Abstract
We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (Ple...
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PMID: 21521614
PDF is available here.
Leigh B LB Waddell,
Frances A FA Lemckert,
Xi F XF Zheng,
Jenny J Tran,
Frances J FJ Evesson,
Joanne M JM Hawkes,
Angela A Lek,
Neil E NE Street,
Peihui P Lin,
Nigel F NF Clarke,
Andrew P AP Landstrom,
Michael J MJ Ackerman,
Noah N Weisleder,
Jianjie J Ma,
Kathryn N KN North and
Sandra T ST Cooper
Abstract
Our results suggest that longitudinal tubules of the t-system may represent sites of physiological membrane damage targeted by this membrane repair complex....
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PMID: 21412170
PDF is available here.
Abstract
When compared to the control group (group B), subjects in group A required a significantly (p...
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PMID: 21395473
PDF is available here.
Abstract
We presently investigated a role for the inhibitory neurotransmitters GABA and glycine in scratch-evoked inhibition of spinal itch-signaling neurons in a mouse model of chronic dry skin itch. Superficial dorsal horn neurons ipsilateral to hindpaw dry skin treatment exhibited a high level of spontane...
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PMID: 21818363
PDF is available here.
Abstract
Sensory stimuli evoke responses in cerebellar Purkinje cells (PCs) via the mossy fiber-granule cell pathway. However, the properties of synaptic responses evoked by tactile stimulation in cerebellar PCs are unknown. The present study investigated the synaptic responses of PCs in response to an air-pu...
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PMID: 21818384
PDF is available here.
Abstract
In previous studies of interference in vibrotactile working memory, subjects were presented with an interfering distractor stimulus during the delay period between the target and probe stimuli in a delayed match-to-sample task. The accuracy of same/different decisions indicated feature overwriting wa...
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PMID: 21818331
PDF is available here.
Abstract
Multichannel single-unit recordings were used to investigate the activity of individual neurons and neuronal ensembles in the rat brain following the application of noxious laser stimuli of increasing intensity to the hindpaw. Four brain regions were monitored, including two within the lateral senso...
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PMID: 21864358
PDF is available here.
Abstract
We investigated the neural correlates of automatic processes induced by subliminal stimuli. We demonstrated that the automatic activation of motor programs elicited unconsciously in the medial premotor cortex was normally restricted to specific contexts set by the environment, but can occur below th...
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PMID: 21311759
PDF is available here.
Abstract
These results raise the possibility that certain forms of synaptic plasticity may occur within the cortex while synaptic potentiation takes place within synapses in the hippocampus and amygdala. This hypothesis is supported by electrophysiological evidence obtained from freely moving animals that ne...
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PMID: 21912749
PDF is available here.
Abstract
The aim of the study was to characterise mechanically induced cough threshold and reactivity by exposing the trachea to stimuli of variable duration in rabbit.
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PMID: 21452765
PDF is available here.
Abstract
The goal of this project was to determine if mechanical stimulation to the posterolateral oropharynx would elicit the urge-to-cough and/or cough.
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PMID: 21452760
PDF is available here.
Abstract
We identify a neural circuit responsive to cVA, a pheromone that elicits sexually dimorphic behaviours. We have combined neural tracing using an improved photoactivatable green fluorescent protein (PA-GFP) with electrophysiology, optical imaging and laser-mediated microlesioning to map this circuit...
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PMID: 21124455
PDF is available here.
Abstract
Quantitative sensory testing (QST) is a noninvasive method of assessing sensory and pain perception that has been used in the past 30 years primarily for analysis of cutaneous and mucosal perception. In recent years, several published studies have demonstrated that QST may be useful in the analysis...
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PMID: 20857243
PDF is available here.
Abstract
These results suggest that a combination of constraint-induced therapy and specific motor control retraining may be a successful strategy for the treatment of musicians' FHD. Furthermore, the results suggest that retraining strategies may need to be carried out for at least 8 months before statistic...
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PMID: 21170477
PDF is available here.
Abstract
Tissue injury is associated with the local release of inflammatory and nociceptive mediators and the development of hyperalgesia. It is unclear whether interrupting neuronal signaling using regional anesthetic techniques at the time of the injury modifies local nociceptive and inflammatory processes...
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PMID: 20975465
PDF is available here.
Abstract
The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerab...
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PMID: 20975464
PDF is available here.
Abstract
Our results suggest the presence of central and peripheral sensitization mechanisms in individuals with either LE or CTS....
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PMID: 21041964
PDF is available here.
Abstract
In this work, the potential of using peripheral autonomic (PA) responses as control signals for body-machine interfaces that require no physical movement was investigated. Electrodermal activity, skin temperature, heart rate and respiration rate were collected from six participants and hidden Markov...
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PMID: 20834114
PDF is available here.
Abstract
We show here that acute pain can also be reduced by multisensory integration through self-touch, which provides proprioceptive, thermal, and tactile input forming a coherent body representation [4, 5]. We combined self-touch with the thermal grill illusion (TGI) [6]. In the traditional TGI, particip...
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PMID: 20869246
PDF is available here.
Abstract
We investigated the dependence of the negative BOLD response in ipsilateral SI on the intensity of somatosensory stimulation. Functional MRI was performed in 12 healthy subjects during electrical median nerve stimulation at four different intensities. A monotonic relationship between stimulus intens...
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PMID: 20538064
PDF is available here.
Abstract
It is well known that primary and non-primary areas of human somatosensory cortex are involved in the processing of adequate deviant/rare stimuli and omission of frequent stimuli. However, the relative weight and interaction of these variables is poorly known. This functional magnetic resonance imag...
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PMID: 20598908
PDF is available here.
Abstract
We found that enrichment increased all SEP response components subsequent to the initial thalamocortical input, but only when evoked by single stimuli; the thalamocortical component remained unchanged across all animal groups. The optical signal exhibited no changes in amplitude or latency between g...
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PMID: 20654700
PDF is available here.
Abstract
We show that two migrating passerine birds treated with a strong magnetic pulse, designed to alter the magnetic sense, migrated in a direction that differed significantly from that of controls when tested in natural conditions. The orientation of treated birds was different depending on the alignmen...
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PMID: 20453067
PDF is available here.
Abstract
Our results indicate: 1) the presence of a rate-dependent long-term adaptation effect induced only by the tactile stimulation of the digits; and 2) shorter recovery lifetimes for the digits compared with the lips stimulation.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 20561996
PDF is available here.
Abstract
We examined the effect of high frequency tactile stimulation (tHFS) on tactile and motor performance as well as tactile-motor interactions. Seventeen right-handed participants (66-78 years) underwent a pretest (tactile frequency and spatial discrimination task, manual dexterity test, and precision g...
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PMID: 21051788
PDF is available here.
Abstract
We analyzed mechanical allodynia in SCI rats that were treated with either vehicle, VEGF-A isoform 165 (VEGF(165)), or neutralizing VEGF(165)-specific antibody. We have observed that exogenous administration of VEGF(165) increased both the number of SCI rats that develop persistent mechanical allody...
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PMID: 20698758
PDF is available here.
Abstract
In healthy individuals the strongest component was dominated by alpha oscillations, and was associated not only with activity in somatosensory regions but also in the insula and anterior cingulate cortex (the salience network). In schizophrenia, the strongest component had low alpha power and activi...
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PMID: 20554246
PDF is available here.
Abstract
We conclude that video conferencing could be an acceptable medium to assist pianism retraining in pianists with FD when location prevents on-site retraining. However, in this study it did not seem as effective as previously reported, similar, one-on-one retraining in the same location....
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PMID: 21120271
PDF is available here.
Abstract
PRF treatment was more effective when applied in the early stages of mechanical allodynia (1 week) in rats. Increased exposure time to PRF current from 2 to 6 minutes showed a significant antiallodynic effect without motor impairment. We propose the application of PRF current for 6 minutes adjacent...
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PMID: 20601454
PDF is available here.
Abstract
We asked whether this influence arises from somatosensory experience, the proximity to the person and/or an attribution of the somatosensory experience to the person. Moreover, we were interested in whether and how touch affects the processing of ensuing events. To this end, we presented neutral and...
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PMID: 20711939
PDF is available here.
Abstract
This study aimed at measuring the static coefficient of friction (mu) between bone and skeletal muscle tissues in order to support finite element (FE) modeling in orthopaedic and rehabilitation research, where such contact conditions need to be defined. A custom-made friction meter (FM) that employs...
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PMID: 20670064
PDF is available here.
Abstract
A finite element model was developed for numerical simulations of nanoindentation tests on cortical bone. The model allows for anisotropic elastic and post-yield behavior of the tissue. The material model for the post-yield behavior was obtained through a suitable linear transformation of the stress...
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PMID: 20670057
PDF is available here.
Abstract
We recently reported a significant attenuation of PRV-152 labeling of the intermediolateral cell column (IML) and celiac ganglia after complete T4 spinal cord transection versus sham injury in rats at 96 h after PRV-152 inoculation of the left kidney. Here we found a significant increase in noxious...
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PMID: 20528165
PDF is available here.
Abstract
For experiments 1 and 2, decreased centre of foot pressure displacements were observed in the Vision relative to the No vision and in the Tactile stimulation relative to the No tactile stimulation condition. For experiments 3 and 4, more accurate and more consistent repositioning performances were o...
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PMID: 20628325
PDF is available here.
Abstract
We explored the roles of visual, olfactory and tactile stimulation in the induction of behavioural gregarization in the Australian plague locust, Chortoicetes terminifera. We show that the primary gregarizing input is tactile stimulation of the antennae, with no evidence for an effect of visual and...
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PMID: 20438734
PDF is available here.
Abstract
Implicit structural changes in the joint tissues, not apparent in gross appearance and related to age and mild degeneration, represent potentially important biomechanical factors that could influence the vulnerability of the joint to trauma. The hypothesis of this study was that micro-level structur...
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PMID: 20483514
PDF is available here.
Abstract
We show that the electric fish Apteronotus leptorhynchus can learn to recognize individual conspecifics based on a simple cue, the beat frequency of their summed sinusoidal electric organ discharges (EOD). Male fish produce transient communication signals (chirps) in response to mimic EODs. The chir...
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PMID: 20506470
PDF is available here.
Abstract
We undertook a forward genetic screen in zebrafish (Danio rerio) to identify mutants exhibiting abnormal touch-evoked behaviors, despite the presence of sensory neurons and peripheral neurites. One family, subsequently named touché, was found to harbor a recessive mutation which produced offspring...
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PMID: 20631165
PDF is available here.
Abstract
We have used infrared thermography and ultrasound Doppler flowmetry to investigate characteristics of the temperature variation of the hand and the blood flow after cold stimuli. We have also developed an image processing algorithm to measure temperature of various parts of the hand via sequential t...
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PMID: 20542263
PDF is available here.
Abstract
We investigated nociceptive behaviours and the properties of C and A fibre intact afferents running adjacent to damaged afferents following a partial ligation injury of the saphenous nerve (PSNI). Animals developed mechanical and cold allodynia by 3 days after PSNI. Intact mechanosensitive C fibre a...
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PMID: 19942464
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
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PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
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PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.
Abstract
We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
Extracephalic allodynia was asse...
|
PMID: 20582997
PDF is available here.