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Glycolipids (3):
Recent article
Glycolipids
Journal of Proteomics (74)3 2011
Abstract
Milk fat globule membranes (MFGM) are three-layered structures that enclose fat droplets, and are composed by an internal monolayer of endoplasmic reticulum origin, surrounded by a bilayer derived from the apical membrane of the lactating cell. In this work, an optimized protein extr...
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PMID: 21147282
PDF is available here.
PDF is available here.
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Abstract
We designed and developed an efficient synthesis of carbohydrate-functionalized β-cyclodextrins (βCDs) and liposomes for hepatocyte-specific delivery. For targeting of ASGPR, rhodamine B-loaded βCDs were functionalized with glycodendrimers. Liposomes were equipped with synthetic glycolipids conta...
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PMID: 20820666
PDF is available here.
PDF is available here.
Abstract
A halophilic archaeon, strain RO1-6(T), was isolated from a marine solar saltern in eastern China. Cells of strain RO1-6(T) were pleomorphic and motile and stained Gram-negative. Strain RO1-6(T) grew well on complex medium and colonies were red-pigmented. It was able to grow at 20-50°C (optimum 37...
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PMID: 19946053
PDF is available here.
PDF is available here.
Abstract
The need for new products derived from natural sources for the replacement of the commonly used non-ionic surfactants containing ethylene oxide units with degradable carbohydrate headgroups has become an important area of research. Glycolipids offer a wide range of applications in the pharmaceutical...
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PMID: 20716018
PDF is available here.
PDF is available here.
Abstract
Ethanol ingestion is well known to induce morphological and biochemical changes in intestine and is responsible for intestinal dysfunctions. Luminal surface of enterocytes is rich in glycolipids, but the effects of ethanol ingestion on membrane glycolipids are not well characterized. In the present...
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PMID: 20708369
PDF is available here.
PDF is available here.
Growth inhibition of Microcystis aeruginosa by a glycolipid-type compound from Bacillus subtilis C1.
Abstract
We attempted to identify the compound responsible for the growth inhibition of Microcystis aeruginosa occurring when a culture broth of Bacillus subtilis C1 was added to the medium. The active compound was purified from B. subtilis C1 culture broth by adsorption chromatography and HPLC, and was iden...
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PMID: 20798589
PDF is available here.
PDF is available here.
Abstract
Production of the QS-dependent virulence factor rhamnolipids by colonising P aeruginosa isolates is associated with development of VAP....
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PMID: 20685744
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (309)1 2010
Abstract
We have cloned a synthetic operon consisting of the lipC structural gene and the foldase gene lipH obtained from the lipA/lipH operon and have constructed, in parallel, a lipC-deficient P. aeruginosa mutant. Inactivation of the lipC gene significantly impaired type IV pilus-dependent twitching and s...
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PMID: 20546309
PDF is available here.
PDF is available here.
Abstract
We performed step-wise screening assays on a focused library of 25 alpha-GalCer analogues. Assays included quantification of the magnitude of stimulatory activity against human iNKT cells in vitro, binding affinity to human and murine CD1d molecules, and binding affinity to the invariant t cell rece...
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PMID: 20616071
PDF is available here.
PDF is available here.
Abstract
We isolated and purified rhamnolipids from Pseudomonas aeruginosa strain BS-161R and these purified rhamnolipids were used to synthesize silver nanoparticles. The purified rhamnolipids were further characterized and the structure was elucidated based on one- and two-dimensional (1)H and (13)C NMR, F...
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PMID: 20668398
PDF is available here.
PDF is available here.
Archives of Microbiology (192)7 2010
Abstract
Both the lipid and the protein components of biological membranes can be modified by the covalent addition of polysaccharides. Whereas eukaryal and bacterial pathways of lipid and protein glycosylation are relatively well defined, considerably less is known of the parallel processes in Archaea. Rece...
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PMID: 20458469
PDF is available here.
PDF is available here.
Abstract
We report crystallographic and biophysical data that demonstrate a previously unidentified direct interaction of MD-1 with LPS. The crystal structure of chicken MD-1 (cMD-1) at 2.0 A resolution exhibits a beta-cup-like fold, similar to MD-2, that encloses a hydrophobic cavity between the two beta-sh...
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PMID: 20534476
PDF is available here.
PDF is available here.
Abstract
We have characterized the TCR repertoire of a CD1d-restricted type II NKT cell subset reactive to sulfatide involved in the regulation of autoimmunity and antitumor immunity. The sulfatide/CD1d-tetramer(+) cells isolated from naïve mice show an oligoclonal TCR repertoire with predominant usage of t...
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PMID: 20534460
PDF is available here.
PDF is available here.
Biotechnology Letters (32)6 2010
Abstract
Tensioactive properties of rhamnolipids produced by a Pseudomonas aeruginosa strain were investigated in the presence or absence of Sr(2+) or Pb(2+). Surface and interfacial properties, and aggregate forming properties and morphologies were studied by various techniques including scanning electron m...
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PMID: 20155387
PDF is available here.
PDF is available here.
Abstract
We examined primary structure of cholinephosphotransferase (mf1) and glucosyltransferase (mf3) genes, which engage GGPL-I and GGPL-III synthesis, in 20 strains, and found four types of variations in the mf1 gene but the mf3 gene in two strains was not detected by PCR. These results may have importan...
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PMID: 20134120
PDF is available here.
PDF is available here.
Abstract
We developed a facile and high-yield synthesis of the corresponding disaccharide. Herein, the non-reducing disaccharide segment of phenolic glycolipid I from Mycobacterium leprae, O-(3,6-di-O-methyl-beta-D-glucopyranosyl)-(1-->4)-O-2,3-di-O-methyl-alpha-L-rhamnopyranose was synthesized by an improve...
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PMID: 20462755
PDF is available here.
PDF is available here.
Abstract
Fast migrating cerebrosides (FMC) are derivatives of galactosylceramide (GalCer). The structures of the most hydrophobic FMC-5, FMC-6, and FMC-7 were determined by electrospray ionization linear ion-trap mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy complementing previous N...
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PMID: 20154333
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)12 2010
Abstract
We present evidence suggesting that iron-regulated production of the biosurfactant rhamnolipid is important to facilitate the formation of flat unstructured biofilms. We show that under iron limitation the timing of rhamnolipid expression is shifted to the initial stages of biofilm formation (versus...
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PMID: 20154129
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate the milk quality of Massese ewes receiving diets with different forage:concentrate ratios (FC ratio), specially on milk fat globules characteristics and fatty acids composition. The diet is one of the main environmental factors that influence the lipidic content...
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PMID: 20196898
PDF is available here.
PDF is available here.
Journal of Proteomics (73)6 2010
Abstract
We report the qualitative and quantitative profiling of two MFGM-enriched milk fractions, a whey protein concentrate (WPC) and a buttermilk protein concentrate (BMP), as derived from three different analytical workflows. First, an LC-MS/MS-based shotgun approach revealed 244 protein identities in WP...
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PMID: 19944786
PDF is available here.
PDF is available here.
Nature Immunology (11)4 2010
Abstract
We used multiphoton microscopy to visualize the dynamics and activation of iNKT cells in lymph nodes. After antigen administration, iNKT cells became confined in a CD1d-dependent manner in close proximity to subcapsular sinus CD169(+) macrophages. These macrophages retained, internalized and present...
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PMID: 20228797
PDF is available here.
PDF is available here.
Abstract
We have shown before that it is important to simultaneously analyze both pharmacokinetic factors such as the blood concentration and pharmacodynamic factors such as the site of drug action, when searching for genetic information that can be used to predict the treatment effects of fluvoxamine for de...
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PMID: 20491281
PDF is available here.
PDF is available here.
International Immunology (22)4 2010
Abstract
We synthesized alpha-carba-GalCer, which has an alpha-linked carba-galactosyl moiety; here, the 5a'-oxygen atom of the D-galactopyranose ring of alpha-GalCer is replaced by a methylene group. The alpha-carba-GalCer was more stable and showed higher affinity to the NKT receptor. It thus enhanced and...
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PMID: 20181652
PDF is available here.
PDF is available here.
Abstract
A glycolipid analogue, GM4-type ganglioside, was obtained by a combination of chemical synthesis and biosynthetic processes in animal cells with dodecyl beta-D-galactoside (Gal C12) as primer. The primer was conveniently prepared in two steps: glycosylation, followed by deacetylation...
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PMID: 20151390
PDF is available here.
PDF is available here.
Pediatric Research (67)2 2010
Abstract
We isolated Ureaplasma spp. from 63 preterm placentas among 151 specimens, which were delivered at <32 wk of gestation. Of the 63 placentas, 52 (83%) revealed CAM in cultures positive for Ureaplasma spp., however, CAM was observed only in 30% (26/88) of cultures negative for Ureaplasma spp. (p < 0.0...
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PMID: 19858776
PDF is available here.
PDF is available here.
Abstract
We hypothesized that P. freudenreichii possesses secreted lipolytic esterase(s). For 12 putative esterase genes previously identified from the genome of P. freudenreichii CIRM1, the level of expression was quantified by real-time reverse transcriptase (RT)-PCR, and the subcellular localization of es...
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PMID: 20038704
PDF is available here.
PDF is available here.
Methods in Molecular Biology (626)626 2010
Abstract
NKT cells are a distinct lineage of T lymphocytes that are usually identified by the co-expression of the semi-invariant CD1d-restricted alphabeta TCR and the NK1.1 allelic marker of NK lineage receptors in the C57BL/6 mice and related strains. NKT cells can be subdivided based on CD4/CD8 expression...
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PMID: 20099127
PDF is available here.
PDF is available here.
Abstract
We show that the mouse and human CD1d present glycolipids having different fatty acids, based in part upon a difference at a single amino acid position that is involved in positioning the sugar epitope. CD1d also can bind nonantigenic lipids, however, but unexpectedly, mouse CD1d orients the two ali...
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PMID: 20080535
PDF is available here.
PDF is available here.
Abstract
It has been established that activity of trehalosephosphate synthase (key enzyme of trehalosemycolates synthesis) under cultivation of Rhodococcus erythropolis EK-1 on the medium with n-hexadecane was 10 times higher, and amount of synthesized surface-active substances 4 times higher as compared to...
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PMID: 20455436
PDF is available here.
PDF is available here.
Abstract
Liposomes are widely investigated for their applicability as drug delivery systems. However, the unstable liposomal constitution is one of the greatest limitations, because the liposomes undergo fast elimination after application to the human body. In the presented study, novel archeal lipids were u...
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PMID: 20072874
PDF is available here.
PDF is available here.
Abstract
A low-cost microBR (microbioreactor) made from PTFE [poly(tetrafluoroethylene)] was used to cultivate a model organism, Pseudomonas aeruginosa DS10-129. The progress of bioprocessing was monitored by comparing the growth of the organism in a microBR, a conventional bench scale bioreactor and a shake...
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PMID: 19958287
PDF is available here.
PDF is available here.
Journal of Oleo Science (59)5 2010
Abstract
Mannosylerythritol lipids (MELs), are produced from feedstock by the genus Pseudozyma, and are the most promising biosurfactants known due to its versatile interfacial and biochemical actions. In order to broaden the application in cosmetics, the hair care properties of MELs were investigated using...
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PMID: 20431244
PDF is available here.
PDF is available here.
Abstract
Glycolipids with one or two sugar residues attached to different lipid backbones are found in biomembranes of bacteria, fungi, plants and animals in the form of steryl glycosides, glycosylceramides and diacylglycerol glycosides. They contain different sugar residues, mainly glucose and galactose, in...
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PMID: 19939496
PDF is available here.
PDF is available here.
Abstract
Abstract
We examine the biochemical and genetic mechanism of rhamnolipid production by P. aeruginosa and propose the application of QS signal molecules in enhancing the rhamnolipid production....
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PMID: 21415897
PDF is available here.
PDF is available here.
Abstract
Certain species of Pseudomonas are able to produce and excrete a heterogeneous mixture of biosurfactants with a glycolipid structure. These are known as rhamnolipids. In the biosynthetic process, rhamnolipid production is governed by both the genetic regulatory system and central metabolic pathways...
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PMID: 20545285
PDF is available here.
PDF is available here.
Abstract
This chapter deals with two types of biosurfactants that are not in the spotlight of general research: glycoglycerolipids and oligosaccharide lipids. The main focus is on glycolglycerolipids from marine bacteria like Microbacterium spec. DSM 12583, Micrococcus luteus (Hel 12/2) and Bacillus pumilus...
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PMID: 20545283
PDF is available here.
PDF is available here.
Abstract
Marine environment occupies the vast majority of the earth's surface and is a rich source of highly potent and active compounds. In recent years, microbial surfactants and emulsifiers have been reported from marine microflora. Surfactant and emulsifier molecules having diverse chemical nature such a...
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PMID: 20545276
PDF is available here.
PDF is available here.
Abstract
During the last years, several applications of biosurfactants with medical purposes have been reported. Biosurfactants are considered relevant molecules for applications in combating many diseases and as therapeutic agents due to their antibacterial, antifungal and antiviral activities. Furthermore,...
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PMID: 20545275
PDF is available here.
PDF is available here.
Abstract
We offer an overview of the physicochemical and biological properties of rhamnolipid surfactants associated with the applications of these molecules in different circumstances....
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PMID: 20545282
PDF is available here.
PDF is available here.
Abstract
Our results suggest that dirhamnolipid, having a large polar headgroup and a smaller hydrophobic portion, behaves as an inverted-cone shaped molecule, conferring positive curvature to membranes, which might be behind its disrupting effects on membranes....
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PMID: 20545272
PDF is available here.
PDF is available here.
Abstract
Biosurfactant (BS)/bioemulsifier (BE) produced by varied microorganisms exemplify immense structural/functional diversity and consequently signify the involvement of particular molecular machinery in their biosynthesis. The present chapter aims to compile information on molecular genetics of BS/BE p...
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PMID: 20545271
PDF is available here.
PDF is available here.
Annual ryegrass toxicity in Thoroughbred horses in Ceres in the Western Cape Province, South Africa.
Abstract
An outbreak of annual ryegrass toxicity occurred on a Thoroughbred stud in Ceres in the Western Cape Province of South Africa. This is the 1st report of annual ryegrass toxicity in horses in South Africa, although the condition has been reported in cattle and sheep populations in the past. Annual ry...
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PMID: 20458861
PDF is available here.
PDF is available here.
Cell and Tissue Research (338)2 2009
Abstract
We describe a novel marker of the oligodendrocyte lineage recognised by the monoclonal antibody clone 4860. It selectively labels the surfaces of differentiated oligodendrocytes in culture and clearly differs from other oligodendrocyte markers. Importantly, the 4860 epitope highlights developing whi...
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PMID: 19798513
PDF is available here.
PDF is available here.
Abstract
An automatic immunoassay system for an assay of sialoglycoconjugates was developed based on the sequential injection technique. A cost effective plain glass capillary tube was used as a solid surface for immobilization of biomolecules via a simple physical adsorption which is adequate to tolerate th...
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PMID: 19635348
PDF is available here.
PDF is available here.
Phytopathology (99)10 2009
Abstract
Flocculosin is an antifungal cellobiose lipid linked to the biocontrol activity of Pseudozyma flocculosa and whose structure is very similar to that of ustilagic acid produced by Ustilago maydis. In this work, homologs of the U. maydis cyp1 gene, involved in the biosynthesis of ustilagic acid, were...
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PMID: 19740027
PDF is available here.
PDF is available here.
Abstract
Our data indicate that monitoring anti-PGL-1 levels during MDT may be a sensitive tool for evaluating treatment efficacy. These data also indicate that the control of leprosy infection can be obtained with 12 months of MDT in MB patients....
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PMID: 19784481
PDF is available here.
PDF is available here.
Biotechnology Letters (31)10 2009
Abstract
Rhamnolipids, produced predominantly by Pseudomonas aeruginosa, are biosurfactants with important applications. For efficient culture screening according to rhamnolipid productivity, the method using agar plates containing methylene blue (MB) and cetyl trimethylammonium bromide (CTAB) was re-examine...
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PMID: 19547929
PDF is available here.
PDF is available here.
Abstract
Eight compounds (1-8) were isolated from a methanol extract of Cibotium barometz rhizomes including two new furan derivatives, cibotiumbarosides A (1) and B (2), and a new glycoglycerolipid, cibotiglycerol (4). Their structures were elucidated by chemical and spectroscopic methods. Compounds 2-5 eac...
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PMID: 19739599
PDF is available here.
PDF is available here.
Abstract
We report that the hormone norepinephrine increases P. aeruginosa PA14 growth, virulence factor production, invasion of HCT-8 epithelial cells, and swimming motility in a concentration-dependent manner. Transcriptome analysis of P. aeruginosa exposed to 500 microM, but not 50 microM, norepinephrine...
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PMID: 19517106
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (113)32 2009
Abstract
Concanavalin A (Con A) binding to the surfaces of mannose-functionalized binary monolayers was enhanced by surface molecular imprinting technique. The protein surface imprinting was prepared from binary Langmuir monolayers at the air-water interface through lateral reorganization of glycolipids dire...
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PMID: 19618948
PDF is available here.
PDF is available here.
Abstract
Four 3''- and 4''-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the...
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PMID: 19535248
PDF is available here.
PDF is available here.
Abstract
The TSA and LSA concentrations in the alcohol abuse patients were significantly higher than that of healthy controls. Taking into consideration the presence of hepatocellular injury, the concentration of LSA differs between subgroups with elevated and normal liver enzymes activity but the levels of...
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PMID: 19856873
PDF is available here.
PDF is available here.
Abstract
We propose that the observed anticancer activity is due to their potential to inhibit cell differentiation and proliferation via interaction with the membranes of cancer cells....
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PMID: 19342127
PDF is available here.
PDF is available here.
Abstract
Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d. Recent work has s...
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PMID: 19646850
PDF is available here.
PDF is available here.
Abstract
The effects of high-pressure homogenisation (HPH) in the pressure range 100-300 MPa on the gel formation and rheological properties of rennet-induced skim milk (0.08%, fat, w/w) and standardised milk (3.60% fat, w/w) gels at pH 6.60 were studied. The average casein micelle size in skim milk was sign...
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PMID: 19445828
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)31 2009
Abstract
We have identified an M. marinum isolate, M. marinum 7 (Mma7), which failed to produce LOS-IV but instead accumulated large amounts of LOS-III. Local genomic comparison of the LOS biosynthetic cluster established the presence of a highly disorganized region in Mma7 compared with the standard M strai...
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PMID: 19491094
PDF is available here.
PDF is available here.
Mucosal Immunology (2)5 2009
Abstract
We discuss the role of natural killer T cells (NKT cells) in intestinal immunology. NKT cells are a subset of non-conventional T cells recognizing endogenous and/or exogenous glycolipid antigens when presented by the major histocompatibility complex (MHC) class I-like antigen-presenting molecules CD...
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PMID: 19587641
PDF is available here.
PDF is available here.
Biological Chemistry (390)7 2009
Abstract
We briefly refer to the principles of numerous platforms since the introduction of carbohydrate microarrays in 2002, and we highlight platforms that are beyond proof-of-concept and have provided new biological information....
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PMID: 19426131
PDF is available here.
PDF is available here.
Clinical Immunology (132)1 2009
Abstract
In this study, the membrane lipids of B. burgdorferi were separated into 16 fractions; the components in each fraction were identified, and the immunogenicity of each fraction was determined by ELISA using sera from Lyme disease patients. Only the 2 glycolipids, acylated cholesteryl galactoside (ACG...
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PMID: 19342303
PDF is available here.
PDF is available here.