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Schizophrenia and Disorders with Psychotic Features (4):
Recent article
Schizophrenia and Disorders with Psychotic Features
Psychological Medicine (40)12 2010
Abstract
We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia.
FMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 age-matched healthy comparison subjects....
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PMID: 20214840
PDF is available here.
PDF is available here.
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Schizophrenia Research (119)1-3 2010
Abstract
Our findings suggest that the left posterior STG subregions are commonly reduced in diseases of the schizophrenia spectrum; whereas, schizophrenia patients exhibit further progressive STG changes associated with overt psychosis in the early years of the illness.
Copyright (c) 2009 Elsevier B.V. All...
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PMID: 20051316
PDF is available here.
PDF is available here.
Schizophrenia Research (119)1-3 2010
Abstract
Compared to healthy controls, first-episode schizophrenia patients gave more incorrect descriptions and used less ToM-related vocabulary when responding to socially complex ToM video sequences. No group differences were revealed for videos with random movements. ToM abilities correlated significantl...
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PMID: 20060686
PDF is available here.
PDF is available here.
Psychological Medicine (40)6 2010
Abstract
Intellectually impaired subjects judged to be at elevated risk of schizophrenia on the basis of clinical assessment exhibit structural imaging findings which distinguish them from the generality of learning disabled subjects. Within this population reduced amygdala volume may be associated with nega...
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PMID: 19732477
PDF is available here.
PDF is available here.
Schizophrenia Research (119)1-3 2010
Abstract
In apparent contradiction to the notion of cognitive impairment as a core feature of schizophrenia, some studies have described a subgroup of patients neuropsychologically within normal limits. It remains to be determined whether this subgroup has intact cognitive functioning or a higher premorbid f...
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PMID: 20335007
PDF is available here.
PDF is available here.
Biological Psychiatry (67)10 2010
Abstract
Increased anhedonia is associated with a reduced experience of valence in both patients and control subjects, and group differences in experienced valence are likely driven by individual differences in anhedonia. Reduced activation of the striatum and amygdala may contribute to symptoms of anhedonia...
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PMID: 20004364
PDF is available here.
PDF is available here.
Schizophrenia Research (118)1-3 2010
Abstract
The individuals at ultra-high risk for schizophrenia performed more poorly than did normal controls with regard to the processing of facial configuration but not the facial feature and did not differ significantly from the patients with schizophrenia with regard to the processing of facial configura...
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PMID: 20133107
PDF is available here.
PDF is available here.
Schizophrenia Research (118)1-3 2010
Abstract
Deficits in visual processing are now recognized as a core feature of schizophrenia. In the 1940s, Louis Thurstone developed a series of tests designed to evaluate specific aspects of visual perceptual processing including the Closure Flexibility Test (CFT), which was designed to measure "the abilit...
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PMID: 20110157
PDF is available here.
PDF is available here.
Neuropsychology (24)2 2010
Abstract
These results support the hypothesis that a narrower visual span may underlie impaired visual search performance among patients with schizophrenia.
Copyright 2010 APA, all rights reserved...
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PMID: 20230113
PDF is available here.
PDF is available here.
Comprehensive Psychiatry (51)2 2010
Abstract
The results of our study suggest that depressive symptoms are significantly associated with a low subjective well-being in newly admitted patients with schizophrenia and that the relationship is significant even after controlling for the influence of potential confounding variables. Detection and ap...
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PMID: 20152297
PDF is available here.
PDF is available here.
Abstract
There is an expanding interest to study psychosis in the realm of daily life. The study of the person in the context of daily life may provide a powerful addition to more conventional and cross-sectional research strategies in the study of psychosis. This article first discusses the nature of experi...
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PMID: 19947784
PDF is available here.
PDF is available here.
L' Encephale (35 Suppl 6) 2009
Abstract
At index episode, the sample was characterized by severe impairment, high rates of psychotic features (N = 50, 62,5%), a long duration of stay (mean = 80,4 days), and an overall good improvement at discharge from hospital (86% very much or much improved). Half had a psychological testing before disc...
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PMID: 20141776
PDF is available here.
PDF is available here.
Fa yi xue za zhi (25)5 2009
Abstract
There were 322 cases in which opinions to diagnosis and law-related items were both given. One hundred and forty-five cases were schizophrenias (45.03%), 51 were mental retardation (15.84%), 78 were others (24.22%), and 48 showed no psychosis (14.91%). In legal conclusion, 211 cases (65.53%) were ev...
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PMID: 20000047
PDF is available here.
PDF is available here.
L' Encephale (35)4 2009
Abstract
Clinical approach: there is no greater family history of dementia disorders in LOS/VLOSP than in the general population. Neuropsychological pattern between LOS and Alzheimer's disease (AD) seems different, with more impairment in delayed recall in AD, and in short-term memory in LOS. Some longitudin...
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PMID: 19748376
PDF is available here.
PDF is available here.
L' Encephale (35)4 2009
Abstract
Presently, two distinct and complementary cognitive remediation methods have been developed: the compensatory and the restorative approaches: (A) restorative approaches attempt to improve function by recruiting relatively intact cognitive processes to fill the role of those impaired, or by using pro...
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PMID: 19748372
PDF is available here.
PDF is available here.
Abstract
This investigation demonstrated the potential value of a relatively new sustained attention paradigm for research in schizophrenia spectrum disorders.
(C) 2009 Lippincott Williams & Wilkins, Inc....
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PMID: 19741328
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)9 2009
Abstract
We defend the two psychoses positions, but suggest two flaws in the heuristic application: (1) overlapping features, such as psychotic symptoms, are not decisive in differential diagnosis; and (2) each disorder is a syndrome, not a disease entity. An alternative paradigm based on domains of patholog...
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PMID: 19295511
PDF is available here.
PDF is available here.
Schizophrenia Bulletin (35)4 2009
Abstract
Dropout is often used as an outcome measure in clinical trials of antipsychotic medication. Previous research is inconclusive regarding (a) differences in dropout rates between first- and second-generation antipsychotic medications and (b) how trial design features reduce dropout. Meta-analysis of r...
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PMID: 18303093
PDF is available here.
PDF is available here.
Abstract
We propose that negative appraisals about acceptance instigate communication anomalies in individuals with a pre-existing diathesis for imperfect speech production....
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PMID: 19379529
PDF is available here.
PDF is available here.
Abstract
TOGHs were common (20% of the total sample), and occurred across all diagnostic categories, although at different rates by diagnosis. TOGHs were correlated with each other and with other hallucinations, and were associated with specific clinical features such as somatic delusions, delusions of contr...
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PMID: 19521636
PDF is available here.
PDF is available here.
Neuroscience Research (63)4 2009
Abstract
We review overlapping epidemiological, clinical, neuropathological and neuroimaging features of these two diseases. We discuss the role of temporal and other brain areas in the development of schizophrenia-like psychosis of epilepsy. We underline the importance of ventricular enlargement in both con...
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PMID: 19367784
PDF is available here.
PDF is available here.
Abstract
Findings suggest differences in the underlying mechanisms behind PSW and ASA, confirming that PSW is a primary negative symptom, while ASA is related more to positive symptoms....
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PMID: 19363384
PDF is available here.
PDF is available here.
Abstract
We may think, and that there could well be a symptomatic continuum between people who have and people who have not been diagnosed with indisputable psychotic disorders. In the nonclinical population, voices are mainly positive and nonthreatening. Conversely, in the psychiatric population, they tend...
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PMID: 19321018
PDF is available here.
PDF is available here.
Medical Journal of Australia (190)4 Suppl 2009
Abstract
We propose that various measures of brain structure or function, gene expression and proteomic technologies can be used to guide better treatment of schizophrenia and other psychotic disorders. These measures are not used to establish a specific diagnosis. Their purpose is to predict variations in u...
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PMID: 19220170
PDF is available here.
PDF is available here.
Medical Journal of Australia (190)4 Suppl 2009
Abstract
Neuroimaging studies of individuals at risk of psychosis have the potential to identify markers predictive of illness onset and features that progress with transition. To date, reduced brain volumes have shown weak predictive value for onset of psychotic illness. All published longitudinal studies o...
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PMID: 19220166
PDF is available here.
PDF is available here.
Abstract
We aimed to quantify motor activity during the waking hours of the day as assessed by wrist actigraphy in 16 patients with cycloid psychosis and 16 patients with paranoid schizophrenia. All patients were matched for gender and age, and wrist actigraphic assessment took place during acute episodes. T...
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PMID: 18609426
PDF is available here.
PDF is available here.
Abstract
Psychosis is thought to have a strong genetic component, but many efforts to discover the underlying putative schizophrenia genes have yielded disappointing results. In fact, no strong associations emerged in the first genome-wide association studies in psychiatry and weakly observed associations we...
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PMID: 19526737
PDF is available here.
PDF is available here.
Abstract
Cases and their parents took significantly more time than controls on Part B of the TMT. There were no statistically significant differences between cases and parents on any of the TMT parameters. Using regression analysis, the most significant correlates of all TMT parameters among cases were with...
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PMID: 19242070
PDF is available here.
PDF is available here.
Abstract
In addition to psychotic features and clinical states, comorbid AUD should be taken into consideration when comparing the level of insight among patients with different psychiatric diagnoses....
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PMID: 19068005
PDF is available here.
PDF is available here.
Abstract
Studies suggest a complex relationship between schizophrenia and sexually offensive behaviour. The mental disorder itself, antisocial personality traits, drug abuse and adverse childhood experiences are suggested to have an impact on sexual offending in mentally disordered offenders. Similarities in...
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PMID: 18763227
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (48)11 2008
Abstract
We speculate that the antibodies may cause inhibition of NMDAR, rather than stimulation, in presynaptic GABAergic interneurons, causing a reduction of release of GABA. This results in disinhibition of postsynaptic glutamatergic transmission, excessive release of glutamate in the prefrontal/subcortic...
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PMID: 19198118
PDF is available here.
PDF is available here.
Abstract
Results from this preliminary study suggest that patients with PsyNOS, BrPsy, or schizotypal personality disorder features in adolescence should be followed as separate risk groups in prodromal studies of schizophrenia and bipolar disorder. Executive function deficits and absence of anxiety disorder...
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PMID: 18928412
PDF is available here.
PDF is available here.
Schizophrenia Research (105)1-3 2008
Abstract
The way schizophrenia patients perceive the world is largely mysterious. Understanding and appreciating the visual world begins with the perception of basic visual features, which is altered in this mental disorder. Yet, the roles basic visual features play in functional activities such as appreciat...
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PMID: 18708280
PDF is available here.
PDF is available here.
Biological Psychiatry (64)5 2008
Abstract
Our data provide significant levels of support for NRG1 as a susceptibility gene for both major forms of psychosis, and this cannot be interpreted as being due to population stratification. More tentatively, they also might indicate the presence of multiple alleles that influence the psychosis pheno...
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PMID: 18466881
PDF is available here.
PDF is available here.
Schizophrenia Bulletin (34)5 2008
Abstract
This article reviews empirical studies of affective traits in individuals with schizophrenia spectrum disorders, population-based investigations of vulnerability to psychosis, and genetic and psychometric high-risk samples. The review focuses on studies that use self-report trait questionnaires to a...
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PMID: 18667393
PDF is available here.
PDF is available here.
Abstract
Both the UHR and GHR groups exhibited significantly impaired social functioning compared with the HC group, and the UHR group was more impaired than the GHR group. In the UHR group, duration of prodromal symptoms was related to impaired 'interpersonal behaviour'. Positive and negative symptoms were...
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PMID: 18622775
PDF is available here.
PDF is available here.
Schizophrenia Research (103)1-3 2008
Abstract
These results provide the first evidence that improvements in emotion recognition following METT training are associated with changes in visual attention to the feature areas of emotional faces. These findings support the contribution of visual attention abnormalities to emotion recognition impairme...
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PMID: 18565733
PDF is available here.
PDF is available here.
European Psychiatry (23)5 2008
Abstract
Inappropriate affect, positive thought disorder and deterioration from premorbid level of function associate with very early-onset schizophrenia, while slowed activity and dysphoria relate to young-onset. These symptoms correlate significantly with the age at onset. DISCUSSION: Differences in the cl...
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PMID: 18455370
PDF is available here.
PDF is available here.
Schizophrenia Research (103)1-3 2008
Abstract
These results suggest that the same seasonal factor that contributes to the risk of deficit schizophrenia may affect brain development and personality characteristics in the general population....
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PMID: 18261884
PDF is available here.
PDF is available here.
Abstract
The early recognition and treatment of schizophrenia in children and adolescents is one of the most important therapeutic goals because of the postulated relation between delayed initiation of treatment and an unfavourable developmental course. The duration of untreated psychosis (DUP) seems to be s...
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PMID: 18654955
PDF is available here.
PDF is available here.
Schizophrenia Bulletin (34)3 2008
Abstract
Many previous observers have reported some qualitative similarities between the normal mental state of dreaming and the abnormal mental state of psychosis. Recent psychological, tomographic, electrophysiological, and neurochemical data appear to confirm the functional similarities between these 2 st...
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PMID: 17942480
PDF is available here.
PDF is available here.
Abstract
Years before the onset of psychotic symptoms, individuals with schizophrenia, as a group, demonstrate mean IQ scores approximately one-half of a standard deviation below that of healthy comparison subjects....
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PMID: 18413704
PDF is available here.
PDF is available here.
Psychological Medicine (38)5 2008
Abstract
Social functioning (as measured through direct observation of social skills performance) was related to cognitive ability in out-patients with schizophrenia. Addressing such cognitive impairment may help to improve social functioning and result in greater overall quality of life....
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PMID: 17803830
PDF is available here.
PDF is available here.
Brain Research Bulletin (75)5 2008
Abstract
We tested whether brain metabolic abnormalities also occur in a transgenic mouse model of schizophrenia. In vivo(1)H-magnetic resonance spectroscopy at 4.7T of the chakragati mouse brain revealed abnormalities in relative levels of choline and N-acetylaspartate compounds. These results are consisten...
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PMID: 18355631
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (266)1-2 2008
Abstract
Young patient with psychiatric manifestations with clues like history of jaundice, family history of neuropsychiatric manifestations and sensitivity to neuroleptics should be evaluated for WD to avoid delay in diagnosis and associated morbidity. SIGNIFICANT OUTCOMES: The study reemphasizes the impor...
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PMID: 17904160
PDF is available here.
PDF is available here.
Schizophrenia Bulletin (34)2 2008
Abstract
Recent years have witnessed widespread interest in the early phase of schizophrenia and other psychotic disorders. Strategies have been introduced to attempt to identify individuals in the prepsychotic or prodromal phase. The most widely used of these approaches is the ultra-high risk (UHR) approach...
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PMID: 17702990
PDF is available here.
PDF is available here.
Psychiatric Services (59)3 2008
Focus on geriatric psychiatry: schizophrenia in later life: clinical symptoms and social well-being.
Abstract
The number of persons aged 55 and older with a diagnosis of schizophrenia is projected to double over the next 20 years. A tripartite classification system of early-onset schizophrenia, late-onset schizophrenia, and very-late-onset schizophrenia-like psychosis has been proposed. This column reviews...
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PMID: 18308900
PDF is available here.
PDF is available here.
Schizophrenia Research (99)1-3 2008
Abstract
We explored the neural activation of discrete brain regions implicated in social cognitive and face processing in schizophrenia subgroups and autism spectrum disorders during complex social judgments of faces. Twelve individuals with autism spectrum disorders (ASD), 12 paranoid individuals with schi...
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PMID: 18053686
PDF is available here.
PDF is available here.
Abstract
We observed that the rates, the diversity of diagnoses, the high comorbidity, the severity and the age of onset of the clinical diagnoses tended to be similar with those already reported in the offspring of affected parents with a low familial loading. Although the sample size was small, HRSZ and HR...
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PMID: 18028250
PDF is available here.
PDF is available here.
BMC Psychiatry (8)1 2008
Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays.
Abstract
We found that 110 transcripts are differentially regulated (p < 0.001) in psychosis after adjusting for confounding variables with a multiple regression model. Using a quantitative PCR, we validated a set of genes such as up-regulated metallothioneins (MT1E, MT1F, MT1H, MT1K, MT1X, MT2A and MT3) and...
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PMID: 18992145
PDF is available here.
PDF is available here.
Abstract
These findings demonstrate that prospective ascertainment of individuals at risk for psychosis is feasible, with a level of predictive accuracy comparable to that in other areas of preventive medicine. They provide a benchmark for the rate and shape of the psychosis risk function against which stand...
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PMID: 18180426
PDF is available here.
PDF is available here.
Journal of Clinical Psychiatry (69 Suppl 4) 2008
Abstract
Early-onset psychotic illnesses in children and adolescents are not as rare as is commonly believed. These disorders, which include schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, and major depression with psychotic features, often have a chronic and severe course...
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PMID: 18533765
PDF is available here.
PDF is available here.
Abstract
We present two cases of probable cycloid psychosis, review the history of the concept, and propose that it be reconsidered as a clinically useful category whose validity and utility for prognosis and treatment can be further tested.(HARV REV PSYCHIATRY 2008;16:167–180.)...
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PMID: 18569038
PDF is available here.
PDF is available here.
Schizophrenia Bulletin (34)1 2008
Abstract
Kraepelin said severe mental illness was due to 2 diseases subsequently characterized as disorders of thought vs disorders of mood, ie, the Kraepelinian dichotomy. Schizophrenia, traditionally considered the disorder of thought, has been defined by the presence of hallucinations, delusions, catatoni...
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PMID: 17515440
PDF is available here.
PDF is available here.
Collegium Antropologicum (32 Suppl 1) 2008
Abstract
Since early neuropathological findings, temporal lobe has been related to the pathophysiology of some disorders with psychotic features. The aim of this study was to compare temporal lobe volumes and asymmetry differences in patients with schizophrenia, schizoaffective and bipolar disorders, disorde...
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PMID: 18405073
PDF is available here.
PDF is available here.
Hippocampus (18)2 2008
Abstract
We used induction of the immediate early gene Fos, to test the hypothesis that the amygdala may affect neuronal activation of the hippocampus in response to different spatial environments (familiar, modified, and novel). Exploratory and anxiety related behaviors were also assessed. In vehicle-treate...
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PMID: 17960646
PDF is available here.
PDF is available here.
Schizophrenia Research (98)1-3 2008
Abstract
Morphological abnormalities of the cerebral cortex have been reported in a number of MRI-studies in schizophrenia. Uncertainty remains regarding cause, mechanism and progression of the alterations. It has been suggested that antipsychotic medication reduces total gray matter volumes, but results are...
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PMID: 17933495
PDF is available here.
PDF is available here.
Psychopathology (41)3 2008
Ontological assumptions of psychiatric taxonomy: main rival positions and their critical assessment.
Abstract
The scientific classification of human psychopathology raises a host of important philosophical issues ranging over all major areas of philosophical inquiry; logic, semantics, ontology, epistemology and ethics. The paper focuses on the major views of the ontological status of our psychodiagnostic co...
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PMID: 18187962
PDF is available here.
PDF is available here.
Abstract
Schizophrenic patients at risk of suicide are more likely to be young, male, white, never married, with post-psychotic depression, and a history of substance abuse and suicide attempts. Hopelessness, social isolation, awareness of illness and hospitalization are also related to suicide risk. Deterio...
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PMID: 18088201
PDF is available here.
PDF is available here.
Abstract
We identified the following tasks as essential to ensure an efficient intervention using telemedicine: identifying a suitable technology, a suitable location, and a local collaborator; providing training and creating awareness; establishing peripheral telepsychiatry centers and ensuring case documen...
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PMID: 18548517
PDF is available here.
PDF is available here.