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Technology, Pharmaceutical (9):
Recent article
Technology, Pharmaceutical
Abstract
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Abstract
Nifedipine is a dihydropyridine calcium channel antagonist effective in the clinical management of cardiovascular disease. Due to nifedipine's poor water solubility and erratic bioavailability, complexation with selected cyclodextrins was studied in order to overcome these limitation...
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PMID: 21091429
PDF is available here.
PDF is available here.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (60)2 2011
Abstract
During the second half of the last century, pelletization methods based on wetting were developed, e.g. agglomeration in coating pans, pelletization plates or fluid-bed equipment, layering of the drug in solution or suspension on inactive spherical cores, extrusion/spheronization and later on also ro...
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PMID: 21650006
PDF is available here.
PDF is available here.
Abstract
To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed.
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PMID: 21598536
PDF is available here.
PDF is available here.
Journal of Chromatography A (1217)48 2010
Abstract
A push-pull sampling system interfaced on-line to high-performance liquid chromatography (HPLC) was developed for micro-volume real-time monitoring of reaction mixtures. The device consists of concentric tubes wherein sample was continuously withdrawn through the outer tube and reaction quenchant co...
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PMID: 20970142
PDF is available here.
PDF is available here.
European Journal of Cancer (46)15 2010
Abstract
In order to decide whether a new treatment should be used in patients, a robust estimate of efficacy and toxicity is no longer sufficient. As a result of increasing healthcare costs across the globe healthcare payers and providers now seek estimates of cost-effectiveness as well. Most trials current...
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PMID: 20655197
PDF is available here.
PDF is available here.
Abstract
To establish a baking method of Platycladi Cacumen Carbonisatum for providing a new idea to Carbonic Herbs' research.
Samples were prepared in an oven for different time at different temperatures separately. Then the fingerprints of the samples were determined by UPLC. According to the standard fing...
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PMID: 21137332
PDF is available here.
PDF is available here.
Abstract
We examine approaches taken to design immunogens, expression systems and delivery strategies that are medically feasible and immunologically effective while retaining key benefits of a plant production platform. We identify three 'target areas' in which plant-made immunogens may offer particular adv...
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PMID: 20673007
PDF is available here.
PDF is available here.
Abstract
The use of contained plant systems for the production of biopharmaceuticals represents a powerful alternative to current methods, combining the benefits of whole-plant systems and cell cultures. In vitro contained production systems include plant cell suspensions, hairy root cultures, novel plants g...
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PMID: 20673011
PDF is available here.
PDF is available here.
Abstract
Molecular farming in plants or plant cell cultures represents a viable alternative technology that holds great promise for the low-cost and large-scale production of recombinant proteins. The particular case of plant-based vaccines for the prevention of autoimmune diseases is addressed here, present...
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PMID: 20673017
PDF is available here.
PDF is available here.
Abstract
We report recent promising advances in the production of prophylactic and therapeutic vaccines against human papillomavirus by expression of the relevant antigens in plants, and discuss future prospects for the use of such vaccines....
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PMID: 20673013
PDF is available here.
PDF is available here.
Abstract
The introduction of highly active antiretroviral therapy has drastically changed HIV infection from an acute, very deadly, to a chronic, long-lasting, mild disease. However, this requires continuous care management, which is difficult to implement worldwide, especially in developing countries. Sky-r...
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PMID: 20673014
PDF is available here.
PDF is available here.
Abstract
We analyze the data on development of plant-based HBV vaccines....
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PMID: 20673016
PDF is available here.
PDF is available here.
Abstract
We highlight the current research directions taken with four diseases considered as important constraints to international trade in animals: avian influenza, Newcastle disease, foot-and-mouth disease and diarrheal disease caused by enterotoxigenic Escherichia coli. We also discuss appropriate plant...
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PMID: 20673018
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated plant-made pharmaceutical patents between the years 2002 and 2008. There was a clear downward trend in the number of patents filed between these years and a greater number of patents were filed by public sector institutions or inventors than by the private sector. The USA dominated p...
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PMID: 20673006
PDF is available here.
PDF is available here.
Abstract
We discuss the possibilities to use this knowledge for the rational design of plant-expressed vaccines....
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PMID: 20673008
PDF is available here.
PDF is available here.
Abstract
We review the development of mucosally administered vaccines expressed in transgenic plants. In particular, we evaluate the advantages and disadvantages of using plants for the production of mucosal vaccines against widespread infectious diseases such as HIV, hepatitis B and TB....
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PMID: 20673015
PDF is available here.
PDF is available here.
Abstract
Recombinant antigen production in plants is a safe and economically sound strategy for vaccine development, particularly for oral/mucosal vaccination, but subunit vaccines usually suffer from weak immunogenicity and require adjuvants that escort the antigens, target them to relevant sites and/or act...
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PMID: 20673009
PDF is available here.
PDF is available here.
Abstract
We survey here the current state-of-the-art of this research field. Several vectors have been designed on the basis of DNA- and RNA-based plant virus genomes and viral vectors are used both as single- and multicomponent expression systems in different combinations depending on the protein of interes...
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PMID: 20673010
PDF is available here.
PDF is available here.
Circulation Research (107)1 2010
Abstract
We developed a simple technique to construct large series of EHT and automatically evaluate contractile activity. The method shall be useful for drug screening and disease modeling....
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PMID: 20448218
PDF is available here.
PDF is available here.
Abstract
Given the important role of insulin in the treatment of diabetes mellitus and in light of common barriers to insulin use, new strategies for insulin delivery by routes other than intravenous and subcutaneous injection have been investigated since the discovery of insulin in the 1920s. Most companies...
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PMID: 20462282
PDF is available here.
PDF is available here.
Abstract
During the 2010 HIV Diagnostics Conference, which took place in Orlando (FL, USA) between 24 and 26 March 2010, salient new data related to three aspects of HIV testing (rapid point-of-care testing, laboratory assays and new technologies) were presented and discussed. A conundrum central to HIV diag...
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PMID: 20521890
PDF is available here.
PDF is available here.
Abstract
This article focuses on the process analytical technology (PAT) of pharmaceutical dry milling. The first objective is to compare different modes of dynamic image analysis namely, on-line, in-line and at-line for monitoring powder milling. The second objective is to introduce time evolving size and s...
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PMID: 20188807
PDF is available here.
PDF is available here.
Abstract
Solid silicon microneedle arrays with different needle lengths (ranging from 100 to 1100 microm) and needle densities (ranging from 400 to 11,900 needles/cm(2)) were used to penetrate epidermal membrane of human cadaver skin. After this pretreatment, the electrical resistance of the skin and the flu...
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PMID: 20188808
PDF is available here.
PDF is available here.
Abstract
Abstract
The objective of this work was to explore the potential and safety of trimethyl chitosan (TMC) and PEGylated TMC for improved absorption of insulin after nasal administration.
The nasal absorption of insulin nanocomplexes of TMC or PEGylated TMC was evaluated in anaesthetized rats. Concomitantly, th...
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PMID: 20609059
PDF is available here.
PDF is available here.
Abstract
The aim was to synthesize molecularly imprinted polymers (MIPs) with high recognition properties towards glycyrrhizic acid and to evaluate the performance of these materials to act as base excipients in glycyrrhizic acid sustained release in gastrointestinal simulating fluids.
MIPs were synthesized...
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PMID: 20609058
PDF is available here.
PDF is available here.
Nature Reviews: Genetics (11)5 2010
Abstract
Synthetic biology is bringing together engineers and biologists to design and build novel biomolecular components, networks and pathways, and to use these constructs to rewire and reprogram organisms. These re-engineered organisms will change our lives over the coming years, leading to cheaper drugs...
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PMID: 20395970
PDF is available here.
PDF is available here.
Abstract
The Recombinant Vaccines: Strategies for Candidate Discovery and Vaccine Delivery conference, organized by EuroSciCon, hosted a group of UK-based and international scientists from as far afield as Malaysia and Australia. Genomic analyses of pathogens and elucidation of mechanisms of pathogenesis has...
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PMID: 20450319
PDF is available here.
PDF is available here.
Abstract
We identified a falsely elevated whole-blood tacrolimus immunoassay result in a renal transplant patient. Twelve hours after the patient received his first dose, the blood concentration was 24.4 ng/mL using the Siemens Dimension RxL immunoassay. Immunoabsorption studies showed that the cause of the...
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PMID: 20216109
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
Conventional aerosol delivery systems and the availability of new technologies have led to the development of "intelligent" nebulizers such as the I-neb Adaptive Aerosol Delivery (AAD) System. Based on the AAD technology, the I-neb AAD System has been designed to continuously adapt to changes in the...
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PMID: 20373904
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The in vitro characterization of device-related parameters such as the rate of aerosol output, total aerosol output, particle size, and fine particle fraction, is essential when assessing the potential performance of a nebulizer or making comparisons with other nebulizers as they are indicative of p...
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PMID: 20373905
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The trial showed that it was possible to build telehealth technology into an advanced nebulizer system, and that patient acceptance of the technology was unlikely to be a barrier to the adoption of such a telehealth system....
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PMID: 20373906
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
This study provides preliminary evidence of the acceptability of the TIM breathing maneuver in patients with CF and their ability to perform repeated TIM breathing during simulated nebulizer therapy with the I-neb AAD System....
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PMID: 20373907
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Intelligent nebulizers in the age of the Internet: The I-neb Adaptive Aerosol Delivery (AAD) system.
Abstract
Abstract
The aim was to compare different film-forming materials used for the preparation of fast-dissolving oral films.
Films were prepared with and without caffeine and caffeine citrate as model drugs. The disintegration/dissolution behaviour of films was investigated using the newly developed slide frame...
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PMID: 20604845
PDF is available here.
PDF is available here.
Abstract
This review summarizes the analytical approaches reported in the literature relating to epoxide and hydroperoxide impurities. It is intended that it should provide guidance for analysts faced by the need to control such impurities, particularly where this is due to concerns relating to their potenti...
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PMID: 20031361
PDF is available here.
PDF is available here.
Pharmacogenomics (11)4 2010
Abstract
We interrogate the human genome. These tools have facilitated rapid biomarker discovery, uncovered novel targets for therapeutic intervention and enabled mechanistic studies that have helped unravel the mode of drug action. The assessment of drug toxicity based on genomic signatures associated with...
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PMID: 20350126
PDF is available here.
PDF is available here.
Abstract
The PURE system is a highly controllable cell-free protein synthesis system composed of individually prepared components that are required for protein synthesis in Escherichia coli. The PURE system contains neither nucleases nor proteases, both of which degrade DNA or mRNA templates and proteins. Th...
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PMID: 20210745
PDF is available here.
PDF is available here.
Abstract
We have developed a high-pH, pH-shift refolding "Ph-Fold technology", both for academic research and industrial protein drug development applications. Using this technology, we were able to refold some "difficult-to-refold" proteins, some of which are proven important drug targets and protein drug c...
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PMID: 20210740
PDF is available here.
PDF is available here.
Abstract
Abstract
Inertial impaction is generally regarded as the 'gold standard' for the in vitro assessment of aerodynamic deposition of inhaled formulations. Despite the availability of several impactors, few studies have compared measurements of aerodynamic deposition using multiple impactors and none employed a...
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PMID: 20026261
PDF is available here.
PDF is available here.
Abstract
An alternative procedure for achieving formulation design in a high-shear wet granulation process has been developed. Particularly, a new formulation map has been proposed which describes the onset of a significant granule growth as a function of the formulation variables (diluent, dry and liquid bi...
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PMID: 19969055
PDF is available here.
PDF is available here.
Abstract
We report here, a high level of surface heterogeneity on the native mannitol crystal surfaces. When the surfaces of both D-mannitol samples (powder and large single crystals) were modified by dichlorodimethylsilane to induce surface hydrophobicity, both IGC and contact angle revealed a homogeneous s...
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PMID: 20006691
PDF is available here.
PDF is available here.
Abstract
In the present study, thin-coating as a potential method for improving flow properties of cohesive ibuprofen powder was introduced. Briefly, the technique was based on the successive deposition of ultrasound-assisted fine polymer mist onto the surface of the powdered active pharmaceutical ingredient...
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PMID: 20005929
PDF is available here.
PDF is available here.
Abstract
A neural model based on a numerical molecular representation using CODES program to predict oral absorption of any structure is described. This model predicts both high and low-absorbed compounds with a global accuracy level of 74%. CODES/ANN methodology shows promising utilities not only as a conve...
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PMID: 20022146
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To prepare sinomenine hydrochloride delayed-onset sustained-release tablets. METHOD: The tablets containing sinomenine hydrochloride were prepared by dry-compression coating technique with the ratio of HPMC in core tablet and the ratio of HPMC in coating film as the influence factors and...
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PMID: 20545191
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE:To establish a HPLC-PDA method for the determination of baicalin, wogonoside, baicalein, wogonin and glycyrrhizic acid in Xiaochaihu Tang. METHOD: A Symmetry Shield RP18 (4.6 mm x 250 mm, 5.0 microm) was used with a mobile phase of acetonitrile-0.01% H3PO4 in gradient elution. The detectio...
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PMID: 20545192
PDF is available here.
PDF is available here.
Abstract
To choose the optimal conditions for the formation of the complex with total flavonoids in hawthorn fruit and phospholipid.
Solvent evaporation process was used to prepare hawthorn total flavonoids phospholipid complex. The evaluation criterion was the complex ratio. The experiment inspected the sig...
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PMID: 20681311
PDF is available here.
PDF is available here.
Abstract
To optimize the process of extracting effective constituents from Aralia elata by response surface methodology.
The independent variables were ethanol concentration, reflux time and solvent fold, the dependent variable was extraction rate of total saponins in Aralia elata. Linear or no-linear mathem...
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PMID: 20681312
PDF is available here.
PDF is available here.
Abstract
To prepare an oral nutritional liquid for protecting liver and antialcoholic from defatted oyster powder.
The orthogonal design was used to determine the optimal enzymatic hydrolytic condition and the enzymolysis liquid from oyster was deodorized and seasoned.
The optimum hydrolytic conditions were...
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PMID: 20681313
PDF is available here.
PDF is available here.
Abstract
To study the preparation technique of total lactone of Ginkgo controlled release pellet.
Aquacoat as controlled release material, DBS as plasticizer, HPMC as diffusion promoter, the best manufacture technique was got according to the factors affecting the release of the pellet.
The controlled releas...
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PMID: 20681314
PDF is available here.
PDF is available here.
Abstract
Adsorption profiles of insulin on porous materials and release profiles of insulin entrapped on folded-sheet mesoporous silica (FSM) were studied. Three types of FSM with different pore sizes (3.0, 6.1, and 9.2 nm) were used as candidates. A simple technique of repeated freezing and...
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PMID: 19931606
PDF is available here.
PDF is available here.
Abstract
A rapid expansion of supercritical solution (RESS) technology was presented for the micronization of Chinese medicinal material. Magnolia bark extract (MBE) obtained by supercritical carbon dioxide (scCO(2)) extraction technology was chosen as the experimental material. RESS process produced 4.7 mic...
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PMID: 20118572
PDF is available here.
PDF is available here.
Abstract
An in-line sampling system with dilution units for aqueous droplet aerosols from single dose inhalers (Berodual Respimat, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany) for an optical particle counter is described. The device has been designed to interface with a white light aerosol spectromete...
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PMID: 19874891
PDF is available here.
PDF is available here.
Drug Delivery (17)2 2010
Abstract
The aim of the present study was to develop a sumatriptan succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone((R)) was added as a permeability enhancer. The physical characteristics, mechanical pro...
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PMID: 20067437
PDF is available here.
PDF is available here.
Drug Delivery (17)2 2010
Abstract
Buccoadhesive wafers (BW) containing Nimodipine (N) were prepared using the solvent casting method. Chitosan lactate was used as the mucoadhesive polymer with different ratios to PVP K-30 in preparation of the sustained release layer. Sodium carboxymethyl cellulose low viscosity (SCMC LV) in differe...
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PMID: 20070241
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study effect of alcohol concentration in water extraction and alcohol precipitation on the preparation of effervescent tablets of Banlangen. METHOD: Effects of different concentrations of alcohol precipitation on the Banlangen extract rate, metastasis rate of index components, extract...
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PMID: 20422990
PDF is available here.
PDF is available here.
Abstract
To study the extraction technology of anti-diabetes active constituents from Potentilla chinesis.
Through single factor test, the effects of factors such as concentration of ethanol, temperature, ratio of liquid-solid, extraction time and times of extraction were investigated. Through orthogonal exp...
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PMID: 20575426
PDF is available here.
PDF is available here.