2 antiphase synchronization. In addi...
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PMID: 21517531
PDF is available here.
PDF is available here.
Abstract
We propose a simple complexity indicator of classical Liouvillian dynamics, namely the separability entropy, which determines the logarithm of an effective number of terms in a Schmidt decomposition of phase space density with respect to an arbitrary fixed product basis. We show that linear growth o...
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PMID: 21517471
PDF is available here.
PDF is available here.
Abstract
We question this separation. We study an example of two interacting repressilators (artificial regulatory oscillators based on cyclic repression). We show that changing the cooperativity of transcription repression (Hill coefficient) and reaction timescales dramatically alter synchronization propert...
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PMID: 21517519
PDF is available here.
PDF is available here.
Abstract
We illustrate how this result can be successfully applied in several kernel discriminant analysis algorithms. Experimental results, using a large number of databases and classifiers, demonstrate the utility of the proposed approach. The paper also shows (theoretically and experimentally) that a kern...
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PMID: 20820072
PDF is available here.
PDF is available here.
Abstract
Cancer begins to be recognized as a highly complex disease, and advanced knowledge of the carcinogenic process claims to be acquired by means of supragenomic strategies. Experimental data evidence that tumor emerges from disruption of tissue architecture, and it is therefore conseque...
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PMID: 21319994
PDF is available here.
PDF is available here.
Abstract
I studies and later were updated with data from a phase IIb study. The population pharmacokinetic model described differences between the liquid-filled capsule used in phase I and phase IIb and the hot-melt extruded (HME) tablet formulation introduced in phase III, allowing for bridging of the two f...
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PMID: 21347617
PDF is available here.
PDF is available here.
Abstract
The objectives of this study were to evaluate the pharmacokinetics of voriconazole in liver transplant patients, probe covariate effects on voriconazole pharmacokinetics, externally validate the model and explore limited sampling strategies (LSSs) using Bayesian approaches.
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PMID: 21294597
PDF is available here.
PDF is available here.
Abstract
This paper studies the problem of stabilization for sampled-data neural-network-based control systems with an optimal guaranteed cost. Unlike previous works, the resulting closed-loop system with variable uncertain sampling cannot simply be regarded as an ordinary continuous-time system with a fast-v...
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PMID: 20601315
PDF is available here.
PDF is available here.
Abstract
We provide a rigorous proof of the main results of the previous paper and extend the method to nonlinear multi-compartment systems. A novel concept of compartment expansion is introduced to facilitate the development of our method. This formulation resolves computational difficulties associated with...
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PMID: 21165682
PDF is available here.
PDF is available here.
Abstract
This paper proposes a new approach to improve the amount of information extracted from the speech aiming to increase the accuracy of a system developed for the automatic detection of pathological voices. The paper addresses the discrimination capabilities of 11 features extracted usi...
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PMID: 21257362
PDF is available here.
PDF is available here.
Abstract
We propose a method of dual-frequency excitation to further enhance the CTR of subharmonic imaging. A dual-frequency excitation pulse is an amplitude-modulated waveform which consists of two sinusoids with frequencies of f₁ (e.g., 9 MHz) and f₂ (e.g., 6 MHz) and the resulting envelope component...
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PMID: 21342823
PDF is available here.
PDF is available here.
Abstract
Golay-encoded excitation in combination with the third harmonic (3f₀) transmit phasing is examined for both signal-to-noise ratio (SNR) and contrast-to-tissue ratio (CTR) improvements in harmonic imaging of contrast microbubbles. To produce the cancellation pair of tissue harmonic...
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PMID: 21342820
PDF is available here.
PDF is available here.
Abstract
SURF contrast imaging, as described previously in the literature, is a contrast agent detection technique achieved by processing of the received signals from transmitted dual frequency band pulse complexes with overlapping high-frequency (HF) and low-frequency (LF) pulses. The transm...
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PMID: 21342814
PDF is available here.
PDF is available here.
Abstract
To probe into the new idea along with establishment of a novel method for dynamic monitoring and early-warning on the wild resources of traditional Chinese medicines (TCMs).
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PMID: 21585022
PDF is available here.
PDF is available here.
Abstract
The purpose of this study has been to describe motor activity data obtained by using wrist-worn actigraphs in patients with schizophrenia and major depression by the use of linear and non-linear methods of analysis. Different time frames were investigated, i.e., activity counts measured every minute...
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PMID: 21297977
PDF is available here.
PDF is available here.
Abstract
A portable close-loop control FES system, whose controller is a microcomputer, was proposed in this chapter. Considering the time-varying nonlinear of the muscle system, a self-adaptive PI control strategy was used. It included a neural network identifier (NNI) and a PI controller. NNI could get the...
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PMID: 21431603
PDF is available here.
PDF is available here.
Abstract
Neuroeconomic conditions for "rational addiction" (Becker and Murphy, 1988) have been unknown. This paper derived the conditions for "rational addiction" by utilizing a nonlinear time-perception theory of "hyperbolic" discounting, which is mathematically equivalent to the q-exponenti...
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PMID: 21712792
PDF is available here.
PDF is available here.
Abstract
Mathematical models of the immune response to the Human Immunodeficiency Virus demonstrate the potential for dynamic schedules of Highly Active Anti-Retroviral Therapy to enhance Cytotoxic Lymphocyte-mediated control of HIV infection.
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PMID: 21619634
PDF is available here.
PDF is available here.
Abstract
In this paper, a detailed description and comparison of speckle reduction of medical ultrasound, and in particular echocardiography, is presented. Fifteen speckle reduction filters are described in a detailed fashion to facilitate implementation for research and evaluation. The filte...
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PMID: 21244977
PDF is available here.
PDF is available here.
Abstract
Research suggests that individuals recovering from a stroke often experience social isolation, which is linked to increased depressive symptomatology and decreased ability to manage activities of daily living. Research also indicates that different racial and ethnic groups are more adversely affected...
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PMID: 21371987
PDF is available here.
PDF is available here.
Abstract
We demonstrate various electrical phenomena such as resistive switching and related nonlinear conduction, current hysteresis, and negative differential resistance intrinsic to a thin layer of SiO(x). These behaviors can largely mimic numerous electrical phenomena observed in molecules and other nano...
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PMID: 21175171
PDF is available here.
PDF is available here.
Abstract
We automate the process of finding parameters. To configure a single neuron we derive a maximum likelihood method for configuring a neuron model, specifically the Mihalas-Niebur Neuron. Similarly, to configure neural circuits, we show how we use genetic algorithms (GAs) to configure parameters for a...
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PMID: 20959265
PDF is available here.
PDF is available here.
Abstract
This paper presents a study of possible models to describe the relation between the scintillation light point-of-origin and the measured photo detector pixel signals in monolithic scintillation crystals. From these models the X, Y and depth of interaction (DOI) coordinates can be estimated simultane...
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PMID: 20959686
PDF is available here.
PDF is available here.
Abstract
We propose a mechanism to alter the nature of the potential barriers when a biased brownian particle undergoes a constrained motion in narrow periodic channel. By changing the angle of the external bias, the nature of the potential barriers changes from purely entropic to energetic, which in turn af...
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PMID: 21230458
PDF is available here.
PDF is available here.
Abstract
We found that at sufficiently high shear rates, the slip flow over atomically flat crystalline surfaces is anisotropic. It is demonstrated numerically that the friction coefficient at the liquid-solid interface (the ratio of viscosity and slip length) undergoes a transition from a constant value to...
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PMID: 21230484
PDF is available here.
PDF is available here.
Abstract
This study compared the ability of binary logistic regression (BLR) and non-linear causal resource analysis (NCRA) to utilize a range of cognitive, sensory-motor, personality and demographic measures to predict driving ability in a sample of cognitively healthy older drivers. Participants were sixty...
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PMID: 20728627
PDF is available here.
PDF is available here.
Nature Neuroscience (13)11 2010
Abstract
I discuss how extracellular cues, including synaptic activity and neurotrophic factors, influence epigenetic modifications and regulate the neuronal transcriptional response. I also summarize additional mechanisms that induce chromatin remodeling events by combinatorial assembly of multiprotein comp...
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PMID: 20975757
PDF is available here.
PDF is available here.
Physiological Measurement (31)11 2010
Abstract
We propose here a simple algorithm for automated detection of spontaneous activity transients (SATs) in early preterm electroencephalography (EEG). The parameters of the algorithm were optimized by supervised learning using a gold standard created from visual classification data obtained from three...
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PMID: 20938065
PDF is available here.
PDF is available here.
Psychological Reports (107)2 2010
Abstract
First, a discussion is presented of some previous research results on the relation of a person's assessment of the importance ("value") of an object and his or her attitude toward that object, in particular on the relation of work values with job satisfaction. Then, a model is formulated and simulat...
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PMID: 21117465
PDF is available here.
PDF is available here.
Abstract
We review some of the key intellectual developments in epidemiology facilitated by long-term data. We identify research frontiers at the interface of ecology and epidemiology and their associated data needs....
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PMID: 20800928
PDF is available here.
PDF is available here.
Ergonomics (53)10 2010
Abstract
Since 1958 more than 80 journal papers from the mainstream ergonomics literature have used either the words 'complex' or 'complexity' in their titles. Of those, more than 90% have been published in only the past 20 years. This observation communicates something interesting about the way in which con...
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PMID: 20865602
PDF is available here.
PDF is available here.
Abstract
To assess under load the biomechanical behavior of the cementing system of feldspathic vs alumina porcelain veneers.
A 3D model of a maxillary central incisor, the periodontal ligament (PDL) and the alveolar bone was generated. Incisors restored with alumina and feldspathic porcelain veneers were co...
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PMID: 20157681
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: A population pharmacokinetic study of orally dosed azithromycin was conducted in order to determine if the antibiotic usage in clinical practice is reasonable and individualized. METHOD: A nonlinear mixed effect model with various oral azithromycin formulations was constructed using the N...
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PMID: 20875372
PDF is available here.
PDF is available here.
Abstract
We want curative or near-curative therapy that will return patients to a normal state of health at a feasible cost, much better diagnostic and therapeutic technologies need to be developed. This review addresses the vexing group of heart failure etiologies that include cardiomyopathies and other ven...
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PMID: 20869655
PDF is available here.
PDF is available here.
Optics Express (18)20 2010
Abstract
A generalized exponential spectrum model is derived, which considers finite turbulence inner and outer scales and has a general spectral power law value between the range 3 to 5 instead of standard power law value 11/3. Based on this generalized spectrum model, a new generalized long exposure turbul...
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PMID: 20941023
PDF is available here.
PDF is available here.
Applied Spectroscopy (64)9 2010
Abstract
Transient dispersed vibrational echo (DVE) spectroscopy is a practical alternative to transient-absorption spectroscopy because it affords increased sensitivity as well as greater signal-to-noise ratio without the need to detect a reference spectrum. However, as a third-order nonlinear probe, the ex...
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PMID: 20828441
PDF is available here.
PDF is available here.
Abstract
We focus on the brain from the perspective of a dynamic network and discuss the role of its network constituents in shaping brain dynamics. These constituents include the brain's structural connectivity, the population dynamics of its network nodes and the time delays involved in signal transmission...
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PMID: 21175008
PDF is available here.
PDF is available here.
Abstract
Early in life, brain development carries with it a large number of structural changes that impact the functional interactions of distributed neuronal networks. Such changes enhance information processing capacity, moving the brain from a deterministic system to one that is more stochastic. The evide...
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PMID: 21175017
PDF is available here.
PDF is available here.
Abstract
As systems evolve over time, their natural tendency is to become increasingly more complex. Studies in the field of complex systems have generated new perspectives on management in social organizations such as hospitals. Much of this research appears as a natural extension of the cross-disciplinary...
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PMID: 20798616
PDF is available here.
PDF is available here.
Abstract
We describe a dynamic causal model [DCM] of how anticipatory, evoked, and spontaneous skin conductance changes are generated by sudomotor nerve activity. Inversion of this model, using variational Bayes, provides a means of inferring the most likely sympathetic nerve activity, given observed skin co...
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PMID: 20599582
PDF is available here.
PDF is available here.
Abstract
We summarize common structural features of GSMs, pick up the controversial discussion regarding their mechanism of action, and show how computational analysis of pharmacophoric features can help reveal their pharmacological profile.
Copyright 2010 Elsevier Ltd. All rights reserved....
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PMID: 20591508
PDF is available here.
PDF is available here.
Psychiatry Research (186)1 2011
Abstract
We collected data and constructed logistic models from a sample of 78 normal adults and 33 patients (aged 50-85 years). To determine accuracy, we compared logistic regression results to a geriatrician's diagnosis of MCI or dementia that included Alzheimer's disease, vascular dementia or mixed dement...
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PMID: 20817309
PDF is available here.
PDF is available here.
Clinical Neurophysiology (121)9 2010
Abstract
MSE measures identified an abnormal complexity profile across different temporal scales and their relation to the severity of AD. SIGNIFICANCE: These findings indicate that entropy-based analytic methods with applied at temporal scales may serve as a complementary approach for characterizing and und...
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PMID: 20400371
PDF is available here.
PDF is available here.