Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Weightlessness Simulation (1):
Recent article
Weightlessness Simulation
Abstract
We tested the hypothesis that the acute 0-G induced increase in cardiac output (CO) is primarily caused by redistribution of blood from the vasculature above the legs to the cardiopulmonary circulation. In seated subjects (n = 8), 20 s of 0 G induced by parabolic flight increased CO by 1.7 ± 0.4 l...
|
PMID: 21636570
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Autonomic Neuroscience (160)1-2 2011
Abstract
We hypothesized that vasoconstriction of skin microcirculatory bed should be altered following 7 days of simulated microgravity in order to maintain cardiovascular homeostasis during active standing. Eight healthy men were studied before and after 7 days of simulated microgravity modeled by dry imme...
|
PMID: 21071283
PDF is available here.
PDF is available here.
Abstract
The effect of reducing gravity on locomotion has been studied using microgravity analogues. However, there is no known literature comparing locomotion in actual microgravity (AM) to locomotion in simulated microgravity (SM).
Five subjects were tested while walking at 1.34 m x s(-1) and running at 3....
|
PMID: 21197853
PDF is available here.
PDF is available here.
Abstract
Our analysis showed 882 genes that were downregulated and 505 genes that were upregulated after exposure to simulated microgravity. Gene ontology clustering revealed a wide variety of affected genes with respect to cell compartment, biological process, and signaling pathway clusters. The data sets s...
|
PMID: 20807102
PDF is available here.
PDF is available here.
Abstract
We examined the global gene expression patterns in sedentary men (n = 7, mean age ± SD = 22.1 ± 3.7 yr) following 48 h unloading (UL) via unilateral lower limb suspension and 24 h reloading (RL). Biopsy samples of the left vastus lateralis muscle were collected at baseline, 48 h UL, and 24 h RL. E...
|
PMID: 20798274
PDF is available here.
PDF is available here.
Abstract
The incidence of adverse effects in our subjects was low and pre-chamber clinical selection appeared to be effective in reducing the risk of barotitis....
|
PMID: 20824995
PDF is available here.
PDF is available here.
Abstract
We presumed that microgravity might affect the toxin production of toxic cyanobacteria too. Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the grow...
|
PMID: 20156472
PDF is available here.
PDF is available here.
Abstract
The CMG demonstrated consistently higher scores on the BART (Days 20 to 40; Mean: CMG, 43.0 to 46.2 and CG, 30.2 to 25.5) and lower levels of arousal on the Affect Grid (Days 7 to 40; Mean: CMG, 6.9 to 6.7 and CG, 8.1 to 8.0) than did the CG. The CMG showed significantly higher performance on the Ar...
|
PMID: 20681235
PDF is available here.
PDF is available here.
Abstract
Space flight induces acute changes in normal physiology in response to the microgravity environment. Articular cartilage is subjected to high loads under a ground reaction force on Earth. The objectives of this study were to investigate the site dependence of morphological and ultrasonic parameters...
|
PMID: 20620696
PDF is available here.
PDF is available here.
Abstract
The observation of results and statistical comparison showed that despite different hemodynamic conditions and with significant variation of blood pressure related to posture, elasticity/distensibility did not change significantly. DISCUSSION: The elasticity/distensibility of arterial vessels is the...
|
PMID: 20556920
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to analyze and compare the deposition of cartilage-specific extracellular matrix components and cellular organization in scaffold-free neocartilage produced in microgravity and simulated microgravity.
Porcine chondrocytes were seeded (100 x 1...
|
PMID: 20141387
PDF is available here.
PDF is available here.
Abstract
To study the effects of strontium ranelate on osteoporosis induced by simulated weightlessness in male rats.
Twenty-seven male SD rats were randomly divided into 3 groups, namely the normal control group (group A) and two groups of weightlessness simulated by tail sus...
|
PMID: 20423860
PDF is available here.
PDF is available here.
Abstract
Whole-organ culture of a sensory organ in a rotating wall vessel bioreactor provides a powerful in vitro model for physiological and pathophysiological investigation as previously demonstrated for the postnatal inner ear. The model is of specific relevance as a tool for regeneration research. In the...
|
PMID: 19355813
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2010
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Journal of Oral Science (52)3 2010
Abstract
In astronauts and cosmonauts, exposure to microgravity has been associated with several physiological changes, including an osteoporosis like loss of bone mass. It has been reported that head-down tilt bed-rest studies mimic many of the observations seen in space flights. There has been no study of...
|
PMID: 20881330
PDF is available here.
PDF is available here.
Abstract
The results of study of embryo development in B. rapa plants, as well as the rate and the character of nutrient substances accumulation in their cells under slow horizontal clinorotation and laboratory control are presented. Significant similarity of the peculiarities of embryo differentiation and c...
|
PMID: 20480807
PDF is available here.
PDF is available here.
Abstract
We report that mouse mitotic spermatogonia cultured under SM with a rotary cell culture system (RCCS) enter into meiosis in the absence of any added exogenous factor or contact with somatic cells. We found that isolated Kit-positive spermatogonia under the RCCS condition enter into the prophase of t...
|
PMID: 20140225
PDF is available here.
PDF is available here.
Gerontology (56)2 2010
Abstract
The abnormal physiology that manifests itself in healthy humans during their adaptation to the microgravity of space has all the features of accelerated aging. The mechano-skeletal and vestibulo-neuromuscular stimuli which are below threshold in space, result in an overall greater than 10-fold more...
|
PMID: 19851058
PDF is available here.
PDF is available here.
Abstract
When cultured in simulated microg, human chondrocytes start forming 3D cell assemblies within 5 days. After 24h, we could not detect caspase-3, Fas, p53 or Bcl-2 proteins in these cells, Annexin V flow cytometry, however, revealed 18% of apoptotic chondrocytes in 1g cultures but only 10% on the RPM....
|
PMID: 20332636
PDF is available here.
PDF is available here.
Abstract
We have performed a theoretical analysis based on nonuniform vibrating surface to quantify the levitation force produced by the air film and also conducted experimental tests to verify our model. Modal analysis was performed using ANSYS on the flexural plate radiator to obtain its natural frequency...
|
PMID: 20040404
PDF is available here.
PDF is available here.
Artificial Organs (34)2 2009
Abstract
Bone constructs have been grown in vitro with use of isolated cells, biodegradable polymer scaffolds, and bioreactors. In our work, the relationships between the composition and mechanical properties of engineered bone constructs were studied by culturing bone marrow mesenchymal stem...
|
PMID: 19817729
PDF is available here.
PDF is available here.
Astrobiology (9)8 2009
Abstract
Spaceflight experiments have suggested a possible effect of microgravity on the plasmid transfer among strains of the Gram-positive Bacillus thuringiensis, as opposed to no effect recorded for Gram-negative conjugation. To investigate these potential effects in a more affordable expe...
|
PMID: 19845449
PDF is available here.
PDF is available here.
Reproductive Sciences (16)10 2009
Abstract
We tested whether microgravity affects mouse development during a period when gravity cues chick and frog embryo development. A rotating vessel developed approximately 0.1% simulated microgravity (MGS) for embryos. Microgravity simulation resulted in blocked cell accumulation in E2.5 embryos. E1.5 a...
|
PMID: 19546324
PDF is available here.
PDF is available here.
Abstract
We describe a delayed type of formation of 3D structures of ECs that was initiated when ECs cultured on a desktop RPM remained adherent for the first 5 days but spread over neighboring adherent cells, forming little colonies. After 2 weeks, tube-like structures (TSs) became visible in these cultures...
|
PMID: 19226201
PDF is available here.
PDF is available here.
Abstract
The force data were consistent with values recorded previously in sustained microgravity aboard Mir and the Space Shuttle. A training program for astronauts might be designed to encourage fine-control motions (i.e., multiple, weaker peaks) as these reduce the risk of injury and increase controllabil...
|
PMID: 19522362
PDF is available here.
PDF is available here.
Abstract
We hypothesized that an exercise prescription, combining supine aerobic treadmill exercise in a lower body negative pressure (LBNP) chamber followed by 10 min of resting LBNP, three to four times a week, and flywheel resistive training every third day would maintain orthostatic tolerance (OT) in wom...
|
PMID: 19247686
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (101)5 2009
Abstract
Thrombosis and Haemostasis (101)5 2009
Abstract
We show that platelet aggregation induced by ristocetin or collagen and platelet adhesion to von Willebrand factor (VWF) were significantly decreased after platelets were exposed to simulated microgravity. Conversely, these platelet functions were increased after platelets were exposed to hypergravi...
|
PMID: 19404544
PDF is available here.
PDF is available here.
Abstract
Furosemide administration caused an approximate 10% reduction in plasma volume, with CVP decreasing by 1.2 mmHg. Steady state MBP and mean CBFV did not change. However, transfer function gain in the low-frequency range significantly decreased, implying a decrease in the magnitude of transfer from MB...
|
PMID: 19456004
PDF is available here.
PDF is available here.
Abstract
To study the effect of a Chinese herbal prescription on external calcium deposition to weight-bearing bone in simulated weightlessness rats. METHOD: Twenty-one male Wistar rats were divided into 3 groups: control group, tail suspension group, tail suspension with Chinese medicine group which takes a...
|
PMID: 19685751
PDF is available here.
PDF is available here.
Abstract
Skeletal abnormalities reported in humans and laboratory animals after spaceflight, include cancellous osteopenia, decreased cortical and cancellous bone formation, aberrant matrix ultrastructure, decreased mineralization and reduced bone strength. Although considerable effort has be...
|
PMID: 19627820
PDF is available here.
PDF is available here.
Muscle & Nerve (39)4 2009
Abstract
We determined the impact of 60-day bedrest (BR, n=8), 60-day bedrest with exercise-training (BRE, n=8), and 60-day bedrest with a leucine-enriched, high-protein diet (BRN, n=8) on muscle protein composition. Vastus lateralis and soleus muscle biopsies were analyzed for global protein fractions (mixe...
|
PMID: 19229964
PDF is available here.
PDF is available here.
Abstract
The exercise ventilatory response (DeltaV(E)/DeltaV(CO2)) and the HCVR were unchanged following HDR in both groups. However, ventilation was significantly elevated after HDR at rest, during submaximal exercise, and while breathing 6% CO2. End-tidal P(CO2) was significantly reduced at rest, during su...
|
PMID: 19378912
PDF is available here.
PDF is available here.
Critical Care Medicine (37)2 2009
Abstract
Weightlessness protects against thoracic compliance changes that are inherent in IAH during induced pneumoperitoneum in gravity. The technique-related physiologic cost of performing LS in space deconditioned astronauts should be incorporated into design concepts for space surgery systems....
|
PMID: 19114906
PDF is available here.
PDF is available here.
Abstract
We used the hind-limb suspension (HLS) rat model to simulate microgravity-induced bone losses for 45 days. In order to compare the resulting changes, mineralogical (bone mineral density [BMD], calcium [Ca], and phosphorus [P]), biochemical (osteocalcin, alkaline phosphatase [ALP], and type I collage...
|
PMID: 19774112
PDF is available here.
PDF is available here.
Abstract
Antiorthostatic hindlimb suspension (unloading) decreased the resting membrane potential (RMP) of skeletal muscle fibers in fast extensor digitorum longus (EDL) and slow soleus (SOL) muscle of the rat by about 10% within 7 days and more. Inactivation of the membrane Na+,K+-pump by ouabain brought ab...
|
PMID: 19761352
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated hemodynamic responses of conscious Wistar rats to 45? head-down tilt (HDT) for 7 days. Arterial blood pressure (BP) was recorded by telemetry. Heart rate (HR), spectral properties and the spontaneous baroreflex sensitivity (sBRS) were calculated. Head-up tilt (HUT) was applied for 2...
|
PMID: 18198992
PDF is available here.
PDF is available here.
Abstract
Effects of load deprivation on gaze fixation were studies in two primates (Macaca mulatta) immersed neck-deep twice with a two-week interval. Gaze fixation was traced using electrooculography and measurement of head turn velocity in 5 hours since the beginning of immersion. Decrease of the maximum h...
|
PMID: 20120914
PDF is available here.
PDF is available here.
Abstract
Subpopulations of lymphocytes, activation potential of T-, B- and NK-cells as well as cytokines production by immunocompetent cells in peripheral blood were studied in five volunteers for 7-day dry immersion without use of countermeasures. Results of the investigation revealed several negative shift...
|
PMID: 20120915
PDF is available here.
PDF is available here.
Abstract
To study lucigenin-dependent chemiluminescence (ChL), samples of whole heparinized blood and isolated neutrophils of human blood were put in special cells between an indifferent wet dialysis membrane and a plate of solid material (polymer, metal or other) stimulating activation of polymorphonuclear...
|
PMID: 20120917
PDF is available here.
PDF is available here.
Abstract
Eight test-subjects participated in 120 treadmill tests (drive power of 10 and 85 kW) aimed to compare the walking patterns at 1 and reduced gravity. The temporal pattern of steps was noted to change significantly on the low-power treadmill. On the strength of convergence of calculated and experimen...
|
PMID: 20120918
PDF is available here.
PDF is available here.
Abstract
Effects of simulated microgravity (cell clinostatting and containment in the Random Positioning Machine (RPM), Dutch Space, The Netherlands) on interleukins production by mesenchymal stromal cells (MSC) of the human marrow and MSC osteogenous derivatives obtained through cell stimulation by growth f...
|
PMID: 19711862
PDF is available here.
PDF is available here.
Abstract
The myoelectrode technique and microiontophoresis of physiologically active substances were applied to cats immobilized with neuromuscular relaxant to show that the classic neuromediators (acetylcholine, norepinephrine, GABA etc.) and regulatory peptides (enkephalins, TRHs, vasoactive intestinal pep...
|
PMID: 19621799
PDF is available here.
PDF is available here.
Abstract
Cytochrome oxidase activity as well as neurons' body and nuclei sizes were measured in the spinal L5 ganglia receiving the hindlimb afferent input during primary and repeated 14-d tail-suspension of rats. The measurements were performed using the quantitative cytochemical and morphometric techniques...
|
PMID: 19621798
PDF is available here.
PDF is available here.
Abstract
After 12 days on space fight, body mass of gerbils decreased by 32.9%; however, the effective systems of regulation did not let changes in the concentration of Na, K, Mg ions in fresh samples of the renal cortex. These data are viewed as a reflection of the regulation systems strategy to preserve th...
|
PMID: 19621797
PDF is available here.
PDF is available here.
Abstract
The cytochrome oxidase activity, sizes of bodies, nuclei, and nucleoli of alpha-motoneurons from the L5 anterior horns were investigated in rats once or repeatedly suspended by tails to model the effects of microgravity. Rats were suspended 30 days, then held in vivarium 30 days w/o any behavior res...
|
PMID: 19462785
PDF is available here.
PDF is available here.
Abstract
These results infer that monitoring of blood alpha1-AT and ApoA in the period of adaptation to a changed environment may provide information useful for assessment of individual adaptability....
|
PMID: 19462783
PDF is available here.
PDF is available here.
Abstract
Functioning of the digestive system was investigated in 10 volunteers for 7-day dry immersion. The experimental conditions were found to raise secretory activities of the stomach, pancreas and liver, and to increase spectral indices of the GI electrical activity on the background of a higher than us...
|
PMID: 19462782
PDF is available here.
PDF is available here.
Abstract
We focused on two goals: firstly, the conception of a microsurgical module to test complex microsurgical procedures in rats and secondly, the construction of a surgical workstation with specific air filtration device and define surgical and anaesthetic protocols to carry on a surgery in man. In Sept...
|
PMID: 18930573
PDF is available here.
PDF is available here.
Abstract
These results show that, notwithstanding the drop of SV, moderate-intensity dynamic exercise elicited a normal pressure response after 14 days of HDTBR....
|
PMID: 18716791
PDF is available here.
PDF is available here.