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beta-Lactam Resistance (2):
Recent article
beta-Lactam Resistance
Avian Diseases (55)3 2011
Abstract
We identified 11 species of bacteria from masked booby (Sula dactylatra) and Christmas shearwater (Puffinus nativitatis); five species of gram-negative bacilli, four species of Streptococcus (Enterococcus), and 2 species of Staphylococcus. In addition, 6 types of bacteria were determined barely to t...
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PMID: 22017052
PDF is available here.
PDF is available here.
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Abstract
Extended-spectrum ß-lactamase-producing Enterobacteria (ESBL-PE) emerged at the end of the 1980s, causing nosocomial outbreaks and/or hyperendemic situations in hospitals and long-term care facilities. In recent years, community-acquired infections due to ESBL-PE have spread worldwide, especially ac...
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PMID: 21829498
PDF is available here.
PDF is available here.
Abstract
We explored the chromosomally-encoded determinants that contribute to the phenotype of susceptibility of P. aeruginosa to ceftazidime, imipenem and carbapenem. Using a comprehensive library of transposon-tagged insertion mutants, we found 37 loci in the chromosome of P. aeruginosa that contributed t...
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PMID: 21304266
PDF is available here.
PDF is available here.
Abstract
Among 62 clinical strains of enterobacteria, isolated from intestinal tract, representatives of genus Escherichia made--67.4%, Klebsiella--4.84%, Citrobacter--4.84%, Enterobacter--8.06%, Proteus--6.45%, Morganella of 8.06%. Preparations of fluorquinolone group--gatifloxacin and moxifloxacin, the numb...
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PMID: 21598655
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (45)1 2011
Abstract
Infections caused by extended-spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella spp. constitute severe problems. Carbapenems are commonly used to treat these infections. However, infections caused by carbapenem-resistant gram-negative bacteria show an increasing trend recently....
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PMID: 21341156
PDF is available here.
PDF is available here.
Abstract
We recorded three cases of iatrogenic meningitis after lumbar puncture. Two cases occurred in newborn admitted for suspicion of neonatal infection and one in a 2-month-old infant admitted for exploration of hyperpyretic convulsion. In all patients, the initial cerebrospinal fluid was normal. All pat...
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PMID: 21103965
PDF is available here.
PDF is available here.
Lancet Infectious Diseases (10)11 2010
Abstract
Abstract
Of the 97 patients diagnosed with ESBL-producing E. coli bacteremia, six were excluded owing to incomplete follow-up and missing data. Comparisons were made between 91 patients and their controls. Multivariate analysis identified urinary catheterization [odds ratio (OR) = 6.21, 95% confidence interv...
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PMID: 20688291
PDF is available here.
PDF is available here.
Abstract
Molecular epidemiology at local scale in Sicily (Italy) of ampicillin resistance in Salmonella spp. isolates from municipal wastewater (n = 64) and clinical specimens (n = 274) is described in comparison with previously examined Escherichia coli isolates (n = 273) from wastewater. High prevalence of...
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PMID: 20367333
PDF is available here.
PDF is available here.
Abstract
The increased prevalence of beta-lactamases in Pseudomonas aeruginosa has begun to reduce the clinical efficacy of beta-lactams against the most common opportunistic pathogen. Of over 800 beta-lactamases identified from Gram-negative bacilli, at least 120 beta-lactamases have been detected in P. aer...
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PMID: 20482453
PDF is available here.
PDF is available here.
Journal of Chemotherapy (22)4 2010
Abstract
We confirm the common association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase (ESbetaL) production. This is the first finding in Italy of qnrB9 and TEM-116 in a non-clinical or animal strain....
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PMID: 20685627
PDF is available here.
PDF is available here.
Journal of Chemotherapy (22)4 2010
Abstract
Ertapenem and piperacillin/tazobactam are beta-lactam antibiotics with a broad spectrum of activity, used for the treatment of mixed infections, in which Bacteroides fragilis plays an important etiological role. The aim of this study was to select strains of B. fragilis resistant to these drugs and...
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PMID: 20685630
PDF is available here.
PDF is available here.
Tijdschrift voor diergeneeskunde (135)13 2010
Abstract
Journal of Medical Microbiology (59)Pt 7 2010
Abstract
Journal of Medical Microbiology (59)Pt 7 2010
Abstract
To investigate the antimicrobial resistance, extended-spectrum beta-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates...
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PMID: 20360396
PDF is available here.
PDF is available here.
Abstract
Fifteen nonrepetitive ampicillin-resistant Salmonella spp. were identified among 91 Salmonella sp. isolates during nationwide surveillance of Salmonella in waste from 131 chicken farms during 2006 and 2007. Additional phenotyping and genetic characterization of these 15 isolates by u...
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PMID: 20525869
PDF is available here.
PDF is available here.
Tijdschrift voor diergeneeskunde (135)12 2010
Abstract
Tijdschrift voor diergeneeskunde (135)12 2010
Abstract
Southern Medical Journal (103)5 2010
Abstract
An Enterobacter cloacae blood culture isolate expressing carbapenem resistance via the Klebsiella pneumoniae carbapenemase KPC-2 gene is reported. To our knowledge, this is the first report of a nosocomial isolate with carbapenemase-mediated resistance causing infection in a patient from Tennessee....
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PMID: 20375954
PDF is available here.
PDF is available here.
Abstract
ChromID extended-spectrum beta-lactamase (ESBL) culture medium is routinely used for screening ESBL producers. This medium was tested for detecting carbapenemase-producing Enterobacteriaceae isolates from a collection of reference strains and compared to the CHROMagar KPC culture medium previously e...
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PMID: 20237104
PDF is available here.
PDF is available here.
Abstract
This study analyzed the prevalence of antibiotics resistance and the distribution of genes responsible for carbapenems resistance in Acinetobacter baumannii isolates. Clinical A. baumannii isolates were cultured, identified, and collected during the period from May 2007 to February 2009. Antibiotics...
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PMID: 20186452
PDF is available here.
PDF is available here.
Abstract
We report the first outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in Germany. The presence of KPC was confirmed by polymerase chain reaction (PCR). The KPC-encoding plasmid was analysed by transconjugation experiments, DNA sequencing, Southern blotting and isoelectric...
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PMID: 20213255
PDF is available here.
PDF is available here.
Abstract
The presence of 3 clones among the CR-AB isolates suggests that cross-transmission was the main mechanism responsible for dissemination of OXA-23 producers. PFGE pattern A was genotypically similar to that of the first OXA-23-producing A baumannii clone identified in Curitiba in 1999. This clone per...
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PMID: 20123152
PDF is available here.
PDF is available here.
Abstract
Extended-spectrum AmpC beta-lactamase (ESAC) Escherichia coli producers were investigated over a 5-year period. Eleven isolates presenting a strong ampC promoter and different strategic AmpC mutations, including two newly described modifications (A292V and an L-A-A insertion at 295), were characteri...
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PMID: 20145079
PDF is available here.
PDF is available here.
Abstract
We obtained the three-dimensional structure of OXA-46, which shows the overall fold of active serine beta-lactamases and a dimeric quaternary structure. Significant differences with currently available structures of class D beta-lactamases were found in the loops located close to the active site, wh...
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PMID: 20145076
PDF is available here.
PDF is available here.
Abstract
Abstract
We aimed to identify the role of various antibiotics as risk factors for the isolation of extended-spectrum-beta-lactamase (ESBL)-producing Klebsiella spp. in hospitalized patients at a tertiary-care hospital. A parallel multivariable model was created to compare two groups of cases with either noso...
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PMID: 20211888
PDF is available here.
PDF is available here.
Abstract
The Capnocytophaga sputigena isolate NOR, responsible for septicemia, was resistant to amoxicillin and narrow-spectrum cephalosporins. In a cloning experiment, a new gene, bla(CSP-1), was identified; this gene encodes a novel extended-spectrum beta-lactamase (ESBL) that shares only 52% and 49% ident...
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PMID: 20308380
PDF is available here.
PDF is available here.
Abstract
We analyzed data from 6 phase 3 multinational doripenem clinical trials on ciprofloxacin-resistant Enterobacteriaceae isolates consisting of all genera (CIPRE) and ESBL-producing Enterobacteriaceae isolates consisting of Escherichia coli, Klebsiella spp., and Proteus spp. with ceftazidime MICs of >o...
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PMID: 20211892
PDF is available here.
PDF is available here.
Abstract
Zentralblatt für Chirurgie (135)2 2010
Abstract
The transmission of multidrug-resistant organisms (MRSA, VRE and ESBL producing bacteria) occurs predominantly if health-care workers are not compliant with hand hygiene procedures. The impact of single-room isolation in transmission prevention is often overestimated. As long as hand disinfection is...
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PMID: 20379942
PDF is available here.
PDF is available here.
Abstract
Increase in ESBL and carbapenem resistant K. pneumoniae is a serious threat to public health requiring continuous surveillance and use of appropriate screening tests for laboratory detection....
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PMID: 20225774
PDF is available here.
PDF is available here.
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive (18)1 2010
Abstract
Abstract
We describe the development and validation of an oligonucleotide microarray for the rapid identification of ESBLs in gram-negative bacteria by simultaneously genotyping bla(TEM), bla(SHV), and bla(CTX-M). The array consists of 618 probes that cover mutations responsible for 156 amino acid substituti...
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PMID: 20007393
PDF is available here.
PDF is available here.
Abstract
Intensive care unit (ICU)-acquired infections as a result of multidrug-resistant Gram-negative pathogens remain a serious problem in critically ill patients. Adult ICU patients who received intravenous fosfomycin were prospectively examined to assess its safety and effectiveness as a...
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PMID: 19694767
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)2 2010
Abstract
To monitor the changing trend of extended-spectrum beta-lactamase (ESBL)-producing bacteria, a 7-year continuous study was launched in 2001 at the largest tertiary hospital in Taiwan. A significant increase over the study period was evident for ESBL-producing isolates of Escherichia coli (4.8-10.0%)...
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PMID: 19619387
PDF is available here.
PDF is available here.
Abstract
Proteus sp. rods are opportunistic human pathogens, isolated mainly from urinary tract infections. They are naturally susceptible to most antimicrobials. However, acquisition of genes for extended spectrum beta-lactamases on plasmids and irrational antimicrobial treatment increase amount of multidru...
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PMID: 20976952
PDF is available here.
PDF is available here.
Abstract
Antibiotic resistance poses a serious threat to the successful treatment of hospitalized patients. Micro-organisms that produce carbapenamases, such as Klebsiella pneumoniae carbapenamases (KPCs) represent the next step in the continuously emerging problem of antibiotic resistance. Restrictions on a...
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PMID: 21029499
PDF is available here.
PDF is available here.
Abstract
Abstract
P. aeruginosa rods are opportunistic pathogens responsible generally for nosocomial infections. Resistance to carbapenems, observed among them, is a serious threat due to ability to be transmitted between bacterial species. The aim of our study was to evaluate the usefulness of PCR-RAPD technique in...
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PMID: 21114013
PDF is available here.
PDF is available here.
Abstract
P. aeruginosa rods are dangerous pathogens mainly responsible for nosocomial infections of different localization. Resistance to carbapenems, observed among them, is a serious threat due to ability to be transmitted between bacterial species. The aim of our study was to retrospectively evaluate the...
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PMID: 21114014
PDF is available here.
PDF is available here.
Abstract
We obtained 20 carbapenem-resistant, OXA-23-producing isolates from different regions. Their clonal relationship was assessed by pulsed-field gel electrophoresis and multilocus sequence typing. We identified 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European...
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PMID: 20031040
PDF is available here.
PDF is available here.
Abstract
Abstract
Salmonella enterica serovar Typhimurium circulating in food animal populations and carrying resistance to antimicrobial agents represents a human health risk. Recently, a new clade of S. Typhimurium, WA-TYP035/187, was reported in cattle and humans in the Pacific Northwest, United States of America....
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PMID: 19880639
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)1-2 2010
Abstract
Abstract
Beta-lactam antibiotics remain the drugs of choice for treatment of S. pneumoniae infections in spite of growing level of resistance. The formation of S. pneumoniae resistance to these drugs is mediated by modifications of the penicillin-binding proteins (PBPs), the targets of the antibiotic action....
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PMID: 20882772
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)1-2 2010
Abstract
Resistance of 2134 clinical isolates of etiologically significant species of gramnegative bacteria to 5 beta-lactam antibiotics, i. e. cefepime, piperacillin/tazobactam, cefoperazone/sulbactam, imipenem and ceftazidime (the 3rd generation cephalosporin) as the reference drug was investigated for the...
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PMID: 20583554
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)9-10 2010
Abstract
Nosocomial bacterial isolates collected within 2003-2004 (n=411) and 2005-2007 (n=422) were highly resistant to cephalosporins III-IV and antibacterials of other groups (aminoglycosides, fluoroquinolons, chloramphenicol, and co-trimoxazole). Genes encoding TEM, SHV, CTX-M, OXA-2, and AmpC types of be...
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PMID: 21400746
PDF is available here.
PDF is available here.
Revista Medico-Chirurgicala (114)2 2010
Abstract
We evaluated the performances and analyzed practicability of an ESBL-detecting chromogenic agar medium (chromID ESBL, bioMerieux) for the screening of ESBL production.
We have tested 112 enterobacteria strains, isolated in 2009 year, in North Eastern region of Romania. Each bacterial strain was cult...
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PMID: 20700996
PDF is available here.
PDF is available here.
Indian Pediatrics (46)12 2009
Abstract
This study reports the prevalence of extended-spectrum b-lactamase producing Escherichia coli and Klebsiella spp among septicemic neonates. Over a five year period, there were 94 isolates of Klebsiella spp and E .coli. Of these, 68 (72.3%) were ESBL producers. Forty (80%) of the Klebsiella spp isola...
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PMID: 20061592
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)12 2009
Abstract
Outbreaks of carbapenem-resistant Acinetobacter species have emerged, especially in Singapore. Combination therapy may be the only viable option until new antibiotics are available. The objective of this study was to identify potential antimicrobial combinations against carbapenem-resistant Acinetob...
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PMID: 19876075
PDF is available here.
PDF is available here.
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine (15 Suppl 9) 2009
Abstract
1. Extended-spectrum beta-lactamase(ESBL) resistance in Enterobacter spp may be under-recognised. 2. Detection methods for ESBL resistance in Enterobacter spp may need to be modified.
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PMID: 20393215
PDF is available here.
PDF is available here.
Abstract
In the clinical isolates, the sensitivity of the tests was 99.5% for Vitek and 95.3% for Phoenix. There were no significant differences between the 2 systems in the control strains. Execution of the expert system raised the sensitivity of Phoenix to 100%. However, the Vitek 2 expert system considere...
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PMID: 19473732
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (58)Pt 10 2009
Abstract
Isolates of Klebsiella pneumoniae harbouring the carbapenemase KPC may have carbapenem MICs that remain in the susceptible range, and may therefore go unrecognized. To understand the mechanisms contributing to the variability in carbapenem MICs, 20 clinical isolates, all belonging to either of two c...
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PMID: 19556371
PDF is available here.
PDF is available here.
Abstract
Acinetobacter baumannii colonization and infection, frequent in Intensive Care Unit (ICU) patients, is commonly associated with high morbimortality. Several outbreaks due to multidrug-resistant (MDR) A. baumanii have been reported but few of them in Brazil. This study aimed to identify risk factors...
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PMID: 20428632
PDF is available here.
PDF is available here.
Abstract
Increasing reports of Acinetobacter infections that cause pneumonia, meningitis, endocarditis, and bacteriaemia underline the clinical importance of this pathogen. Members of the genus Acinetobacter, particularly Acinetobacter baumannii, are now recognized as significant nosocomial pathogens, partic...
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PMID: 20034329
PDF is available here.
PDF is available here.
Veterinary Research Communications (33 Suppl 1)s1 2009
Abstract
Abstract
The purpose of the current study was to investigate the presence and molecular type(s) of extended-spectrum beta-lactamases (ESBLs) in Salmonella spp. isolates obtained from patients with diarrhea in hospitals of Tehran, Iran. Over a period of 17 months, 129 Salmonella spp. were isolated from fecal...
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PMID: 19762986
PDF is available here.
PDF is available here.
Abstract
Extended spectrum beta-lactamases (ESBL) are capable of inhibiting the action of extended spectrum cephalosporins and monobactams. The objective of this work is to describe six isolates of ESBL producing Pseudomonas aeruginosa, retrieved from intensive care patients. The susceptibility test was perf...
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PMID: 19802399
PDF is available here.
PDF is available here.
Abstract
Of 2697 E coli, K pneumoniae, and K oxytoca cultured, 26 ESBL producers were isolated from 16 children. Rates of ESBL production among cultured isolates significantly increased, from 0.53% in the first half of the study period to 1.4% in the second. Incidence of a primary ESBL infection also increas...
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PMID: 19155096
PDF is available here.
PDF is available here.