Abstract
Lipospheres made from soy bean oil and a combination of the cationic lipid Metafectene and the helper lipid dioleoylphosphatidyl-ethanolamine were functionalized with magnetic nanoparticles (NPs) and small interfering RNA (siRNA). The resulting magnetic lipospheres loaded with siRNA...
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PMID: 20836536
PDF is available here.
Abstract
The aim of this paper is to describe a comprehensive metabolic monitoring strategy within an Australian public mental health service.
Patient physical health was identified as a high priority within the mental health service. A survey of staff attitudes informed the development of metabolic monitori...
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PMID: 20863187
PDF is available here.
Abstract
We hypothesized that physiological cardiovascular disease (CVD) risk factors would influence BP response during exercise in children and adolescents. This is a cross-sectional study of 439 Danish third-grade children and 364 ninth-grade adolescents. Systolic blood pressure (SBP) was measured with sp...
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PMID: 20634358
PDF is available here.
Abstract
We aimed to investigate the relationship between 25(OH)D concentration and insulin-sensitivity, using the glucose clamp technique. In total, 39 subjects with no known history of diabetes mellitus were recruited. The association of 25(OH)D concentration with insulin-sensitivity was evaluated by hyper...
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PMID: 20150902
PDF is available here.
Abstract
To determine the relationship between plasma adiponectin levels and obesity, inflammation, blood lipids and insulin resistance in type 2 diabetics (T2DM) and non-diabetics in a patient population in Trinidad.
A cohort study of a total of 126 type 2 diabetic (42 males...
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PMID: 20580627
PDF is available here.
Abstract
The aim of this study was to evaluate the combined effects of a 10-week exercise program with ingestion of caffeine and epigallocatechin-3-gallate (EGCG) on body composition, cardiovascular fitness, and strength in overweight and obese women. In a double-blind, placebo-controlled app...
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PMID: 20962916
PDF is available here.
Abstract
Although matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS)--often but not exclusively coupled with a time-of-flight (TOF) mass analyzer--is primarily established in the protein field, there is increasing evidence that MALDI MS is also very useful in lipid research: MALDI...
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PMID: 20643161
PDF is available here.
Abstract
The purpose of the study was to assess the impact of alcohol abuse on the composition of serum lipids in patients with tonsillitis. The values of the serum lipid spectrum were studied in 100 alcohol abusers with Streptococcus-induced lacunar tonsillitis, 100 alcoholics without markers of viral hepat...
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PMID: 21162182
PDF is available here.
Abstract
We followed 828 diabetic patients, aged ≥30 years, without baseline CVD and not taking antihypertensive drugs. The hazard ratios (HRs) for CVD were calculated for a 1 standard deviation (SD) change in each BP measure using Cox proportional regression analysis.
During median 8.4 year- follow up, 13...
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PMID: 20496314
PDF is available here.
Abstract
We measured circulating OEA, AEA and 2-AG in patients with sleep apnea (n = 20) and healthy control subjects (n = 57). Respiratory distress index (RDI) as measured by polysomnography was used as a quantitative index of sleep apnea.
In patients with sleep apnea OEA serum concentrations were significa...
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PMID: 20429051
PDF is available here.
Abstract
We have discussed the role of APO E polymorphisms in cerebrovascular and coronary heart diseases. The status of APO E polymorphisms and their disease associations in Asian Indians besides, other populations has also been discussed. Further, studies elucidating the pathophysiology of apo E deficiency...
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PMID: 20966513
PDF is available here.
Abstract
We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-...
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PMID: 20975768
PDF is available here.
Abstract
Thirty-eight obese Korean children (21 boys, 17 girls), whose ages were between 9 and 15, were divided into either the intervention group (19 obese children: BMI>95P) or the age- and sex-matched obese control group. The intervention group performed an intensive exercise program under the supervision...
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PMID: 21158218
PDF is available here.
Abstract
We found that specific and sustained GH1 expression did not improve muscle exercise performance despite inducing local muscle hypertrophy. Injection of rAAV2/1-CMV-GH1 had some systemic effects on the liver and heart and on lipid metabolism in the healthy rats. Serum levels of hGH (human growth horm...
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PMID: 20204528
PDF is available here.
Abstract
The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.
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PMID: 20657923
PDF is available here.
Abstract
Corticosteroids are therapeutic agents widely used in the pharmacological treatment of skin diseases such as eczema or psoriasis. Unfortunately, their use is restricted by the side effects that frequently occur at the systemic level. The goal of the research described here was to develop and characte...
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PMID: 20839362
PDF is available here.
Abstract
We have demonstrated that droplet conversion is feasible for clinically relevant sized droplets and acoustic exposures....
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PMID: 20693614
PDF is available here.
Abstract
In overweight cats, citrus flavanones supplementation of the saturated fat diet was associated with lower energy intake and with lower plasma lipids and urinary F2-isoprostane concentrations than in cats fed the saturated fat alone. Monounsaturated fat feeding resulted in lower food intake than in c...
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PMID: 20807143
PDF is available here.
Abstract
A fast and convenient spectroscopic methodology to determine the water uptake capacity of amphiphile assemblies studied in multilayer films is presented. This method was developed to provide a reliable but relatively simple tool for estimating the binding potency of such complex systems. The water-b...
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PMID: 20635078
PDF is available here.
Abstract
We hypothesized that constantly degraded endogenous antigen only accumulates upon inhibition of alpha-galactosidase A (alpha-Gal-A) in lysosomes. Here, we show that alpha-Gal-A deficiency caused vigorous activation of NKT cells. Moreover, microbes induced inhibition of alpha-Gal-A activity in antige...
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PMID: 20727792
PDF is available here.
Abstract
Amphotericin B (AmB) is used in the treatment of fungal infections; however, its clinical use is limited by its toxic side effects. In this study, AmB-loaded cationic liposome gels were formulated with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-3-trimethylammonium-propane (DO...
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PMID: 20192816
PDF is available here.
Abstract
We show here that the first step in data analysis, the assembly of two-dimensional diffraction patterns from a large set of raw diffraction data, is crucial to obtaining reconstructions of highest possible consistency. We have developed software that automates this process and results in consistentl...
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PMID: 20940752
PDF is available here.