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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Lipids (18):
Recent article
Lipids
Journal of Biological Chemistry (286)40 2011
Abstract
We report that lipopolysaccharide (LPS) and Pam(3)CysSerLys(4) exerted more profound effects on release of the proinflammatory cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNFα), in glia prepared from CD200(-/-) mice compared with wild type mice. This effect is explained by...
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PMID: 21835925
PDF is available here.
PDF is available here.
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Abstract
We examined the association between ambulatory activity and biological markers of health in smokers.
Baseline data from 985 subjects enrolled in a pharmacologic smoking cessation trial were examined. Body size, blood pressure, total cholesterol (TC), low density lipoprotein cholester...
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PMID: 21885891
PDF is available here.
PDF is available here.
Journal of Chromatography B (879)24 2011
Abstract
We investigated and compared the profiles of metabolites in nude mice with alcohol-induced liver injury or bearing a HCC xenograft (HCCX). Alcohol-induced liver injury was achieved by daily administration of grain liquor, and HCC xenografts were generated by subcutaneous inoculation of HepG2 cells i...
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PMID: 21763219
PDF is available here.
PDF is available here.
Abstract
We discovered that curcuminoids were mainly present as glucuronides in plasma, whereas in free form in tumor tissue. A validated LC/MS/MS method was established to determine the three free curcuminoids in tumor homogenate. Samples were separated on a Zorbax SB-C(18) column, eluted with acetonitrile-...
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PMID: 21856253
PDF is available here.
PDF is available here.
Abstract
This study aimed to examine the participation of Australian Chinese in cardiovascular risk factor and cancer screening.
A telephone survey of a random sample of Chinese in New South Wales, Australia, was conducted. The presence of, and participation in screening for,...
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PMID: 21819359
PDF is available here.
PDF is available here.
Abstract
We discuss the various modes of intramembrane protein-lipid interactions in cellular membranes, including examples for both annular and nonannular bound lipids. Furthermore, we will discuss possible functional roles of such specific protein-lipid interactions as well as roles of lipids as chaperones...
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PMID: 21536707
PDF is available here.
PDF is available here.
Transplantation (91)9 2011
Abstract
Cardiovascular disease, the most common cause of death with a functioning graft among kidney transplant recipients, can be exacerbated by immunosuppressive drugs, particularly the calcineurin inhibitors. Belatacept, a selective co-stimulation blocker, may provide a better cardiovascu...
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PMID: 21372756
PDF is available here.
PDF is available here.
Abstract
Our results showed that this sPLA(2) induced a marked increase in LB numbers in macrophages, induced the recruitment of ADRP in macrophages, and up-regulated ADRP expression. Ultrastructural analysis showed the presence of weakly and strongly osmiophilic LBs in sPLA(2)-stimulated cells. Enlargement...
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PMID: 21478270
PDF is available here.
PDF is available here.
Abstract
It has been shown that elevated levels of alanine and aspartate aminotransferases (ALT and AST) are associated with insulin resistance and type 2 diabetes mellitus; however, the pattern of this association in diabetic patients with negative or mild steatosis is not well understood. T...
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PMID: 21091060
PDF is available here.
PDF is available here.
Abstract
We used an 18-gauge open-flow microperfusion (OFM) catheter to induce local inflammation in the subcutaneous adipose tissue (SAT) of healthy volunteers and to sample interstitial fluid (IF) specifically from the inflamed tissue. In two crossover studies, nine subjects received either an intravenous...
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PMID: 21088675
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits...
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PMID: 21258713
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits...
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PMID: 21258713
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed various obesity-related experiments in vitro and in vivo. In adipogenesis assay, LFE blocked the differentiation of 3T3-L1 preadipocyte in a dose-dependent manner with an IC50 of 2.5 μg/ml. In addition, LFE suppressed the expression of lipogenic genes, while increasing the expression o...
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PMID: 21389766
PDF is available here.
PDF is available here.
Molecular Therapy (19)3 2011
Abstract
A major hurdle for harnessing small interfering RNA (siRNA) for therapeutic application is an effective and safe delivery of siRNA to target tissues and cells via systemic administration. While lipid nanoparticles (LNPs) composed of a cationic lipid, poly-(ethylene glycol) lipid and...
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PMID: 21179008
PDF is available here.
PDF is available here.
Abstract
Our primary goal was to determine whether OPG provided independent prognostic information in patients with chronic HF, and to examine its potential interactions with statin therapy.
OPG as a risk factor for the primary end point (cardiovascular death, nonfatal myocardial infarction,...
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PMID: 21216833
PDF is available here.
PDF is available here.
Abstract
To measure the changes in subcutaneous and intra-abdominal fat and other metabolic parameters in patients with psychotic disorders, who were newly started on olanzapine treatment and in drug-free controls. The correlation between changes in visceral fat and other metabolic parameters...
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PMID: 21837851
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate the effect of exenatide on fat deposition and a metabolic profile in patients with metabolic syndrome.
An uncontrolled, open clinical study was carried out in 10 patients with metabolic syndrome and without pharmacological treatme...
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PMID: 20874425
PDF is available here.
PDF is available here.
Abstract
In an effort to develop an alternative formulation of paclitaxel (PTX) suitable for intravenous administration, PTX-loaded sterically stabilized solid lipid nanoparticles (SLNs) were prepared and their pharmacokinetics and biodistribution were investigated. The pegylated SLNs were comprised of trimyr...
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PMID: 21380818
PDF is available here.
PDF is available here.
Abstract
A statistically significant extension of contrast circulation time was observed for animals breathing medical air compared to breathing pure oxygen. Simulations support experimental observations and indicate that enhanced contrast persistence may be explained by reduced ventilation/perfusion mismatc...
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PMID: 21246710
PDF is available here.
PDF is available here.
Natural Product Reports (28)1 2011
Abstract
Chlorosulfolipids have been isolated from freshwater algae and from toxic mussels. They appear to have a structural role in algal membranes and have been implicated in Diarrhetic Shellfish Poisoning. Further fascinating aspects of these compounds include their stereochemically complex polychlorinate...
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PMID: 21125121
PDF is available here.
PDF is available here.
Abstract
We also present methods for the determination of compositions of constituent fatty acids, distribution of fatty acids between sn-1 and sn-2 positions, and determination of contents of individual lipid classes by gas-liquid chromatography. These methods are applicable to isolated chloroplasts or some...
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PMID: 20960124
PDF is available here.
PDF is available here.
Abstract
The cytochrome b6f complex from the filamentous cyanobacteria (Mastigocladus laminosus, Nostoc sp. PCC 7120) and spinach chloroplasts has been purified as a homo-dimer. Electrospray ionization mass spectroscopy showed the monomer to contain eight and nine subunits, respectively, and dimeric masses o...
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PMID: 20960122
PDF is available here.
PDF is available here.
Abstract
We have shown that hESCs can be stably transfected with a plasmid in which expression of the green fluorescent protein (GFP) is under the control of the Oct-4 promoter using chemical transfection. The expression pattern of transgenic Oct-4-GFP reflects that of endogenous Oct-4....
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PMID: 21042987
PDF is available here.
PDF is available here.
Abstract
We developed a model to examine cardiometabolic plasticity (i.e., changes in Si and plasma lipids) in MA compared to NHW adults in response to a diet-exercise intervention.
Sedentary subjects (20 NHW: 11F, 9M, 23.0 y, 25.5 kg/m(2); 17 MA: 13F, 4M, 22.7 y, 25.4 kg/m(2)) consumed their...
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PMID: 21364957
PDF is available here.
PDF is available here.
Abstract
We determined the mutually independent quantitative contributions of IA and liver fat to components of the syndrome, fasting serum (fS) insulin, and liver enzymes and measures of hepatic insulin sensitivity in 356 subjects (mean age 42 years, mean BMI 29.7 kg/m²) in whom liver fat and abdominal fat...
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PMID: 20539297
PDF is available here.
PDF is available here.
Abstract
We sought to compare the predictive value of various lipid measures for coronary events and to further examine the incremental value of novel lipid parameters over traditional cardiovascular risk factors in estimating cardiac risk.
We performed a post-hoc analysis of the National Hea...
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PMID: 21392721
PDF is available here.
PDF is available here.
Abstract
We orally infected C57BL/6 and C57BL/6.KOR-Apoe(shl) (B6.Apoeshl) mice with Porphyromonas gingivalis, which is a representative periodontopathic bacterium, and evaluated atherogenesis, gene expression in the aorta and liver and systemic inflammatory and lipid profiles in the blood. Furthermore, the...
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PMID: 21625524
PDF is available here.
PDF is available here.
Abstract
We have evaluated the immunostimulatory role of the highly-conserved outer membrane lipoprotein P6 from non-typeable Haemophilus influenzae (NTHI) to determine whether the presence of the lipid motif plays a critical role on its immunogenicity. We undertook a systematic analysis of the role that the...
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PMID: 21611194
PDF is available here.
PDF is available here.
Abstract
We present a detailed AFM study on multilayered dry lipid films prepared from aqueous vesicle suspensions. Different preparation techniques were applied in order to optimize the preparation of homogeneous lipid films of various film thicknesses. Suspensions of preformed DOPC/DPPC vesicles were adsor...
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PMID: 20832257
PDF is available here.
PDF is available here.
Tsitologiia (53)5 2011
Abstract
Epithelium of the hepatic region of the intestine in Saccoglossus mereschkowskii, a representative of enteropneusts (Enteropneusta, Hemichordata) standing at the base of Chordata, has been investigated using electron microscope. The ultrastructure of ciliated and granular epithelial cells, elements o...
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PMID: 21786687
PDF is available here.
PDF is available here.
Hepato-gastroenterology (58)107-108 2011
Abstract
To investigate the early effects of peginterferon alpha-2b plus ribavirin therapy on blood pressure and related cardiovascular risk parameters, and also insulin resistance in patients with chronic hepatitis C virus (HCV) infection.
Twenty-nine patients with chronic he...
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PMID: 21830408
PDF is available here.
PDF is available here.
British Journal of Nutrition (105)1 2011
Abstract
Optimum levels and types of dietary fibre that provide the greatest beneficial effects on metabolic syndrome risk factors in overweight and obese individuals have yet to be determined in clinical trials. The present parallel design study compared the effects of fibre intake from a healthy diet v. a...
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PMID: 20727237
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)4 2011
Abstract
These results indicated that ASX could ameliorate diabetic endothelial dysfunction by inhibiting the ox-LDLLOX-1-eNOS pathway. Treatment with ASX might be clinically useful for diabetic complications associated with endothelial dysfunction....
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PMID: 21650083
PDF is available here.
PDF is available here.
Abstract
This study was aimed at examining the therapeutic effects of marine collagen peptides (MCPs) from fish hydrolysate in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 100 diabetic patients and 50 healthy controls were recruited. Diabetic patients were randomized into...
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PMID: 21164551
PDF is available here.
PDF is available here.
Abstract
We retrospectively investigated serial intravascular ultrasound (IVUS) findings in 380 peri-stent reference segments (184 proximal and 196 distal to the stent) in 196 patients (simvastatin group, n = 132 vs. non-statin group, n = 64). Quantitative volumetric IVUS analysis was performed in 5-mm vesse...
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PMID: 21179272
PDF is available here.
PDF is available here.
Bioresource Technology (101)23 2010
Abstract
The prospects of utilizing pretreated seawater for the culture of Arthrospira (Spirulina) platensis was evaluated under laboratory conditions with three seawater media and a control: (1) Zarrouk media (freshwater-control) (2) seawater media SW 1 (3) seawater media SW2 and (4) seawater media SW 3. Th...
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PMID: 20655201
PDF is available here.
PDF is available here.
Acta clinica Croatica (49)4 2010
Abstract
Recent evidence suggests that lower HDL-cholesterol (HDL-C) may worsen the atherosclerotic process by promoting inflammation and progression from subclinical lesion to clinical event. Carotid intima-media thickness (CIMT) is recognized as a marker of early atherosclerosis and used to...
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PMID: 21830454
PDF is available here.
PDF is available here.
Clinical Nephrology (74)6 2010
Abstract
Our goal was therefore not only to establish the frequency but also the severity of exocrine pancreatic insufficiency in hemodialysis patients.
the study included 50 hemodialysis patients with no history of acute or chronic pancreatitis or upper abdominal symptoms of uncertain origin. All patients w...
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PMID: 21084049
PDF is available here.
PDF is available here.
Abstract
To study the utility of high-resolution spectral domain optical coherence tomography (HR SOCT) in imaging the contact lens (CL) to cornea relationships with advanced CL designs for ecstatic corneas and corneal refractive therapy.
Copernicus HR SOCT (Optopol Technology SA, Zawiercie, Poland) was used...
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PMID: 20847664
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)11 2010
Abstract
Bitter gourd (BG, Momordica charantia) exerts proven blood glucose- and body weight-lowering effects. To develop an effective and safe application, it is necessary to identify the bioactive compounds and biochemical mechanisms responsible for these effects in type 2 diabetes. A total of forty-five 4...
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PMID: 20615270
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)11 2010
Abstract
We investigated the effects of supplementation with EPA (1 g/kg body weight per d) or fish oil (3 g/kg body weight per d) on the age of onset of T2DM and circulating glucose, insulin, lipids, leptin and adiponectin in UC Davis (UCD)-T2DM rats. Animals were divided into three groups starting at 1 mon...
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PMID: 20735878
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
We investigated whether the epidural space can be identified with optical spectroscopy, using a custom needle with optical fibers integrated into the cannula.
Insertion of the needle tip into the epidural space was performed with midline and paramedian approaches in a swine. In each insertion, optic...
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PMID: 21068654
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
A microfluidic device is presented for the serial formation, storage and retrieval of water microdroplets in oil. The principle of operation is similar to that of an electronic shift register. Droplets, considered as units of information, can be arrayed and serially shifted within the device, allowi...
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PMID: 20856984
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
A series of new (phenoxyethyl)aminoalkanol derivatives were synthesized and evaluated for their anticonvulsant activity. The most promising compound seemed to be (R,S)-1N-[(2,6-dimethyl)phenoxyethyl]amino-2-butanol, which displayed anti-MES activity (in mice, i.p.) with protective index (TD(50) /ED(...
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PMID: 20662109
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
A new class of amphiphilic dendrimers, which can be readily adsorbed on the surface of singlewalled carbon nanotubes (SWNTs) to improve their dispersibility in aqueous medium, were synthesized. The adsorbed dendrimers can be replaced by other amphiphiles, such as sodium dodecylbenzene sulfonate (SDB...
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PMID: 20838696
PDF is available here.
PDF is available here.
Experimental Cell Research (316)19 2010
Abstract
We characterize here ORP11, a member of the oxysterol-binding protein family. ORP11 is present at highest levels in human ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Immunohistochemistry demonstrates abundant ORP11 in the epithelial cells of kidney tubules, testicular tubules,...
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PMID: 20599956
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We show that PhoPN, on its own, demonstrates PhoR-dependent phosphorylation. PhoPC, the truncated variant bearing the DNA binding domain, binds in vitro to the target site with affinity similar to that of the full-length protein. To complement the finding that residues spanning Met(1) to Arg(138) of...
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PMID: 20814030
PDF is available here.
PDF is available here.
Abstract
We have noted a distinctive histologic variant that we have termed steatohepatitic hepatocellular carcinoma (SH-HCC) with features resembling non-neoplastic steatohepatitis, including large droplet steatosis, ballooning of malignant hepatocytes, Mallory-Denk bodies, inflammation, and pericellular fi...
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PMID: 20975341
PDF is available here.
PDF is available here.
Abstract
We utilized the novel technique of imaging mass spectrometry (IMS).
We obtained VV tissues from 10 limbs of 10 VV patients who underwent great saphenous vein stripping. As control vein samples, we harvested segmental vein tissues from 6 limbs of 6 patients with peripheral artery occlusive disease wh...
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PMID: 20817502
PDF is available here.
PDF is available here.
Abstract
Pedometer programs can increase physical activity in sedentary individuals, a population that is at risk for developing metabolic syndrome and each of its individual components. Although the popular 10,000 steps/day recommendation has shown to induce many favorable health benefits, it may be out of...
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PMID: 21088304
PDF is available here.
PDF is available here.
Abstract
We review how phosphoinositide metabolism generates multiple second messengers with important roles in T-cell development and function. They include soluble inositol(1,4,5)trisphosphate, long known for its Ca(2+)-mobilizing function, and phosphatidylinositol(3,4,5)trisphosphate, whose generation by...
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PMID: 20943760
PDF is available here.
PDF is available here.
Abstract
This review aims to address the latest research on hepatic desaturases and metabolic disorders, with focus on stearoyl-CoA desaturase-1 (SCD-1) indices in observational studies.
In animal studies, SCD-1 inhibition protects against features of the metabolic syndrome and is associated with improved he...
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PMID: 20823776
PDF is available here.
PDF is available here.
Abstract
To compare the efficacy and safety of generic (Utmos) and original (Actos) 30 mg Pioglitazone tablets.
A multicenter, parallel randomized, double-blinded, controlled study.
Type 2 diabetic patients, with glycosylated hemoglobin (HbA,) > or = 7.0%, who received Metformin not less than 1000 mg/day ove...
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PMID: 21114202
PDF is available here.
PDF is available here.
Abstract
Glucocorticoid (GC) action depends on GC plasma concentration, cellular GC receptor expression, and the pre-receptor hormone metabolism catalyzed by 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-Hydroxysteroid dehydrogenase exists in 2 isoforms; 11β-HSD1 converts inactive cortisone to cortisol...
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PMID: 20688460
PDF is available here.
PDF is available here.
Abstract
We aimed to review evidence on the potential association of ECOC's dietary guidelines to health and disease indices, and to explore research and dietetics' practice perspectives. Eleven publications were identified, providing data from prospective, cross-sectional, and case–control studies co...
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PMID: 20459365
PDF is available here.
PDF is available here.
Bioresource Technology (101)22 2010
Abstract
Activated sludge with its high lipid content is a potential raw material for producing biodiesel. Sub-critical water (SCW) treatment has been known to be a cheap and effective method for reducing organic compounds, especially carcinogenic aromatic compounds such as polycyclic aromatic hydrocarbons o...
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PMID: 20643543
PDF is available here.
PDF is available here.
Waste Management (30)11 2010
Abstract
This study investigates changes in waste microbial community composition and biomass during in situ aeration in laboratory-scale columns over 32 weeks. Microbial profiles were assessed in solid and leachate samples in relation to physical-chemical parameters using phospholipid ester linked fatty aci...
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PMID: 20483579
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)10 2010
Abstract
We performed a parallel, 8-week intervention study in which sixty-eight healthy male volunteers were randomised to consume either a daily meal with 150 g farmed trout raised on either marine or vegetable-based feed, or a reference meal containing 150 g chicken. Twenty-four hour BP, pulse wave veloci...
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PMID: 20594395
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
Ever since the advent of surface plasmon resonance (SPR) and SPR imaging (SPRi) in the early 1990s, their use in biomolecular interaction analysis (BIA) has expanded phenomenally. An important research area in SPR sensor development is the design of novel and effective interfaces that allow for the...
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PMID: 20830330
PDF is available here.
PDF is available here.