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Vancomycin Resistance (0):
Recent article
Vancomycin Resistance
New England Journal of Medicine (364)15 2011
Abstract
We evaluated the effect of surveillance for MRSA and VRE colonization and of the expanded use of barrier precautions (intervention) as compared with existing practice (control) on the incidence of MRSA or VRE colonization or infection in adult ICUs. Surveillance cultures were obtained from patients...
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PMID: 21488763
PDF is available here.
PDF is available here.
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Rinsho Ketsueki (52)4 2011
Abstract
Abstract
The principal objective of this study was to evaluate the antibacterial activities of macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA) generated from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci (VREs) and methicillin-resistant Staphylococcus aureus. The minimal inhi...
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PMID: 21468926
PDF is available here.
PDF is available here.
Abstract
We examined the frequency of stool, skin, and environmental contamination with C. difficile and VRE in hospitalized patients with SCl....
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PMID: 21528623
PDF is available here.
PDF is available here.
Versicherungsmedizin / herausgegeben von Verband der Lebensversicherungs-Unternehmen e.V. und Verband der Privaten Krankenversicherung e.V (62)4 2010
Abstract
The Methicillin-resistant Staphylococcus aureus (MRSA) is a Staphylococcus aureus (S. aureus) resistant against all kinds of beta-lactam antibiotics. Moreover, resistances against other antibiotics have gradually started to develop. In the last decades, MRSA started as a serious problem only in hosp...
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PMID: 21192484
PDF is available here.
PDF is available here.
Abstract
To determine the pattern of antibiotic resistance in the clinical isolates of Staphylococcus (S.) aureus, Methicillin Resistant S. aureus (MRSA) and define the possible emergence of Vancomycin resistant S. aureus (VRSA) in Karachi.
An observational study.
Essa Laboratories and Department of Molecula...
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PMID: 21078245
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)10 2010
Abstract
We performed an 8-year retrospective study of all hospitalized patients with recurrent VRE colonization after they were documented as being clear of VRE and compared the primary colonization isolates and recolonization isolates by pulsed-field gel electrophoresis and Tn1546 typing. Review of the med...
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PMID: 20109265
PDF is available here.
PDF is available here.
Abstract
Contaminated environmental surfaces are important reservoirs in the transmission of many human pathogens. Although several options exist for disinfecting contaminated environmental surfaces, few are compatible with use on both hard smooth non-porous (hard) and soft porous surfaces (soft) while still...
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PMID: 20574884
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)9 2010
Abstract
We hypothesized that the BIVR phenomenon might be exerted by a peptidoglycan derivative(s) generated as a consequence of β-lactam antibiotic action. To verify this hypothesis, we isolated the fraction that mimicked the effect of β-lactam antibiotics by the enzymatic treatment of the crude cell wal...
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PMID: 20588304
PDF is available here.
PDF is available here.
Abstract
We retrospectively studied 306 pediatric methicillin-resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration (MIC) change over time using Etest, agar dilution, and broth microdilution (MicroScan) methods. Vancomyc...
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PMID: 20453708
PDF is available here.
PDF is available here.
Abstract
This descriptive study was conducted in a public hospital from May 2005 to October 2007, with the purpose to determine the epidemiological aspects that involve vancomycin-resistant enterococci (VRE) and describe the evolution of patients. The data was obtained from registers on patient records and t...
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PMID: 20964050
PDF is available here.
PDF is available here.
Abstract
We observed difficulties in controlling colonization with measures directed mainly by surveillance cultures and differences between responses of E faecium and E faecalis.
Copyright 2010 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights rese...
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PMID: 20006408
PDF is available here.
PDF is available here.
American Journal of Infection Control (38)5 Suppl 1 2010
Abstract
Health care-associated infections (HAI) remain a major cause of patient morbidity and mortality. Although the main source of nosocomial pathogens is likely the patient's endogenous flora, an estimated 20% to 40% of HAI have been attributed to cross infection via the hands of health care personnel, w...
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PMID: 20569853
PDF is available here.
PDF is available here.
Orthopaedic Nursing (23)5 2010
Abstract
Abstract
Enterococcus faecium has emerged as an important nosocomial pathogen worldwide, and this trend has been associated with the dissemination of a genetic lineage designated clonal cluster 17 (CC17). Enterococcal isolates were collected prospectively (2006 to 2008) from 32 hospitals in Colombia, Ecuador...
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PMID: 20220167
PDF is available here.
PDF is available here.
Journal of Infection (60)5 2010
Abstract
Based on these results, we conclude that this assay is considerably more sensitive than traditional microbiological methods for detecting vancomycin-resistant enterococci from rectal swabs. It is also much faster than culture. We believe that the implementation of this assay in routine clinical labo...
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PMID: 20211201
PDF is available here.
PDF is available here.
Abstract
Overall, hGISA is associated with a poor clinical course in patients with bacteremia. Information is still lacking regarding the actual prevalence of hGISA as well as the extent of its clinical impact. A uniform method of diagnosis must be established in order to better account for all cases of hGIS...
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PMID: 20332341
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
Vancomycin is a key tool in the treatment of serious Gram-positive infections. A progressive increase in vancomycin resistance with consequent treatment failure has been observed in staphylococci. Therefore, new dosing guidelines advocating much higher vancomycin doses have been issued. Target troug...
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PMID: 20182415
PDF is available here.
PDF is available here.
Abstract
We evaluated 117 curative adult prescriptions from nine hospitals. Glycopeptide indications were adequate in 71% with either a clinical (55%) or microbiological justification (27%). The indication was more frequently adequate for vancomycin than for teicoplanin (77% vs. 60%, p=0.04). De-escalation t...
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PMID: 19959309
PDF is available here.
PDF is available here.
Abstract
A case of enterococcal meningitis in a toddler is presented. The organism was highly resistant to all drugs previously used for pediatric Gram-positive meningitis. She was successfully treated with intraventricular and intravenous daptomycin and intravenous tigecycline. The organism was characterize...
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PMID: 20010311
PDF is available here.
PDF is available here.
Zentralblatt für Chirurgie (135)2 2010
Abstract
The transmission of multidrug-resistant organisms (MRSA, VRE and ESBL producing bacteria) occurs predominantly if health-care workers are not compliant with hand hygiene procedures. The impact of single-room isolation in transmission prevention is often overestimated. As long as hand disinfection is...
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PMID: 20379942
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Infections caused by Gram-positive organisms have increased in frequency and severity. Daptomycin offers a therapeutic option in an era of increasing resistance. AREAS COVERED IN THIS REVIEW: Literature from 1986 to present was reviewed for pharmacological, preclinical and c...
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PMID: 20163272
PDF is available here.
PDF is available here.
Abstract
We investigated the prevalence and the molecular characteristics of vancomycin-intermediate Staphylococcus aureus (VISA) among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical samples at tertiary or general hospitals participating in a nationwide surveillance program...
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PMID: 20372039
PDF is available here.
PDF is available here.
Abstract
A total of 359 vancomycin-resistant enterococci (344 Enterococcus faecium and 15 E. faecalis) collected during 2007 from eight tertiary-care hospitals in Greece were analysed for genotypic characteristics. Four common clones, ST412, ST203, ST16 and ST17, were identified among E. faec...
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PMID: 20016994
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)3 2010
Abstract
These results support the notion that Tn1549 is a member of a MOB(p) clade. Interestingly, the Tn1549-derived constructs were mobilized by RP4 in E. coli, suggesting that a relaxosome resulting from DNA cleavage by Orf28 interacted with the coupling protein TraG. This demonstrates the capacity of Tn...
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PMID: 19966009
PDF is available here.
PDF is available here.
Abstract
We retrospectively evaluated 410 patients with coinfection or cocolonization due to vancomycin-resistant (VR) enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). The prevalence rate was 19.8%. Risk factors included isolation of VR Enterococcus faecalis and use of linezolid or...
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PMID: 20007403
PDF is available here.
PDF is available here.
Abstract
We describe the epidemiology of heterogeneously resistant Staphylococcus aureus (hVISA) identified in Canadian hospitals between 1995 and 2006. hVISA isolates were confirmed by the population analysis profiling-area under the curve method. Only 25 hVISA isolates (1.3% of all isolates) were detected....
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PMID: 19949062
PDF is available here.
PDF is available here.
Abstract
Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglyca...
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PMID: 19933802
PDF is available here.
PDF is available here.
Abstract
Healthcare-associated infections (HAIs) take a major human toll on society and reduce public confidence in the healthcare system. The current convergence of scientific, public, and legislative interest in reducing rates of HAI can provide the necessary momentum to address and answer important questi...
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PMID: 20038249
PDF is available here.
PDF is available here.
Fertility and Sterility (93)1 2010
Abstract
OBJECTIVE: To report infection and pyometra after ovum retrieval for IVF. DESIGN: Case report. SETTING: Community hospital. PATIENT(S): A 43-year-old woman with a recent history of ovum retrieval presented with high fever, chills, and no gynecologic symptoms. The patient was admitted to the medical...
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PMID: 19939375
PDF is available here.
PDF is available here.
Abstract
These results suggest that the presence of Salmonella in the finished products may be due to postprocessing contamination. This study has also revealed that the rendering industry has microbiologically improved its products since earlier studies were conducted....
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PMID: 20130695
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)1 2010
Abstract
We describe the crystal structure, biochemical characteristics, and expression profile of PBP4, a low-molecular-mass PBP from Staphylococcus aureus strain COL. The crystal structures of PBP4-antibiotic complexes reported here were determined by molecular replacement, using the atomic coordinates dep...
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PMID: 19854906
PDF is available here.
PDF is available here.
Abstract
We must also increase our understanding of the drug-resistant mechanisms of bacteria. In this issue we wish to introduce the recent worldwide trend in antimicrobial-resistant bacteria, especially multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant...
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PMID: 20077765
PDF is available here.
PDF is available here.
Renal Failure (32)9 2010
Abstract
We document a patient who developed peritonitis for the first time with VRE infection after shifting from HD to PD over 4 weeks. We suggest that physicians consider VRE a possible cause of PD peritonitis in patients who have recently shifted from HD to PD, especially in cases involving previous vanc...
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PMID: 20863220
PDF is available here.
PDF is available here.
Pharmacotherapy (30)1 2010
Abstract
Resistance to antibiotics among gram-positive bacteria, especially enterococci and staphylococci, has led to the need to develop new antibiotics. Vancomycin, a glycopeptide antibiotic, has been used for over 3 decades to treat serious methicillin-resistant Staphylococcus aureus infections. The incre...
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PMID: 20030476
PDF is available here.
PDF is available here.
BMC Infectious Diseases (10)1 2010
Abstract
In a high vancomycin MIC group in Taiwan, SCCmec III, spa type t037, was the predominant strain of MRSA identified. Patients with MRSA bacteremia in the ICU or who had prolonged hospitalization were more likely to be infected with S. aureus strains with high vancomycin MICs. The mortality rate was h...
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PMID: 20529302
PDF is available here.
PDF is available here.
Abstract
A superhydrophilic surface was successfully prepared using electrolytic plasma oxidation of aluminum (Al) followed by electroplating of copper (Cu) in a Cu-dotted form. Both Cu plate and Cu-dotted oxide surfaces had excellent antimicrobial activities against E. coli ATCC 25922, methicillin-resistant...
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PMID: 20843373
PDF is available here.
PDF is available here.
Abstract
Gene swapping is a simple but effective genetic tool for characterizing the functioning of a gene, where the gene in question is known to fulfil a distinctive biological role in the cell. VanS is a sensor kinase which, in conjunction with its cognate response regulator VanR, triggers resistance to v...
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PMID: 20401585
PDF is available here.
PDF is available here.
Abstract
Nemonoxacin (TG-873870) is a novel nonfluorinated quinolone with potent broad-spectrum activity against Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus, penicillin- and quinolone-resistant Streptococcus pneumoniae, and vancomycin-intermediate and vanc...
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PMID: 19884368
PDF is available here.
PDF is available here.
Pharmacotherapy (29)11 2009
Abstract
We summarize the conclusions and highlight the recommendations from the consensus statement. We determined that the area under the concentration-time curve (AUC): minimum inhibitory concentration (MIC) ratio is the most useful pharmacodynamic parameter to predict vancomycin effectiveness and suggest...
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PMID: 19873687
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (43)4 2009
Abstract
The widespread use of antimicrobial agents in the hospitals and environmental contamination with heavy metals are increasingly related to resistance progression in microorganisms. The aim of this study was to investigate the resistance of enterococci to high level aminoglycosides and some heavy meta...
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PMID: 20084907
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (43)4 2009
Abstract
Our results were in parallel with the data of other national and international studies, emphasizing that linezolid is a new and effective choice in treatment of infections caused by resistant gram-positive bacteria....
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PMID: 20084917
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (43)4 2009
Abstract
We aimed to search for the presence of VRE isolates in the unit, to determine the resistance genotypes and to evaluate the clonal relationships among isolates. A total of 28 rectal swabs and 28 skin swabs from the patients, 12 skin swabs from the staff giving care to the patients, 15 skin swabs from...
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PMID: 20084906
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)9 2009
Abstract
The antimicrobial activities of N(4)-octyl-6,6-dimethyl-N(2)-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitor...
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PMID: 19575042
PDF is available here.
PDF is available here.
Intestinal Enterococcus faecium colonization improves host defense during polymicrobial peritonitis.
Abstract
VR E. faecium infection, originating from a natural source (the intestinal tract), does not worsen the outcome of CLP-induced polymicrobial peritonitis and sepsis but rather facilitates bacterial clearance and attenuates host inflammatory responses....
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PMID: 19604046
PDF is available here.
PDF is available here.
Abstract
Journal of Antibiotics (62)10 2009
Abstract
I and type II PKS genes. The presumed products of this locus, TLN-05220 (1) and TLN-05223 (2), bear a core backbone composed of six fused rings starting with a 2-pyridone moiety. The structures were confirmed by conventional spectral analyses including MS, and 1D and 2D NMR experiments. Comparison o...
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PMID: 19680283
PDF is available here.
PDF is available here.
Abstract
We report the results of surveillance in ICU and onco-hematological wards from 2002 to 2008, with analysis of possible risk factors: demographical data, use and type of antibiotic, days of hospitalization prior to sampling, and year of hospitalization. Colonization rate increased from 0.03 cases per...
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PMID: 19802409
PDF is available here.
PDF is available here.
Abstract
We implemented a laboratory protocol to speed up the VRE screening from rectal samples. The protocol combines a medium for selective VRE isolation (VREBAC(R), Probac, São Paulo) and a multiplex PCR for detection and identification of vanA and vanB resistance genes. The screening performance was ana...
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PMID: 20231993
PDF is available here.
PDF is available here.
Abstract
The effect of freezing temperature (-7, -15, -30 and -80 degrees C), number of freeze/thaw cycles (1 to 5 cycles) and sample volume (100 mL and 100 microL) on the viability of a pathogenic and an opportunistically pathogenic Escherichia coli, a vancomycin-resistant and a vancomycin-sensitive Enteroc...
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PMID: 19774859
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)10 2009
Abstract
A library of 5''-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities w...
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PMID: 19629142
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Vancomycin-resistant enterococci pose an emerging health risk. The limitation in therapeutic options has resulted in the development of new drugs such as quinupristin/ dalfopristin and linezolid. AIM, SETTING AND DESIGN: This study investigated the species prevalence and antibacterial re...
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PMID: 19700910
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (43)3 2009
Abstract
Vancomycin-resistant enterococci (VRE) have been increasingly reported from most countries around the world following initial isolation from patients in United States and European countries. A vancomycin-resistant Enterococcus faecium (VREF) outbreak was determined by hospital infection control comm...
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PMID: 19795611
PDF is available here.
PDF is available here.
Pharmacotherapy (29)7 2009
Abstract
Patients were included if they received daptomycin and had a blood culture positive for VRE at the time daptomycin was started. The primary end point was microbiologic cure, defined as negative blood cultures for VRE at the end of therapy. Secondary outcomes were clinical outcomes, adverse events, a...
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PMID: 19558253
PDF is available here.
PDF is available here.
Abstract
We evaluated Vitek software version 2.01 by the CLSI-recommended broth dilution method as well as the CDC-recommended vancomycin screen agar and Etest for vancomycin susceptibility testing of Staphylococcus spp. Of the 105 isolates of Staphylococci tested by the above methods, Vitek 2.01 gave 16 (15...
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PMID: 19628909
PDF is available here.
PDF is available here.
Abstract
Recently, strains of methicillin-resistant Staphylococcus aureus (MRSA) with reduced susceptibility to vancomycin (VCM) have been clinically isolated. The antibacterial activity of a new drug, linezolid (LZD), in such a strain was evaluated by measuring bacterial metabolic activity. A total of 73 MR...
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PMID: 19652523
PDF is available here.
PDF is available here.
Abstract
Suboptimal cleaning practices were documented by determining aerobic colony counts and by use of an ATP bioluminescence assay. ATP readings provided quantitative evidence of improved cleanliness of high-touch surfaces after the implementation of an intervention program....
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PMID: 19489715
PDF is available here.
PDF is available here.
Abstract
A series of bis-benzimidazole diamidine compounds containing different central linkers has been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Seven compounds have shown potent antibacterial activities. The anti-MRSA and a...
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PMID: 19481935
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)11 2009
Abstract
The predominant MRSA clone at Beijing Chaoyang Hospital from 2006 to 2007 had the type III SCCmec element. All of the MRSA isolates were multiresistant to antimicrobial agents. Emergence of coexistence of MRSA and VRE in the same patient was not rare. Physicians should pay more attention to infectio...
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PMID: 19567138
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to determine the types and frequencies of VRE in terms of the existence of Van genes and to investigate the efficacy of newly introduced antibiotics. Totally 297 enterococcal strains were isolated from patients' specimens. Minimum inhibitory concentration of resistant isola...
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PMID: 19803118
PDF is available here.
PDF is available here.