Abstract
In order to unravel the mechanisms underlying the "sudden" onset of spontaneous absences in genetically prone subjects, we investigated the immediate precursors of spike-wave discharges (SWDs) produced in cortico-thalamo-cortical neuronal networks.
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PMID: 21093357
PDF is available here.
Abstract
We reported smaller volume and width of the outer cortex (layers I-III), especially in the left hemisphere, among subjects with schizophrenia. In the present study, we measured neuron density and size in the same PT samples, and also in prefrontal area 9 of the same brains. In the PT, separate stere...
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PMID: 21377842
PDF is available here.
Abstract
We injected micron-sized silver particles into the mouse brain by stereotactic procedures. After 7 days, 14 days and 9 months, the silver-exposed animals had considerable brain damage seen as cavity formation and inflammation adjacent to the injected metallic silver particles. The tissue loss involv...
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PMID: 21205224
PDF is available here.
Abstract
Up to one-third of patients with mild traumatic brain injury (TBI) demonstrate persistent cognitive deficits in the 'executive' function domain. Mild TBI patients have shown prefrontal cortex activity deficits during the performance of executive tasks requiring active information mai...
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PMID: 20703959
PDF is available here.
Abstract
Erythropoietin (EPO) is a potent neuroprotective agent that could be developed as a new treatment for stroke. However, the blood-brain barrier (BBB) is intact in the early hours after stroke when neuroprotection is still possible, and EPO does not cross the intact BBB. To enable BBB transport, human...
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PMID: 20833153
PDF is available here.
Abstract
The inability of axons in central nervous system (CNS) to regenerate after injury is related partly to multiple endogenous axon growth inhibitors including Nogo receptor (NgR). This study tested the hypothesis that silencing NgR expression by adenovirus-mediated RNA interference (RNAi) (AD-NgR) may...
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PMID: 20828545
PDF is available here.
Abstract
We have previously shown that deficits in vocal learning occur in zebra finches after reduction of FoxP2 in Area X, a striatal nucleus involved in song acquisition. We recently showed that FoxP2 is expressed in newly generated spiny neurons (SN) in adult Area X as well as in the ventricular zone (VZ...
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PMID: 20528955
PDF is available here.
Abstract
Spinal metastases are the most frequently encountered spinal tumour and can affect up to 50% of cancer patients. Both the incidence and prevalence of metastases are thought to be rising due to better detection and treatment options of the systemic malignancy resulting in increased patient survival....
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PMID: 20627705
PDF is available here.
Abstract
Modern cancer treatment techniques, such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), have greatly increased the demand for more accurate treatment planning (structure definition, dose calculation, etc) and dose delivery. The ability to use fast and...
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PMID: 20668343
PDF is available here.
Abstract
In the clinical office, during surgical planning, or in the operating room, neurosurgeons have been surrounded by the digital world either recreating old tools or introducing new ones. Technological refinements, chiefly based on the use of computer systems, have altered the modus operandi for neuros...
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PMID: 20802430
PDF is available here.
Abstract
Radiation therapy is commonly used in the treatment of cancer. The normal tissue tolerance can be a limit to deliver enough dose to the tumor to be curative. The synchrotron beam presents some interesting physical properties, which could decrease this limitation. Synchrotron beam is a medium energy...
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PMID: 20537443
PDF is available here.
Abstract
The present study provides quantitative analysis of cannula placement and infusate distribution using real-time MR imaging and defines an optimal zone for infusion in the nonhuman primate thalamus and brainstem. Cannula placement recommendations developed from such translational nonhuman primate stu...
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PMID: 20367078
PDF is available here.
Abstract
We investigated natural and lesion-induced apoptosis in the developing rat dorsal lateral geniculate nucleus (dLGN). These lesions involved: i) monocular enucleation, and ii) unilateral ablation of the visual cortex at different postnatal ages before eye opening. We identified dying cells as apoptot...
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PMID: 20471376
PDF is available here.
Abstract
Intracranial monitoring for temporal lobe seizure localization to differentiate neocortical from mesial temporal onset seizures requires both neocortical subdural grids and hippocampal depth electrode implantation. There are 2 basic techniques for hippocampal depth electrode implantation. This first...
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PMID: 20170311
PDF is available here.
Abstract
The tuberculoma diagnosis was established in 12 out of 13 cases (92%). Seizure control was achieved in all patients admitted with a history of seizures. There was no procedure-related mortality, none of the patients suffered permanent disability and most procedures were uneventful. Total resection w...
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PMID: 20669101
PDF is available here.
Shannon E Fogh,
David W Andrews,
Jon Glass,
Walter Curran,
Charles Glass,
Colin Champ,
James J Evans,
Terry Hyslop,
Edward Pequignot,
Beverly Downes,
Eileen Comber,
Mitchell Maltenfort,
Adam P Dicker and
Maria Werner-Wasik
Abstract
Younger age (P = .001), smaller GTV (P = .025), and shorter time between diagnosis and recurrence (P = .034) were associated with improvement in survival from H-SRT. Doses of radiation > or = 35 Gy approached significance (P = .07). There was no significant benefit of surgical resection or chemother...
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PMID: 20479391
PDF is available here.
Abstract
Most patients with cancer will be looked after by a diverse team made up of members from community- and hospital-based services. This team will include radiation oncologists. Radiotherapy is an important part of radical or palliative management in about 50% of patients with cancer. In recent years t...
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PMID: 21125059
PDF is available here.
Abstract
Upgrade to malignancy occurred in 20 (19.8%) of the 101 cases. The upgrade rate was significantly higher in cases of three or more foci of ADH (15 [28%] of 53 cases) than in cases of fewer than three foci (five [10%] of 48 cases) (P = .02). Upgrade rates were similar, regardless of whether all mammo...
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PMID: 20173103
PDF is available here.
Abstract
We implanted 19 gold markers into the inner pancreatic tumours of 16 pancreatic carcinoma patients percutaneously under B-ultrasonographic guidance. The marked motion of pancreatic lesions in the x (right-left), y (superoinferior) and z (anteroposterior) directions was measured using an X-ray simula...
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PMID: 20505031
PDF is available here.
Abstract
The angle between the anterior semicircular canal plane and sagittal plane was 35.3 +/- 4.1 degrees; posterior semicircular canal plane and sagittal plane, 50.9 +/- 4.7 degrees; and horizontal semicircular canal plane and sagittal plane, 90.4 +/- 7.0 degrees. The angle between the anterior and poste...
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PMID: 19916897
PDF is available here.
Abstract
Several studies indicated the involvement of serotonin-3 ([5-hydroxy tryptamine] 5-HT(3)) receptors in regulating alcohol-drinking behavior. The objective of this study was to determine the involvement of 5-HT(3) receptors within the ventral tegmental area (VTA) in regulating ethanol self-administra...
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PMID: 20682192
PDF is available here.
Abstract
Stereotactic body radiation therapy (SBRT) has emerged as a novel treatment modality for spinal metastases. Due to advances in radiation delivery technologies, it is now possible to deliver ablative doses to spinal metastases safely and effectively, and in particular high-dose re-irradiation. Data f...
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PMID: 20423672
PDF is available here.
Abstract
We review the different types of breast biopsy devices currently available together with various localization techniques used, focusing on their advantages, limitations and current controversial clinical management issues....
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PMID: 20338392
PDF is available here.
Abstract
In the context of reaching local control being still the main problem of Klatskin tumour patients, SFRT seems to be a very promising method for the treatment of these tumours.
Copyright 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20347169
PDF is available here.
Abstract
The average angle between the floor and the handle of the three-pin holder in the supine position and the Concorde position was 135 degrees (SD +/- 5.45) and 95 degrees (SD +/- 3.26) respectively (Figure 4) All the patient's body including the shoulders was within the borders of the operation table....
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PMID: 20401840
PDF is available here.
Abstract
MR spectroscopic images diagnosed the lesions as accurately as stereotaxic biopsies. CONCLUSION: Although stereotaxic biopsy keeps the label of "gold standard" when establishing a diagnosis for these lesions, modern radiological modalities are quite reliable....
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PMID: 20401849
PDF is available here.
Abstract
The treatment modality was well tolerated by the patients with radiological and neurological tumor control after 42 and 39 months of follow up. There were no additional complications. CONCLUSION: Fractionated regimens of Gamma Knife surgery offer a very good alternative for lesions such as optic gli...
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PMID: 20401852
PDF is available here.
Abstract
Innovative surgery teeters on the horns of a dilemma. Although a surgical innovation may offer substantial improvement over conventional treatment strategies on one hand, it may on the other be perceived as involving significant risk by both the surgeon and the patient. Based on prim...
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PMID: 20181545
PDF is available here.
Neurosurgery (66)3 Suppl Operative 2010
Abstract
The accuracy of identifying the correct brain location was 98.5%. Sensitivity of detecting passes intersecting the STN was 100%, and specificity was 84.9%. Anatomical location of the MER passes was calculated with a mean error of 0.06 mm (95% confidence interval, -0.54 to 0.42 mm) in the medial-late...
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PMID: 20173561
PDF is available here.
Neurosurgery (66)3 Suppl Operative 2010
Abstract
This technique allows safe and accurate placement of instrumentation in the posterior occipitocervical junction using 3-dimensional image guidance in which the reference arc is attached to the headholder....
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PMID: 20173564
PDF is available here.
Neurosurgery (66)3 Suppl Operative 2010
Abstract
In healthy subjects, the CM complex of the thalamus can be reliably contrasted on axially oriented slices by means of proton density weighted turbo-spin-echo MRI. An in-plane resolution of at least 0.6 x 0.6 mm2 is crucial at a slice thickness between 2 and 3 mm. Effective suppression of head motion...
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PMID: 20173580
PDF is available here.
Neurosurgery (66)3 Suppl Operative 2010
Abstract
Almost all intrathalamic substructures, nuclei, and white matter laminae were identified. Using 3D analysis, a simplified classification of intrathalamic nuclei into 9 groups was proposed, based on topographic MRI anatomy, designed for clinical practice: anterior (oral), posterior, dorsal, intermedi...
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PMID: 20173566
PDF is available here.
Abstract
The authors' technical approach to placement of DBS electrodes adapts the procedure to a standard configuration 1.5-T diagnostic MR imaging scanner in a radiology suite. This method simplifies DBS implantation by eliminating the use of the traditional stereotactic frame and the subsequent requiremen...
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PMID: 19681683
PDF is available here.
Abstract
Approximately 10% of the injected NSCs migrated into the tumor region by 50 minutes after NSC injection. The number of NSCs in the tumor region increased slowly up to 5 days post-injection and increased significantly up to 15 days post-injection. Changes in tumor volume showed similar patterns. The...
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PMID: 20087133
PDF is available here.
Abstract
Two effects could be differentiated: 1) greatest brain deformation of up to 1.7 mm predominantly located around central brain structures in the lateral direction and a less pronounced change after position changes in posterior-anterior direction, and 2) the brain boundary shift integral depicted pos...
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PMID: 20087139
PDF is available here.
Abstract
GKR is an excellent option for patients with glomus jugulare tumours after complete or subtotal resection or at recurrence. Appropriately planned frame placement allows successful treatment delivery without difficulty. GKR improved symptoms, prevented neurological progression and achieved radiograph...
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PMID: 20080472
PDF is available here.
Abstract
Viral vector-mediated gene delivery is an attractive procedure for introducing genes into the brain, both for purposes of basic neuroscience research and to develop gene therapy for neurological diseases. Replication-defective adenoviruses possess many features which make them ideal vectors for this...
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PMID: 20066657
PDF is available here.
Abstract
We demonstrate how to lesion the left nigro-striatal pathway of anesthetized mice by slowly delivering 2.0 microL of 6-OHDA through a stereotaxically inserted micro-syringe needle. The loss of dopaminergic input occurs within days, and the functional impairments can be monitored over post-operative...
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PMID: 20081770
PDF is available here.
Abstract
We use a patient-customized microstereotactic frame, which we call a "microtable" because it consists of a small tabletop sitting on legs. The orientation of the legs controls the alignment of the tabletop such that it is perpendicular to a specified trajectory.
Prospective.
Tertiary referral center...
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PMID: 20019561
PDF is available here.
Abstract
We have recently developed methods in which viruses encoding for light-sensitive proteins can sensitize specific cell types to millisecond-timescale activation and silencing in the intact brain. We here present the design and implementation of an injector array capable of delivering viruses (or othe...
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PMID: 20094028
PDF is available here.
Abstract
We use, clip was delivered through the biopsy probe. We report a case with malfunctioning of the ST DVAB system during the procedure, and thus the clip could not be placed through the biopsy probe. To salvage the procedure, we placed the clip to the biopsy site via a hemostasis introducer sheath....
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PMID: 20813305
PDF is available here.
Abstract
The objective of this retrospective study was to report initial results of CyberKnife stereotactic radiotherapy (SRT) boost for tumors in the head and neck area. Between March 2008 and August 2009, 10 patients were treated with SRT boost using CyberKnife system due mainly to unfavorable condition su...
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PMID: 20508374
PDF is available here.
Abstract
The purpose of this study was to evaluate the effect of megavoltage photon beam attenuation (PBA) by couch tops and to propose a method for correction of PBA. Four series of phantom measurements were carried out. First, PBA by the exact couch top (ECT, Varian) and Imaging Couch Top (ICT, BrainLAB) w...
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PMID: 20508376
PDF is available here.
Abstract
A 77-year-old female presented with a rare cavernous sinus cavernous hemangioma with extension to the sella turcica, neuroradiologically mimicking nonfunctioning pituitary macroadenoma. The lesion was partially removed via transsphenoidal surgery, and the histological diagnosis was cavernous hemangi...
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PMID: 20448429
PDF is available here.
Abstract
Stereotactic aspiration of intracerebral hemorrhage (ICH) improves the general condition of patients, promotes improvement of consciousness, and decreases the incidence of pneumonia, but may induce rebleeding. The present study investigated the effects of stereotactic aspiration and factors that inh...
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PMID: 20671378
PDF is available here.
Abstract
Bilateral STN DBS is an effective and safe treatment for patients with advanced PD. Bilateral STN DBS contributes to improvement of parkinsonian symptoms in the off state and levodopa-induced dyskinesia. This can be correlated with a 50% reduction of daily levodopa dose 5 years postoperatively....
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PMID: 20358480
PDF is available here.
Abstract
We investigated the position and variability of the intercommissural line in the minipig brain using in vivo MRI. From these data, standard coordinates for the minipig basal ganglia were estimated. We found the variability of the intercommissural line to be small in the Göttingen minipig and the va...
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PMID: 20357521
PDF is available here.
Abstract
The device was easy to handle and enabled accurate electrophysiologically guided targeting of the substantia nigra with minimal local tissue damage. CONCLUSION: The IMI is suitable for clinical use and may prove useful for various stereotactic procedures that require high levels of precision and/or...
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PMID: 20051711
PDF is available here.
Abstract
Method of cryodestruction of deep subcortical structures is used in functional stereotactic operations in patients with chronic progressing diseases of the central nervous system. The PAH device produces cooling the tissues in the target point of the brain to -70 degrees C, which allows to obtain th...
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PMID: 21137271
PDF is available here.
Abstract
A head fixation device with pins is commonly used for immobilization of the patients during neurosurgical procedures. Despite its appropriate management, it may be the cause of some serious complications such as skull perforation and intracranial injuries.We report the case of a 19-years-old young a...
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PMID: 19967324
PDF is available here.
Hiroko Okazaki,
Fumio Tsujimoto,
Ichirou Maeda,
Tomoyuki Ohta,
Yoshihide Kanemaki,
Kyoko Okamoto,
Hiroshi Shimamoto,
Yukari Yabuki,
Haruki Ogata,
Tomohiko Ohta,
Mamoru Fukuda and
Yasuo Nakajima
Abstract
In 154 of 191 samples (80.6%), the PHF on US corresponded with microcalcifications on MMG and histopathology. The overall sensitivity and specificity were 85.3% and 80.0%, respectively, for US, and 89.7% and 90.7%, respectively, for MMG. There were no significant differences between values for US an...
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PMID: 20035416
PDF is available here.
Abstract
All patients presented headache; six had papilledema, one had gait disturbance and one had third-nerve palsy. Neuroimaging showed hydrocephalus and a IIIVT CC with 14.4-mm mean diameter. After surgery all patients presented clinical and image improvement. Only two patients presented transient morbid...
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PMID: 20069224
PDF is available here.
Abstract
Considering diagnosis confirmation when inflammatory hypothesis were made, our accuracy was of 76%, with 94% of those cases having clinic-pathological correspondence after an average of 65.2 months of follow up. Considering diagnosis confirmation with the preoperative hypothesis of neoplasm, our acc...
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PMID: 20069220
PDF is available here.
Abstract
Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these pr...
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PMID: 18336954
PDF is available here.
Abstract
We report a molecular stereotactic biopsy technique that combines histopathologic diagnosis with small sample size-adjusted molecular genetic analysis of low-grade gliomas that are ineligible for tumor resection. Loss of heterozygosity (LOH) of 1p/19q and TP53 mutations were analyzed in 1-mm tissue...
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PMID: 19816195
PDF is available here.
Abstract
This unit describes the materials, methods, and analytical techniques available for the study of electrical activity of neural tissue in rodents in both homeostatic and disease states, with emphasis on epileptogenesis. A table containing a list of suppliers of relevant materials and equipment is als...
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PMID: 19802816
PDF is available here.