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Diglycerides (0):
Recent article
Diglycerides
New Phytologist (188)1 2010
Abstract
We labelled the tobacco cell line BY-2 and pollen tubes with a fluorescent derivative of phosphatidylcholine and assayed for patterns of fluorescently labelled products. Growth of pollen tubes was analysed. • We observed a significant decrease of labelled diacylglycerol (DAG) in cells treated with...
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PMID: 20629955
PDF is available here.
PDF is available here.
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Abstract
A fast and convenient spectroscopic methodology to determine the water uptake capacity of amphiphile assemblies studied in multilayer films is presented. This method was developed to provide a reliable but relatively simple tool for estimating the binding potency of such complex systems. The water-b...
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PMID: 20635078
PDF is available here.
PDF is available here.
Abstract
We used a series of molecules known to inactivate various elements of the pathway. W-7 prevents CaM from interacting with other molecules. Neomycin isolates PIP(2) from PLC. U-73122 directly inactivates PLC. 2-APB blocks IP(3) receptors which would otherwise cause release of Ca(2+). Verapamil and Cd...
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PMID: 20416320
PDF is available here.
PDF is available here.
Abstract
We explored the potential role of transient receptor potential (TRP) channels in this process. Previously, we observed that after metabolism AEA and arachidonic acid (ArA) can be recycled into new endocannabinoid molecules. Consistent with these previous findings, we found that Cath.a differentiated...
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PMID: 20466028
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
We have shown that both kinases are robustly activated at the Golgi following stimulation of G(q)-coupled receptor signaling pathways, displaying activation signatures at the Golgi that are distinct from those at the plasma membrane. Here we report that Ca(2+) is the mediator that allows signals rec...
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PMID: 20519514
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
This study examined the effect of H(2)O(2) on the TRPC6 channel and its underlying mechanisms using a TRPC6 heterologous expression system. In TRPC6-expressing HEK293T cells, H(2)O(2) significantly stimulated Ca(2+) entry in a dose-dependent manner. Electrophysiological experiments showed that H(2)O...
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PMID: 20501650
PDF is available here.
PDF is available here.
The Lancet (375)9733 2010
Abstract
Insulin resistance has long been associated with obesity. More than 40 years ago, Randle and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles through inhibition of glycolysis at key points. However, work over the past two decades has shown that lip...
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PMID: 20609972
PDF is available here.
PDF is available here.
Abstract
These results demonstrate the utility of deep transcriptional profiling with multiple tissues as a gene discovery strategy for low-abundance proteins. They also show that EaDAcT is the acetyltransferase necessary and sufficient for the production of acTAGs in Euonymus seeds, and that this activity c...
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PMID: 20439724
PDF is available here.
PDF is available here.
Abstract
The aim of this work is to report the production of mono- and diglycerides from olive oil at ambient condition and in pressurized n-butane as solvent medium. For this purpose, a commercial immobilized lipase (Novozym 435) was employed as catalyst and sodium (bis-2-ethyl-hexyl) sulfos...
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PMID: 19641856
PDF is available here.
PDF is available here.
Abstract
Ferulic acid and its esters are known to be effective antioxidants. Feruloyl dioleoylglycerol was assessed for its ability to serve as an antioxidant in model membrane phospholipid vesicles. The molecule was incorporated into single-lamellar vesicles of 1,2-dioleoyl-sn-glycero-3-phosphocholine at 1...
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PMID: 20394373
PDF is available here.
PDF is available here.
Abstract
Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzy...
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PMID: 20444420
PDF is available here.
PDF is available here.
Abstract
NMR spectroscopy was employed for the detection of adulteration of refined olive oil with refined hazelnut oil. Fatty acids and iodine number were determined by (1)H NMR, whereas (31)P NMR was used for the quantification of minor compounds including phenolic compounds, diacylglycerols, sterols, and...
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PMID: 20152467
PDF is available here.
PDF is available here.
Abstract
We therefore set out in this study to evaluate whether fixing and counting cells showing translocation could mend this issue.
Altogether three different genetically encoded indicators for diacylglycerol and inositol-1,4,5-trisphosphate were transiently expressed in Chinese hamster ov...
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PMID: 19583704
PDF is available here.
PDF is available here.
Abstract
PGC-1alpha regulates reactive oxygen species generation and apoptosis in endothelial cells by increasing fatty acid oxidation and enhancing ATP/ADP translocase activity. Measures to increase PGC-1alpha expression or ATP/ADP translocase activity in vascular cells may aid in the prevention or treatmen...
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PMID: 19965780
PDF is available here.
PDF is available here.
Abstract
Liposomes are widely investigated for their applicability as drug delivery systems. However, the unstable liposomal constitution is one of the greatest limitations, because the liposomes undergo fast elimination after application to the human body. In the presented study, novel archeal lipids were u...
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PMID: 20072874
PDF is available here.
PDF is available here.
Voprosy pitaniya (79)2 2010
Abstract
The impact of different doses of food biologically active additive (BAA) on base lipid sea-hydrobions on the condition of water-electrolyte and nitrogen metabolism, proteinosynthesis and hepatobiliary functions of liver has been studied for rats with the experimental cardio-vascular pathology. BAA i...
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PMID: 20560480
PDF is available here.
PDF is available here.
Abstract
Our study (Study 1) demonstrated that DAG suppressed postprandial increase in TG-rich lipoprotein, very low density lipoprotein (VLDL), and insulin as compared with TAG in young male individuals. Further, our another study using the apolipoprotein C-II deficient subject demonstrated that DAG suppres...
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PMID: 20169943
PDF is available here.
PDF is available here.
Abstract
The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inosi...
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PMID: 19754460
PDF is available here.
PDF is available here.
British Journal of Nutrition (102)7 2009
Abstract
A commercially available vegetable oil containing a high concentration (87 %, w/w) of diacylglycerol (DAG) has been investigated in humans and animals for potential beneficial effects in reducing serum TAG concentrations in fasting and postprandial states. Effects of DAG oil as a sole dietary fat so...
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PMID: 19397837
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
We illustrate that activation of native TRPC ROCs and SOCs involves different phospholipase-mediated transduction pathways linked to generation of diacylglycerol (DAG). Moreover we describe recent novel data showing that the endogenous phospholipid phosphoinositol 4,5-bisphosphate (PIP(2)) has profo...
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PMID: 19324408
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
We need much more information about lipid-sensing by TRPCs if we are to fully appreciate its significance, but the available data suggest that lipid-sensing is a key, but not exclusive, aspect of TRPC biology....
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PMID: 19324410
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
We will discuss the recent laboratory findings for the phospholipase A(2) (PLA(2))/protein kinase C (PKC) pathway within cellular calcium networks. The complexity and connectivity of these ubiquitous cellular signals make interpretation of experimental results extremely challenging. We present here...
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PMID: 19345415
PDF is available here.
PDF is available here.
Biophysical Journal (96)9 2009
Abstract
We studied the contribution of different negatively charged phospholipids and diacylglycerols to membrane binding. Three different C1B domains of PKCs were studied (the classical gamma, and the novel delta and epsilon), together with different lipid mixtures containing three types of acidic phosphol...
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PMID: 19413969
PDF is available here.
PDF is available here.
Abstract
The results confirm the usefulness of SLNs as carriers for topical administration and suggest the potential of SLMs for the delivery of drugs to the skin....
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PMID: 19405993
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1791)5 2009
Abstract
We have studied the influence of G protein-coupled receptors on the localization of SphK1. Activation of Gq-coupled receptors induced a profound, rapid (half-life 3-5 s) and long-lasting (> 2 h) translocation of SphK1 to the plasma membrane. This was mimicked by expression of constitutively active G...
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PMID: 19830907
PDF is available here.
PDF is available here.
EMBO Journal (28)8 2009
Abstract
We show that DGKzeta is targeted to excitatory synapses through its direct interaction with the postsynaptic PDZ scaffold PSD-95. Overexpression of DGKzeta in cultured neurons increases the number of dendritic spines, which receive the majority of excitatory synaptic inputs, in a manner requiring it...
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PMID: 19229292
PDF is available here.
PDF is available here.
Cancer Letters (275)1 2009
Abstract
Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-...
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PMID: 19028010
PDF is available here.
PDF is available here.
European Journal of Pharmacology (602)2-3 2009
Abstract
We investigated the activation mechanism of TRPC3, the Canonical Transient Receptors Potential 3 Channels, by histamine via a non-capacitative Ca(2+) entry pathway. TRPC3 was transfected into HEK293 cells and the cells were treated with thapsigargin to deplete the intracellular Ca(2+) stores; re-add...
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PMID: 19032951
PDF is available here.
PDF is available here.
Marine Drugs (7)2 2009
Abstract
Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(...
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PMID: 19597573
PDF is available here.
PDF is available here.
Abstract
We have used gene array analysis to identify the initial direct effects of cytokines on CNS glia by comparing changes in early gene expression in CNS glial cultures treated for 6 hours with cytokines typical of those secreted by Th1 and Th2 lymphocytes and monocyte/macrophages (M/M)....
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PMID: 19159481
PDF is available here.
PDF is available here.
Abstract
We had previously shown in vitro using human acute leukemia cells with various sensitivity to MTX (T-lymphoblastic CCRF-CEM line and resistant CEM/MTX subline) that MTX incorporation into liposomes as a lipophilic prodrug, diglyceride conjugate (MTX-DG), allows for the overcoming of cell resistance...
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PMID: 19928057
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the effects of insulin and several adipokines on the fatty acid uptake by these cells as obesity and insulin resistance syndrome have been suggested to affect breast cancer risk. We report for the first time that AA was predominantly taken up by these cells compared with EPA and OA....
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PMID: 19217762
PDF is available here.
PDF is available here.
Abstract
We conclude that diacylglycerols but not ceramides are increased in NAFL. The human fatty liver is also characterized by depletion of long polyunsaturated fatty acids in the liver and increases in hepatic SCD1 and lipogenic activities....
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PMID: 18952834
PDF is available here.
PDF is available here.
Biochemical Journal (417)1 2009
Abstract
We show that G(q) and G(12/13) pathways regulate the Thr(505) and Tyr(311) phosphorylation on PKCdelta in an interdependent manner. DiC8 (1,2-dioctanoylglycerol), a synthetic analogue of DAG (diacylglycerol), caused Thr(505), but not Tyr(311), phosphorylation on PKCdelta, whereas selective activatio...
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PMID: 18652571
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)1 2009
Abstract
The lipid diacylglycerol (DAG) analogue 1-oleoyl-2-acetyl-sn-glycerol (OAG) was used to verify the existence of DAG-sensitive channels in cortical neurons dissociated from E13 mouse embryos. Calcium imaging experiments showed that OAG increased the cytosolic concentration of Ca(2+) ([Ca(2+)]i) in ne...
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PMID: 19094061
PDF is available here.
PDF is available here.
Iubmb Life (60)12 2008
Abstract
The lipid second messenger diacylglycerol (DAG) controls the rate, amplitude, duration, and location of protein kinase C (PKC) activity in the cell. There are three classes of PKC isozymes and, of these, the conventional and novel isozymes are acutely controlled by DAG. The kinetics of DAG productio...
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PMID: 18720411
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (59 Suppl 7) 2008
Abstract
We examined the fatty acid transporter protein expression as well as the lipid content and profiles of free fatty acids (FFA), diacylglycerols (DGs) and triacylglycerols (TGs) in skeletal muscles of IL-6 deficient mice at 4 and 12 months of age. FAT/CD36 and FABPpm protein content was increased in r...
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PMID: 19258660
PDF is available here.
PDF is available here.
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] (33)6 2008
Abstract
Compared with control group,the levels of IP3 and DAG in cerebral vascular smooth muscle were significantly increased in model 1 h, 3 h and 6 h subgroups (P<0.01). Compared with the corresponding model subgroups,the levels of IP3 and DAG were significantly decreased in EA-CI-1 h, EA-CI-3 h and EA-CI...
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PMID: 19288900
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (46)12 2008
Abstract
Extensive efforts have been made, recently, to find surfactants with lower irritancy potential than those presently commercially employed in pharmaceutical and cosmetic preparations. Cytotoxic and phototoxic effects of novel mono and diacylglycerol amino acid-based surfactants (glutamic acid, or arg...
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PMID: 18977405
PDF is available here.
PDF is available here.
Abstract
We analyzed the size-based distributions of postprandial lipoproteins in the lymph and serum using gel filtration-based high-performance liquid chromatography. In thoracic duct lymph pooled for 3 h after oral administration of TAG or DAG, the size-based distributions of postprandial lymphatic lipopr...
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PMID: 19155588
PDF is available here.
PDF is available here.
European Journal of Pharmacology (599)1-3 2008
Abstract
Application of 1-oleoyl-2-acetyl-sn-glycerol (OAG), an analogue of diacylglycerol (DAG) formed via M(3) muscarinic receptors, induced inward cationic currents via a protein kinase C-independent mechanism and produced membrane depolarization with increased action potential discharges in mouse intesti...
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PMID: 18845139
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)49 2008
Abstract
We recently modeled transient receptor potential (TRP) channels using the Gestalt Domain Detection Algorithm-Basic Local Alignment Tool (GDDA-BLAST), which derives structural, functional, and evolutionary information from primary amino acid sequences using phylogenetic profiles ( Ko, K. D., Hong, Y....
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PMID: 19043047
PDF is available here.
PDF is available here.
Abstract
Interest in ultrasound contrast agents (lipid-shelled microbubbles) as delivery vehicles is increasing; however, the biodistribution of these agents remains uncharacterized, both with and without ultrasound. In this study, an (18)F-labeled lipid ([(18)F]fluorodipalmitin), incorporate...
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PMID: 18718854
PDF is available here.
PDF is available here.
Journal of Lipid Research (49)11 2008
Abstract
We report lipid levels in eggs, sperm, and during fertilization in Xenopus laevis. Sperm were found to contain different amounts of phospholipids as compared with eggs. During fertilization, total phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, and phosphatidylserine decreased, and cer...
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PMID: 18577769
PDF is available here.
PDF is available here.
Journal of Neurochemistry (107)3 2008
Abstract
We have also exploited GFP-Tubby selectively to visualize, for the first time, real-time changes in PIP(2) in hippocampal neurons....
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PMID: 18665913
PDF is available here.
PDF is available here.
Abstract
These results show that the microbubble suspensions are viscoelastic and exhibit power law behavior. The relationship between the air fraction of the suspension and fluid viscosity is determined....
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PMID: 18774143
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)43 2008
Abstract
We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by an antagonist of the G(q)-coupled P2Y1 receptor but also upon blockade of the G(i)-coupled P2Y12 receptor. The role of G(i) on PKC regulation required stimulation of pho...
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PMID: 18755689
PDF is available here.
PDF is available here.
Abstract
We demonstrate that cell-permeable ether-linked DGs reduce vascular smooth muscle cell growth by inhibiting platelet-derived growth factor-stimulated ERK in a PKC-epsilon-dependent manner. This inhibition is specific to the ERK pathway, since ether-linked DGs do not affect growth factor-induced acti...
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PMID: 18723771
PDF is available here.
PDF is available here.
Abstract
We investigated the presence and contribution to Ca(2+) transients of TRPC channels in dorsal root ganglion neurons. We found that six of the seven known TRPC subtypes were expressed in lumbar DRG, with TRPC1, C3, and C6 being the most abundant. Microfluorimetric calcium measurements showed Ca(2+) i...
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PMID: 18663462
PDF is available here.
PDF is available here.
Abstract
Intranuclear lipid metabolism modifications in relation to cell proliferation and/or apoptosis were demonstrated in hepatocytes. The aim of this study was to establish whether nuclear lipid metabolites influence cell function in different experimental models using a rat thyroid cell line (FRTL-5) tr...
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PMID: 18682246
PDF is available here.
PDF is available here.
Abstract
It is suggested that di- and triheptanoin have a hepatoprotector effect against HS, in rats, in a dose-dependent manner....
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PMID: 19082303
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)38 2008
Abstract
We demonstrate that ROCK is a new member of the split PH domain family of proteins. The ROCK split PH domain folds into a canonical PH domain structure. The insertion of the atypical C1 domain in the middle does not alter the structure of the PH domain. We further show that the C1 domain of ROCK lac...
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PMID: 18640982
PDF is available here.
PDF is available here.
Abstract
We describe herein a series of novel DAG-lactones containing heterocyclic moieties (pyridines, quinolines, and indoles) as alpha-arylidene fragments. Some of the DAG-lactones obtained show selective binding to RasGRP3 as compared to PKCalpha by more than 2 orders of magnitude and possess subnanomola...
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PMID: 18707088
PDF is available here.
PDF is available here.
Abstract
We have termed "chemical zip codes", are able to transform a relatively small chemical space into a larger universe of biological activities, as membrane-containing organelles within the cell appear to be able to decode these "chemical zip codes". It is postulated that after binding to protein kinas...
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PMID: 18698758
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)37 2008
Abstract
We present evidence for the dynamic interaction between endogenously expressed Orai1 and both STIM1 and hTRPC1 regulated by depletion of the intracellular Ca(2+) stores, using the pharmacological tools thapsigargin plus ionomycin, or by the physiological agonist thrombin, independently of extracellu...
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PMID: 18644792
PDF is available here.
PDF is available here.
Abstract
Lipid A isolated from several bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, and various strains of Yersinia) showed abundant formation of pyrophosphate anions upon ion dissociation. Pyrophosphate [H(3)P(2)O(7)](-) and/or [HP(2)O(6)](-) anions were observed as dominant frag...
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PMID: 18753624
PDF is available here.
PDF is available here.
Abstract
We fed C57BL/6J mice a high-fat diet and simultaneously treated them with an antisense oligonucleotide (ASO) against ADRP for 4 wk. Glucose homeostasis was assessed with clamp and tracer techniques. ADRP ASO decreased the levels of triglycerides and diacylglycerol in the liver, but fatty acids, long...
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PMID: 18669627
PDF is available here.
PDF is available here.
Abstract
The patients (n=61) were randomly assigned to one of three groups, who consumed TAG (control), DAG or PS/DAG oil. The average intake of PS from the PS/DAG oil during the test period was significantly higher than that for TAG and DAG oils (502 vs. 49 and 38 mg/day, P<0.05). Significant cholesterol-lo...
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PMID: 17964767
PDF is available here.
PDF is available here.
Abstract
Diacylglycerol (DAG) oil is a novel edible oil with similar taste and usability characteristics as conventional edible oils. Recent studies suggest that DAG oil may be helpful in the prevention and management of obesity. The objective of the present two-generation study was to evaluate potential adv...
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PMID: 18619512
PDF is available here.
PDF is available here.