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Micelles (0):
Recent article
Micelles
Biomacromolecules (12)9 2011
Abstract
We investigated the properties of micellar siRNA delivery vehicles prepared with poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLL) comprising lysine amines modified to contain amidine and thiol functionality. Lysine modification was achieved using 2-iminothiolane (2-IT) [yielding PEG-b-PLL(N2IM...
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PMID: 21863796
PDF is available here.
PDF is available here.
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Abstract
The phytochemical analysis indicated that total phenolic, flavonoid, and condensed tannin contents in the extract were 45.21 +/- 0.96 mg gallic acid equivalents/g extract, 15.39 +/- 0.58 mg catechin equivalents/g extract, and 4.90 +/- 0.20 catechin equivalents/g extract, respectively. In addition, t...
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PMID: 21780550
PDF is available here.
PDF is available here.
Abstract
We have developed multifunctional nanomicelles for both drug and gene delivery application. Polyethylenimine (PEI) was modified by grafting stearic acid (SA) and further formulated to polymeric micelles (PEI-SA) with positive surface charge for gene delivery evaluation. Our results showed that PEI-S...
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PMID: 21465641
PDF is available here.
PDF is available here.
Abstract
Pyrazine-labeled multicompartment nanostructures are shown to exhibit enhanced pH-responsive blue-shifted fluorescence emission intensities compared to their simpler core-shell spherical analogs. An amphiphilic linear triblock terpolymer of ethylene oxide, N-acryloxysuccinimide, and styrene, PEO(45)-...
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PMID: 21574617
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
We investigated the gradual disassembly of the AcrB trimer and bound DARPin ligands in dependence on laser intensity in solution. At low laser intensity, the release of the detergent molecule micelle from the AcrB/DARPin complex was observed. By increasing laser intensity, dimeric and monomeric AcrB...
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PMID: 21616055
PDF is available here.
PDF is available here.
Abstract
The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability coefficient obtained with that of drug solution and micellar...
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PMID: 21454158
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)8 2011
Abstract
Alyteserin-1c (GLKEIFKAGLGSLVKGIAAHVAS.NH(2)), first isolated from skin secretions of the midwife toad Alytes obstetricans, shows selective growth-inhibitory activity against Gram-negative bacteria. The structures of alyteserin-1c and its more potent and less haemolytic analogue [E4K]alyteserin-1c we...
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PMID: 21565166
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)8 2011
Abstract
We explain why this limited, all-or-none leakage could nevertheless account for the killing of virtually all fungi whereas the same extent of graded vesicle leakage may be biologically irrelevant. Then, crystallization of AS1 and micellization of plipastatins cause a cut-off in leakage at 15% that m...
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PMID: 21545788
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
The stabilizing effect of cholesterol on oxidized membranes has been studied in planar phospholipid bilayers and multilamellar 1-palmitoyl-2-linoleoyl-phosphatidylcholine vesicles also containing either 1-palmitoyl-2-glutaroyl-phosphatidylcholine or 1-palmitoyl-2-(13-hydroxy-9,11-octadecanedienoyl)-p...
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PMID: 21600189
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
We present here a computational study that compares the effect of symmetric and asymmetric arrangements of melittin peptides in the toroidal pore formation. We also investigate the role of the peptide secondary structure during the pore formation. Two sets of the symmetric and asymmetric pores are p...
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PMID: 21640071
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
We studied the conformation of SRE bound to SDS micelle, a suitable model for the membrane-bound SRE. In fact, highly similar circular dichroism (CD) spectra were obtained for SRE bound to sodium dodecylsulphate (SDS) and to a phospholipid bilayer, indicating the conformational equivalence of SRE in...
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PMID: 21658366
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)5 2011
Abstract
I provide an overview of different useful approaches to study these complexes and identify eight different issues which define central concepts in the field. (1) Are proteins denatured by monomeric surfactant molecules, micelles or both? (2) How does unfolding of proteins in surfactant compare with...
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PMID: 21397738
PDF is available here.
PDF is available here.
Abstract
Due to the eye's specific anatomical and physiological conformation, the treatment of eye diseases is a real challenge for pharmaceutical therapy. The presence of efficient protective barriers (i.e., the conjunctival and corneal membranes) and protective mechanisms (i.e., blinking and nasolachrymal d...
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PMID: 21440104
PDF is available here.
PDF is available here.
Abstract
Many biomolecules have specific binding properties in the nanostructure formation; they are attractive materials for nanotechnology. One such promising construction material for growing a well-defined nanostructure is deoxyribonucleic acid, due to its π-electron hydrophobic core and predictable reco...
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PMID: 21382609
PDF is available here.
PDF is available here.
Abstract
We have previously developed micelles of methoxy poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization and delivery of cyclosporine A (CsA). These micelles were able to reduce the renal uptake and nephrotoxicity of CsA. The purpose of the current study was to test the effic...
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PMID: 21336534
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)4 2011
Abstract
Amyloid fibers in human semen known as SEVI (semen-derived enhancer of viral infection) dramatically increase the infectivity of HIV and other enveloped viruses, which appears to be linked to the promotion of bridging interactions and the neutralization of electrostatic repulsion between the host and...
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PMID: 21262195
PDF is available here.
PDF is available here.
Abstract
The solubilization of phenanthrene (PHE) and pyrene (PYR) by rhamnolipid biosurfactant was systematically investigated. The solubilities of both polycyclic aromatic hydrocarbons (PAHs) were increased linearly with the biosurfactant concentration at above critical micelle concentration. A competitive...
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PMID: 21520755
PDF is available here.
PDF is available here.
Voprosy pitaniya (80)3 2011
Abstract
Our findings are consistent with the results of research on certain vitamins, conducted by other methods. The developed technique can be used in analysis of water-soluble vitamins in premixes and fortified food products....
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PMID: 21842759
PDF is available here.
PDF is available here.
Abstract
Although membrane proteins account for 20-30% of the coding regions of all sequenced genomes and play crucial roles in many fundamental cell processes, there are relatively few membranes proteins with known 3D structure. This is likely due to technical challenges associated with membrane protein ext...
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PMID: 20978985
PDF is available here.
PDF is available here.
Abstract
Peculiarities of synthesis of surface-active substances (SAS) are studied at periodical cultivation of Rhodococcus erythropolis EK-1 in the AK-210 fermenter on medium containing n-hexadecane. Maximum indicators of SAS synthesis (concentration of extra cellular SAS is 7.2 g/l; factor of emulsification...
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PMID: 21950118
PDF is available here.
PDF is available here.
Abstract
We report our studies carried out on the interaction between IMP and gelatin in aqueous medium at 25°C using conductimetry, surface tensiometry and circular dichroism (CD) techniques. Both surface tensiometry and conductimetry results indicate that the drug interacts with the gelatin in a surfactan...
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PMID: 20870394
PDF is available here.
PDF is available here.
Abstract
We report the micellization, aggregation behavior and thermodynamics of a cationic surfactant viz. cetyltrimethylammonium bromide (CTAB) in absence and presence of tyrosine-hydantoin (TH) drug. The solution behavior of the mixture of CTAB and TH drug has been determined using conductivity, surface t...
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PMID: 20850280
PDF is available here.
PDF is available here.
Abstract
We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and...
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PMID: 20850281
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We characterize the conformational changes in BAK and MCL-1 using detergents to mimic the membrane environment and study their interaction by in vitro pulldown experiments, size exclusion chromatography, titration calorimetry, and NMR spectroscopy. The nonionic detergent IGEPAL has little impact on...
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PMID: 21036904
PDF is available here.
PDF is available here.
Abstract
Supramolecular aggregates obtained by self-aggregation of five new cationic amphiphilic CCK8 peptides have been obtained in water solution and characterized for: (i) aggregate structure and stability; (ii) CCK8 peptide conformation and bioavailability on the external aggregate surfac...
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PMID: 21157624
PDF is available here.
PDF is available here.
Abstract
We have compared antibacterial activities, outer and inner membrane permeabilizations, LPS binding affinity, perturbation of LPS micelles structures by MSI-594 and MSI-594F5A peptides. Our results demonstrated that the MSI-594F5A has lower activities against Gram-negative bacteria, due to limited pe...
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PMID: 21128620
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)3 2011
Abstract
These results show the new detergents as promising tools to expand the arsenal for membrane protein studies....
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PMID: 21130727
PDF is available here.
PDF is available here.
Abstract
We investigate how adsorption and micelle formation affects the effective interaction between two colloidal particles, and hence, the stability of the colloidal dispersion. For solvophilic colloidal surfaces, we observe a short-ranged oscillatory solvation pressure that is hardly affected by the pre...
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PMID: 20949141
PDF is available here.
PDF is available here.
Abstract
Core-shell micelles with biodegradability, thermo- and pH-response were successfully demonstrated by poly(2-oxepane-1,5-dione-co-epsilon-caprolactone) (P(OPD-co-CL)) grafted with hydrophilic segments of amine-terminated poly(N-isopropylacrylamide) (At-PNIPAM). To compare with the graft copolymer, P(...
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PMID: 20579857
PDF is available here.
PDF is available here.
Journal of Lipid Research (51)11 2010
Abstract
To investigate the effects of abolished cholic acid (CA) synthesis in the ApoE knockout model [apolipoprotein E (apoE) KO],a double-knockout (DKO) mouse model was created by crossbreeding Cyp8b1 knockout mice (Cyp8b1 KO), unable to synthesize the primary bile acid CA, with apoE KO mice. After 5 month...
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PMID: 20675645
PDF is available here.
PDF is available here.
Biomaterials (31)28 2010
Abstract
Doxorubicin (DOX) is an effective chemotherapeutic against a wide range of solid tumors. However, its clinical use is limited by severe side effects such as cardiotoxicity as well as inherent and acquired drug resistance of tumors. DOX encapsulation within self-assembled polymeric micelles has the p...
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PMID: 20598741
PDF is available here.
PDF is available here.
Biophysical Chemistry (151)3 2010
Abstract
The "hydrophobic hydration processes" can be satisfactorily interpreted on the basis of a common molecular model for water, consisting of two types of clusters, namely W(I) and W(II) accompanied by free molecules W(III). The principle of thermal equivalent dilution (TED) is the potent tool (Ergodic...
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PMID: 20656401
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Most current research has focused on using ceramic microfiltration (MF) membranes for micellar casein concentrate production, but little research has focused on the use of polymeric spiral-wound (SW) MF membranes. A method for the production of a serum protein (SP)-reduced micellar casein concentrat...
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PMID: 20854984
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Our objective was to demonstrate the effect of various processing factors on the performance of a microfiltration system designed to process skim milk and separate casein (CN) from serum proteins (SP). A mathematical model of a skim milk microfiltration process was developed with 3 stages plus an ad...
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PMID: 20855027
PDF is available here.
PDF is available here.
Abstract
These results suggest that the novel micelles could be a promising candidate with excellent therapeutic efficacy for targeting the drugs to cancer cells....
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PMID: 20831277
PDF is available here.
PDF is available here.
Optics Express (18)18 2010
Abstract
We present a new method to make liquid lenses. It is based on the microfluidics method and involves the preparation of emulsions one drop at a time. Tests of lenses by image formation are presented. Experimental results are compared with results of an optical design program. We also present a new ty...
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PMID: 20940763
PDF is available here.
PDF is available here.
Abstract
We present a first investigation about the non-linear flow properties and transient orientational-order fluctuations observed in the shear-thinning lecithin-water-cyclohexane wormlike micellar system at a concentration near to the zero-shear isotropic-nematic phase transition. From rheological measu...
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PMID: 20532324
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)2 2011
Abstract
We describe applications of NMR spectroscopy to both p7 and Vpu. Isotopically labeled p7 and Vpu samples were prepared by heterologous expression in bacteria, initial isolation as fusion proteins, and final purification by chromatography. The purified proteins were studied in the model membrane envi...
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PMID: 20727848
PDF is available here.
PDF is available here.
Abstract
We have explored coarse-grained computer simulations (dissipative particle dynamics (DPD) and coarse-grained molecular dynamics using the MARTINI force field) of polymer-drug interactions to study the encapsulation of prednisolone (log p = 1.6), paracetamol (log p = 0.3) and isoniazid (log p = -1.1)...
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PMID: 20519214
PDF is available here.
PDF is available here.
Abstract
The aim of this work was to demonstrate the advantage of using paclitaxel (PTX)-loaded Pluronic P123/F127 mixed micelles (PF-PTX) against non-small cell lung cancer (NSCLC) compared to Taxol. Modulation of multidrug resistance (MDR) by Pluronic mixed micelles was evaluated in lung resistance protein...
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PMID: 20451605
PDF is available here.
PDF is available here.
Abstract
Aqueous dispersions of fluorescent semiconducting polymer nanospheres (SPNs) have been synthesised by two methods; miniemulsion and micellar encapsulation. The colloidal and optical stability of SPNs synthesised by these two methods has been compared in order to assess the potential of these fluores...
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PMID: 20585697
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)8 2010
Abstract
Abstract
The effect of novel surfactants on the aqueous solubility and the permeability of paclitaxel across a Caco-2 cell monolayer were examined in this work. The solubility and permeability of paclitaxel was evaluated in the presence of four soft surfactants (SS) KXN441, KXN424, KXN437, an...
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PMID: 20198687
PDF is available here.
PDF is available here.
Abstract
The purpose of the present study was to study the impact of free fatty acid and monoglyceride level and ratio on the nanostructural composition and solubilizing capacity of media simulating fed state intestinal fluids (SIFs). SIFs, without or with oleic acid/monoolein (OA/MO) in rati...
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PMID: 20564382
PDF is available here.
PDF is available here.
Abstract
We discard the initial assumption, and extended the Monte Carlo simulation study to examine the influence of both input variable variation and product performance measurement variation on the uncertainty in DOE model coefficients. The Monte Carlo simulations presented in this article illustrate the...
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PMID: 20564385
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)8 2010
Abstract
Both PTX-loaded plain micelles and mixed micelles had similar in vitro release profile. Mixed micellar PTX significantly reduced IC(50) of PTX in MCF-7/ADR cells compared to free PTX and plain micellar PTX, and mixed micelles substantially enhanced cellular accumulation of R 123 in MCF-7/ADR cells c...
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PMID: 20411408
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)8 2010
Abstract
The thermosensitive micelles based on the poly(PEG:CPP:SA) terpolymer composed of poly(ethylene glycol) (PEG), 1,3-bis(carboxyphenoxy) propane (CPP) and sebacic acid (SA) were fabricated for application as a promising drug carrier.
The terpolymer can self-assemble int...
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PMID: 20428931
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
We used cryoelectron microscopy to characterize structural changes induced in lipid vesicles by exposure to endophilin. The vesicles convert rapidly to coated tubules whose morphology reflects the local concentration of endophilin. Their diameters and curvature resemble those of synaptic vesicles in...
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PMID: 20484046
PDF is available here.
PDF is available here.
Abstract
Well-defined AB2 Y-shaped miktoarm star copolymers of PNIPAM-b-(PZLL)2 and PNIPAM-b-(PLL)2 were synthesized through the combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and click chemistry, where PNIPAM, PZLL, and PLL are poly(N-isopropylacrylamide), pol...
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PMID: 20536122
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
The chromatographic behavior of model ions of biomedical and environmental significance was investigated by using nonionic micellar mobile phases modified with ion-pair additives. The influence of concentrations of polyoxyethylene (23) lauryl ether and ornithine hydrochloride in the mobile phase on...
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PMID: 20629040
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We report the controlled formation of highly monodisperse cylindrical block copolymer micelles (length dispersity < or = 1.03; length range, approximately 200 nm to 2 microm) by the use of very small (approximately 20 nm) uniform crystallite seeds that serve as initiators for the crystallization-dri...
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PMID: 20571575
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)7 2010
Abstract
Recent studies have shown that nanostructuring of scaffolds for tissue engineering has a major impact on their interactions with cells. The current investigation focuses on nanostructuring of a biocompatible, biosynthetic polymeric hydrogel scaffold made from crosslinked poly(ethylen...
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PMID: 19615475
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We report the controlled formation of highly monodisperse cylindrical block copolymer micelles (length dispersity < or = 1.03; length range, approximately 200 nm to 2 microm) by the use of very small (approximately 20 nm) uniform crystallite seeds that serve as initiators for the crystallization-dri...
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PMID: 20571575
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We report the controlled formation of highly monodisperse cylindrical block copolymer micelles (length dispersity < or = 1.03; length range, approximately 200 nm to 2 microm) by the use of very small (approximately 20 nm) uniform crystallite seeds that serve as initiators for the crystallization-dri...
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PMID: 20571575
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We report the controlled formation of highly monodisperse cylindrical block copolymer micelles (length dispersity < or = 1.03; length range, approximately 200 nm to 2 microm) by the use of very small (approximately 20 nm) uniform crystallite seeds that serve as initiators for the crystallization-dri...
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PMID: 20571575
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We report the controlled formation of highly monodisperse cylindrical block copolymer micelles (length dispersity < or = 1.03; length range, approximately 200 nm to 2 microm) by the use of very small (approximately 20 nm) uniform crystallite seeds that serve as initiators for the crystallization-dri...
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PMID: 20571575
PDF is available here.
PDF is available here.
Abstract
We investigated the expression of these transporters and secretion of their substrates in female control and lactating Sprague Dawley rats and C57BL/6 mice. Expression of Abcg5/Abcg8 mRNA was decreased by 97 and 60% by midlactation in rats and mice, respectively; protein levels of Abcg8 were below d...
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PMID: 20413720
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1804)7 2010
Abstract
We have solved the 2.7 A crystal structure of group-IB sPLA2 complexed with 12 molecules of octyl sulfate (C8S) in a form consistent with a tetrameric oligomeric that exists during the E1# phase of premicellar complexes. The alkyl tails of the C8S molecules are centered in the middle of the tetramer...
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PMID: 20302975
PDF is available here.
PDF is available here.
Abstract
Partially folded proteins, characterized as exhibiting secondary structure elements with loose or absent tertiary contacts, represent important intermediates in both physiological protein folding and pathological protein misfolding. To aid in the characterization of the structural state(s) of such pr...
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PMID: 20524659
PDF is available here.
PDF is available here.
Abstract
All but five of the N-terminal 23 residues of the HA2 domain of the influenza virus glycoprotein hemagglutinin (HA) are strictly conserved across all 16 serotypes of HA genes. The structure and function of this HA2 fusion peptide (HAfp) continues to be the focus of extensive biophysical, computation...
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PMID: 20534508
PDF is available here.
PDF is available here.