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Lipopeptides (2):
Recent article
Lipopeptides
British Journal of Nutrition (105)1 2011
Abstract
The ingestion of fatty meals is associated with a transient, low-grade systemic inflammatory response in human subjects, involving the activation of circulating monocytes and the secretion of pro-inflammatory cytokines. However, it is not yet clear how different foodstuffs may promote inflammatory s...
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PMID: 20849668
PDF is available here.
PDF is available here.
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Cancer Science (102)3 2010
Abstract
We focused on the hypoxia-selective cytotoxin, Rakicidin A. A previous report showed that Rakicidin A, a natural product produced by the Micromonospora strain, induced hypoxia-selective cytotoxicity in solid tumors. Here, we describe Rakicidin A-induced cell death in hypoxia-adapted (HA)-CML cells w...
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PMID: 21166958
PDF is available here.
PDF is available here.
Abstract
Lipopeptides constitute a structurally diverse group of metabolites produced by various bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled by their antimicrobial, antitumour, immunosuppressant and surfactant activities. However, the natural functions of lipope...
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PMID: 20412310
PDF is available here.
PDF is available here.
Abstract
A 76-year-old man who was being treated for bronchial asthma and pulmonary emphysema by his family physician experienced dyspnea and was referred to our department with suspected pneumonia. The patient responded poorly to sulbactam/cefoperazone and clarithromycin. A cavity lesion appeared in the lef...
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PMID: 21141064
PDF is available here.
PDF is available here.
Abstract
Two related peptide metabolites, one a cyclic depsipeptide, hoiamide B (2), and the other a linear lipopeptide, hoiamide C (3), were isolated from two different collections of marine cyanobacteria obtained in Papua New Guinea. Their structures were elucidated by combining various techniques in spect...
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PMID: 20687534
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)9 2010
Abstract
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)5 2010
Abstract
We report a case of renal transplant recipient (RTR) who developed disseminated invasive aspergillosis. The patient was treated with micafungin with complete clinical and radiological response....
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PMID: 20814131
PDF is available here.
PDF is available here.
Abstract
All tested stimulants up-regulated the expression of IRAK-M in HGECs. The P. gingivalis lipopolysaccharide or PAM(3)CSK(4) increased MCP-1 expression, whereas live P. gingivalis down-regulated the MCP-1 expression in HGECs. However, IRAK-M RNAi increased the expression of MCP-1 irrespective of up- o...
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PMID: 20412419
PDF is available here.
PDF is available here.
Bioresource Technology (101)15 2010
Abstract
I and II, was analyzed by matrix assisted laser desorption/ionization time of flight (MALDI TOF) mass spectrometry and tandem mass spectrometry (MS/MS). Both compounds are novel cyclic lipopeptides with a palmitic acid connected to the terminal amino group of eighth amino acid in peptide moiety. The...
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PMID: 20303744
PDF is available here.
PDF is available here.
Abstract
We conducted a single-dose prospective study of the intrapulmonary and plasma PKPD of 150 mg of micafungin administered intravenously in 20 adult lung transplant recipients. Epithelial lining fluid (ELF) and alveolar cell (AC) samples were obtained via bronchoalveolar lavage performed 3, 5, 8, 18, o...
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PMID: 20439610
PDF is available here.
PDF is available here.
Liver International (30)7 2010
Abstract
Alcoholic chronic liver disease (ACLD) is a common form of acquired immunodeficiency.
To evaluate ex vivo toll-like receptor (TLR) 2 and TLR4 innate immune response in stable ACLD.
Blood was collected from 26 males with stable ACLD and from 17 controls. Serum was used for lipopolysaccharide (LPS), s...
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PMID: 20492495
PDF is available here.
PDF is available here.
Parasitology Research (107)2 2010
Abstract
Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to tr...
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PMID: 20467753
PDF is available here.
PDF is available here.
Abstract
We report the mode of action of theonellamides, bicyclic peptides derived from marine sponges. We generated a chemical-genomic profile of theonellamide F using a collection of fission yeast strains in which each open reading frame (ORF) is expressed under the control of an inducible promoter. Cluste...
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PMID: 20543850
PDF is available here.
PDF is available here.
Abstract
Chronic HBV infection is the leading cause of liver cirrhosis and hepatocellular carcinoma (HCC). Synthetic peptides derived from the N-terminus of the large HBV envelope protein (L-protein) have been shown to efficiently block HBV entry. Myr-HBVpreS/2-78, the parent compound of these drugs, inhibit...
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PMID: 20657392
PDF is available here.
PDF is available here.
Biophysical Chemistry (149)1-2 2010
Abstract
We present direct structural evidence from cryo-electron tomography data that thread-like micelles with a uniform diameter of 6.5 nm are organized into loops of different sizes at a surfactin concentration of > 15 mol%.
2010 Elsevier B.V. All rights reserved....
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PMID: 20406718
PDF is available here.
PDF is available here.
Medical Mycology (48)4 2010
Abstract
We have conducted an in vitro evaluation of the efficacy of a voriconazole-micafungin combination against Candida albicans. When used alone, both micafungin and voriconazole decreased the metabolic activity of planktonic cells, but only micafungin displayed potent anti-biofilm activity. Their combin...
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PMID: 19958255
PDF is available here.
PDF is available here.
Abstract
We report that TLR4 and TLR2 specifically activated the endoplasmic reticulum (ER) stress sensor kinase IRE1alpha and its downstream target, the transcription factor XBP1. Previously described ER-stress target genes of XBP1 were not induced by TLR signaling. Instead, TLR-activated XBP1 was required...
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PMID: 20351694
PDF is available here.
PDF is available here.
Abstract
The antifungal broth microdilution (BMD) method of the European Committee on Antibiotic Susceptibility Testing (EUCAST) and the Etest agar diffusion method were compared with the Clinical and Laboratory Standards Institute (CLSI) BMD method M27-A3 for anidulafungin, caspofungin, and micafungin susce...
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PMID: 20335424
PDF is available here.
PDF is available here.
Abstract
A homozygous hot-spot mutation in GSC1, caused by mutation in one allele and then loss of heterozygosity, is required for high-level echinocandin resistance in C. albicans. Both alleles of GSC1 contribute equally and independently to beta-1,3-glucan synthase activity....
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PMID: 20233776
PDF is available here.
PDF is available here.
Abstract
Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (-0.06 to -0.05 CFU/ml...
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PMID: 20145083
PDF is available here.
PDF is available here.
Bioresource Technology (101)7 2010
Abstract
The biosurfactant production of a marine actinobacterium Brevibacterium aureum MSA13 was optimized using industrial and agro-industrial solid waste residues as substrates in solid state culture (SSC). Based on the optimization experiments, the biosurfactant production by MSA13 was increased to three...
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PMID: 19959354
PDF is available here.
PDF is available here.
The activity of silver against Escherichia coli biofilm is increased by a lipopeptide biosurfactant.
Abstract
Biological contamination of surfaces, both in industry and in health care, plays an important role as a potential vector of disease transmission. Metals have been described to be effective antibiofilm agents, and the efficacy of silver ions as a disinfectant has been known for centuries. The activit...
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PMID: 20453915
PDF is available here.
PDF is available here.
Critical Care Medicine (38)3 2010
Abstract
Critical Care Medicine (38)3 2010
Abstract
Preconditioning by TLR2 agonist Pam3CSK4 reduces myocardial infarct size after myocardial ischemia/reperfusion. One of the mechanisms involved is a diminished chemokine release from cardiomyocytes, which subsequently limits leukocyte infiltration....
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PMID: 20081527
PDF is available here.
PDF is available here.
Investigative Radiology (45)2 2010
Abstract
VEGFR2-targeted ultrasound contrast agents such as BR55 will likely prove useful in human for the early detection of tumors as well as for the assessment of response to specific treatments....
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PMID: 20027118
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)2 2010
Abstract
We found that platelets express MyD88 and interleukin 1 receptor-associated kinase (IRAK-1), which are proteins important in TLR signalling. However, Pam3CSK4 did not stimulate a rapid (within 10 minutes) phosphorylation of IRAK-1 in platelets. In conclusion, the results show that Pam3CSK4-induced p...
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PMID: 20024498
PDF is available here.
PDF is available here.
Abstract
We showed that this activity is linked to the production of a new cyclic lipopeptide containing 14 amino acids and a 3-C(10)OH fatty acid that we called entolysin. Three nonribosomal peptide synthetases (EtlA, EtlB, EtlC) were identified as responsible for entolysin biosynthesis. Two additional comp...
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PMID: 20023108
PDF is available here.
PDF is available here.
Abstract
The mode of action of two cosmetic active ingredients (AIs), palmitoyl glycine (PG) and cocoyl alanine (CA) was studied with cDNA array experiments and quantitative PCR confirmations, which were performed on experimentally aged human fibroblasts. These preliminary studies revealed co...
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PMID: 19732187
PDF is available here.
PDF is available here.
Abstract
We found strain Bs- M49 decreased spore formation and the development of competence. Blast comparison of the sequences from Bs- 916 and M49 indicate that there is no difference in the srfA operon promoter PsrfA, but there are differences in the coding sequence of the comA gene. These differences res...
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PMID: 20208433
PDF is available here.
PDF is available here.
Abstract
We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid....
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PMID: 19933794
PDF is available here.
PDF is available here.
Abstract
TLR-1-6 stimulation produced higher concentrations of proinflammatory cytokines (IL-1beta, IL-6, and IL-8) in cord blood compared to adult blood, with the exception of TLR-4-stimulated TNF-alpha production, which was significantly lower in cord blood (319 pg/ml) compared to adult blood (645 pg/ml; p...
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PMID: 19955831
PDF is available here.
PDF is available here.
Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp.
Abstract
We tested a global collection of Candida sp. strains against anidulafungin, caspofungin, and micafungin, using CLSI M27-A3 broth microdilution (BMD) methods, in order to define wild-type (WT) populations and epidemiological cutoff values (ECVs). From 2003 to 2007, 8,271 isolates of Candida spp. (4,2...
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PMID: 19923478
PDF is available here.
PDF is available here.
Abstract
Both UV-killed LGG and Bb enhanced IL-12, IFN-gamma, TNF-alpha and IL-10, and reduced IL-13 secretion when added directly to stimulated PBMC, similar to live bacteria. IEC reduced IL-13, IFN-gamma and IL-10 secretion by stimulated PBMC. Apically added LGG, TLR2 and NOD2 ligands,but not Bb, enhanced...
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PMID: 20016198
PDF is available here.
PDF is available here.
Abstract
Eosinophilic inflammation was clearly reduced by TLR2/6 agonism. This effect was also seen without simultaneous administration of IFN-gamma. However, lymphocyte counts were not affected among the different treatment groups. More precise determination of the lymphocyte-mediated immune reaction showed...
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PMID: 20016195
PDF is available here.
PDF is available here.
Abstract
A bacterial strain isolated from soil for its potential to control the anthracnose disease caused by Colletotrichum gloeosporioides was identified as a Bacillus subtilis. Bacillus subtilis CMB32 produced antifungal agents on M9 broth at 30degreesC. Biosurfactant lipopeptides produced by Bacillus sub...
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PMID: 20134245
PDF is available here.
PDF is available here.
Veterinary Research (41)3 2010
Abstract
We found that HEK293 cells transfected with bovine TLR2 (boTLR2) were able to respond to diacylated lipopeptides but did not recognize triacylated lipopeptides, even after cotransfection with the so far published sequence of boTLR1. In this study we now could show that primary bovine cells were in g...
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PMID: 20167196
PDF is available here.
PDF is available here.
Mediators of Inflammation (2010) 2010
Abstract
We question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue. These receptors are expressed in omental and subcutaneous human fat tissue,...
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PMID: 20339530
PDF is available here.
PDF is available here.
Nature Protocols (5)1 2010
Abstract
We report a rapid microwave-assisted, solid-phase synthetic protocol to prepare the fatty-acid conjugated, triple-helical peptides containing the cleavage site for the enzyme matrix metalloproteinase-9 (MMP-9). We employed a PEG-based resin as the solid support and the amino acids were protected wit...
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PMID: 20057380
PDF is available here.
PDF is available here.
Abstract
Biosurfactants are of considerable industrial value as their high tenside activity in combination with their biocompatibility makes them attractive for many applications. In particular members of the lipopeptide family of biosurfactants contain significant potentials for the pharmaceutical industry...
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PMID: 20545281
PDF is available here.
PDF is available here.
Abstract
Even after forty years of its discovery by Arima et al, surfactin, a potent lipopeptide biosurfactant, still attracts attention and fancy of the applied microbiologists and biotechnologists worldwide, mainly due to its versatile bioactive properties and potential industrial implications. Starting fr...
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PMID: 20545293
PDF is available here.
PDF is available here.
Abstract
Lichenysins are most potent anionic cyclic lipoheptapeptide biosurfactants produced by Bacillus licheniformis on hydrocarbonless medium with mainly glucose as carbon source. They have the capacity to lower the surface tension of water from 72 to 27 mN/m. Based on species specific variations they are...
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PMID: 20545292
PDF is available here.
PDF is available here.
Abstract
This study compared nine susceptibility testing methods and 12 endpoints for anidulafungin, caspofungin, and micafungin with the same collection of blinded FKS hot spot mutant (n = 29) and wild-type isolates (n = 94). The susceptibility tests included EUCAST Edef 7.1, agar dilution, Etest, and disk...
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PMID: 19884370
PDF is available here.
PDF is available here.
Abstract
Abstract
Surfactin, purified from Bacillus subtilis natto TK-1, inhibited proliferation of human breast cancer MCF-7 cells in a dose- and time-dependent manner, with IC(50) at 24, 48, and 72 h of 82.6, 27.3, and 14.8 microM, respectively. Surfactin-induced cell death was considered to be apoptotic by observi...
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PMID: 19669740
PDF is available here.
PDF is available here.
Cell and Tissue Research (338)2 2009
Abstract
We have found high expression of TSLP in the epithelium from patients with allergic rhinitis with recruitment and infiltration of DCs. In vitro, TSLP is significantly produced in HNECs after treatment with a toll-like receptor 2 (TLR2) ligand, Pam(3)Cys-Ser-(Lys)(4), and a mixture of interleukin-1be...
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PMID: 19763625
PDF is available here.
PDF is available here.
Abstract
We evaluated both the short-and long-term efficacy of micafungin in patients with chronic pulmonary aspergillosis (CPA). We treated 26 patients with CPA, 19 with chronic necrotizing pulmonary aspergillosis (CNPA) and 7 with aspergilloma, with micafungin between February 2003 and September 2005. On c...
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PMID: 19994592
PDF is available here.
PDF is available here.
Abstract
Water-soluble lipopolymers and lipopeptides are nonviral gene-transfer reagents that combine the advantages of lipids, which increase permeability of DNA through cell membranes, with the DNA-condensing and enhanced endosomal release properties of polycations. This protocol describes the synthesis an...
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PMID: 20147051
PDF is available here.
PDF is available here.
Abstract
We evaluated the use of micafungin as a prophylaxis in very-low-birth-weight infants. Micafungin was first administered to 25 very-low-birth-weight infants 12 to 24 hours after birth at a dose of 1 mg/kg/d. the apparent volume of distribution, the apparent elimination rate constant, the elimination...
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PMID: 19636279
PDF is available here.
PDF is available here.
Abstract
We report that radicicol, a heat shock protein 90 (Hsp90) inhibitor, reduces the paradoxical effect of micafungin. We also confirm that radicicol reduces the tolerance to voriconazole, one of the new azoles, which is consistent with a previous report. Our results may therefore imply that common stre...
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PMID: 19762993
PDF is available here.
PDF is available here.
Abstract
Bacillus subtilis fmbR-1 was obtained from wild-type B. subtilis fmbR by replacement of the native promoter of the surfactin operon with the inducible promoter Pspac. The recombinant B. subtilis fmbR-1 produced more antibacterial substances than the wild-type strain. The overproducing phenotype was...
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PMID: 19898540
PDF is available here.
PDF is available here.
Endocrinology (150)8 2009
Abstract
We examined the antiinflammatory effects of PIO on TLR2 and TLR4 expression in human monocytes exposed to Pam3CSK4 (Pam; TLR2 ligand) and purified lipopolysaccharide (LPS; TLR4 ligand) using flow cytometry and real-time RT-PCR. Monocytes were isolated from healthy human volunteers and pretreated wit...
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PMID: 19389833
PDF is available here.
PDF is available here.
Prescrire international (18)102 2009
Abstract
Abstract
We bring together recent published and unpublished data that illuminates the status of epitope-based herpes vaccine development and present an overview of our recent approach to an 'asymptomatic epitope'-based lipopeptide vaccine....
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PMID: 19627185
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (102)1 2009
Abstract
We investigated these processes after immune versus thrombotic platelet stimulation. We examined selected signalling pathways and found that phosphorylation kinetics of Akt, ERK1/2 and p38 differed dramatically between agonists. Next, we investigated platelet protein-protein interactions by mass spe...
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PMID: 19572074
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of surfactin on antigen-presenting property of macrophages. Thioglycollate-elicited mouse peritoneal macrophages were tested for surface molecule expression, cytokine production, phagocytosis, capacity to induce T cell activation by mixed lymphocyte reaction, and underlyin...
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PMID: 19336264
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of surfactin on antigen-presenting property of macrophages. Thioglycollate-elicited mouse peritoneal macrophages were tested for surface molecule expression, cytokine production, phagocytosis, capacity to induce T cell activation by mixed lymphocyte reaction, and underlyin...
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PMID: 19336264
PDF is available here.
PDF is available here.
Abstract
A 72-year-old man was admitted to our hospital because of a low grade fever and malaise. He had received a middle to lower esophagectomy and proximal gastrectomy with reconstruction of a gastric conduit for esophageal cancer 12 years previously. Chest X-ray and CT scan revealed massive pleural effus...
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PMID: 19601522
PDF is available here.
PDF is available here.
Abstract
These data suggest that 15 mg/kg dosing in premature neonates corresponds to an exposure of approximately 5 mg/kg in adults. No adverse events related to micafungin were observed....
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PMID: 19319022
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)6 2009
Abstract
We found three peptide antibiotics, leucinostatin (A and B), alamethicin I and tsushimycin, which exhibited potent or moderate antitrypanosomal activity. We report here the in vitro and in vivo antitrypanosomal properties and cytotoxicities of leucinostatin A and B, alamethicin I and tsushimycin com...
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PMID: 19407848
PDF is available here.
PDF is available here.
Abstract
We identified and analyzed the operon Bac in Bs-916 responsible for synthesis of iturin-like lipopeptides. The research plays an important part in genetic engineered Bs-916 for further improving its bio-control activity. Taking advantage of homologous recombination method, the one mutant obtained by...
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PMID: 19621630
PDF is available here.
PDF is available here.