Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Trimethoprim Resistance (0):
Recent article
Trimethoprim Resistance
Abstract
We evaluated a series of propargyl-linked antifolate lead compounds for inhibition of the mutant enzyme. For the propargyl-linked antifolates, the F98Y mutation generates minimal (between 1.2- and 6-fold) losses of affinity and the H30N mutation generates greater losses (between 2.4- and 48-fold). C...
|
PMID: 20026215
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
A hospital-based surveillance study of class 1 integron-positive Acinetobacter isolates in the Urals and Siberia (Russia) demonstrated that dihydrofolate reductase gene (dfrA5) was located in a functional gene cassette insertion driven from a promoter of a weak type. This insertion is an example of...
|
PMID: 20578528
PDF is available here.
PDF is available here.
Abstract
The genetic context of the blaIMP-1 gene was evaluated in 9 Klebsiella pneumoniae isolates recovered from 2 hospitals in São Paulo, Brazil. All isolates harbored a copy of In86 carrying blaIMP-1, aac(6′)-31, and aadA1. Eight strains from the same hospital also carried another class 1 integron harb...
|
PMID: 18990526
PDF is available here.
PDF is available here.
Abstract
Trimethoprim-sulfamethoxazole (SXT) reduces morbidity and mortality among HIV-infected persons in Africa, but its impact on antimicrobial resistance is of concern.
HIV-uninfected (group A), HIV-infected but not requiring SXT (group B), and HIV-infected and eligible fo...
|
PMID: 18285712
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Two multiplex PCR (mPCR) methods were developed to screen large collections of trimethoprim-resistant Escherichia coli isolates for the most prevalent resistance determinants. Five common integron-carried genes (dfrA1, dfrA5, dfrA7, dfrA12 and dfrA17) were selected as PCR targets. Primers and condit...
|
PMID: 17725650
PDF is available here.
PDF is available here.
Abstract
The primary analysis included data on 164 225 coliform isolates from urine samples submitted from 240 general practices over the 7-year study period. These practices served a population of 1.7 million patients. The quartile of practices that had the greatest decrease in total antibiotic dispensing d...
|
PMID: 17925135
PDF is available here.
PDF is available here.
Abstract
We determined the crystal structure of DHFR from B. anthracis (baDHFR) in complex with methotrexate (MTX; 1) at 2.4 Angstrom resolution. The structure reveals the crucial interactions required for MTX binding and a putative molecular basis for how baDHFR has natural resistance to trimethoprim (TMP;...
|
PMID: 17696333
PDF is available here.
PDF is available here.
Abstract
Abstract
Within the community setting, exposure to antibiotics is a strong risk factor for a resistant E. coli UTI. High-dose, shorter-duration antibiotic regimens may reduce the pressure on the emergence of antibiotic resistance....
|
PMID: 17540675
PDF is available here.
PDF is available here.
Abstract
Two Escherichia coli isolates resistant to trimethoprim but negative for integrons carried two new resistance genes, dfrA24 and dfrA26, remotely similar to one another and to the cassette-independent genes dfrA8 and dfrA9. The dfrA24 gene was not associated with known mobile elements...
|
PMID: 17307981
PDF is available here.
PDF is available here.
Abstract
We analyzed an international collection of 55 S. maltophilia TMP/SMX-sensitive (S) (n=30) and -resistant (R) (n=25) strains for integrons; sul1, sul2 and dhfr genes; and insertion element common region (ISCR) elements. sul1, as part of a class 1 integron, was detected in 17 of 25 TMP/SMX-R. Nine TMP...
|
PMID: 17553270
PDF is available here.
PDF is available here.
Abstract
In ascending order, the relative activities (% susceptible) were penicillin (51.8%), trimethoprim/sulfamethoxazole (TMP/SMX) (57.6%), erythromycin (59.5%), cefuroxime (62.0%), amoxicillin/clavulanate (85.5%), clindamycin (86.1%), levofloxacin (99.4%), and linezolid (100%; for 2004 and 2005 respirato...
|
PMID: 17321864
PDF is available here.
PDF is available here.
Abstract
The erythromycin resistance plasmid pRSB105 was previously isolated from an activated sludge bacterial community of a municipal wastewater treatment plant. Compilation of the complete pRSB105 nucleotide sequence revealed that the plasmid is 57,137 bp in size and has a mean G+C conten...
|
PMID: 17261525
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (55)Pt 11 2006
Abstract
These results suggest that this is a viable approach for the rapid AST of purified strains, and that it may be able to deal with mixed populations. The microscopic examination of microcolonies during AST is an advantage of this method which revealed additional information. Filamentation triggered by...
|
PMID: 17030910
PDF is available here.
PDF is available here.
Abstract
Patients with uncomplicated UTI caused by trimethoprim-resistant organisms had significantly worse clinical outcomes than those with trimethoprim-susceptible organisms. Nevertheless, trimethoprim resistance was rarer than predicted from routine laboratory submissions and we calculate that 23 women r...
|
PMID: 16998209
PDF is available here.
PDF is available here.
Abstract
dfrA25 encodes a dihydrofolate reductase of 157 amino acids with closest identity (85%) to dfrA5 dihydrofolate reductase. dfrA25 was located on a transferable plasmid (approximately 150 kb) that also harboured the tetracycline resistance gene tet(A)....
|
PMID: 16980698
PDF is available here.
PDF is available here.
Abstract
Abstract
The microorganism disseminated from the lungs (pneumonia) to the eye and brain. The ocular lesion appeared to be a yellowish, lobulated subretinal abscess with irregular surface and superficial retinal hemorrhages. As it was not responding to empiric therapy for nocardia, pars plana vitrectomy and a...
|
PMID: 16911989
PDF is available here.
PDF is available here.
Abstract
A sixth gene cassette containing a dfrB-type gene, dfrB6, was found in a dfrB6-aadA1 cassette array in class 1 integrons. This array was isolated from several multiply antibiotic-resistant Salmonella enterica serovar Infantis strains that appear to be clonally related. The DfrB6 dihydrofolate reduct...
|
PMID: 16870788
PDF is available here.
PDF is available here.
Abstract
Multiple and complex mechanisms involving mobile genetic elements in class 1 and class 2 integrons and antibiotic resistance have been developed in the evolution of Shigella strains....
|
PMID: 16766536
PDF is available here.
PDF is available here.
Journal of Infection (53)1 2006
Abstract
CgA can cause community-acquired bloodstream infections, but does not appear to cause a disproportionate number of severe extraintestinal infections. This study provides evidence that UTI-causing clonal groups can cause a wide spectrum of disease and are an important clinical and public health conce...
|
PMID: 16269177
PDF is available here.
PDF is available here.
Trends in Microbiology (14)5 2006
Abstract
The introduction and wide use of antibacterial drugs has resulted in the emergence of resistant organisms. DfrB dihydrofolate reductase (DHFR) is a bacterial enzyme that is uniquely associated with mobile gene cassettes within integrons, and confers resistance to the drug trimethoprim. This enzyme h...
|
PMID: 16584884
PDF is available here.
PDF is available here.
Abstract
We show that the use of a culture medium containing streptomycin, sulfamethoxazole, and trimethoprim (the antibiotic selection technique [AST]) can significantly enhance the isolation of environmental V. cholerae O1 with epidemic potential (P<.001). The AST was also used to monitor the recent emerge...
|
PMID: 16518766
PDF is available here.
PDF is available here.
Abstract
Horizontal gene transfer plays a larger role than clonal expansion in the increase of trimethoprim-sulfamethoxazole resistance levels in Europe and Canada....
|
PMID: 16464890
PDF is available here.
PDF is available here.
Abstract
E. coli isolates resistant to quinolones, trimethoprim/sulfamethoxazole and especially fluoroquinolones were associated with reductions in virulence traits and shifts to non-B2 phylogenetic groups. Moreover, fluoroquinolone resistance usually occurred in low-virulence E. coli group A isolates rather...
|
PMID: 16390858
PDF is available here.
PDF is available here.
Abstract
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encou...
|
PMID: 16424339
PDF is available here.
PDF is available here.
Abstract
These results suggest that DHPS mutations are currently as rare in Brazil as in other developing countries....
|
PMID: 16872298
PDF is available here.
PDF is available here.
Abstract
A multiply resistant Staphylococcus aureus isolate, WBG7410, harbours plasmids of 38, 26, 2.8, 2.4 and 1.9 kb and transfers trimethoprim and kanamycin resistance at high frequencies by conjugation. The transconjugants contained the 38-kb plasmid, pWBG707, and the 2.8-kb plasmid. Plasmid pWBG707 was s...
|
PMID: 1427013
PDF is available here.
PDF is available here.
Abstract
Shigella spp. infect approximately 450,000 persons annually in the United States, resulting in over 6,000 hospitalizations. Since 1999, the National Antimicrobial Resistance Monitoring System (NARMS) for Enteric Bacteria has tested every 10th Shigella isolate from 16 state or local public health lab...
|
PMID: 16377666
PDF is available here.
PDF is available here.
New Zealand Medical Journal (118)1225 2005
Abstract
216 dipstick positive specimens were collected in the survey period; 105 of these fulfilled criteria for significant bacteriuria. Trimethoprim resistance was found in 16 (15.2%) overall, with a resistance rate for Escherichia coli (E. coli) to trimethoprim of 17.7%. When compared to the proportions...
|
PMID: 16286940
PDF is available here.
PDF is available here.
New Microbiologica (28)4 2005
Abstract
We applied the ERIC AP-PCR and the SmaI PFGE RFLP methods. Overlapping drug resistances with these two molecular profiles, no significant correlation was obtained. The emergence of methicillin resistance in a multiple resistant strain is of great concern for resistance spreading surveillance in Moza...
|
PMID: 16386017
PDF is available here.
PDF is available here.
Abstract
This is the first report of trimethoprim, chloramphenicol and sulphonamide resistance genes and class 1 integrons in B. bronchiseptica isolates....
|
PMID: 16046466
PDF is available here.
PDF is available here.
Abstract
We have shown that epigallocatechin gallate is an efficient inhibitor of S. maltophilia dihydrofolate reductase, a strategic enzyme that is considered an attractive target for the development of antibacterial agents. The inhibition of S. maltophilia dihydrofolate reductase by this tea compound was s...
|
PMID: 15980368
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (245)2 2005
Abstract
Escherichia coli isolates from calf diarrhea cases (n=22) in the Beijing surrounding region in China were characterized for disease serotype, virulence factors, antimicrobial susceptibility pattern and class 1 integrons. 59% (n=13) of the isolates were positive for the int I1 gene. The presence and...
|
PMID: 15837385
PDF is available here.
PDF is available here.
Abstract
The presence of class 1, 2 and 3 integrons in Helicobacter pylori, which in other species are usually related to antimicrobial resistance, were looked for in 40 epidemiologically-unrelated isolates. The presence of the class 2 integrase, which led to the discovery of Tn7, was found in 15 of 35 diffe...
|
PMID: 15784316
PDF is available here.
PDF is available here.
Abstract
The MICs for 162 diarrheagenic Escherichia coli strains and 28 Shigella strains were determined on the basis of NCCLS guidelines. More than 75% of the strains were resistant to ampicillin, chloramphenicol (53.6% of Shigella strains), and trimethoprim-sulfamethoxazole. Multiresistance was detected in...
|
PMID: 15673777
PDF is available here.
PDF is available here.
Abstract
Treatment of uncomplicated urinary tract infections (UTIs) has changed in the past few years with researchers advocating empiric treatment for shorter periods of time without the use of cultures. Researchers report that antibiotic resistance of Escherichia coli (E. coli) to commonly prescribed antib...
|
PMID: 16255319
PDF is available here.
PDF is available here.
Abstract
A novel trimethoprim resistance gene, designated dfrA20, was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. The dfrA20 gene codes for a dihydrofolate reductase of 169 amino acids. Sequence comparisons revealed that the DfrA20 protein differed distinctly from all dihydrofolate redu...
|
PMID: 15616323
PDF is available here.
PDF is available here.
Abstract
These results confirm the natural resistance of B. anthracis to TMP and clarify that the resistance is correlated to a lack of selectivity for the chromosomally encoded gene product. These findings will assist in the development of narrow-spectrum antimicrobial agents for treatment of anthrax....
|
PMID: 15561838
PDF is available here.
PDF is available here.
Microbiology (150)Pt 11 2004
Abstract
Ten different antibiotic resistance plasmids conferring high-level erythromycin resistance were isolated from an activated sludge bacterial community of a wastewater treatment plant by applying a transformation-based approach. One of these plasmids, designated pRSB101, mediates resistance to tetracy...
|
PMID: 15528650
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (79)8 2004
Abstract
We review options for management of uncomplicated UTIs in light of these considerations....
|
PMID: 15301333
PDF is available here.
PDF is available here.
Clinical Infectious Diseases (38)11 2004
Abstract
We studied all human immunodeficiency virus (HIV)-infected patients with invasive pneumococcal disease who received their diagnosis during 1996-2002 to investigate the incidence of this disease in the highly active antiretroviral therapy era and to study the influence of CD4 lymphocyte count on the...
|
PMID: 15156452
PDF is available here.
PDF is available here.
Abstract
Practices showed considerable variation in both the prevalence of trimethoprim resistance (26-50% of bacteria isolated) and trimethoprim prescribing (67-357 prescriptions per 100 practice patients). Although variation in prescribing showed no association with resistance at the practice level after a...
|
PMID: 15166067
PDF is available here.
PDF is available here.
Abstract
From October 1999 through January 2000, an Escherichia coli clonal group (designated "CgA") was isolated from the urine of nearly one-half of all women with urinary tract infections (UTIs) caused by trimethoprim-sulfamethoxazole (TMP-SMZ)-resistant E. coli in a California community. This study descr...
|
PMID: 14727201
PDF is available here.
PDF is available here.
Abstract
Iclaprim, a new selective dihydrofolate inhibitor was synthesized based on rational drug design. Iclaprim's interaction with a resistant Staphylococcus aureus dihydrofolate reductase (DHFR) is outlined in comparison to trimethoprim (TMP). This compound is active against methicillin, TMP and vancomyc...
|
PMID: 14623005
PDF is available here.
PDF is available here.
Abstract
Sulphonamide resistance gene sul3, which is widespread among pigs in Switzerland, has now also been identified in two different clinical isolates of Escherichia coli, located in urinary tract infections in patients in Sweden....
|
PMID: 14585855
PDF is available here.
PDF is available here.
Abstract
Significant bacteriuria was found in 187 samples (60%). E coli was isolated from 153 (82%) of these samples. Other isolated uropathogens were S saprophyticus 18 (10%), Proteus spp 6 (3%), Klebsiella spp 4 (2%), Enterobacter spp 2 (1%), enterococci 1 (0.5%) and other Gram-positive bacteria 3 (1,5%)....
|
PMID: 12934120
PDF is available here.
PDF is available here.
Abstract
We describe an alternative, faster and easier method, based on PCR amplification and RFLP analysis, to discriminate up to sixteen different dfr genes....
|
PMID: 12944023
PDF is available here.
PDF is available here.
Abstract
A five year retrospective study was performed to identify organisms isolated from the urinary tract of 2815 children in the community and 1314 children with underlying renal problems and their antimicrobial susceptibilities. Isolates from children in the latter group were generally more resistant to...
|
PMID: 12716722
PDF is available here.
PDF is available here.
Abstract
Our data show partial cross-resistance between PYR/TRM and SDX/SMX (r = 0.85 and 0.65). Correlation was not observed between different dhps genotypes and the in vitro outcome to SDX and SMX (r = 0.30 and 0.34). The lack of correlation could be due to folates and para-aminobenzoic acid in the RPMI me...
|
PMID: 12812351
PDF is available here.
PDF is available here.
Disease-a-Month (49)2 2003
Abstract
Management of uncomplicated urinary tract infections (UTIs) has traditionally been based on 2 important principles: the spectrum of organisms causing acute UTI is highly predictable (Escherichia coli accounts for 75% to 90% and Staphylococcus saprophyticus accounts for 5% to 15% of isolates), and th...
|
PMID: 12601340
PDF is available here.
PDF is available here.
Abstract
A high rate of antibiotic resistance was associated with the Salmonella isolates and the genes responsible for the resistance are located on conjugative plasmids. Also, there appears to be minimal diversity associated with the isolates. SIGNIFICANCE AND IMPACT OF THE STUDY: As a result of the increa...
|
PMID: 12534821
PDF is available here.
PDF is available here.
Abstract
A single Salmonella enterica serovar Typhimurium isolate with an UT2 phage type producing an extended-spectrum beta-lactamase (ESBL) was identified in Canada in 2000. The isolate harbored two plasmids, one containing a bla(TEM-1) gene and the other containing a bla(SHV-2a) gene. The ESBL gene was lo...
|
PMID: 12517894
PDF is available here.
PDF is available here.
Ugeskrift for laeger (164)40 2002
Abstract
Managed care interface (15)6 2002
Abstract
Escherichia coli is typically the causative organism in uncomplicated urinary tract infection (UTI). Resistance rates of E. coli to trimethoprim/sulfamethoxazole (TMP/SMX) are increasing, exceeding 10% in many communities. Guidelines recommend using alternative treatments in these areas. Providers m...
|
PMID: 12087605
PDF is available here.
PDF is available here.
Abstract
This is the first report of a patient diagnosed with sinusitis due to Stenotrophomonas maltophilia. Despite the organism being resistant to trimethoprim-sulfamethoxazole, the infection was cured by drainage and treatment with intravenous piperacillin, followed by oral ciprofloxacin.
|
PMID: 11928848
PDF is available here.
PDF is available here.
Abstract
Two class 1 integrons, In-t1 and In-t2, were previously identified in IncFI plasmids of Salmonella enterica serotype Typhimurium. Molecular analysis revealed a close physical link between the two integrons. In-t1 is preceded by the transposase genes of Tn21, whereas In-t2 is located downstream the 3...
|
PMID: 12002644
PDF is available here.
PDF is available here.
Abstract
Information on V. cholerae eltor isolated in the focus of cholera in Kazan in 2001 at different periods of the outbreak is presented. The identity of strains isolated from patients, vibriocarriers and environmental objects, including their antibioticograms (sensitivity to cyprofloxacin and resistanc...
|
PMID: 12043149
PDF is available here.
PDF is available here.