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All › Investigative Techniques › Drug Discovery

Drug Discovery (2)

Articles on Drug Discovery

  1. Bridging gaps in discovery and development: chemical and biological sciences for affordable health, wellness and sustainability.
    Chauhan PM

    Future Med Chem 3(7):783-8 (2011) PMID 21644823

  2. Changing the substrate specificity of P450cam towards diphenylmethane by semi-rational enzyme engineering.
    Gregor Hoffmann, Kathrin Bönsch, ... Meike Ballschmiter

    Protein Eng Des Sel 24(5):439-46 (2011) PMID 21273340

    A focused library comprising nine residues of the active site of P450cam monooxygenase resulting in ∼ 300,000 protein variants was screened for activity on diphenylmethane (DPM). The assay was based on the depletion of NADH by an in vitro reconstituted P450cam system in a 96-well scale. The through...
  3. It is anticipated that as is usually the case, financial motivation will move TZ from its current status “potential anti-MDR/XDR agent,” to ...
    Leonard L Amaral

    Recent Pat Antiinfect Drug Discov 6(2):76 (2011) PMID 21796848

  4. Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22.
    Kongkiat K Trisuwan, Vatcharin V Rukachaisirikul, ... Jariya J Sakayaroj

    Arch Pharm Res 34(5):709-14 (2011) PMID 21656354

    Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7),...
  5. Drug discovery and development focusing on existing medicines: drug re-profiling strategy.
    Tohru Mizushima

    J Biol Chem 149(5):499-505 (2011) PMID 21436140

    We still do not understand the underlying mechanisms of action of many existing medicines, and as such the cellular responses that give rise to their main effects and side effects are yet to be elucidated. To this extent, identification of the mechanisms underlying the side effects of medicines offe...
    PDF not found
  6. NF-κB in type 1 diabetes.
    Yuxing Y Zhao, Balasubramanian B Krishnamurthy, ... Helen E HE Thomas

    Inflammation & Allergy Drug Targets 10(3):208-17 (2011) PMID 21495968

  7. FDA not NIH can speed new drugs.
    Henry I HI Miller

    Nature 472(7342):169 (2011) PMID 21490657

  8. Rare disease day.
    Keith K Hansen

    S D Med 64(4):123 (2011) PMID 21560993

  9. Irradiation of human tumor tissue cultures: optimizing ion radiation therapy.
    Felicitas Merz and Ingo Bechmann

    Per Med 7(4):489-91 (2011) PMID 21463137

  10. Fix the antibiotics pipeline.
    Matthew A Cooper and David Shlaes

    Nature 472(7341):32 (2011) PMID 21475175