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Perfusion (1):
Recent article
Perfusion
Abstract
Currently, the main hurdle in the tissue engineering field is how to provide sufficient blood supply to grafted tissue substitutes in the early post-transplanted period. For three-dimensional, cell-dense, thick tissues to survive after transplantation, treatments are required for hyp...
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PMID: 21548841
PDF is available here.
PDF is available here.
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Nihon Naika Gakkai Zasshi (100)8 2011
Abstract
Abstract
The purpose of this study was to provide direct evidences that rotor ablation suppresses atrial fibrillation (AF) inducibility.
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PMID: 21718913
PDF is available here.
PDF is available here.
Abstract
We consider here polymeric scaffold-based perfusion bioreactors, where an interstitial fluid supplies nutrients and oxygen to the growing biomass. At the same time, the fluid-induced shear acts as a physiologically relevant stimulus for the metabolic activity of cells, provided that the shear stress...
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PMID: 20865436
PDF is available here.
PDF is available here.
Abstract
We evaluated the long-term outcome of Bacillus Calmette-Guérin (BCG) perfusion therapy for CIS of UUT. We retrospectively reviewed the medical records of 24 patients who underwent BCG perfusion therapy for CIS of UUT between August 1993 and August 2009. Patients received at least one course of BCG...
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PMID: 21832868
PDF is available here.
PDF is available here.
Abstract
We adapted techniques of intravital microscopy that permitted TPM of organs maintained within the thoracoabdominal cavity of living, breathing rats or mice. We obtained extended intravital TPM imaging of the intact lung, arguably the organ most susceptible to both respiratory and cardiac motion. Int...
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PMID: 21703395
PDF is available here.
PDF is available here.
Abstract
We hypothesized that cardiac-restricted aPKCε improves mitochondrial response to hypobaric hypoxia by altered substrate fuel selection via a GSK3β/HIF-1α-dependent mechanism. aPKCε and wild-type (WT) mice were exposed to 14 days of hypobaric hypoxia (45 kPa, 11% O(2)) and cardiac metabolism, fun...
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PMID: 21660969
PDF is available here.
PDF is available here.
Abstract
Inhomogeneous and uncontrolled cellular and tissue responses in bone tissue engineering constructs, as a result of heterogeneous oxygen delivery throughout the scaffold volume, is one of the hurdles hampering clinical transfer of cell-scaffold combinations. This study presents an acc...
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PMID: 21332298
PDF is available here.
PDF is available here.
Journal of Urology (185)6 2011
Abstract
We report initial data on the safety and functional outcomes of renal hypothermia with arterial cold perfusion during partial nephrectomy.
From June 2007 to June 2009, 31 consecutive patients underwent laparoscopic partial nephrectomy with hypothermia using renal arterial perfusion w...
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PMID: 21497840
PDF is available here.
PDF is available here.
Journal of Urology (185)6 2011
Abstract
We report initial data on the safety and functional outcomes of renal hypothermia with arterial cold perfusion during partial nephrectomy.
From June 2007 to June 2009, 31 consecutive patients underwent laparoscopic partial nephrectomy with hypothermia using renal arterial perfusion w...
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PMID: 21497840
PDF is available here.
PDF is available here.
Journal of Urology (185)6 2011
Abstract
We report initial data on the safety and functional outcomes of renal hypothermia with arterial cold perfusion during partial nephrectomy.
From June 2007 to June 2009, 31 consecutive patients underwent laparoscopic partial nephrectomy with hypothermia using renal arterial perfusion w...
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PMID: 21497840
PDF is available here.
PDF is available here.
Abstract
After cardioplegia and subsequent reperfusion of the myocardium as employed in cardiac surgery, ischemia/reperfusion injury of the myocardium can induce apoptosis. The aim of this study was to evaluate the anti-apoptotic properties of resveratrol, a phenolic phytoalexin present in grape skins and esp...
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PMID: 21577194
PDF is available here.
PDF is available here.
Abstract
Association between preoperative perfusion pattern and reperfusion after carotid endarterectomy (CEA) is an important yet unexplored topic. Therefore, the aim of our study was to determine whether 99mTc-ECD single-photon emission computed tomography (SPECT) performed before carotid endarterectomy in...
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PMID: 21525813
PDF is available here.
PDF is available here.
Abstract
Primary transradial percutaneous coronary intervention (TRI) is shown to be efficacious in stable patients with acute coronary syndrome. We aimed to evaluate the application of primary TRI for acute ST elevation myocardial infarction (STEMI), including among high-risk patients from our registry.
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PMID: 21552786
PDF is available here.
PDF is available here.
Abstract
TNFα, IL1β and IL10 did not increase significantly after surgery in either group. Whole-blood cultures response to LPS and SAC stimulation decreased for IL1β at the end of surgery in the two groups and returned to normal within 24 h after surgery. LPS- and SAC-induced IL10 production increased...
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PMID: 21418155
PDF is available here.
PDF is available here.
Abstract
Abstract
Tissue engineered cartilage can be grown in vitro with the use of cell-scaffold constructs and bioreactors. The present study was designed to investigate the effects of perfusion bioreactors on the chondrogenic potential of engineered constructs prepared from porous silk fibroin scaf...
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PMID: 20949478
PDF is available here.
PDF is available here.
Abstract
We describe the methods to perform perfusion-decellularization of the liver, such that an intact liver bioscaffold that retains the structure of major blood vessels is obtained. Further, we describe methods to recellularize these bioscaffolds with adult primary hepatocytes, creating a liver graft th...
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PMID: 21339718
PDF is available here.
PDF is available here.
Abstract
The hexosamine biosynthesis pathway (HBP) flux and protein O-linked N-acetyl-glucosamine (O-GlcNAc) levels have been implicated in mediating the adverse effects of diabetes in the cardiovascular system. Activation of these pathways with glucosamine has been shown to mimic some of the...
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PMID: 21494549
PDF is available here.
PDF is available here.
BMC Medicine (9)1 2011
Abstract
Cerebral microdialysis (MD) is used to monitor local brain chemistry of patients with traumatic brain injury (TBI). Despite an extensive literature on cerebral MD in the clinical setting, it remains unclear how individual levels of real-time MD data are to be interpreted. Intracrania...
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PMID: 21366904
PDF is available here.
PDF is available here.
Abstract
There are several types of bioreactors currently available for the culture of orthopaedic tissue engineered constructs. These vary from the simple to the complex in design and culture. Preparation of samples for bioreactors varies depending on the system being used. This chapter presents data and de...
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PMID: 21042966
PDF is available here.
PDF is available here.
Abstract
It was found that changes of resistance, capacity and exchange vessel functions of the skeletal muscle depended on values of amplitude and frequency of perfusion blood flow in acute experiments on cats. Amplitude-frequency characteristics of hemodynamic parameters of these functions were nonlinear. R...
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PMID: 21516748
PDF is available here.
PDF is available here.
Abstract
This study demonstrates that a dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) perfusion parameter may indicate vascular abnormality in a brain tumor model and reflects an effect of dexamethasone treatment. In addition, X-ray computed tomography (CT) measurements of vascular tort...
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PMID: 21305001
PDF is available here.
PDF is available here.
Abstract
Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that physiological situations such as physical exercise also result in splanchnic hypoperfusion, the consequences of flow redistribution at the expense of abd...
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PMID: 21811592
PDF is available here.
PDF is available here.
Abstract
In cerebral ischemia, measurement of cerebral blood flow (CBF) alone is not a sensitive or specific predictor of tissue survival. Measurements of oxygen metabolism, which are directly related to cellular energy metabolism, are better predictors of tissue survival and the best of these is the "oxygen...
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PMID: 21445790
PDF is available here.
PDF is available here.
Abstract
The hemisphere with reduced cerebral vascular reserve (CVR) showed a regional cerebral baseline blood flow (CBF) of 5.58 ± 1.69 and a regional cerebral baseline blood volume (CBV) of 2.41 ± 0.76 before surgery. Mean transit time (MTT) was 4.16 ± 0.9 s and time to peak (TTP) 3.25 ± 1.62 s. After...
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PMID: 21691983
PDF is available here.
PDF is available here.
Gaceta medica de Mexico (147)1 2011
Abstract
Drainage after radical neck dissection (RND) is routine and several factors impact the postoperative drainage number of days (PODND). Objective: to determine the impact of trans-operative intravenous fluid management (TOFM) in in PODND.
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PMID: 21412390
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
Abstract
A promising approach to bone tissue engineering lies in the use of perfusion bioreactors where cells are seeded and cultured on scaffolds under conditions of enhanced nutrient supply and removal of metabolic products. Fluid flow alterations can stimulate cell activity, making the eng...
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PMID: 20872752
PDF is available here.
PDF is available here.
Lab On a Chip (10)23 2010
Abstract
We describe the design, fabrication, and testing of a microfabricated metering rotary nanopump for the purpose of driving fluid flow in microfluidic devices. The miniature peristaltic pump is composed of a set of microfluidic channels wrapped in a helix around a central camshaft in which a non-cylin...
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PMID: 20959938
PDF is available here.
PDF is available here.
Abstract
Abstract
Although hypothermic selective cerebral perfusion (SCP) is widely used for cerebral protection during aortic surgery, little is known about the ideal pump-flow management during this procedure. This study explored cerebral hemodynamics and metabolism at two different flow rates.
Fourteen pigs (33 to...
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PMID: 21095348
PDF is available here.
PDF is available here.
Abstract
We evaluated the therapeutic potential of a novel small molecule GPR119 agonist, AS1535907, which was modified from the previously identified 2,4,6-tri-substituted pyrimidine core agonist AS1269574. AS1535907 displayed an EC50 value of 4.8 μM in HEK293 cells stably expressing human GPR119 and stimu...
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PMID: 20937249
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We hypothesized that this can be improved by electro-spun, supramolecular polymer membranes which show clear benefits in ease of processability. We found that after 7 d, in comparison to conventional microporous membranes, renal tubular cells cultured on top of our fibrous supramolecular membranes...
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PMID: 20715132
PDF is available here.
PDF is available here.
Abstract
In theory, the application of the two-compartment exchange model (2CXM) to data from a dynamic contrast-enhanced (DCE) MRI exam allows the estimation of the plasma flow, plasma volume, extraction flow and extravascular-extracellular volume. The aim of this paper was to explore whether simulations ba...
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PMID: 20952813
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
These results suggest that the inhibition of contractile activity during IPost prevents cardiomyocyte oncosis and enhances cardioprotection through PI3K-dependent restoration of sarcolemmal dystrophin....
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PMID: 20877127
PDF is available here.
PDF is available here.
Abstract
The Kana Pick-out Test (KPT), which was developed in Japan, is suitable for evaluating frontal lobe function and screening for mild dementia. However, the neural substrates involved remain to be elucidated. The aim of the present study was to identify the regional perfusion patterns in the brain asso...
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PMID: 20946703
PDF is available here.
PDF is available here.
Lab On a Chip (10)18 2010
Abstract
We present a microfluidic perfusion system that is built without using specialized microfabrication infrastructure, simple to use because only a pipette is needed for liquid handling, and yet allows for rapid media exchange and simultaneous fluorescence microscopy imaging. Yeast cells may be introdu...
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PMID: 20714499
PDF is available here.
PDF is available here.
Brain research (1352) 2010
Abstract
We found that acidification of the ESOc increased the number of c-fos positive neurons in the area postrema (AP), vestibular nucleus (VN), parabrachial nucleus (PBN), nucleus ambiguus (NA), dorsal motor nucleus (DMN), and all subnuclei of the nucleus tractus solitarius (NTS), but one. Acidification...
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PMID: 20655885
PDF is available here.
PDF is available here.
Abstract
I ADH1 was isolated from male Sprague-Dawley rats and characterized by steady-state kinetics in the Krebs-Ringer perfusion buffer with supplements. Nonrecirculating liver perfusion with constant input of ethanol at near physiological hepatic blood flow rate was performed in situ. Ethanol and the rel...
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PMID: 20724102
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
Temperature-based optimization proves to be superior to SAR-based optimization both under variation of perfusion level as well as under the application of intratissue variation. The spread in achieved temperatures is comparable. These results are valid under the assumption of constant perfusion at h...
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PMID: 20964171
PDF is available here.
PDF is available here.
Abstract
Bradykinin induced a greater increase in CBF in KH-RBC-perfused hearts than in Krebs-Henseleit-perfused hearts (263 +/- 78 versus 134 +/- 35% of baseline, P < 0.001). Sodium nitroprusside induced a greater increase in CBF in KH-RBC-perfused than in Krebs-Henseleit-perfused hearts (257 +/- 70 versus...
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PMID: 20179600
PDF is available here.
PDF is available here.
Abstract
We therefore wanted to find out whether the polyol pathway also contributes to acute hyperglycemia-induced cardiac contractile dysfunction, and determine the mechanism involved. Rat hearts were isolated and retrogradely perfused with Krebs buffer containing either normal or high concentrations of gl...
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PMID: 20573996
PDF is available here.
PDF is available here.
Abstract
We describe detailed findings on breath-hold perfusion SPECT-CT fusion images in 2 patients with SPE. Regardless of absence or nonspecific morphologic abnormality in these patients, the fusion images showed multiple wedge-shaped segmental/subsegmental perfusion defects along specific pulmonary arter...
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PMID: 20706061
PDF is available here.
PDF is available here.
Abstract
We describe the use of a microfluidic device to micropattern cells in a microchannel and investigated the behavior of these cells under a concentration gradient. The microfluidic device consisted of 3 parts: a branched channel for generating a stable concentration gradient, a main channel for cultur...
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PMID: 20547384
PDF is available here.
PDF is available here.
Abstract
I review current knowledge concerning assessment of the microcirculation with special emphasis on methods that could be used at the bedside.
(c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20692624
PDF is available here.
PDF is available here.
Abstract
We have developed an inferior vena cava (IVC) occluder that can safely and conveniently drain blood from the IVC. This device has been clinically applied in one patient, as described herein. The framework for this device is made from a single superelastic nitinol wire, 0.30 mm in diameter. Diameter...
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PMID: 20166838
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
We created a focal forelimb motor cortex injury in rats and found that axons from cell bodies located in the hindlimb motor cortex (spared by the cortical injury) become secondarily damaged in the spinal cord. To assess axonal degeneration in the spinal cord, we quantified silver staining in the cor...
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PMID: 20515316
PDF is available here.
PDF is available here.
Academic Radiology (17)8 2010
Abstract
Positive correlations were found between duration and longitudinal diameter (r = 0.66; P < .001), transverse diameter (r = 0.66; P < .001), distance of ablation beyond the electrode tip (r = 0.56; P < .001), and volume of lesions (r = 0.66; P < .001). Temperature was also positively correlated with...
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PMID: 20599156
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)2 2010
Abstract
Clearance mechanisms for recombinant activated human FVII (rFVIIa; NovoSeven), a heterogeneously glycosylated protein, have yet to be fully elucidated, but may involve the liver. The effects of the gamma-carboxy glutamic acid (Gla) domain and the sialic acid content of the protein on rFVIIa clearance...
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PMID: 20508904
PDF is available here.
PDF is available here.
Abstract
A 39-year-old woman underwent transcervical resection (TCR) of submucosal uterus myoma. Induction and maintenance of anesthesia were managed with total intravenous anesthesia using propofol, remifentanil and rocuronium bromide. Patient had stable condition from the anesthesia induction until 75 minu...
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PMID: 20715527
PDF is available here.
PDF is available here.
Optics Letters (35)14 2010
Abstract
We report a novel multispectral optoacoustic tomography system for deep tissue small animal imaging. The previously undocumented capacity of whole-body optoacoustic tomography at a video rate has been demonstrated by visualizing mouse kidney perfusion using Indocyanine Green in vivo....
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PMID: 20634868
PDF is available here.
PDF is available here.
Abstract
We demonstrate the formation of nano-thin, poly(ethylene glycol) (PEG)-rich functional conformal coatings on individual islets via layer-by-layer assembly technique. The surface of the islets is modified with biotin-PEG-N-hydroxysuccinimide (NHS), and the islets are further covered by streptavidin (...
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PMID: 20163204
PDF is available here.
PDF is available here.
Abstract
Nitrates are used in the treatment of coronary heart disease and heart failure. The major drawback of their therapeutic use is the rapid development of tolerance.
To investigate the effect of different nitrates on isolated rabbit hearts and aortic strips and the mecha...
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PMID: 20414121
PDF is available here.
PDF is available here.
Heart and Vessels (25)4 2010
Abstract
Intravenous application of amiodarone is commonly used in the treatment of life-threatening arrhythmias, but the underlying mechanism is not fully understood. The purpose of the present study is to investigate the acute effects of amiodarone on spiral wave (SW) re-entry, the primary organization mac...
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PMID: 20676844
PDF is available here.
PDF is available here.
Abstract
Single administration of Evasin-3 during myocardial ischemia significantly reduced infarct size by preventing CXC chemokine-induced neutrophil recruitment and reactive oxygen species production in myocardial ischemia/reperfusion....
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PMID: 20413731
PDF is available here.
PDF is available here.
Optics Express (18)14 2010
Abstract
Laser speckle imaging (LSI) is able to provide full-field perfusion maps of the renal cortex and allows quantification of the average LSI perfusion within an arbitrarily set region of interest and the recovery of LSI perfusion histograms within this region. The aim of the present stu...
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PMID: 20639991
PDF is available here.
PDF is available here.
Optics Express (18)14 2010
Abstract
Laser speckle imaging (LSI) is able to provide full-field perfusion maps of the renal cortex and allows quantification of the average LSI perfusion within an arbitrarily set region of interest and the recovery of LSI perfusion histograms within this region. The aim of the present stu...
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PMID: 20639991
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We examined the adhesion of Plasmodium sporozoites, the motile form of the malaria parasite transmitted by the mosquito, to flat surfaces. Experiments using total internal reflection fluorescence microscopy and analysis of sporozoites under flow revealed a stepwise and developmentally regulated adhe...
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PMID: 20159960
PDF is available here.
PDF is available here.
Abstract
PURPOSE. To describe the distribution of ocular perfusion pressure and its relationship with open-angle glaucoma (OAG) in a Malay population. METHODS. This was a population-based, cross-sectional study comprising 3280 (78.7% response) ethnic Malays. Intraocular pressure (IOP) was measured with Goldm...
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PMID: 20164462
PDF is available here.
PDF is available here.