Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Toxicity Tests (9):
Recent article
Toxicity Tests
Abstract
A quarantine treatment using bale compression (32 kg/cm2 pressure) and phosphine fumigation (61 g/28.3 m3 aluminum phosphide for 7 d at 20 degrees C) was approved to control Hessian fly, Mayetiola destructor (Say), in large-size, polypropylene fabric-wrapped bales exported from the western states to...
|
PMID: 21735895
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
To compare the acute toxicity and content of daphnoretin among extracts of unprocessed indian string-bush root and its two different processed products, and to provide a basis for discussion of the mechanism of two processed methods.
|
PMID: 21842643
PDF is available here.
PDF is available here.
Abstract
These results provide the first documentation of the relative toxicity of these neonicotinoid insecticides to B. occiduus....
|
PMID: 21404859
PDF is available here.
PDF is available here.
Abstract
In 2010, the EU FP NanoSustain project (247989) has been successfully launched with the objective to develop innovative solutions for the sustainable use, recycling and final treatment of engineered nanomaterials (ENMs). The same year, NanoValid (263147), a large-scale integrating EU...
|
PMID: 21485776
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (22)2 2011
Abstract
These results suggest that the Gal-PHEA-DOX conjugate has great potential for use in hepatocellular carcinoma chemotherapy because of its enhanced antitumor effect with reduced systemic toxicity including hepatotoxicity....
|
PMID: 20966743
PDF is available here.
PDF is available here.
Abstract
Hepatic systems toxicology is the integrative analysis of toxicogenomic technologies, e.g., transcriptomics, proteomics, and metabolomics, in combination with traditional toxicology measures to improve the understanding of mechanisms of hepatotoxic action. Hepatic toxicology studies that have employ...
|
PMID: 20970440
PDF is available here.
PDF is available here.
Abstract
Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells.
Abstract
Nanoparticles were first characterized by size, surface charge, dispersion and solubility. Cytotoxicity of NPs was then evaluated in IP15 (glomerular mesangial) and HK-2 (epithelial proximal) cell lines. ZnO and CdS NPs significantly increased the cell mortality, in a dose-dependent manner. Cytotoxi...
|
PMID: 21371295
PDF is available here.
PDF is available here.
Abstract
The results of this study suggest that the light curing units and resin composites should be harmonized to one another and the curing distance between the tip of the light curing unit and the restoration surface should be as close as possible in order to achieve maximal biocompatibility....
|
PMID: 21196876
PDF is available here.
PDF is available here.
Abstract
Estragole is a natural organic compound that is used as an additive, flavoring agent, or fragrance in a variety of food, cleaning, and cosmetic products; as an herbal medicine; as an antimicrobial agent against acid-tolerant food microflora; and to produce synthetic anise oil. Estragole was nominated...
|
PMID: 21445103
PDF is available here.
PDF is available here.
Molecular BioSystems (7)1 2011
Abstract
We have used an NMR-based metabolic profiling approach to characterise for the first time the metabolome of the RPTEC/TERT1 cell line, an immortalised non-tumour human renal epithelial cell line that recapitulates phenotypic characteristics that are absent in other in vitro renal cell models. RPTEC/...
|
PMID: 21103459
PDF is available here.
PDF is available here.
Molecular BioSystems (7)1 2011
Abstract
We have used an NMR-based metabolic profiling approach to characterise for the first time the metabolome of the RPTEC/TERT1 cell line, an immortalised non-tumour human renal epithelial cell line that recapitulates phenotypic characteristics that are absent in other in vitro renal cell models. RPTEC/...
|
PMID: 21103459
PDF is available here.
PDF is available here.
Molecular BioSystems (7)1 2011
Abstract
We have used an NMR-based metabolic profiling approach to characterise for the first time the metabolome of the RPTEC/TERT1 cell line, an immortalised non-tumour human renal epithelial cell line that recapitulates phenotypic characteristics that are absent in other in vitro renal cell models. RPTEC/...
|
PMID: 21103459
PDF is available here.
PDF is available here.
Chemosphere (82)3 2011
Abstract
This work investigates the ecotoxicological evaluation of contaminated dredged sediments from French Mediterranean navy harbour (A), commercial port (B) and two composite specimens (C) and (D) coming from the mixture of A and B with other port sediments. The toxicity of elutriates from these sedimen...
|
PMID: 21035165
PDF is available here.
PDF is available here.
Abstract
Xenobiotics, including therapeutic agents, can produce a variety of beneficial, as well as adverse, effects in mammals. One potential source of drug-mediated toxicity stems from metabolic activation of the parent compound, typically catalyzed by one or more members of the cytochrome P450 family of e...
|
PMID: 20972760
PDF is available here.
PDF is available here.
Abstract
We recommend that, whenever possible, the preclinical study strategy is discussed with the regulatory authorities....
|
PMID: 20972744
PDF is available here.
PDF is available here.
Abstract
The Frog Embryo Teratogenesis Assay Xenopus (FETAX) test is a development toxicity screening test. Due to the small amount of compound needed and the capability to study organogenesis in a short period of time (96 h), FETAX test constitutes an efficient development toxicity alert test when performed...
|
PMID: 20972758
PDF is available here.
PDF is available here.
Abstract
Mitochondrial dysfunction is a major mechanism whereby drugs can induce liver injury and other serious side effects, such as lactic acidosis and rhabdomyolysis, in some patients. Several in vitro and in vivo investigations can be performed in order to determine if drugs can disturb mitochondrial fat...
|
PMID: 20972757
PDF is available here.
PDF is available here.
Abstract
A pediatric assessment is now a required component of every New Drug Application in North America or Marketing Authorization Application in Europe, unless a waiver has been granted previously. Nonclinical juvenile toxicity studies are usually required as part of this assessment. The protocols for ju...
|
PMID: 20972745
PDF is available here.
PDF is available here.
Abstract
The embryonic zebrafish model offers the power of whole-animal investigations (e.g., intact organism, functional homeostatic feedback mechanisms, and intercellular signaling) with the convenience of cell culture (e.g., cost- and time-efficient, minimal infrastructure, small quantities of nanomateria...
|
PMID: 20972759
PDF is available here.
PDF is available here.
Abstract
We previously established a novel assay method based on cardiac field potential as an endpoint. However, cardiac specificity of this field potential is not yet clarified, because beating cells have not been rigorously evaluated as skeletal or cardiomyocyte. Here, we investigated the relationships be...
|
PMID: 21139340
PDF is available here.
PDF is available here.
Toxicology In Vitro (24)8 2010
Abstract
Abstract
The DR-H4IIE.Luc bioassay is based on the ability of dioxin and dioxin-like contaminants to activate the AhR and its signal transduction pathway, a mechanism through which these contaminants elicit their toxic effects. The bioassay was used to examine the total dioxin-equivalent (TEQ) toxicity in go...
|
PMID: 20863569
PDF is available here.
PDF is available here.
Abstract
We found specific effects on growth retardation above 30.6 mg/l for carbamazepine, on hatching, yolk sac and tail deformation above 1.5mg/l for diclofenac, and on scoliosis and growth retardation above 12.6 mg/l for metoprolol. Scoring all effect parameters, the 72-h-EC(50) values were: for carbamaz...
|
PMID: 20832863
PDF is available here.
PDF is available here.
Safety and toxicological evaluation of Aflapin: a novel Boswellia-derived anti-inflammatory product.
Abstract
Boswellia serrata gum resin has been used for treatment of various ailments in different cultures for thousands of years. Aflapin(®) is a novel synergistic composition derived from B. serrata gum resin (Indian Patent Application No. 2229/CHE/2008). Aflapin is significantly better as...
|
PMID: 20874664
PDF is available here.
PDF is available here.
Abstract
In order to minimize risks to human and environmental health, chemical safety assessment programs are being reinforced with toxicity tests more specifically designed for detecting endocrine disrupters. This includes the necessity to detect thyroid-disrupting chemicals, which may operate through a va...
|
PMID: 20684730
PDF is available here.
PDF is available here.
Abstract
We have identified a species difference almost certainly responsible for this disparate immunopharmacology.
Polychromatic flow cytometry and intracellular cytokine staining were employed to dissect the in vitro immunopharmacology of TGN1412 and other therapeutic mAbs at the cellular level to identif...
|
PMID: 20880392
PDF is available here.
PDF is available here.
Abstract
We discuss the implications for the TGN1412 catastrophe and for preclinical evaluation of biologicals in animal models in general....
|
PMID: 20880391
PDF is available here.
PDF is available here.
Abstract
A number of high molecular weight (HMW) lignin derivatives possessing varied chemical properties were screened for their biological effects in order to obtain more information on the possible structural features of HMW lignin-related effects. The studied compounds were both commercial and in-house e...
|
PMID: 20494440
PDF is available here.
PDF is available here.
Abstract
These results suggest that in vivo toxicity tests based on this specific biomarker are sensitive and present advantages over conventional acute tests based on mortality. Behavioural studies of test organisms conducted in conjunction with measurement of AChE inhibition will provide data to clarify th...
|
PMID: 20701973
PDF is available here.
PDF is available here.
Abstract
Wastewater management receives a great deal of attention with various methods being proposed for discharge hazard estimation via ecotoxicological results. Policy-makers, stakeholders and the general public do not generally possess an adequate level of understanding on this matter, so it is rather ha...
|
PMID: 20599272
PDF is available here.
PDF is available here.
Abstract
The management of dredged sediments is a priority issue in the Mediterranean sea where sediments are historically polluted. The aims of this study were to evaluate the toxicity of port sediment samples and the effect of three mineral additives (hematite, zerovalent iron (ZVI) and natural zeolite (NZ...
|
PMID: 20708265
PDF is available here.
PDF is available here.
Abstract
In the present study, two conventional (with and without sand filter) and four additional (moving bed biofilm reactor, ozone, moving bed biofilm reactor combined with ozone and a membrane bio reactor) treatment technologies were operated in small-scale at Hammarby Sjöstad sewage treatment plant, St...
|
PMID: 20570351
PDF is available here.
PDF is available here.
Abstract
We introduced an electrophysiological method with a microelectrode array system for the evaluation of differentiated cardiomyocytes. Embryotoxic (valproic acid, verapamil, and 5-fluorouracil) and non-embryotoxic (penicillin G, d-camphor, and isoniazid) compounds were assessed with the system. Mouse...
|
PMID: 20930457
PDF is available here.
PDF is available here.
Abstract
Abstract
Allergic contact dermatitis (ACD) is a significant safety concern for developers of cosmetic, personal care, chemical, pharmaceutical, and medical device products. The guinea pig maximization test (GMPT) and the murine local lymph node assay (LLNA) are accepted methods for determinin...
|
PMID: 20491607
PDF is available here.
PDF is available here.
Abstract
We developed a feed-based treatment regime in which ivermectin was the active ingredient. Rodent feed was compounded with 3 different concentrations of ivermectin (12, 24, and 48 ppm) and γ-irradiated. Postcompounding analysis revealed loss of ivermectin during manufacturing, but the remaining drug...
|
PMID: 20858356
PDF is available here.
PDF is available here.
Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering (45)11 2010
Abstract
The aim of this study was to compare the sensitivity of two Corophidae: Corophium orientale a standardized species and Corophium insidiosum a species more available in the Ionian sea (Southern Italy), in order to evaluate the suitability and applicability of C. insidiosum to sediment toxicity test....
|
PMID: 20694884
PDF is available here.
PDF is available here.
Reproductive Toxicology (30)2 2010
Abstract
Reproductive Toxicology (30)2 2010
Abstract
We introduced a modification to the standard protocol exposing the Embryonic Stem Cells (ES-D3) to nanoparticles only during the first 5 days of the assay. Moreover, we proposed a method to discriminate and compare the embryotoxicity of the substances within the weakly embryotoxic range. Our ID(50)...
|
PMID: 20566333
PDF is available here.
PDF is available here.
Abstract
We have compared the concentration curves and resulting ID(50)s of the new endpoints with mRNA expression for osteocalcin. Osteocalcin is an exclusive marker found only in mineralized tissues, is regulated upon compound treatment and reliably predicts the potential of a chemical entity acting as a b...
|
PMID: 20576515
PDF is available here.
PDF is available here.
Abstract
Although nanoparticles have tremendous potential for a host of applications, their adverse effects on living cells have raised serious concerns recently for their use in the healthcare and consumer sectors. As regards the central nervous system (CNS), research data on nanoparticle interaction with n...
|
PMID: 20519209
PDF is available here.
PDF is available here.
Abstract
The National Academies' Standing Committee on Use of Emerging Science for Environmental Health Decisions held a meeting (21-22 September 2009 in Washington, DC) titled "Computational Toxicology: From Data to Analyses to Applications." This commentary reflects on the presentations and roundtable disc...
|
PMID: 20483702
PDF is available here.
PDF is available here.
Water Research (44)15 2010
Abstract
Mollusk species have been shown to be sensitive to various endocrine disrupting compounds (EDC) at environmentally relevant concentrations. Waste water treatment plant (WWTP) effluents are a major source of potential or known EDC in the aquatic environment. The aim of this study was to develop an in...
|
PMID: 20591464
PDF is available here.
PDF is available here.
Abstract
We exposed primary cultured cortical neurons and mouse neuroblastoma cell lines (neuro2a) to different concentrations of nickel chloride (NiCl(2)) (0.125, 0.25, 0.5, and 1 mm) for 12 hr or 0.5 mm NiCl(2) for various periods (0, 3, 6, 12, and 24 hr). We found that nickel significantly increased react...
|
PMID: 20536687
PDF is available here.
PDF is available here.
Abstract
We evaluated the applicability and predictive capacity of five in vitro tests for eye irritation: the Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) assay; the Chorioallantoic Membrane-Trypan Blue Staining (CAM-TBS) assay; the Fluorescein Leakage Test (FLT); the 3T3-Neutral Red Uptake (3T3-NRU) c...
|
PMID: 20822323
PDF is available here.
PDF is available here.
Abstract
A need for rapid toxicity techniques has seen recent research into developing new microbiological assays and characterising their toxicity responses using a range of substances. A microbiological bioassay that determines changes in ferricyanide-mediated respiration for toxicity measurement (FM-TOX)...
|
PMID: 20602965
PDF is available here.
PDF is available here.
Abstract
Environmental Research (110)5 2010
Abstract
Arsenic is a known human carcinogen, inducing tumors of the skin, urinary bladder, liver and lung. Inorganic arsenic, existing in highly toxic trivalent and significantly less toxic pentavalent forms, is methylated to mono- and di-methylated species mainly in the liver. Due to the low toxicity of pe...
|
PMID: 19758587
PDF is available here.
PDF is available here.
Abstract
The aim of this work is the Toxicity Identification Evaluation (TIE) of highly toxic tank truck cleaning wastewater effluent. Conventional TIE, using EDTA and activated carbon addition, revealed organic compounds as main source of toxicity. Additional toxicant characteristics could be derived from h...
|
PMID: 20378172
PDF is available here.
PDF is available here.
Abstract
This study proposes short-term sublethal assays for the tropics using the fish Poecilia reticulata. Assays were evaluated under realistic exposure scenarios by simulating a runoff over an agricultural area sprayed with deltamethrin (Decis). In situ assays were performed inside microcosms set up to s...
|
PMID: 20427087
PDF is available here.
PDF is available here.
Abstract
Lethal effects of trinitrotoluene (TNT) to juvenile sheepshead minnows (JSHM) (Cyprinodon variegatus) were assessed in ten-day water exposures. Ten-day median lethal concentrations (LC50s) were 2.3 and 2.5 mg L(-1), the 10-d median lethal residue value (LR50) was 26.1 micromol kg(-1) wet weight (ww)...
|
PMID: 20219247
PDF is available here.
PDF is available here.
Abstract
Chromium(III) is an essential trace element required for normal protein, fat and carbohydrate metabolism. It also helps in energy production and increasing lean body mass. Chromium(III) dinicocysteinate (CDNC) is a unique form of bioavailable chromium(III). This study was focused on...
|
PMID: 20515439
PDF is available here.
PDF is available here.
Phytotherapy Research (24)7 2010
Abstract
The potential toxicity of fucoidan from Undaria pinnatifida was investigated in vitro and in vivo. By the Ames test, fucoidan showed no mutagenicity up to 500 microL/plate, and inhibited the mutagenicity induced by 4-nitro-quinoline-1-oxide, by up to 71%, compared with controls. In the bone marrow m...
|
PMID: 20578121
PDF is available here.
PDF is available here.
Abstract
We describe an in vitro assay developed to detect and quantify changes in intestinal motility as a surrogate biomarker for constipation/diarrhea-type GADRs. In vitro recordings of intraluminal pressure were used to monitor the presence of colonic peristaltic motor complexes (CPMCs) in mouse colonic...
|
PMID: 20350559
PDF is available here.
PDF is available here.
Abstract
We set out to quantify the exposure and associated toxicity of chemicals with different physicochemical properties toward a fish gill cell line when different solvents and procedural steps are used to introduce test chemicals to cells. Three chemicals with a range of hydrophobicity and volatility we...
|
PMID: 20499932
PDF is available here.
PDF is available here.
Toxicology (273)1-3 2010
Abstract
2,2,5,7,8-Pentamethyl-6-chromanol (PMCol) was administered by gavage in rats for 28 days at dose levels of 0, 100, 500, and 2000mg/kg/day. PMCol administration induced decreases in body weight gains and food consumption, hepatotoxicity (increased TBILI, ALB, ALT, TP; increased relative liver weights...
|
PMID: 20430063
PDF is available here.
PDF is available here.
Abstract
Our data suggest that membrane structure is a major target of methanol toxicity, while proteins were major targets of formaldehyde toxicity....
|
PMID: 19499198
PDF is available here.
PDF is available here.
Abstract
Bifenthrin, chlorfenapyr, fipronil, and thiamethoxam were evaluated for activity against the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae). Mobility impairment and lethal times were determined after topical treatments. Both immobilization and mortality occurred most quick...
|
PMID: 20568621
PDF is available here.
PDF is available here.
Abstract
We present an approach to gain well-dispersed nanoparticles in physiological media. Therefore, a step-by-step procedure is demonstrated on two different tungsten carbide nanopowders which can be transferred to other powders. The procedure includes a comprehensive powder characterization, followed by...
|
PMID: 20795896
PDF is available here.
PDF is available here.