Abstract
The objective of the present study was to develop a nanocarrier based formulation of nadifloxacin and to investigate its in vitro antimicrobial effect against Propionibacterium acnes. Nanocarrier based microemulsion formulations were prepared by aqueous titration method, using oleic...
|
PMID: 21434572
PDF is available here.
Abstract
In forensic medicine autopsy material is primarily investigated to find out the cause of death. But the results of corresponding toxicology measurements often involve more information. With screening methods drugs were detected not being related to the cause of death. Liquid/liquid e...
|
PMID: 21434573
PDF is available here.
Abstract
A series of thiazepines has been studied as new ligands for the benzodiazepine binding site of the GABAA receptor. Compounds with high affinity and weak selectivity regarding alpha beta3gamma2, alpha2beta3gamma2, alpha3beta3gamma2, and alpha5beta3gamma2 subtypes were found. The pharm...
|
PMID: 21434570
PDF is available here.
Abstract
For intralaboratory quality control (IQC) of non-quantitative techniques, estimation of the sensitivity and specificity of laboratory analysis was introduced using the new control samples (CS)2 and CS3. The estimation of the sensitivity of laboratory analysis uses the control CS2 with a true positive...
|
PMID: 21509987
PDF is available here.
Ranjana R Mitra,
Jinseon J Lee,
Jisuk J Jo,
Monica M Milani,
Jeanette N JN McClintick,
Howard J HJ Edenberg,
Kenneth A KA Kesler,
Karen M KM Rieger,
Sunil S Badve,
Oscar W OW Cummings,
Ahmed A Mohiuddin,
Dafydd G DG Thomas,
Xianghua X Luo,
Beth E BE Juliar,
Lang L Li,
Clementina C Mesaros,
Ian A IA Blair,
Anjaiah A Srirangam,
Robert A RA Kratzke,
Clement J CJ McDonald,
Jhingook J Kim and
David A DA Potter
Abstract
Four genomic markers, DBN1 (drebrin 1), CACNB3 (calcium channel beta 3), FLAD1 (PP591; flavin adenine dinucleotide synthetase), and CCND2 (cyclin D2), exhibited highly significant differential expression in recurrent tumors in the training set (P<0.001). In the validation set, DBN1, FLAD1 (PP591) an...
|
PMID: 21242119
PDF is available here.
S Helene SH Richter,
Joseph P JP Garner,
Benjamin B Zipser,
Lars L Lewejohann,
Norbert N Sachser,
Chadi C Touma,
Britta B Schindler,
Sabine S Chourbaji,
Christiane C Brandwein,
Peter P Gass,
Niek N van Stipdonk,
Johanneke J van der Harst,
Berry B Spruijt,
Vootele V Võikar,
David P DP Wolfer and
Hanno H Würbel
Abstract
We have recently shown in mice that standardization may generate spurious results in behavioral tests, accounting for poor reproducibility, and that this can be avoided by population heterogenization through systematic variation of experimental conditions. Here, we examined whether a simple form of...
|
PMID: 21305027
PDF is available here.
Gloria S GS Omosa-Manyonyi,
Walter W Jaoko,
Omu O Anzala,
Hilda H Ogutu,
Sabina S Wakasiaka,
Roselyn R Malogo,
Jacqueline J Nyange,
Pamela P Njuguna,
Jeckoniah J Ndinya-Achola,
Kirana K Bhatt,
Bashir B Farah,
Micah M Oyaro,
Claudia C Schmidt,
Frances F Priddy and
Patricia P Fast
Abstract
With the persistent challenges towards controlling the HIV epidemic, there is an ongoing need for research into HIV vaccines and drugs. Sub-Saharan African countries--worst affected by the HIV pandemic--have participated in the conduct of clinical trials for HIV vaccines. In Kenya, the Kenya AIDS Vac...
|
PMID: 21283743
PDF is available here.
Abstract
Meloxicam is a cyclooxygenase-2, preferential inhibitor non-steroidal anti-inflammatory drug (NSAID) and belongs to an enolic acid (oxicam) class used for the treatment of osteoarthritis and rheumatoid arthritis. The purpose of this single dose randomized cross-over study was to assess bioequivalence...
|
PMID: 21485709
PDF is available here.
Abstract
Reduced maximal, peripheral muscle strength is associated with exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). Therefore, it is important to accurately evaluate muscle strength to identify patients with muscle weakness and to prescribe adequate loads for resistanc...
|
PMID: 20724932
PDF is available here.
Abstract
To evaluate the accuracy of the sub-classification of renal cortical neoplasms using molecular signatures.
|
PMID: 21818257
PDF is available here.
Abstract
We investigate a spherical harmonics descriptor for shape-based virtual screening....
|
PMID: 21818259
PDF is available here.
Abstract
Urinary bladder cancer (UBC) ranks ninth in worldwide cancer. In Egypt, the pattern of bladder cancer is unique in that both the transitional and squamous cell types prevail. Despite much research on the topic, it is still difficult to predict tumor progression, optimal therapy and c...
|
PMID: 21760912
PDF is available here.
Abstract
We compared the rate of reporting of positive outcomes in clinical trials to describe potential bias.
In total, 307 Chinese papers, 117 Indian papers, and 304 Western papers were included. Reports of Indian trials were slightly better than Chinese papers on the trial reporting quality indicators and...
|
PMID: 20554429
PDF is available here.
Abstract
We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical sol...
|
PMID: 21818304
PDF is available here.
Abstract
Genomic instability in cancer leads to abnormal genome copy number alterations (CNA) as a mechanism underlying tumorigenesis. Using microarrays and other technologies, tumor CNA are detected by comparing tumor sample CN to normal reference sample CN. While advances in microarray technology have impro...
|
PMID: 21269491
PDF is available here.
Abstract
We present a linear model for predicting the binding affinity of a protein toward DNA sequences based on PBM data. Our model represents the measured intensity of an individual probe as a sum of the binding affinity contributions of the probe's subsequences. These subsequences characterize a DNA bind...
|
PMID: 21637853
PDF is available here.
Abstract
Light emitting diode fluorescence microscopes have many practical advantages over conventional mercury vapour fluorescence microscopes, which would make them the preferred choice for laboratories in both low- and high-resource settings, provided performance is equivalent.
|
PMID: 21811622
PDF is available here.
Abstract
In March 2008 and June 2009, an ad hoc working group of nephrologists discussed the status of anaemia therapy with erythropoiesis-stimulating agents [ESA] in patients on chronic haemodialysis, the phenomenon of fluctuations of haemoglobinaemia, and the need for individualisation of ESA treatment. The...
|
PMID: 21630609
PDF is available here.
Author(s) unavailable
Abstract
Development of micro technologies based approach for express diagnostics of toxigenic C. diphtheriae strains.
|
PMID: 21598618
PDF is available here.