Abstract
Recently, the assessment of the muscles using limb MRI and whole body MRI has become widely available and more frequent. In cases of muscular dystrophies it may help to select the optimal muscles for biopsy, because the severely atrophic and degenerated muscles are not suitable for h...
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PMID: 21835742
PDF is available here.
Abstract
We aimed at validating the use of DXA in monitoring change in the thigh lean soft tissue mass (LSTM) and fat mass (FM) when compared with thigh skeletal muscle mass (SM) and FM, measured using MRI as the reference standard, from childhood to midadolescence. At baseline, 22 healthy children (16 boys...
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PMID: 21658984
PDF is available here.
Abstract
Colorectal cancer is commonly diagnosed in the United State and is one of the leading causes of cancer deaths. Positron emission tomography has been used for the evaluation and management for patients with colorectal cancer. Frequently, abnormal incidental lesions are detected on positron emission to...
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PMID: 20458476
PDF is available here.
Abstract
The imaging of systemic disorders without radiation exposure by whole-body MRI (wb-MRI) represents a paradigm shift for pediatric radiology. The reduction of multiple regional examinations, if necessary under sedation, results in a faster treatment start. Modern scanner techniques using automatic ta...
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PMID: 21161872
PDF is available here.
David A DA Stevenson,
David H DH Viskochil,
John C JC Carey,
Xiaoming X Sheng,
Mary M Murray,
Laurie L Moyer-Mileur,
Judd J Shelton,
William L WL Roberts,
Ashley M AM Bunker,
Heather H Hanson,
Stephanie S Bauer and
Jacques L JL D'Astous
Abstract
We report 25OHD concentrations in 109 children with NF1 and 218 controls matched for age, sex, geographic location, and time of year.
Children with NF1 were recruited (n=109; 2-17 years), and clinical data and dual-energy X-ray absorptiometry measurements were obtained. 25OHD concent...
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PMID: 21648285
PDF is available here.
Abstract
We retrospectively reviewed 389 differentiated thyroid carcinoma patients who underwent a total thyroidectomy and received high-dose RAI from January 2003 through December 2005. The patients were classified according to surveillance DxWBS findings and TSH-stimulated Tg levels 6 to 12 months after th...
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PMID: 21179279
PDF is available here.
Abstract
We propose a method that divides the problem into an atlas constrained registration based on high-contrast organs in Micro-CT (skeleton, lungs and skin), and a soft tissue approximation step for low-contrast organs. We first present a modification of the MOBY mouse atlas (Segars et al., 2004) by par...
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PMID: 20576463
PDF is available here.
Junji J Konishi,
Nagara N Tamaki,
Kunihiro K Nakada,
Kiyoko K Kusakabe,
Masako M Maki,
Masako M Kanbe,
Tatsuya T Higashi,
Keigo K Endo,
Katsuji K Ikekubo,
Kunihiko K Yokoyama,
Atsushi A Kubo and
Naofumi N Ishikawa
Abstract
This study sought to assess the safety, efficacy, impact on hypothyroid symptoms, and pharmacokinetics of SKG-02 (rhTSH, thyrotropin alfa) in the diagnostic follow-up of Japanese patients with well-differentiated thyroid carcinoma (WDTC).
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PMID: 21404570
PDF is available here.
Abstract
Magnetic resonance imaging (MRI) with a continuously moving table (CMT) represents a novel method allowing for the seamless acquisition of an extended field-of-view in the z-direction. One option to realize CMT MRI from a technical point of view is based on very fast sequences like echo planar imagi...
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PMID: 20922644
PDF is available here.
Abstract
We examined the feasibility of using cross-sectional imaging with postmortem multi-slice computed tomography (MSCT) to detect lesions of the skeletal structures and internal organs. For this purpose, we used whole-body MSCT to examine 10 corpses that suffered fatal falls from great height while clim...
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PMID: 20728397
PDF is available here.
Abstract
We have quantitatively compared conventional preoperative lymphoscintigraphy with albumin radiocolloids ((99m)Tc-NanoColl) with optical intraoperative guidance using the near infrared dye indocyanine green (ICG) in an orthotopic mouse model for metastatic breast cancer. Furthermore, we have applied...
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PMID: 20689167
PDF is available here.
Abstract
Osteonecrosis is a well-recognized complication of corticosteroid use resulting in significant morbidity, often requiring surgical intervention. Whole-body MRI is a promising method that allows imaging of the whole patient in a reasonable time without the use of ionizing radiation. This technique ha...
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PMID: 20390263
PDF is available here.
Abstract
We concluded that ground glass opacities were not aspiration of blood but intrapulmonary aerogenic metastases. Continuous active bleeding from the right bronchus (B6) was confirmed by bronchoscopy, and the right lower lobe was resected to remove the bleeding source. Pathologic findings showed pleomo...
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PMID: 20706051
PDF is available here.
Abstract
We experienced a case of a focal pulmonary F-18 fluoro-2-deoxy-D-glucose (FDG) uptake without pulmonary computed tomography (CT) abnormality probably due to the urine FDG in the upper pole calyx of the left kidney. A 76-year-old male patient was referred for evaluation of the postoperative right lun...
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PMID: 20706050
PDF is available here.
Abstract
Post-transplant lymphoproliferative disorder (PTLD) occurs in 1.2% of pediatric renal transplant patients, and is frequently Epstein-Barr Virus mediated. Hodgkin Lymphoma PTLD is the rarest of the 4 types of PTLDs recognized by the World Health Organization, with an incidence of <4% of all PTLD pati...
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PMID: 20706047
PDF is available here.
Abstract
We report 2 cases, confirming that the lesions of NSG are FDG positive, showing a typical pattern of multiple bilateral lung nodules (imaged with PET/CT in 1 case). FDG imaging has a potential role when this distribution is observed on CT, to guide the surgical biopsy and show the actual extent of t...
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PMID: 20706045
PDF is available here.
Abstract
An unexpected vesicocolic fistula can be detected incidentally on routine bone scintigraphy. A 55-year-old man who had a radical colectomy for carcinoma of the sigmoid colon 1 year previously underwent bone scintigraphy to evaluate bone metastasis. Whole-body images showed an abnormal accumulation o...
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PMID: 20706058
PDF is available here.
Abstract
We describe the case of a 14-year-old boy with steroid-induced osteoporosis, who was treated by pamidronate. This patient exhibited linearly increased bilateral uptake in the shafts of his femora, tibiae, radii, and ulnae that were parallel to the growth plates. A simple radiograph corresponding bon...
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PMID: 20706059
PDF is available here.
Abstract
Myeloid sarcoma is a tumor formed by extramedullary accumulation of myeloblasts or immature myeloid cells. These tumors can develop in lymphoid organs, bone, skin, soft tissue, and other organs, and may precede or occur concurrently with acute myeloid leukemia. This is a case of a 42-year-old man wh...
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PMID: 20706048
PDF is available here.
Abstract
We report a rare case of adrenal and renal metastases from papillary thyroid carcinoma (PTC). A 30-year-old man underwent total thyroidectomy with left neck dissection for cytology proven nodal metastases from PTC. This was followed by high-dose radioiodine therapy with a dose of 265 mCi (9.805 GBq)...
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PMID: 20706057
PDF is available here.
Abstract
We discuss the contributions of different MRI techniques than must be integrated in oncologic patients to substantially advance tumor detection and characterization risk stratification, prognosis, predicting and monitoring response to treatment, and development of new drugs....
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PMID: 20851801
PDF is available here.
Abstract
We used bioluminescent strains of Staphylococcus aureus to monitor the formation of infection foci during the first 24 h of hematogenous bacterial dissemination. Clinically derived EDIN-expressing S. aureus strains S25 and Xen36 produced many disseminated foci. EDIN had no detectable impact on infec...
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PMID: 20479081
PDF is available here.
Abstract
We present the case of a 78-year-old woman with systemic sarcoidosis whose (18)F-FDG PET/CT scan showed a pancreatic lesion and multiple lymphatic (thoracic and non-thoracic) and visceral lesions. The abnormal (18)F-FDG uptake in the pancreas was limited to the tail. A second (18)F-FDG PET/CT study...
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PMID: 20638156
PDF is available here.
Abstract
For subjects with COPD, significant increases in (3)He MR imaging-derived VDV (P = .03), VDP (P = .006), and ADC (P = .02) were detected, whereas there was no significant change in forced expiratory volume in 1 second (FEV(1)) (P = .97). For healthy never-smokers, there was no significant change in...
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PMID: 20574101
PDF is available here.
Abstract
OBJECTIVE: This article reviews the current and future contributions of functional imaging techniques to improve diagnosis, prognosis, and treatment of colorectal cancer. In addition, evolving roles and challenges for their implementation will be covered. CONCLUSION: Functional imaging now has a gro...
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PMID: 20566797
PDF is available here.
Abstract
Our results confirm that FDG PET/CT is a superior posttherapy surveillance modality for the detection of recurrent ovarian cancer than diagnostic CT imaging. Furthermore, integrated FDG PET/CT was useful specifically in optimizing the treatment plan and it might play an important role in treatment s...
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PMID: 20309683
PDF is available here.
Junting Liu,
Yabin Wang,
Xiaochao Qu,
Xiangsi Li,
Xiaopeng Ma,
Runqiang Han,
Zhenhua Hu,
Xueli Chen,
Dongdong Sun,
Rongqing Zhang,
Duofang Chen,
Dan Chen,
Xiaoyuan Chen,
Jimin Liang,
Feng Cao and
Jie Tian
Abstract
We developed a dual modality BLT prototype system with Micro-computed tomography (MicroCT) registration approach, and improved the quantitative reconstruction algorithm based on adaptive hp finite element method (hp-FEM). Detailed comparisons of source reconstruction between the heterogeneous and ho...
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PMID: 20588440
PDF is available here.
Abstract
One patient with mild dementia was excluded; in most of the remaining 20 patients, high reproducibility of the breath-holding position was achieved in a short time with the device. In these 20 patients who were able to adapt to use of the device, three-dimensional mean maximum differences in lung ba...
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PMID: 20501729
PDF is available here.
Abstract
We propose strategies to investigate the lineage fate determination of derived human embryonic stem cells (hESC) transplanted in vivo into the CNS. Here, we describe a comprehensive biological Global Positioning System (bGPS) to track transplanted stem cells. But, first, we review, four currently us...
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PMID: 20237964
PDF is available here.
Abstract
Whole-body MRI (W-B MRI) and diffusion-weighted imaging (DWI) are two novel techniques that greatly facilitate the evaluation of many disorders of childhood. In the musculoskeletal system, these techniques primarily aid in the evaluation of the marrow, although there is increasing interest in the st...
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PMID: 20432017
PDF is available here.
Abstract
MRI demonstrated a significantly better diagnostic accuracy regarding musculoskeletal metastases compared with CT (97.7% vs 82%, P<0.001). In contrast, CT was superior in the detection of pulmonary metastases (88.5% vs 71.9%, P<0.001). Both methods had similar diagnostic performance regarding lymph...
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PMID: 20429759
PDF is available here.
Abstract
The average time (+/-SD) taken to change the surface coil from one station to the next station was 53.8 (+/-7.1) s. The average total extra examination time +/- SD was 2 min 41.4 s (+/-15.3 s). Anatomical alignment, image quality at the boundaries of adjacent stations, and overall image quality of a...
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PMID: 19997846
PDF is available here.
Abstract
We studied whether these risk loci influence the distribution of body fat depots. We genotyped 1,469 nondiabetic subjects for the single-nucleotide polymorphisms (SNPs) TMEM18 rs6548238, KCTD15 rs11084753, GNPDA2 rs10938397, SH2B1 rs7498665, MTCH2 rs10838738, and NEGR1 rs2815752. We assessed BMI, wa...
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PMID: 19910938
PDF is available here.
Abstract
Whole-body magnetic resonance imaging (WB-MRI) is a modern imaging method, free of ionizing radiation, which provides high-resolution display of individual organ systems and of the anatomy of the entire body.
Selective literature review
Multi-channel WB-MRI scanners enable both the high-resolution i...
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PMID: 20574553
PDF is available here.
Abstract
(99m)Tc(N)-DBODC5 is a cationic mixed compound under clinical investigation as potential myocardial imaging agent. In spite of this, analogously to the other cationic (99m)Tc-agents, presents a relatively low first-pass extraction. Thus, modification of (99m)Tc(N)-DBODC(5) direct to...
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PMID: 20402465
PDF is available here.
Abstract
Gd chelate containing MR contrast agents can be used at 7T for DCEMRI. Gd-BOPTA demonstrates stronger signal enhancement than standard Gd chelates, in concordance with the results of studies at lower fields. The observed enhancement characteristics for the 3 contrast agents demonstrate that the phar...
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PMID: 20351653
PDF is available here.
Abstract
We also wished to identify interactions between distances from the criterion site (site variants), sex, and body mass index (BMI) categories. Two hundred participants were analysed across the sexes and all BMI categories. Girth measurements were extracted 5, 10, 15, and 20 mm distal and proximal to...
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PMID: 20419554
PDF is available here.
Abstract
We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. Naranjo probability scale indicated a probable...
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PMID: 19533139
PDF is available here.
Abstract
We have shown that a clinically dedicated SPECT camera can be used for thyroid imaging. In our experiments, SPECT imaging allowed the analysis of (99m)Tc pertechnetate accumulation in individual organs and revealed differences in uptake kinetics....
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PMID: 20384490
PDF is available here.
Abstract
To our knowledge, this is the first reported case of a solitary CM from an occult PTC, and also the first that developed an acute cerebellar hemorrhage years after cranial surgery, however, exhibiting the longest reported survival. This case highlights the importance of not only an appropriate initi...
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PMID: 20450434
PDF is available here.
Abstract
In this study cohort, nine positive diagnostic WBS were found compared with 31 positive SPECT scans. In eight of the nine (89%) positive WBS, recurrent thyroid cancer was found at the same location on the SPECT scan. In 56 patients SPECT and WBS were negative. Moreover, eight patients with a positiv...
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PMID: 20154638
PDF is available here.
Abstract
The results show that both coil designs are suitable for small animal imaging on 7 T whole-body systems; the preferred coil depends on the demands of the application....
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PMID: 20527556
PDF is available here.
Abstract
PURPOSE OF THE REPORT: This study investigates whether combined analysis of I-123 metaiodobenzylguanidine (MIBG) kinetics in the heart and in the whole body can improve the accuracy of differential diagnosis between idiopathic Parkinson disease (PD) and a Parkinson variant of multiple system atrophy...
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PMID: 20395701
PDF is available here.
Abstract
We demonstrated that the skin permeability of gentamicin increased with the use of a thioglycolate-based depilatory agent. After transdermal administration, the readthrough activity in skeletal muscle, as determined using a lacZ/luc reporter system, was found to be equivalent to systemic administrat...
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PMID: 19910311
PDF is available here.
Abstract
Recently nuclear and radiological imaging techniques such as Glucose-PET, whole body MRI, coronary CT and various laboratory tests are used to screen asymptomatic patients for cancer and coronary heart disease. This review, based on the current relevant publications, including recent Japanese prospe...
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PMID: 20391314
PDF is available here.
Abstract
The advent of whole-body MRI (WB-MRI) has introduced a systemic approach to oncologic imaging compared to established sequential, multi-modal diagnostic algorithms. Hardware innovations, such as whole-body scanners at 1.5 Tesla and also recently 3 Tesla, combined with acquisition acceleration techni...
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PMID: 20229091
PDF is available here.
Abstract
We review several different types of reporter mice for bioluminescence imaging, including animals that permit in vivo detection of viral replication, trafficking of immune cells, activation of key genes in host immunity to viral infection, and response to tissue damage. By utilizing luciferase enzym...
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PMID: 20417377
PDF is available here.
Abstract
Wb-ce MRA and CAC correlate only moderately in this population. An atherosclerosis index 8 renders a positive predictive value for a CAC 100 of 63.3 %. CONCLUSION: An atherosclerosis index as defined in this study does not fully correlate with the extent of CAD as revealed by catheter angiography or...
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PMID: 19941248
PDF is available here.
Abstract
We have observed Cerenkov photons emitted from beta-emitting radiotracers such as (18)F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the...
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PMID: 20364233
PDF is available here.
Abstract
Overall, 45 circumscribed bone metastases and 107 benign lesions were found. DWIBS performed significantly better in detecting malignant skeletal lesions in patients with more than 10 lesions (sensitivity: 0.97/0.91) compared to skeletal scintigraphy (sensitivity: 0.48/0.42). No statistical differen...
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PMID: 20205350
PDF is available here.
Abstract
Atherosclerotic plaque disruption accounts for the major part of cardiovascular mortality and the risk of disruption appears to depend on plaque composition. Carotid plaques in patients, scheduled for endarterectomy, have been successfully characterised with MRI. MRI has the advantage of combining i...
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PMID: 20112134
PDF is available here.