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Sterols (9):
Recent article
Sterols
Abstract
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Abstract
We do not have a clear picture of their precise intracellular localization. Advances in lipidomics and subcellular fractionation should help to improve this situation. Genetic approaches have provided insights into the diversity of sterol and sphingolipid functions in eukaryotes providing evidence t...
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PMID: 21454248
PDF is available here.
PDF is available here.
Abstract
Voluntary wheel running increased cholesterol turnover in healthy mice owing to an increased fecal bile acid excretion and a decreased intestinal cholesterol absorption. Enhanced cholesterol turnover may contribute to the established reduction of cardiovascular risk induced by regular exercise....
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PMID: 20139791
PDF is available here.
PDF is available here.
Abstract
We characterized the sterol-response element and NF-Y (nuclear factor Y)-binding site in the human FDPS promoter. Using a luciferase assay, electrophoretic mobility-shift assay and chromatin immunoprecipitation assay, we demonstrated that these elements are responsible for the transcription of the F...
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PMID: 20450493
PDF is available here.
PDF is available here.
Abstract
Six new furostanol saponins (1-6), named fistulosaponins A-F, three known furostanol saponins (7-9), and seven known aromatic compounds were isolated from seeds of Welsh onion (Allium fistulosum). The structures of these compounds were characterized by spectroscopic analyses including 2D NMR spectro...
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PMID: 20515043
PDF is available here.
PDF is available here.
Abstract
We present a combination chemical genetic study to explore how the sterol and protein prenylation pathways work together to affect hepatitis C viral replication in a replicon assay. In addition to finding novel targets affecting viral replication, our data suggest that the viral replication is stron...
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PMID: 20531405
PDF is available here.
PDF is available here.
Abstract
We synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity.
Copyright 2010 Elsevier Ltd. All rights reserved....
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PMID: 20409710
PDF is available here.
PDF is available here.
Chemistry and Physics of Lipids (163)4-5 2010
Abstract
We systematically studied the preferential solubilization of cholesterol and sterol/stanol in sodium taurodeoxycholate solutions using relatively minor plant species of sterol/stanol (brassicasterol and stigmasterol) and a non-plant sterol (cholestanol). As relatively major sterol/stanol species (be...
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PMID: 20346931
PDF is available here.
PDF is available here.
Biochemistry (New York) (75)5 2010
Abstract
We showed that nystatin induced changes in the ratios of molecular species of glycoceramides. It was suggested that the modification of the sterol component of plasma membrane could influence membrane functioning by changing the sphingolipid composition of lipid rafts....
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PMID: 20632933
PDF is available here.
PDF is available here.
Abstract
Steroidogenic acute regulatory protein (StAR)D4 is a member of the StAR related lipid transfer family. Homology comes from the approximately 210 amino acid lipid binding domain implicated in intracellular transport, cell signaling, and lipid metabolism. StARD4 was identified as a gene downregulated 2...
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PMID: 19965609
PDF is available here.
PDF is available here.
Abstract
While plasma membrane cholesterol-rich microdomains play a role in cholesterol trafficking, little is known about the appearance and dynamics of cholesterol through these domains in living cells. The fluorescent cholesterol analog 6-dansyl-cholestanol (DChol), its biochemical fractionation, and confo...
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PMID: 20008119
PDF is available here.
PDF is available here.
Abstract
The affinity of amphidinol 3 (AM3) to phospholipid membranes in the presence and absence of sterol was examined by surface plasmon resonance (SPR) experiments. The results showed that AM3 has 1000 and 5300 times higher affinity for cholesterol- and ergosterol-containing liposomes, respectively, than...
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PMID: 20207137
PDF is available here.
PDF is available here.
Abstract
NMR spectroscopy was employed for the detection of adulteration of refined olive oil with refined hazelnut oil. Fatty acids and iodine number were determined by (1)H NMR, whereas (31)P NMR was used for the quantification of minor compounds including phenolic compounds, diacylglycerols, sterols, and...
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PMID: 20152467
PDF is available here.
PDF is available here.
Abstract
A new scalarane sesterterpene, phyllofolactone M (1), and a new sterol, (24E)-5alpha,6alpha-epoxystigmasta-7,24(28)-dien-3beta-ol (3), together with a known sesterterpene, phyllofolactone B (2), were isolated from the South China Sea sponge Phyllospongia foliascens. Their structures were elucidated...
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PMID: 20335950
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)2 2010
Abstract
We investigated this by feeding the hyperlipidemic Sprague-Dawley rats, caused by a high cholesterol diet, with lyophilized powder of spider brake (LSB) and compared the result with the rats fed with beta-sitosterol. The results indicated that the administration of lyophilized powder of spider brake...
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PMID: 20645845
PDF is available here.
PDF is available here.
Abstract
Cell Metabolism (11)2 2010
Abstract
We used a global approach to identify proteins that are differentially expressed when macrophages are loaded with cholesterol in vivo. Our analysis revealed a sterol-responsive network that is highly enriched in proteins with known physical interactions, established roles in vesicular transport, and...
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PMID: 20142100
PDF is available here.
PDF is available here.
Pediatric Research (67)2 2010
Abstract
Current guidelines strongly recommend the identification of genetic forms of hypercholesterolemia (HC) during childhood.The usefulness of non-cholesterol sterols (NCS) in the diagnosis of genetic HC has not been fully explored. Plasma NCS were measured by gas chromatography/mass spectrometry (GC/MS)...
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PMID: 20091938
PDF is available here.
PDF is available here.
Free Radical Research (44)1 2010
Abstract
Oxysterols are oxygenated derivatives of cholesterol generated from exogenous (food) or endogenous (auto-oxidation and enzymatic conversion) sources. Despite their hepatic capacity to transform into bile acids, oxysterols are present in the blood circulation and central nervous system. This review a...
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PMID: 19939198
PDF is available here.
PDF is available here.
Abstract
We examined pyrolysates from polyisoprenes, polyprenols, carotenoids, ubiquinone (CoQ-10), and sterols by pyrolysis gas chromatography/mass spectrometry (PyGC/MS) and determined that the amounts of isoprene and limonene released from polyprenols and polyisoprenes were dependent upon their molecular...
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PMID: 20057156
PDF is available here.
PDF is available here.
Mikrobiologiia (79)1 2010
[Lipid composition of zygomycetous fungi Blakeslea trispora under stimulation of lycopene synthesis]
Abstract
Abstract
We isolated a new noroleanane-type triterpene, pfaffianol A, its glycosides, pfaffiaglycosides A and B, and ecdysterone-type sterol glycosides, pfaffiaglycosides C, D, and E, together with eight known constituents. The structures of new constituents were determined on the basis of physicochemical an...
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PMID: 20460798
PDF is available here.
PDF is available here.
Abstract
Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following die...
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PMID: 20533244
PDF is available here.
PDF is available here.
Journal of Cell Science (123)Pt 1 2010
Abstract
We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12 Delta. Cells carrying the temperature-sensitive brr6-1 allele have been shown to have defects in nucleoporin localization, mRNA metabolism and nuclear transport. Electron microscopy...
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PMID: 20016074
PDF is available here.
PDF is available here.
Abstract
Deregulated translation initiation is implicated extensively in cancer initiation and progression. Several translation initiation factors cooperate with known oncogenes, are elevated in human tumors and have been implicated in drug resistance. Consequently, there is a great deal of i...
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PMID: 21425987
PDF is available here.
PDF is available here.
FEBS Journal (276)24 2009
Abstract
We demonstrated that Ste20p forms a complex with Erg4p, Cbr1p and Ncp1p, which all catalyze important steps in sterol biosynthesis. CLA4 interacts genetically with ERG4 and NCP1. Furthermore, Erg4p, Ncp1p and Cbr1p play important roles in cell polarization during vegetative growth, mating and filame...
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PMID: 20050180
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the constituents of the stems of Periploca forrestii. METHOD: The compounds were separated and purified by silica gel column chromatography, recrystallization and high-performance liquid chromatography. The structures were identified by various spectroscopic methods. RESULT: Nine...
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PMID: 20353006
PDF is available here.
PDF is available here.
Abstract
One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic acti...
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PMID: 20162396
PDF is available here.
PDF is available here.
Abstract
An activity-guided fractionation method was used to isolate anticancer components from Nuruk (Rhizopus oryzae KSD-815:KSD-815). Dried powder of KSD-815 was extracted with 80% methanol and partitioned successively using nhexane, ethyl acetate, n-butanol, and water. The n-hexane and n-butanol fraction...
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PMID: 19996683
PDF is available here.
PDF is available here.
Abstract
Plant cell culture has been developed as an alternative method for the production of an anticancer drug, paclitaxel. However, the sensitivity of plant cells to shear stress has been one of the main obstacles to the scale-up of the plant cell culture. To gain a better understanding of the mechanism o...
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PMID: 19531028
PDF is available here.
PDF is available here.
Abstract
We also conclude from the liposome oxidations that linoleate peroxyl radicals at different positions on the eighteen-carbon chain (at C-9 and C-13) have different kinetic properties. This is in contrast to the results of solution oxidations of linoleate in which the C-9 and C-13 peroxyl radicals hav...
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PMID: 19705847
PDF is available here.
PDF is available here.
Abstract
These results provide insight into the clinical utility of combining efflux pump inhibitors with current antifungals to combat the resistance associated with opportunistic fungal infections caused by C. albicans....
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PMID: 19653640
PDF is available here.
PDF is available here.
Abstract
I (SR-BI). The present study aimed to determine the metabolic effects of an endothelial lipase (EL)-mediated stimulation of HDL cholesterol uptake on liver lipid metabolism and biliary cholesterol secretion in wild-type, SR-BI knockout, and SR-BI overexpressing mice. In each model, injection of an E...
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PMID: 19252221
PDF is available here.
PDF is available here.
Abstract
Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spe...
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PMID: 19467602
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1791)7 2009
Abstract
We review the cellular mechanisms implicated in cholesterol trafficking and distribution. Recent studies have provided new information about the distribution of sterols within cells, including analysis of its transbilayer distribution. The cholesterol interaction with other lipids and its engagement...
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PMID: 19286471
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (326)1-2 2009
Abstract
We studied endoplasmic reticulum (ER)-to-plasma membrane (PM) sterol transport in OSH deletion mutants lacking one, several, or all Osh proteins. In conditional OSH mutants, ER-PM ergosterol transport slowed approximately 20-fold compared with cells expressing a full complement of Osh proteins. Alth...
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PMID: 19125315
PDF is available here.
PDF is available here.
Abstract
Empirical data providing evidence for a colimitation of an herbivore by two or more essential nutrients are scarce, particularly in regard to biochemical resources. Here, a graphical model is presented, which describes the growth of an herbivore in a system with two potentially limiting resources. T...
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PMID: 19324803
PDF is available here.
PDF is available here.
Abstract
We have shown recently that specific inhibition of TC sterol 14alpha-demethylase (TCCYP51) with imidazole derivatives is effective in killing both extracellular and intracellular human stages of TC. An alternative set of TCCYP51 inhibitors has been identified using optical high throughput screening...
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PMID: 19354253
PDF is available here.
PDF is available here.
Abstract
The purpose of this work was to examine the possible involvement of yeast membrane components in the adsorption of browning compounds from oxidized white wine. For this purpose, different yeast strains and growth conditions (aerobiosis and anaerobiosis) were tested for their ability to prevent brown...
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PMID: 19326869
PDF is available here.
PDF is available here.
Abstract
An unusual sterolic mixture (82.3% of 24-isopropylated sterols) and its major component, 24-isopropylcholesterol, isolated from a marine sponge, Ciocalypta sp. (Halichondriidae), reduce cholesterol uptake, basolateral secretion and ACAT-2 mRNA expression and increase the expression of ABCA1 mRNA in...
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PMID: 19160412
PDF is available here.
PDF is available here.
Abstract
We analyzed the effect of cholesterol deficiency on the transcriptome in Neuro2a cells. Transient down-regulation of Dhcr7 by siRNA led to altered expression of multiple molecules that play critical roles in intracellular signaling or vesicular transport or are inserted into membrane rafts (e.g. Egr...
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PMID: 18951487
PDF is available here.
PDF is available here.
Abstract
A series of 25 compounds, some of which previously were described as inhibitors of human liver microsomal oxidosqualene cyclase (OSC), were tested as inhibitors of Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana OSCs expressed in an OSC-defective strain of...
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PMID: 19119009
PDF is available here.
PDF is available here.
Abstract
These results have led the authors to suggest that for some components the PMM resembles the MM lining the midgut cells of R. prolixus, composing a system which covers the microvilli and stretches to the luminal space....
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PMID: 18602023
PDF is available here.
PDF is available here.
Abstract
A new 4alpha-methyl sterol, 4alpha-methyl-ergosta-6,8(14),22E-triene-3beta-ol (1), was isolated along with cholesterol from a Nephthea sp. Bornean soft coral The structure of compound 1 was elucidated on the basis of spectroscopic analysis and comparison of the data with those of the related compoun...
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PMID: 19783930
PDF is available here.
PDF is available here.
Journal of Oleo Science (58)1 2009
Abstract
Previous studies have reported that O/W emulsion prepared using a surfactant with phytosterol as the hydrophobic moiety exhibited unique morphology; a lamellar structure was present on the surface of the emulsified particles. It is suggested that such a unique self-organized structure was due to the...
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PMID: 19075505
PDF is available here.
PDF is available here.
Journal of Oleo Science (58)2 2009
Abstract
Kluyveromyces lactis strain M-16 isolated from raw milk accumulates a high amount of steryl glucoside in the cells. Under high temperature or in the presence of NaCl, this strain did not show better growth than other K. lactis strains that hardly accumulated steryl glucoside. Heat shock elevated the...
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PMID: 19145063
PDF is available here.
PDF is available here.
Abstract
We describe the variables that affect the three major elements of the model: the conformational flexibility of the unliganded (apo) protein, the flexibility of the VDS, and the physicochemical selectivity of the VDR genomic pocket (VDR-GP) and alternative pocket (VDR-AP). We also discuss how these t...
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PMID: 19531804
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the chemical constituents of the red alga Acanthophora spicifera boergesen aiming at searching for bioactive leading compounds. METHOD: Compounds were isolated by various chromatographic techniques including column chromatography over normal phase silica gel and Sephadex LH-20 ge...
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PMID: 19382453
PDF is available here.
PDF is available here.
Abstract
Four new furostanol saponins (1-4), two pairs of diastereoisomers, were isolated from methanolic extracts of Tupistra chinensis rhizomes and their structures were assigned from (1)H and (13)C NMR spectra, DEPT, and by 2D COSY, NOESY, HMQC, and HMBC experiments.
2008 John Wiley & Sons, Ltd.
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PMID: 19003938
PDF is available here.
PDF is available here.
Abstract
The present review summarizes experimental data revealed while studying the mechanism of the adaptogenic effect of furostanol glycosides (FG) extracted from Dioscorea deltoidea Wall cell culture under the conditions of biotic stress in tomato plants Lycopersicon esculenium Mill. induced by the gall...
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PMID: 19845281
PDF is available here.
PDF is available here.
Abstract
We studied the effects of PLE alone and in combination with fluconazole (FLC) on the ergosterol biosynthetic pathway against both FLC-sensitive and FLC-resistant strains by analyzing the sterol content and the ergosterol pathway gene (ERG) expression. Relative quantitative analysis of different ergo...
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PMID: 19122277
PDF is available here.
PDF is available here.
Plant Journal (57)1 2009
Abstract
Auxin transport is mediated at the cellular level by three independent mechanisms that are characterised by the PIN-formed (PIN), P-glycoprotein (ABCB/PGP) and AUX/LAX transport proteins. The PIN and ABCB transport proteins, best represented by PIN1 and ABCB19 (PGP19), have been shown to coordinatel...
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PMID: 18774968
PDF is available here.
PDF is available here.
Abstract
A series of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine were synthesized and evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved and the best results were obta...
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PMID: 19005944
PDF is available here.
PDF is available here.
Abstract
Mitochondrial porins (voltage-dependent anion-selective channels, VDAC) are key contributors to cellular metabolism. When isolated from mitochondria porins copurify with sterols, and some isolated forms of the protein require sterol for insertion into artificial membranes. Nonetheless, the contribut...
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PMID: 19088801
PDF is available here.
PDF is available here.
Journal of Hepatology (49)6 2008
Abstract
Homeostasis of cholesterol metabolism was maintained only in ALF. Metabolism of phytosterols was equal in study groups. PBC- and ALF-patients have differential patterns in their serum sterols and cholesterol metabolism....
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PMID: 18926587
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (46)12 2008
Abstract
The coconut water presents a series of nutritional and therapeutic properties, being a natural, acid and sterile solution, which contains several biologically active components, l-arginine, ascorbic acid, minerals such as calcium, magnesium and potassium, which have beneficial effects on lipid level...
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PMID: 18809454
PDF is available here.
PDF is available here.
Abstract
We showed that cholera toxin subunit B (CTB), which binds the glycosphingolipid, GM1, localizes to this same domain in live sperm. Interestingly, the GM1 undergoes an unexplained redistribution upon cell death. We now demonstrate that GM1 is also enriched in the acrosome, an exocytotic vesicle. Tran...
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PMID: 19012288
PDF is available here.
PDF is available here.
Abstract
We utilized a non-detergent-based method, separating membrane fractions that were reproducibly distinct based on sterol, GM1, phospholipid, and protein compositions (both mass amounts and molar ratios). Based on fraction buoyancy and biochemical composition, we identified at least three highly repro...
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PMID: 19006178
PDF is available here.
PDF is available here.
Abstract
We employed atomistic simulations and experiments to characterize a cholesterol compound with fluorescent boron dipyrromethene difluoride linked to sterol carbon-24 (BODIPY-cholesterol). This probe packed in the membrane and behaved similarly to cholesterol both in normal and in cholesterol-storage...
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PMID: 18647169
PDF is available here.
PDF is available here.
Chemistry and Physics of Lipids (156)1-2 2008
Abstract
Sponges are sessile suspension-feeding organisms whose internal phylogenetic relationships are still the subject of intense debate. Sterols may have the potential to be used as independent markers to test phylogenetic hypotheses. Twenty representative specimens of calcareous sponges (class Calcarea,...
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PMID: 18671957
PDF is available here.
PDF is available here.