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All › Metabolic Phenomena › Metabolome

Metabolome (0)

      Articles on Metabolome

      1. NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases--a diagnostic tool?
        Alexandra J Sinclair, Mark R Viant, ... Stephen P Young

        NMR Biomed 23(2):123-32 (2010) PMID 19691132

        We sought to evaluate the diagnostic accuracy of metabolomic biomarker profiles in neurological conditions (idiopathic intracranial hypertension (IIH), multiple sclerosis (MS) and cerebrovascular disease (CVD) compared to controls with either no neurological disease or mixed neurological diseases)....
      2. The effect of experimental conditions on the detection of spermine in cell extracts and tissues.
        Nicholas G Spencer, Thomas R Eykyn, ... Geoffrey S Payne

        NMR Biomed 23(2):163-9 (2010) PMID 19757478

        The aim of this work was to investigate the effect of experimental conditions on the visibility of polyamines. In solution the chemical shift of the three groups of peaks (at approximately 1.8, 2.1 and 3.1 ppm) were found to be pH dependent. Relaxation times in aqueous solution at pH...
      3. Impact of adenylyltransferase GlnE on nitrogen starvation response in Corynebacterium glutamicum.
        Nadine N Rehm, Sebastian S Buchinger, ... Andreas A Burkovski

        J Biotechnol 145(3):244-52 (2010) PMID 19963018

        Adenylyltransferases regulate glutamine synthetase activity in enterobacteria and actinomycetes such as Streptomyces coelicolor, Mycobacterium tuberculosis and Corynebacterium glutamicum. In this study the effects of a mutation of the glnE gene, coding for adenylyltransferase, on tra...
      4. Metabolic profiling of intracellular metabolites in fermentation broths from @b-lactam antibiotics production by liquid chromatography-tande...
        Beatrix Preinerstorfer, Simone Schiesel, ... Wolfgang Lindner

        J Chromatogr 1217(3):17 (2010) PMID 19954781

        An analytical platform comprising three LC-ESI-MS/MS methods is presented for qualitative and quantitative profiling of more than 200 intracellular metabolites. Employing a silica based zwitterionic stationary phase in the HILIC mode, in total 223 hydrophilic metabolites can be determined. In partic...
      5. Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant pa...
        Joshua A JA Bauer, A Bapsi AB Chakravarthy, ... Jennifer A JA Pietenpol

        Clin Cancer Res 16(2):681-90 (2010) PMID 20068102 PMCID PMC2892225

        Proteomic and validation immunohistochemical analyses revealed that alpha-defensins (DEFA) were overexpressed in tumors from patients with a pCR. Gene expression analysis revealed that MAP2, a microtubule-associated protein, had significantly higher levels of expression in patients achieving a pCR....
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      6. Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicle...
        Xuesong Wen, Dong Li, ... Ray K Iles

        Reprod Biol Endocrinol (2010) PMID 20937107

        We examined follicular fluids and granulosa cell production of steroid from IVF patients in order to test the relationship between steroid levels and fertilization. Follicular fluid and granulosa cells were extracted from 206 follicles of 35 women undergoing controlled ovarian stimulation. Follicula...
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      7. Multivariate classification of urine metabolome profiles for breast cancer diagnosis.
        Younghoon Kim, Imhoi Koo, ... Doheon Lee

        BMC Bioinformatics 11 Suppl 2(suppl 2):S4 (2010) PMID 20406502

        In this study, we successfully showed that multivariate classifications are needed to precisely diagnose breast cancer. After further validation with independent cohorts and experimental confirmation, these marker candidates will likely lead to clinically applicable assays for earlier diagnoses of b...
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      8. Assessing a shift of glucose biotransformation by LC-MS/MS-based metabolome analysis in carbon monoxide-exposed cells.
        Naoharu N Takano, Takehiro T Yamamoto, ... Makoto M Suematsu

        Adv Exp Med Biol (2010) PMID 20204778

        We hypothesized that CO might alter the cellular energetic conditions and thereby modulate oxygen metabolism. To examine this hypothesis, we attempted to establish a method to follow the global flux of (13)C-glucose in the cells using metabolomic approaches with liquid chromatography-mass spectromet...
      9. Long-chain polyunsaturated fatty acid composition of breast milk in pre-eclamptic mothers.
        Kamini D Dangat, Savita S Mehendale, ... Sadhana R Joshi

        Neonatology 97(3):190-4 (2010) PMID 19864925

      10. SVM-based spectral matching for metabolite identification.
        Bin B Zhou, Amrita K AK Cheema, and Habtom W HW Ressom

        Conf Proc IEEE Eng Med Biol Soc (2010) PMID 21095903

        We propose a support vector machine (SVM)-based spectral matching algorithm to combine multiple similarity measures for accurate identification of metabolites. We compared the performance of this approach with several existing spectral matching algorithms on a spectral library we constructed. The re...