Abstract
The educational objectives for this case-based self-assessment module are for the participant to exercise, self-assess, and improve skills in diagnostic radiology with regard to the interpretation of MRI examinations of nontumorous skeletal muscle disease.
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PMID: 21606242
PDF is available here.
Abstract
The herb Arnica montana, in topical formulations, has been reputed to decrease bruising and muscle pain. This claim has been inadequately and incompletely addressed.
To determine whether topical A. montana cream could decrease subjective leg pain following calf raises. Secondary outcomes were effect...
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PMID: 20807867
PDF is available here.
Abstract
Myopathies caused by industrial and biological toxins are uncommon but quite interesting, because its prompt recognition may reduce their damaging effects or prevent a fatal outcome.
To describe the most frequent toxic myopathies.
Toxic myopathies epidemiology, clinical presentations and clinical ma...
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PMID: 20839172
PDF is available here.
Abstract
We tested this hypothesis by following the effect of siRNA AChE silencing on apoptotic markers and by determination of AChE level after staurosporine-induced apoptosis in cultured human myoblasts. Decreased apoptosis in siRNA AChE silenced myoblasts and increased AChE expression in staurosporine-tre...
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PMID: 20338155
PDF is available here.
Abstract
Our findings agree with those showing hypoalgesic effects of ginger in osteoarthritis patients and further demonstrate ginger's effectiveness as a pain reliever.
Copyright 2010 American Pain Society. Published by Elsevier Inc. All rights reserved....
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PMID: 20418184
PDF is available here.
Abstract
The novel automatic duration method is more accurate than other available algorithms in normal and pathological MUAPs. SIGNIFICANCE: Accurate MUAP duration automatic measurement is an important issue in daily clinical practice.
2010 International Federation of Clinical Neurophysiology. Published by...
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PMID: 20427231
PDF is available here.
Abstract
Cholesterol drug lowering is a paradig on how to best apply clinical evidence to clinical practice. Considering the available options, it is essential that statins have a clear safety and tolerability profile and a favourable benefit/risk relationship. Intensive cholesterol drug lowering is not asso...
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PMID: 21180182
PDF is available here.
Abstract
Ankle Foot Orthoses (AFOs) to promote walking ability are a common treatment in patients with neurological or muscular diseases. However, guidelines on the prescription of AFOs are currently based on a low level of evidence regarding their efficacy. Recent studies aiming to demonstrate the efficacy...
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PMID: 20738235
PDF is available here.
Abstract
Statins are the most effective drugs for reducing LDL-cholesterol and have strong evidence based medicine documented by significant reduction of cardiovascular events in wide variety of patients. Despite this fact, they are still underused in common clinical practice. Many physicians have expressed...
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PMID: 21137170
PDF is available here.
Abstract
When observed under a microscope, skeletal muscle exhibits striations due to the highly organized arrangement of muscle proteins that interact with one another to induce muscle contraction. Muscle contraction requires transient increases in intracellular 'Ca(2+)' concentration. In this review, Ca(2+...
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PMID: 20553745
PDF is available here.
Abstract
We hypothesized that the potent negative regulator of muscle mass, myostatin, could play a role in the muscle loss associated with ESLD. In this preliminary investigation, we measured myostatin levels in patients undergoing liver transplant evaluation, using a novel enzyme-linked immunosensitivity a...
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PMID: 20686014
PDF is available here.
Abstract
We show that our method leads to significant improvement when compared to previous work. We are able to distinguish between normal shapes and shapes that possess a pathology with an accuracy of almost 100%. Moreover, we can differentiate between the different pathology groups with an average accurac...
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PMID: 20605487
PDF is available here.
Rosário Santos,
Jorge Oliveira,
Emília Vieira,
Teresa Coelho,
António Leite Carneiro,
Teresinha Evangelista,
Cristina Dias,
Ana Fortuna,
Argemiro Geraldo,
Luís Negrão,
António Guimarães and
Elsa Bronze-da-Rocha
Abstract
The allelic muscle disorders known as limb-girdle muscular dystrophy type 2B (LGMD2B), Miyoshi myopathy and distal anterior compartment myopathy result from defects in dysferlin-a sarcolemma-associated protein involved in membrane repair. Mutation screening in the dysferlin gene (DYSF) enabled the i...
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PMID: 20535123
PDF is available here.
Abstract
The objective of the present work was to study the effect of helium-neon (He-Ne) and gallium-arsenide (Ga-As) laser upon inflammatory biomarkers associated with oxidative stress: fibrinogen, nitric oxide (NO), L-citrulline, and superoxide dismutase (SOD). These were evaluated through histological as...
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PMID: 20662035
PDF is available here.
Abstract
We report a near-infrared fluorescent contrast agent, crimson carrier, which acts as a blood pool contrast agent to detect and quantify injury and disease in live animals. After determining the excitation-emission spectra and pharmacokinetics, crimson carrier was injected into myoinjured mice to mon...
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PMID: 20544935
PDF is available here.
Abstract
We have identified an infant with fatal cardiomyopathy due to a homozygous mutation, p.R943X, in MYBPC3. The patient also had an unexpected skeletal myopathy. The patient expressed the cardiac specific MyBPC isoform in skeletal muscle at transcript and protein levels. Numerous muscle fibres expressi...
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PMID: 19858127
PDF is available here.
Abstract
We present a case of percutaneous sclerotherapy with Sotradecol and ethanol into an extensive lower extremity venous malformation in the setting of orthopedic megaprosthesis. We feel that this led to extensive soft tissue necrosis and infection of the limb and created a precipitous situation....
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PMID: 20442652
PDF is available here.
Abstract
Chronic exertional compartment syndrome should be considered in any runner experiencing exertional leg pain. Runners typically describe a tight, cramping ache over the involved compartment that commences at a reproducible point in the run and resolves with rest. Diagnosis should include a careful hi...
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PMID: 20610031
PDF is available here.
Abstract
Over a 79-month period, 21 extremities (11 thighs and 10 calves) of 16 patients were imaged. Fourteen (88%) patients had type 2 diabetes, and two (12%) had type 1 diabetes. Four patients (25%) had disease in more than one location. In the thigh, the anterior compartment was involved in all patients....
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PMID: 20566817
PDF is available here.
Abstract
Based on the neurophysiological criteria for the assessment and classification of acquired weakness in critically ill patients, myopathy is highly predominant over the neuropathic impairment. Histopathological findings are closely related to the electrophysiological diagnosis of myopathy. Neither ne...
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PMID: 20533250
PDF is available here.
Abstract
The algorithms to predict acute renal failure, moderate/serious myopathy and cataract could be used to identify patients at increased risk of these adverse effects enabling patients to be monitored more closely. Further research is needed to develop a better algorithm to predict liver dysfunction....
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PMID: 20489220
PDF is available here.
Abstract
Pelvic floor muscle (PFM) dysfunction has been recently associated with the development of low back pain (LBP). Transabdominal ultrasound imaging has been established as an appropriate method for visualizing and measuring PFM function. No study has directly evaluated PFM function in individuals with...
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PMID: 20089440
PDF is available here.
Abstract
We provide a summary of the most recent clinical, pathophysiological and genetic information on those risks when the diagnosis is known or suspected preoperatively. Some simple clues are also given to help make a decision in the presence of an infant or child with hypotonia or motor delay but no dia...
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PMID: 20421788
PDF is available here.
Abstract
Pain remains a major clinical challenge, severely afflicting around 6% of the population at any one time. Channelopathies that underlie monogenic human pain syndromes are of great clinical relevance, as cell surface ion channels are tractable drug targets. The recent discovery that loss-of-function...
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PMID: 20142270
PDF is available here.
Abstract
We summarise the recent advances in the understanding of the molecular pathophysiology of hypoPP and consider how these may relate to the reported beneficial effects of acetazolamide. We also consider potential areas for future therapeutic development....
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PMID: 20123788
PDF is available here.
Abstract
Mutations of voltage-gated ion channels cause several channelopathies of skeletal muscle, which present clinically with myotonia, periodic paralysis, or a combination of both. Expression studies have revealed both loss-of-function and gain-of-function defects for the currents passed by mutant channe...
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PMID: 20156847
PDF is available here.
Abstract
We recorded and analyzed the X-ray diffraction patterns of human membrane-permeabilized muscle cells expressing a particular beta-tropomyosin mutation (R133W) associated with a loss in cell force production, in vivo muscle weakness, and distal arthrogryposis. Upon addition of calcium, we notably obs...
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PMID: 20457903
PDF is available here.
Abstract
We report on a patient with muscle pain not associated with muscle weakness. Microscopic examination of the muscle biopsy revealed rod-like cytoplasmic bodies in many fast fibres. By electron microscopy these had a crystalloid structure identical to the hexagonally cross-linked caveolin 3-positive t...
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PMID: 20211563
PDF is available here.
Abstract
The role of myosteatosis (fat infiltration in skeletal muscle) in diabetes has received considerable attention. There is reasonably consistent evidence that myosteatosis contributes to glucose and insulin abnormalities and diabetes, possibly even independent of overall obesity. Novel hypotheses that...
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PMID: 20179586
PDF is available here.
Abstract
We report the first Australian families with inclusion-body myopathy, Paget's disease of the bone and frontotemporal dementia (IBMPFD). The clinical characteristics of the two pedigrees are described including a previously undescribed phenotypic feature of pyramidal tract dysfunction in one family m...
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PMID: 20335036
PDF is available here.
Abstract
We compared the characteristics of rods associated with abnormalities in structural components of skeletal muscle thin filament (3 mutations in the skeletal actin gene ACTA1) with those of rods induced by the metabolic cell stress of adenosine triphosphate depletion. C2C12 and NIH/3T3 cell culture m...
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PMID: 20418783
PDF is available here.
Abstract
The abscess was drained via a minimally invasive posterior pharyngeal wall incision and placement of a suction catheter into the mediastinum through this incision. Residual intrathoracic collections were drained by the cardiothoracic team via percutaneous aspiration. The patient made a full recovery...
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PMID: 20307359
PDF is available here.
Abstract
We report the clinical, myopathological and MRI findings in the first German patient suffering from a myosin storage myopathy due to a heterozygous R 1845W missense mutation....
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PMID: 20376763
PDF is available here.
Abstract
Patients with TMD often present with complex pain symptoms, which can make it difficult to reach a diagnosis. Usually palpation of the masticatory muscles and TM joints, range of motion testing and imaging are used in the diagnostic process. Sometimes it is necessary to evaluate the jaw moving muscl...
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PMID: 20491230
PDF is available here.
Abstract
We discuss sensitivity, specificity and prognostic data brought up by these new imaging tools compared to ENMG and the significant future prospects they offer.
Copyright 2009 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved....
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PMID: 19375829
PDF is available here.
Abstract
We applied confocal single-particle fluorescence spectroscopy. We studied the de novo aggregation properties of desmin in vitro and the aggregation state of desmin in homogenates of transfected cells rendering purification unnecessary. We detected divergent assembly patterns for 3 different desmin m...
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PMID: 20448486
PDF is available here.
Abstract
Calcium salt deposits in the presence of normal calcium/phosphorus metabolism involving tissues that do not physiologically calcify are referred to as dystrophic calcification. The condition may be associated with a variety of systemic disorders. Additionally, injured tissue of any kind is predispos...
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PMID: 20305863
PDF is available here.
Abstract
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either c...
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PMID: 20393192
PDF is available here.
Abstract
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either c...
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PMID: 20393192
PDF is available here.
Abstract
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either c...
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PMID: 20393192
PDF is available here.
Abstract
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either c...
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PMID: 20393192
PDF is available here.
Abstract
Feeding triheptanoin, compared with the corn oil diet, resulted in exercise intolerance; higher plasma creatine kinase (CK) activity and concentrations of C3:0- and C7:0-acylcarnitine and insulin; and lower concentrations of nonesterified fatty acids (NEFA) and C16:0-, C18:1-, and C18:2-acylcarnitin...
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PMID: 20187835
PDF is available here.
Abstract
Topical ketoprofen patches are widely used in the treatment of musculoskeletal pain, but the pharmacokinetics of ketoprofen following topical application remain unclear. This open-label, single-dose pharmacokinetic study was designed to determine the concentrations of ketoprofen in the semitendinosu...
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PMID: 20087696
PDF is available here.
Abstract
Metabolic myopathies comprise a clinically and etiologically diverse group of disorders caused by defects in cellular energy metabolism, including the breakdown of carbohydrates and fatty acids to generate adenosine triphosphate, predominantly through mitochondrial oxidative phosphorylation. Accordi...
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PMID: 20425236
PDF is available here.
Abstract
We will summarize human observations that support this concept, then focus on models that have enabled (or may enable in the future) insight into the co-dependency of muscle and bone. Specifically, we will summarize data generated with three types of models: 1) spinal cord injury models, 2) transgen...
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PMID: 20190377
PDF is available here.