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Parabiosis (1):
Recent article
Parabiosis
Abstract
We show that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice. Accordingly, exposing a young mouse to an old systemic environment or to plasma from old mice decreased synaptic plasticity, and impaired contextual fear con...
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PMID: 21886162
PDF is available here.
PDF is available here.
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Journal of Immunology (181)2 2008
Abstract
We show that the niche for recirculating T cells in the thymus, i.e., their absolute number, is the same in lymphopenic and normal mice. Using a novel combination of TCR-transgenic mice in which the ligand necessary for positive selection of host T cells is only expressed by transferred donor T cell...
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PMID: 18606674
PDF is available here.
PDF is available here.
Abstract
We studied the mobilization of BM cells to circulation by inoculating mice with VEGF polypeptides, adenoviral vectors expressing VEGF, or tumors. We induced angiogenesis by syngeneic melanomas, APCmin adenomas, adenoviral VEGF delivery, or matrigel plugs in four different genetically tagged universa...
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PMID: 18443294
PDF is available here.
PDF is available here.
Abstract
Wild type embryos of the newt Pleurodeles waltl were used to realize parabiosis, a useful model to study the effect of endogenous circulating hormones on gonad development. The genotypic sex of each parabiont (ZZ male or ZW female) was determined early from the analysis of the sex chromosome borne m...
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PMID: 18008317
PDF is available here.
PDF is available here.
Abstract
We hypothesized that circulating osteogenic connective tissue progenitors (CTPs) home to fracture site and contribute to skeletal repair. Parabiotic animals were formed by surgically conjoining transgenic mice constitutively expressing green fluorescent protein (GFP) in no erythroid tissue and synge...
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PMID: 17729300
PDF is available here.
PDF is available here.
FASEB Journal (22)2 2008
Abstract
We established a parabiotic model in which two mice were conjoined subcutaneously without any vascular anastomosis. When wild-type mice were joined with transgenic mice that expressed green fluorescent protein (GFP) in all tissues, GFP-positive cells were detected not only in the peripheral blood bu...
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PMID: 17848623
PDF is available here.
PDF is available here.
Abstract
We found no evidence of circulating dermal fibroblast progenitors that participate in the development of bleomycin-induced skin fibrosis.
(c) 2007 Wiley-Liss, Inc....
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PMID: 17579342
PDF is available here.
PDF is available here.
Journal of Immunology (180)1 2008
Abstract
We previously demonstrated that IL-7 is produced by intestinal goblet cells and is essential for the persistence of colitis. It is well known, however, that goblet cells are decreased or depleted in the chronically inflamed mucosa of animal colitis models or human inflammatory bowel diseases. Thus,...
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PMID: 18097039
PDF is available here.
PDF is available here.
Nature Neuroscience (10)12 2007
Abstract
We investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on t...
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PMID: 18026097
PDF is available here.
PDF is available here.
Abstract
We addressed whether BMDCPCs can transdifferentiate into adipocytes under standard conditions as well as in the settings of diet-induced obesity, rosiglitazone treatment, and exposure to G-CSF. We also addressed the possibility of transdifferentiation to adipocytes in a murine parabiosis model. In e...
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PMID: 18060029
PDF is available here.
PDF is available here.
Abstract
Recent studies involving molecular modification of adult somatic cells have pointed to a remarkable plasticity in cell identity. In this issue of the JCI, Koh and colleagues assessed whether bone marrow-derived cells could alter their fate under circumstances conducive to adipocyte generation in viv...
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PMID: 18060026
PDF is available here.
PDF is available here.
Abstract
We show that muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate and that this conversion is mediated by factors in the systemic environment of the old animals. We also show that this lineage conversion is associated...
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PMID: 17690295
PDF is available here.
PDF is available here.
Circulation Research (101)3 2007
Abstract
Nature Immunology (8)6 2007
Abstract
We found that unequal exchange of DCs between mice joined by parabiosis reflected uneven distribution of DC precursors in blood due to their short half-life in circulation. DCs underwent only a limited number of divisions in the spleen or lymph nodes over a 10- to 14-day period and were replenished...
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PMID: 17450143
PDF is available here.
PDF is available here.
Abstract
Abstract
Nicotine treatment increased the number of EPCs in the bone marrow and spleen, and increased their incorporation into the vasculature of ischemic tissue. Administration of nicotine increased markers of EPC mobilization. This study indicates that the known angiogenic effect of nicotine may be mediate...
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PMID: 17174197
PDF is available here.
PDF is available here.
Journal of Immunology (177)8 2006
Abstract
In pre-Talpha (pTalpha) gene-deleted mice, the positively selectable CD4+ CD8+ double-positive thymocyte pool is only 1% that in wild-type mice. Consequently, their peripheral T cell compartment is severely lymphopenic with a concomitant increase in proportion of CD25+ FoxP3+ regulatory T cells. Usi...
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PMID: 17015684
PDF is available here.
PDF is available here.
Abstract
We show that vascular endothelial cells can differentiate from common myeloid progenitors and granulocyte/macrophage progenitors. Endothelial cells derived from transplanted bone marrow-derived myeloid lineage progenitors expressed CD31, von Willebrand factor, and Tie2 but did not express the hemato...
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PMID: 16920790
PDF is available here.
PDF is available here.
Abstract
Abstract
These results were confirmed by intramyocardial injection of quail bone marrow cells that were found to express markers of myocytes, coronary smooth muscle, and epicardium. Experiments using lacZ-transgenic chick embryos for a second positive cellular marker showed that fusion between chick and quai...
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PMID: 16522159
PDF is available here.
PDF is available here.
Abstract
We have successfully established the two-way paradigm model in mice....
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PMID: 16361150
PDF is available here.
PDF is available here.
Immunology (115)2 2005
Abstract
We found that CD4+ subpopulations displayed characteristic regulator of G-protein signalling (RGS) gene expression profiles. Regulatory T cells express higher levels of RGS1, RGS9 and RGS16 than naive cells. These genes are up-regulated upon cell activation and their level of expression correlates w...
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PMID: 15885123
PDF is available here.
PDF is available here.
Journal of Surgical Research (125)1 2005
Abstract
Small animal isolated heart experiments perfused with blood are more successful, more efficient, and more cost effective when supported with a membrane oxygenator rather than a support animal. Membrane oxygenators reduce complexity, variability, and animal wastage in isolated heart experiments....
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PMID: 15836857
PDF is available here.
PDF is available here.
Abstract
We used parabiosis between intact and SCN-lesioned mice to show that nonneural (behavioral or bloodborne) signals are adequate to maintain circadian rhythms of clock gene expression in liver and kidney, but not in heart, spleen, or skeletal muscle. These results indicate that the SCN regulates expre...
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PMID: 15710878
PDF is available here.
PDF is available here.
Cellular Immunology (233)2 2005
Abstract
We have previously shown that mice with generalised lymphoproliferative disorder (gld) have increased bone mass in addition to autoimmune disease characterised by the accumulation of double negative (dn) T lymphocytes (CD3(+)CD4(-)CD8(-)CD45R(+)). To further explore the association of the immune dis...
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PMID: 15950207
PDF is available here.
PDF is available here.
Immunology (114)1 2005
Abstract
These results suggest that, because circulatory blood is not exchanged in the joints, granulocytes and other lymphocytes are generated in situ in the inflamed joints of mice with collagen-induced arthritis or are possibly supplied by the bone marrow. It is of interest that granulocytes in the joints...
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PMID: 15606803
PDF is available here.
PDF is available here.
Abstract
I alveolar epithelial cells immunostained for green fluorescent protein in wild-type mice. Approximately 5 to 20% of lung fibroblasts primary cultured from injured wild-type mice were green fluorescent protein expressing cells, indicating their blood derivation. This study demonstrates that stem/pro...
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PMID: 15282197
PDF is available here.
PDF is available here.
Experimental Hematology (32)9 2004
Abstract
Surprisingly, we find that stem cells trafficking out of bone marrow and into the circulation do not stably return to bone marrow, although long-lived lymphoid precursors do stably re-engraft. Circulating HSC do, however, take up residence in skeletal muscle, wherein they account for HSC activity. C...
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PMID: 15345289
PDF is available here.
PDF is available here.
Abstract
Memory T cells are distributed throughout the body following infection, but the migratory dynamics of the memory pool in vivo is unknown. The ability of circulating microbe-specific memory T cells to populate lymphoid and nonlymphoid tissues was examined using adoptive transfer and parabiosis system...
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PMID: 15142524
PDF is available here.
PDF is available here.
Journal of Immunology (171)7 2003
Abstract
We now demonstrate that prothymocytes are periodically exported in saturating numbers from the adult mouse bone marrow. Experiments in normal, radioablated, and parabiotic mice document the cyclical accumulation (3-5 wk) of prothymocytes in both the steady state and regenerating bone marrow, followe...
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PMID: 14500653
PDF is available here.
PDF is available here.
Abstract
We created parabiotic mice, joining ROSA26 and PeP3b animals, to study the trafficking of hematopoietic stem cells (HSCs) from marrow to blood and their return to marrow. The transfer of HSCs was assayed by secondary marrow transplantation and was 1.0% to 2.5% after 3, 6, 8, and 12 weeks. Thus, HSC...
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PMID: 12714498
PDF is available here.
PDF is available here.
Abstract
I discuss Hasek's experimental ingenuity, the influence of the Lysenkoist genetic doctrine, Hasek's acceptance of the immunological theory to explain his work and his role in establishing a successful institute at the Czechoslovak Academy of Sciences....
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PMID: 12876561
PDF is available here.
PDF is available here.
Journal of Immunology (170)7 2003
Abstract
We used a similar approach in this study to investigate the importation of the hematogenous precursors of thymic DCs. The results indicate that two developmentally distinct populations of DC precursors normally enter the adult mouse thymus. The first population is indistinguishable from prothymocyte...
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PMID: 12646612
PDF is available here.
PDF is available here.
Abstract
Abstract
We generated chimeric animals by transplantation of a single green fluorescent protein (GFP)-marked HSC into lethally irradiated nontransgenic recipients. Single HSCs robustly reconstituted peripheral blood leukocytes in these animals, but did not contribute appreciably to nonhematopoietic tissues,...
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PMID: 12215650
PDF is available here.
PDF is available here.
Abstract
We report that in mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen. CXCL13 is produced by cells in the omentum and by peritoneal macrophages, and in adoptive transfers, B1 cells home to the omentum and the peritoneal cavity in a CXCL13-d...
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PMID: 11825566
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that repeated UV irradiation can circumvent an immunologic mechanism that might otherwise destroy nascent UV-induced primary tumors that are strongly antigenic....
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PMID: 12481215
PDF is available here.
PDF is available here.
FASEB Journal (15)11 2001
Abstract
Parabiosis studies with obese rodents demonstrated that circulating factors are involved in the long-term control of food intake and energy balance. More than 40 years ago it was hypothesized that rats made obese by hypothalamic or dietary means, as well as genetically obese fa/fa rats and db/db mic...
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PMID: 11532980
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (80)8 2000
Abstract
Survival days of parabiotic rats were significantly prolonged (P = 0.000 5, MST = 63.5 days). After 15 day of parabiosis, the stable skin transplantation tolerance was established. During the first 15 day of parabiosis, the level of chimerism was increased with time, afterwards the chimerism became...
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PMID: 11798826
PDF is available here.
PDF is available here.
Abstract
We recently identified the klotho gene as a possible regulator of human aging. In the present study using the klotho-deficient heterozygous mouse, we examined whether the Klotho protein is a humoral factor protecting against endothelial dysfunction. We further cloned rat klotho cDNA and investigated...
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PMID: 10892340
PDF is available here.
PDF is available here.
Abstract
Pin is as effective a cardioplegic agent as StT; however, its use as a pretreatment or additive to traditional and Pin in low potassium StT provided no additional benefit in functional recovery....
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PMID: 10881806
PDF is available here.
PDF is available here.
Abstract
Ulinastatin improved functional recovery after long cardioplegic arrest and reduced coronary endothelial injury. Administration of ulinastatin at the beginning of cardiopulmonary bypass and just before reperfusion may be useful clinically in cases requiring prolonged aortic cross-clamping....
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PMID: 10800804
PDF is available here.
PDF is available here.
Abstract
Abstract
Parabiotic pairs of B6.Ly5.1 and B6.Ly5.2 mice were used to investigate how lymphocytes in various organs and various lymphocyte subsets mixed with partner cells. The origin of partner cells was determined by using anti-Ly5.1 mAb in conjunction with immunofluorescence tests. Parabiosis was also prod...
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PMID: 10480556
PDF is available here.
PDF is available here.
Endocrinology (140)1 1999
Abstract
These results imply that leptin stimulated release of a circulating growth factor, possibly through activation of the long-form leptin receptor, in ob/ob partners of db/db mice....
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PMID: 9886818
PDF is available here.
PDF is available here.
Immunology (96)1 1999
Abstract
We examined what type of lymphocyte subsets were produced in situ by such stem cells in the small intestine, large intestine and appendix. To investigate this subject, we used parabiotic B6.Ly5.1 and B5.Ly5. 2 mice which shared the same circulation by day 3. The origin of lymphocytes was identified...
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PMID: 10233678
PDF is available here.
PDF is available here.
Abstract
We examined whether such stem cells give rise to extrathymic T cells in these organs in situ. To this end, we used parabiotic B6.Ly5.1 and B6.Ly5.2 mice, i.e. mice sharing the circulation. The origin of lymphocytes was identified by anti-Ly5.1 and anti-Ly5.2 monoclonal antibodies in conjunction with...
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PMID: 9842914
PDF is available here.
PDF is available here.
Abstract
We conclude that avian macrophages/microglia precursors do not penetrate through the wall of embryonic CNS vessels. In combination with published results, this finding strongly supports the view that invasion of migratory macrophages from the pial surface and proliferation inside the CNS generate al...
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PMID: 9436792
PDF is available here.
PDF is available here.
Abstract
Endothelial permeability is transiently elevated in the early phase of lung graft reperfusion. Initial low-pressure reperfusion may be protective by preventing irreversible edema formation during this period....
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PMID: 9456115
PDF is available here.
PDF is available here.
Abstract
Physiology & Behavior (62)1 1997
Abstract
Twenty-two inbred male Lewis rats were made into parabiotic pairs and 7 pairs had a further operation in which the small intestines of the 2 rats were connected so that one rat continually lost food into the upper small intestine and bloodstream of its partner. As a result, these rats showed large a...
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PMID: 9226352
PDF is available here.
PDF is available here.
Abstract
We used mice with a developmental arrest of B cell production to study the ability of a limited number of normal B cell precursors to populate peripheral B cell pools. In chimeras reconstituted with mixtures of bone marrow (BM) cells from normal and B cell-deficient donors, we show that the rate of...
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PMID: 9247595
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (272)6 Pt 2 1997
Abstract
Parabiosis experiments suggest that ob/ob mice are deficient in a circulating "lipostatic" signal but respond to such a signal when it is delivered in the cross circulation from their parabiotic partner. Identification of leptin as the mutation in ob/ob mice leads to the assumption that leptin is th...
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PMID: 9227593
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (272)6 Pt 2 1997
Abstract
These results suggest that, in lean-ob/ob parabiotic pairs, the ob/ob mouse responds to leptin originating in the lean parabiont, whereas the lean partner responds to a circulating signal, originating in the ob/ob mouse, that maintains leptin expression at inappropriate levels for the degree of adip...
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PMID: 9227594
PDF is available here.
PDF is available here.
Revista Clínica Española (197)5 1997
Abstract
Revista Clínica Española (197)5 1997
Abstract
Abstract
Serum cholesterol, triglyceride and phospholipid levels, liver cholesterol concentration, bile flow, biliary cholesterol, phospholipid and bile acid secretion rates, fecal sterol and bile acid levels and their bile acid compositions were examined in young-old parabiotic rats and compared with those...
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PMID: 9113626
PDF is available here.
PDF is available here.
Experimental Hematology (25)3 1997
Abstract
Infection and Immunity (65)1 1997
Abstract
We have used the technique of parabiosis, as a means of adoptive transfer, to demonstrate the relevance of pulmonary T cells to protection. Sensitized and naive partners were joined surgically for a 28-day period, coincident with priming of the immune system. A vascular union rapidly developed, and...
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PMID: 8975890
PDF is available here.
PDF is available here.