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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Diglycerides (0):
Recent article
Diglycerides
Iubmb Life (60)12 2008
Abstract
The lipid second messenger diacylglycerol (DAG) controls the rate, amplitude, duration, and location of protein kinase C (PKC) activity in the cell. There are three classes of PKC isozymes and, of these, the conventional and novel isozymes are acutely controlled by DAG. The kinetics of DAG productio...
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PMID: 18720411
PDF is available here.
PDF is available here.
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Journal of Physiology and Pharmacology (59 Suppl 7) 2008
Abstract
We examined the fatty acid transporter protein expression as well as the lipid content and profiles of free fatty acids (FFA), diacylglycerols (DGs) and triacylglycerols (TGs) in skeletal muscles of IL-6 deficient mice at 4 and 12 months of age. FAT/CD36 and FABPpm protein content was increased in r...
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PMID: 19258660
PDF is available here.
PDF is available here.
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] (33)6 2008
Abstract
Compared with control group,the levels of IP3 and DAG in cerebral vascular smooth muscle were significantly increased in model 1 h, 3 h and 6 h subgroups (P<0.01). Compared with the corresponding model subgroups,the levels of IP3 and DAG were significantly decreased in EA-CI-1 h, EA-CI-3 h and EA-CI...
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PMID: 19288900
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (46)12 2008
Abstract
Extensive efforts have been made, recently, to find surfactants with lower irritancy potential than those presently commercially employed in pharmaceutical and cosmetic preparations. Cytotoxic and phototoxic effects of novel mono and diacylglycerol amino acid-based surfactants (glutamic acid, or arg...
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PMID: 18977405
PDF is available here.
PDF is available here.
Abstract
We analyzed the size-based distributions of postprandial lipoproteins in the lymph and serum using gel filtration-based high-performance liquid chromatography. In thoracic duct lymph pooled for 3 h after oral administration of TAG or DAG, the size-based distributions of postprandial lymphatic lipopr...
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PMID: 19155588
PDF is available here.
PDF is available here.
European Journal of Pharmacology (599)1-3 2008
Abstract
Application of 1-oleoyl-2-acetyl-sn-glycerol (OAG), an analogue of diacylglycerol (DAG) formed via M(3) muscarinic receptors, induced inward cationic currents via a protein kinase C-independent mechanism and produced membrane depolarization with increased action potential discharges in mouse intesti...
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PMID: 18845139
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)49 2008
Abstract
We recently modeled transient receptor potential (TRP) channels using the Gestalt Domain Detection Algorithm-Basic Local Alignment Tool (GDDA-BLAST), which derives structural, functional, and evolutionary information from primary amino acid sequences using phylogenetic profiles ( Ko, K. D., Hong, Y....
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PMID: 19043047
PDF is available here.
PDF is available here.
Abstract
Interest in ultrasound contrast agents (lipid-shelled microbubbles) as delivery vehicles is increasing; however, the biodistribution of these agents remains uncharacterized, both with and without ultrasound. In this study, an (18)F-labeled lipid ([(18)F]fluorodipalmitin), incorporate...
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PMID: 18718854
PDF is available here.
PDF is available here.
Journal of Lipid Research (49)11 2008
Abstract
We report lipid levels in eggs, sperm, and during fertilization in Xenopus laevis. Sperm were found to contain different amounts of phospholipids as compared with eggs. During fertilization, total phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, and phosphatidylserine decreased, and cer...
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PMID: 18577769
PDF is available here.
PDF is available here.
Journal of Neurochemistry (107)3 2008
Abstract
We have also exploited GFP-Tubby selectively to visualize, for the first time, real-time changes in PIP(2) in hippocampal neurons....
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PMID: 18665913
PDF is available here.
PDF is available here.
Abstract
These results show that the microbubble suspensions are viscoelastic and exhibit power law behavior. The relationship between the air fraction of the suspension and fluid viscosity is determined....
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PMID: 18774143
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)43 2008
Abstract
We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by an antagonist of the G(q)-coupled P2Y1 receptor but also upon blockade of the G(i)-coupled P2Y12 receptor. The role of G(i) on PKC regulation required stimulation of pho...
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PMID: 18755689
PDF is available here.
PDF is available here.
Abstract
We demonstrate that cell-permeable ether-linked DGs reduce vascular smooth muscle cell growth by inhibiting platelet-derived growth factor-stimulated ERK in a PKC-epsilon-dependent manner. This inhibition is specific to the ERK pathway, since ether-linked DGs do not affect growth factor-induced acti...
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PMID: 18723771
PDF is available here.
PDF is available here.
Abstract
We investigated the presence and contribution to Ca(2+) transients of TRPC channels in dorsal root ganglion neurons. We found that six of the seven known TRPC subtypes were expressed in lumbar DRG, with TRPC1, C3, and C6 being the most abundant. Microfluorimetric calcium measurements showed Ca(2+) i...
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PMID: 18663462
PDF is available here.
PDF is available here.
Abstract
Intranuclear lipid metabolism modifications in relation to cell proliferation and/or apoptosis were demonstrated in hepatocytes. The aim of this study was to establish whether nuclear lipid metabolites influence cell function in different experimental models using a rat thyroid cell line (FRTL-5) tr...
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PMID: 18682246
PDF is available here.
PDF is available here.
Abstract
It is suggested that di- and triheptanoin have a hepatoprotector effect against HS, in rats, in a dose-dependent manner....
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PMID: 19082303
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)38 2008
Abstract
We demonstrate that ROCK is a new member of the split PH domain family of proteins. The ROCK split PH domain folds into a canonical PH domain structure. The insertion of the atypical C1 domain in the middle does not alter the structure of the PH domain. We further show that the C1 domain of ROCK lac...
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PMID: 18640982
PDF is available here.
PDF is available here.
Abstract
We describe herein a series of novel DAG-lactones containing heterocyclic moieties (pyridines, quinolines, and indoles) as alpha-arylidene fragments. Some of the DAG-lactones obtained show selective binding to RasGRP3 as compared to PKCalpha by more than 2 orders of magnitude and possess subnanomola...
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PMID: 18707088
PDF is available here.
PDF is available here.
Abstract
We have termed "chemical zip codes", are able to transform a relatively small chemical space into a larger universe of biological activities, as membrane-containing organelles within the cell appear to be able to decode these "chemical zip codes". It is postulated that after binding to protein kinas...
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PMID: 18698758
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)37 2008
Abstract
We present evidence for the dynamic interaction between endogenously expressed Orai1 and both STIM1 and hTRPC1 regulated by depletion of the intracellular Ca(2+) stores, using the pharmacological tools thapsigargin plus ionomycin, or by the physiological agonist thrombin, independently of extracellu...
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PMID: 18644792
PDF is available here.
PDF is available here.
Abstract
Lipid A isolated from several bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, and various strains of Yersinia) showed abundant formation of pyrophosphate anions upon ion dissociation. Pyrophosphate [H(3)P(2)O(7)](-) and/or [HP(2)O(6)](-) anions were observed as dominant frag...
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PMID: 18753624
PDF is available here.
PDF is available here.
Abstract
We fed C57BL/6J mice a high-fat diet and simultaneously treated them with an antisense oligonucleotide (ASO) against ADRP for 4 wk. Glucose homeostasis was assessed with clamp and tracer techniques. ADRP ASO decreased the levels of triglycerides and diacylglycerol in the liver, but fatty acids, long...
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PMID: 18669627
PDF is available here.
PDF is available here.
Abstract
The patients (n=61) were randomly assigned to one of three groups, who consumed TAG (control), DAG or PS/DAG oil. The average intake of PS from the PS/DAG oil during the test period was significantly higher than that for TAG and DAG oils (502 vs. 49 and 38 mg/day, P<0.05). Significant cholesterol-lo...
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PMID: 17964767
PDF is available here.
PDF is available here.
Abstract
Diacylglycerol (DAG) oil is a novel edible oil with similar taste and usability characteristics as conventional edible oils. Recent studies suggest that DAG oil may be helpful in the prevention and management of obesity. The objective of the present two-generation study was to evaluate potential adv...
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PMID: 18619512
PDF is available here.
PDF is available here.
Abstract
A recent study using c-Ha-ras proto-oncogene transgenic (rasTg) rats demonstrated possible enhancing effects of diacylglycerol (DAG) on 4-nitroquinoline 1-oxide (4NQO) induced carcinogenesis of the tongue. To assess effects in their Sprague-Dawley back strain, a two-stage carcinogenesis study using...
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PMID: 18694799
PDF is available here.
PDF is available here.