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Neoplasm Transplantation (1):
Recent article
Neoplasm Transplantation
Abstract
We now show that circulating levels of bioactive glucagon-like peptide-1 (GLP-1) (7-36amide) start to increase above control levels exactly at the time of onset of anorexia. At this time-point, bioactive glucagon as well as total glucagon precursors and GLP-1 metabolites are already vastly elevated...
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PMID: 21824258
PDF is available here.
PDF is available here.
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Abstract
9-Substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles were discovered as highly selective and potent anaplastic lymphoma kinase (ALK) inhibitors by structure-based drug design. The high target selectivity was achieved by introducing a substituent close to the E(0) regi...
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PMID: 21823617
PDF is available here.
PDF is available here.
Abstract
Our aim was to construct and characterize (111)In-nuclear translocation sequence (NLS)-7G3, an Auger electron-emitting radioimmunotherapeutic agent that preferentially recognizes the expression of CD123 (interleukin-3 receptor [IL-3R] α-subchain) in the absence of CD131 (IL-3R β-subchain) displayed...
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PMID: 21816968
PDF is available here.
PDF is available here.
Abstract
The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors has been increasing over the past 3 decades. Because of high densities of somatostatin receptors (sstr)--mainly sstr-2--on the cell surface of these tumors, (111)In-diethylenetriaminepentaacetic acid-octreotide scintigraphy...
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PMID: 21852355
PDF is available here.
PDF is available here.
Abstract
We discovered that curcuminoids were mainly present as glucuronides in plasma, whereas in free form in tumor tissue. A validated LC/MS/MS method was established to determine the three free curcuminoids in tumor homogenate. Samples were separated on a Zorbax SB-C(18) column, eluted with acetonitrile-...
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PMID: 21856253
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
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PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
To evaluate the effect of RNA interference (RNAi) mediated silence of signal transduction and activation of transcription (STAT)3 on the growth of human pancreatic cancer cells both in vitro and in vivo.
STAT3 specific shRNA was used to silence the expression of STAT3...
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PMID: 21799645
PDF is available here.
PDF is available here.
Abstract
We applied multilayered polyelectrolyte assemblies on nanoparticles to create viable systemic delivery systems. Focusing on tumor-specific delivery, LbL nanoparticles that exhibit a pH-sensitive outer stealth layer are demonstrated to target and be retained in hypoxic tumor regions. The neutral laye...
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PMID: 21513353
PDF is available here.
PDF is available here.
Abstract
We applied multilayered polyelectrolyte assemblies on nanoparticles to create viable systemic delivery systems. Focusing on tumor-specific delivery, LbL nanoparticles that exhibit a pH-sensitive outer stealth layer are demonstrated to target and be retained in hypoxic tumor regions. The neutral laye...
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PMID: 21513353
PDF is available here.
PDF is available here.
Abstract
We generated mice with combined loss of IFN-γ and the β-common cytokines GM-CSF and IL-3. These immunodeficient mice develop chronic pulmonary inflammation and lung tumors at a high frequency. Examination of the relationship between these tumors and their inflammatory microenvironment revealed a d...
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PMID: 21537082
PDF is available here.
PDF is available here.
Abstract
We show that both mouse iPS and parental ES cells exhibited highly similar in vitro capacity to undergo directed differentiation into DE progenitors. With few exceptions, both cell types displayed similar surges in gene expression of specific master transcriptional regulators and global transcriptom...
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PMID: 21537085
PDF is available here.
PDF is available here.
Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes.
Abstract
Defining key driver mutations in cancer, the resulting aberrations in molecular mechanisms and the subsequent phenotype underpins the development and implementation of novel personalized medicine strategies. The literature is replete with biomarkers of prognosis and therapeutic responsiveness identif...
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PMID: 21516344
PDF is available here.
PDF is available here.
Abstract
To evaluate the biological and clinical characteristics of miR-622 in gastric cancer.
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PMID: 21528065
PDF is available here.
PDF is available here.
Abstract
Despite advancement in therapies, overall survival rates for relapsed pediatric sarcomas are dismal. Newer therapies are needed to effectively salvage these patients. Oncolytic viruses (such as reovirus) and other genetically altered viruses (such as herpes simplex viruses and adenoviruses) have show...
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PMID: 21472724
PDF is available here.
PDF is available here.
Abstract
We aimed to examine the effects of NT-4 on colon tumor angiogenesis, growth, and carcinomatosis. We showed that NT-4 was expressed in human colon cancer cells (LS174). A 20-fold increase in NT-4 expression was stably induced by NT-4 pcDNA in LS174 cells. In vivo, a Matrigel angiogenesis assay showed...
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PMID: 21406174
PDF is available here.
PDF is available here.
Abstract
We have recently shown that allogeneic intrabone marrow-bone marrow transplantation + adult thymus transplantation (TT) is effective for hosts with malignant tumors. However, since thymic and hematopoietic cell functions differ with age, the most effective age for such intervention needed to be...
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PMID: 20672991
PDF is available here.
PDF is available here.
Abstract
We used BM-MSCs engineered with the murine interferon-alpha (IFN-α) gene (BM-MSCs/IFN-α) to assess in a mouse plasmacytoma model the efficacy of this approach toward neoplastic plasma cells. We found that IFN-α can be efficiently produced and delivered inside the tumor microenvironment. Subcutane...
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PMID: 20695752
PDF is available here.
PDF is available here.
Abstract
We studied the biological and genetic characteristics of such cells in CRC cell lines and primary tumors. Three CRC cell lines were sorted in CD133 positive and negative fractions. The respective genetic aberration profiles were studied using array comparative genomic hybridization (aCGH) and expres...
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PMID: 21435437
PDF is available here.
PDF is available here.
Abstract
To establish a gastric cancer nude-mouse model with improved orthotopic implantation and investigate its biological characteristics at different time points.
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PMID: 21472102
PDF is available here.
PDF is available here.
Abstract
Primary lymphomas of the breast are very rare (0.2-1.5% of breast malignancies) and the vast majority (95%) are of B-cell origin. Recently, 40 cases of clinically indolent anaplastic large-cell kinase (ALK)-negative, T-cell, anaplastic, non-Hodgkin lymphomas (T-ALCL) have been reported worldwide.
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PMID: 21425149
PDF is available here.
PDF is available here.
Abstract
In the current study, the authors sought to identify the molecular mechanisms underlying the chemoresistance of lung cancer stem or initiation cells (cancer stem cells).
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PMID: 21425153
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
Although the KRAS mutation is one of critical genetic alterations in endometrial carcinogenesis, the downstream targets are not known.
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PMID: 21411444
PDF is available here.
PDF is available here.
Abstract
We aimed to evaluate what levels of inhibition of integrin expression are needed to achieve tumor stasis in mice, and to compare this to the level of inhibition achieved in humans. Tumor growth inhibition was measured in mice bearing a pancreatic KP-1 tumor, dosed at 12.5-200 mg/kg over 21 days. I...
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PMID: 21387147
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
Carcinoma-associated fibroblasts (CAFs) in tumor stroma play an important role in tumor progression and have been associated with a poor prognosis in oral squamous cell carcinoma (OSCC). However, how CAFs influence OSCC malignancy and whether normalizing CAFs inhibits cancer progression remain unclea...
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PMID: 21385934
PDF is available here.
PDF is available here.
Abstract
To investigate the biological features of hepatitis B virus (HBV)-transfected HepG2.2.15 cells.
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PMID: 21448419
PDF is available here.
PDF is available here.
Abstract
We tested two novel drugs designed to specifically inhibit NF-κB by targeting the IκB kinase (IKK) complex: Compound A and NEMO binding domain (NBD) peptide. Using an established mouse model of cancer cachexia (C26 adenocarcinoma), we determined how these drugs affected the development of tumor-in...
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PMID: 21356358
PDF is available here.
PDF is available here.
Stem Cell Research (6)2 2011
Abstract
We describe simple, time-saving methods to address the current difficulties at these two critical junctures. First, we have developed a method to increase the number of infectious viral units 600-fold. Second, we have developed a TRA-1-81-based positive selection column method for isolating "true" h...
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PMID: 21095172
PDF is available here.
PDF is available here.
Abstract
To verify whether arterial-phase contrast-enhanced ultrasonography (CEUS) of tumor parenchymal tissue is useful for evaluation of anti-angiogenesis agents.
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PMID: 21448357
PDF is available here.
PDF is available here.
Abstract
To gain new insights into tumor metabolism and to identify possible biomarkers with potential diagnostic values to predict tumor metastasis.
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PMID: 21390142
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)7 2011
Abstract
The present study was to examine the effect of sphingosine kinase-1 (SPHK1) on chemotherapeutics-induced apoptosis in non-small cell lung cancer (NSCLC) cells, which is relatively insensitive to chemotherapy, and its clinical significance in NSCLC progression.
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PMID: 21325072
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)7 2011
Abstract
Src is an attractive target because it is overexpressed in a number of malignancies, including ovarian cancer. However, the effect of Src silencing on other Src family kinases (SFKs) is not known. We hypothesized that other SFK members could compensate for the lack of Src activity.
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PMID: 21300758
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
We sought to dissect the role of TGF-β blockade in the formation of ascites....
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PMID: 21278244
PDF is available here.
PDF is available here.
Abstract
To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.
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PMID: 21253388
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
Heparanase promotes myeloma growth, dissemination, and angiogenesis through modulation of the tumor microenvironment, thus highlighting the potential of therapeutically targeting this enzyme. SST0001, a nonanticoagulant heparin with antiheparanase activity, was examined for its inhibition of myeloma...
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PMID: 21257720
PDF is available here.
PDF is available here.
Abstract
To examine the effects of combined treatment of oxaliplatin and phosphatidylinositol 3'-kinase inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) for gastric cancer.
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PMID: 21245990
PDF is available here.
PDF is available here.
Abstract
We summarize recent work focusing on preclinical evaluation of histone deacetylase inhibitors (HDACis) for the treatment of MPNST. HDACis are a novel drug class with anti-cancer therapeutic promise. Using human MPNST cell lines and xenograft models we found that a MPNST subset is highly sensitive to...
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PMID: 21224727
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
To explore the potential of navitoclax in combination with taxane-based chemotherapy in the treatment of non-small cell lung cancer (NSCLC) by defining mechanism of synergy and identifying correlative biomarkers.
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PMID: 21220478
PDF is available here.
PDF is available here.
Abstract
Here we aimed to investigate the effect of COX-2 siRNA on proliferation and angiogenesis of gastric cancer cells.
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PMID: 21266034
PDF is available here.
PDF is available here.
Abstract
We developed a novel vector for 10B (sodium borocaptate: BSH) delivery using HVJ-E and cationized gelatin for treating multiple liver tumors with BNCT without severe adverse events....
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PMID: 21247507
PDF is available here.
PDF is available here.
Abstract
We hypothesized that different VEGF isoforms can exert different effects on the functional and structural characteristics of tumor angiogenesis. We used dynamic contrast-enhanced MRI (DCE-MRI) and steady-state contrast-enhanced MRI (SSCE-MRI) to evaluate in vivo vascular functions (e.g., perfusion a...
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PMID: 21283766
PDF is available here.
PDF is available here.
Abstract
We have previously shown that IRF4, together with IRF8, orchestrates pre-B cell development by limiting pre-B cell expansion and by promoting pre-B cell differentiation. Here, we report that IRF4 suppresses c-Myc induced leukemia in EμMyc mice. Our results show that c-Myc induced leukemia was great...
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PMID: 21818355
PDF is available here.
PDF is available here.
Abstract
We present a protocol for propagating human retinoblastoma tumors in vivo using Rag2(-/-) immune deficient mice. Cultured human retinoblastoma tumorspheres of low passage or cells obtained from freshly harvested human retinoblastoma tumors injected directly into the vitreous cavity of murine eyes fo...
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PMID: 21847079
PDF is available here.
PDF is available here.
Voprosy onkologii (57)2 2011
Abstract
Efficiency of gemcitabine plus lomustine treatment of transplantable lymphosarcoma LIO-1 in mice was significantly higher than that of monotherapy. According to the area under the kinetic curve for tumor growth, antitumor action, for single maximum tolerable dose of gemcitabine 25 mg/kg body, rose 4....
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PMID: 21809669
PDF is available here.
PDF is available here.
Abstract
Realizing the potential that human embryonic stem cells (hESCs) hold, both for the advancement of biomedical science and the development of new treatments for many human disorders, will be greatly facilitated by the introduction of standardized methods for assessing and altering the biological prope...
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PMID: 21042985
PDF is available here.
PDF is available here.
Abstract
Clinical Cancer Research (17)6 2011
Abstract
We examined the effect of Chase-ABC on OV spread and efficacy....
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PMID: 21177410
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
The rapid tumor targeting and pharmacokinetic properties of engineered antibodies make them potentially suitable for use in imaging strategies to predict and monitor response to targeted therapies. This study aims to evaluate C6.5 diabody (C6.5 db), a noncovalent anti-HER2 single-chain Fv dimer, as a...
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PMID: 21177408
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)4 2011
Abstract
We investigated the effect of BI 2536 on neuroblastoma cells in vitro and in vivo to explore PLK1 as a potential target in high-risk neuroblastoma therapy....
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PMID: 21169242
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third cause of global cancer mortality. Increasing evidence suggest that STAT3 is a critical mediator of oncogenic signaling in HCC and controls the expression of several genes involved in proliferation, survival, me...
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PMID: 21131551
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
BIBF 1120 is a potent, orally available triple angiokinase inhibitor that inhibits VEGF receptors (VEGFR) 1, 2, and 3, fibroblast growth factor receptors, and platelet-derived growth factor receptors. This study examined the antitumor effects of BIBF 1120 on hepatocellular carcinoma (HCC) and attempt...
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PMID: 21131553
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
We now investigate whether the addition of lapatinib (L), a dual HER1/2 kinase inhibitor, to T results in more potent inhibition of the pathway and therefore inhibition of tumor growth, and whether reduced dose and intermittent treatment with the combination is equally effective....
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PMID: 21138857
PDF is available here.
PDF is available here.
Abstract
We isolate for the first time viable tumorigenic melanoma CTC and demonstrate that this cell population is capable of metastasis formation in human-to-mouse xenotransplantation experiments. The presence of CTC among peripheral blood mononuclear cells (PBMC) of murine recipients of subcutaneous (s.c....
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PMID: 20977885
PDF is available here.
PDF is available here.
Journal of Neurosurgery (113 Suppl) 2010
Abstract
Our data support the potential for downregulation of Ku70 expression in enhancing the radiosensitivity of gliomas. The findings of our study indicate that targeted gene therapy-mediated inactivation of Ku70 may represent a promising strategy in improving the radioresponsiveness of gliomas to GKT....
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PMID: 21121806
PDF is available here.
PDF is available here.
Abstract
We show a 100-fold range in MIC frequency in human melanoma (1 in 18,000 to 1 in 1,851,000 cells) in the NOD/SCID mouse. In this model, human melanoma cells with high aldehyde dehydrogenase (ALDH) activity were enriched 16.8-fold in tumorigenic cells over unfractionated (UNF) cells, such that 1 in 2...
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PMID: 20739950
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)3 2011
Abstract
Collectively, these data indicate loss of HtrA1 may contribute to the aggressiveness and metastatic ability of endometrial tumors....
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PMID: 21098697
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG, and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and...
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PMID: 20826787
PDF is available here.
PDF is available here.
Abstract
We show that methionine sulfoxide reductase A (MsrA), which is known to protect proteins from oxidation and which acts as a ROS scavenger, is down-regulated in a number of breast cancers. Moreover, levels of MsrA correlate with advanced tumor grade. We therefore investigated the functional role of M...
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PMID: 20937881
PDF is available here.
PDF is available here.
British Journal of Cancer (103)9 2010
Abstract
We investigate the expression and functional relevance of hK1 in human gastrointestinal stromal tumour (GIST).
Vascularisation and hK1 expression of GIST samples were assessed by immunohistochemistry. In two GIST cell lines, hK1 expression was assessed by PCR, and hK1 protein levels and activity wer...
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PMID: 20859288
PDF is available here.
PDF is available here.
Abstract
We generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastasis in particular, and provide a useful platform for...
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PMID: 20921380
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
The BRCA2 gene is responsible for a high number of hereditary breast and ovarian cancers, and studies of the BRCA2 biological functions are limited by the lack of models that resemble the patient's tumour features. The aim of this study was to establish and characterise a new human breast carcinoma...
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PMID: 20877358
PDF is available here.
PDF is available here.