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Macromolecular Substances (3)
Articles on Macromolecular Substances
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.
The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from invading viruses and incorporated into ribonucleoprotein complexes with CRISPR-associated (CAS) proteins, to target and degrade viral DN...
IPET and FETR: experimental approach for studying molecular structure dynamics by cryo-electron tomography of a single-molecule structure.
We demonstrated the adverse effects from image distortion and the measuring tilt-errors (including tilt-axis and tilt-angle errors) both play a major role in limiting the reconstruction resolution. Therefore, we developed a "focused electron tomography reconstruction" (FETR) algorithm to improve the...
Synthesis and anticoagulant activity of the quaternary ammonium chitosan sulfates.
Quaternary ammonium chitosan sulfates with diverse degrees of substitution (DS) ascribed to sulfate groups between 0.52 and 1.55 were synthesized by reacting quaternary ammonium chitosan with an uncommon sulfating agent (N(SO(3)Na)(3)) that was prepared from sodium bisulfite (NaHSO(3...
Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein.
The cAMP receptor protein (CRP) requires cAMP for an allosteric change and regulates more than 150 genes in Escherichia coli. In this study, the modular half of cAMP receptor protein was used to investigate the allosteric signal transmission pathway induced by cAMP binding. The activ...
The effects of electrolysis at room temperature on retrogradation of sweet potato starch.
The effects of electrolysis at room temperature on formation of sweet potato retrograded starch were studied by photographic method in the paper. The optimal parameters of electrolytic preparation of sweet potato retrograded starch were determined. The ratio between sweet potato star...
Light-orchestrated macromolecular "accordions": reversible photoinduced shrinking of rigid-rod polymers.
Light can play: Irradiation causes dramatic changes in the shape of rigid-rod polymers incorporating azobenzene photochromes in the main chain. The embedded photoswitches act as hinges, which upon light-induced isomerization lead to reversible shrinking and stretching of the polymer...
Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions.
We seek to synthesize one such three-dimensional culture system using cytocompatible and wavelength-specific photochemical reactions to create hydrogels that allow orthogonal and dynamic control of material properties through independent spatiotemporally regulated photocleavage of crosslinks and pho...
Single-chain technology using discrete synthetic macromolecules.
We describe in detail these recent advances in macromolecular science and emphasize the possible emergence of technologies based on single-chain devices....
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.
We observed the occurrence of intermittent, non-lethal ruptures of the nuclear envelope in dermal fibroblast cultures of patients with different mutations of lamin A/C. These ruptures, which were absent in normal fibroblasts, could be mimicked by selective knockdown as well as knockout of LMNA and w...
[Application of pre-clinical PET imaging for drug development].
Positron emission tomography (PET) is a sophisticated method for the quantitative and noninvasive imaging of biological functions by monitoring the delivery of tracers labeled with positron emitters (1C, 'aN, '"O, and 8F). The distribution and kinetic patterns of a labeled compound i...