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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cartilage (3):
Recent article
Cartilage
Abstract
Mechanical signals can play a key role in regulating the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to determine if the long-term application of cyclic hydrostatic pressure could be used to improve the functional properties of carti...
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PMID: 21783134
PDF is available here.
PDF is available here.
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Abstract
We will be focusing on ESCs as a promising cell source for cartilage regeneration, the various strategies and approaches employed in chondrogenic differentiation and tissue engineering, the associated outcomes from animal studies, and the challenges that need to be overcome before clinical applicati...
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PMID: 21188652
PDF is available here.
PDF is available here.
Abstract
We consider here polymeric scaffold-based perfusion bioreactors, where an interstitial fluid supplies nutrients and oxygen to the growing biomass. At the same time, the fluid-induced shear acts as a physiologically relevant stimulus for the metabolic activity of cells, provided that the shear stress...
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PMID: 20865436
PDF is available here.
PDF is available here.
Abstract
Articular cartilage has limited repair and regeneration potential, and the scarcity of treatment modalities has motivated attempts to engineer cartilage tissue constructs. The use of chondrocytes in cartilage tissue engineering has been restricted by the limited availability of these...
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PMID: 21338265
PDF is available here.
PDF is available here.
Abstract
Adult cartilage has a limited healing capacity. Damages resulting from disease or injury increase over time and cause severe pain. One approach to reinstate the cartilage function is tissue engineering (TE). However, the generation of TE cartilage is time consuming and expensive and...
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PMID: 21247246
PDF is available here.
PDF is available here.
Abstract
Abstract
These results suggest the potential of CAG cryogels as a good three-dimensional scaffold for cartilage tissue engineering....
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PMID: 20943683
PDF is available here.
PDF is available here.
Developmental Cell (20)3 2011
Abstract
The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (...
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PMID: 21397842
PDF is available here.
PDF is available here.
Developmental Cell (20)3 2011
Abstract
The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (...
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PMID: 21397842
PDF is available here.
PDF is available here.
Abstract
We have investigated the use of a fluorescent image analyser and the application of fluorescence intensity measurements to describe and evaluate a tissue-engineered cartilage-like tissue construct. We evaluated the matrix production of a tissue-engineered cartilage-like tissue (TCL) construct in vit...
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PMID: 20734346
PDF is available here.
PDF is available here.
Abstract
Abstract
With consideration of the need for cartilage grafts of specific sizes and shapes in orthopedics and other fields, immature cartilage explants and grafts have recently been molded in vitro and in vivo. Nonsurgical correction of cartilage deformities and malformations often uses mechan...
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PMID: 20649477
PDF is available here.
PDF is available here.
Abstract
We investigated the histological, biochemical, and integrative features of the neocartilage using swine auricular chondrocytes photoencapsulated into two poly(ethylene glycol) dimethacrylate (PEGDM) copolymer hydrogels of a different degradation profile: degradable (PEG-4,5LA-DM) and nondegradable (...
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PMID: 20695772
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
Electrospun poly(lactic acid) (PLLA) nanofibers (NF) were modified with cationized gelatin (CG) to improve their compatibility with chondrocytes and to show in vitro and in vivo the potential applications of CG-grafted PLLA nanofibrous membranes (CG-PLLA NFM) as a cartilage tissue en...
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PMID: 20728584
PDF is available here.
PDF is available here.
Abstract
Although most in vitro studies indicate that transforming growth factor β3 (TGF-β3) immobilized scaffold is suitable for cartilage tissue engineering, in vivo studies of implanting immobilized scaffold for chondral defect repair are still lacking. This study is to evaluate the pote...
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PMID: 20872747
PDF is available here.
PDF is available here.
Abstract
We suggest that bFGF when combined with periosteal grafts may have excellent repair capacity in the restoration of osteochondral defects....
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PMID: 21067496
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Abstract
Abstract
PURPOSE/OBJECTIVE(S): Locally advanced squamous cell cancers of the head and neck with bone and cartilage invasion (BCI) traditionally have been treated with resection followed up with radiotherapy or less commonly definitive chemoradiotherapy (CRT). However, it is unclear whether bone or cartilage...
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PMID: 20065851
PDF is available here.
PDF is available here.
Abstract
We endeavor to develop an innovative tissue engineering system to overcome these drawbacks through a novel microcavitary hydrogel (MCG)-based scaffolding technology and a novel phase transfer cell culture (PTCC) strategy to enable phenotypically bona fide neo-tissue formation in an injectable artifi...
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PMID: 20666616
PDF is available here.
PDF is available here.
Abstract
We obtained the first evidence of the involvement of a specific micro RNA (miRNA) in the regulation of the chondrocyte phenotype during late stages of differentiation. By use of the microarray technique, miR-1 was identified as this miRNA, the expression of which was most repressed upon hypertrophic...
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PMID: 20937250
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of PG extracted from salmon cartilage on the progression of experimental colitis-induced in severe combined immunodeficiency mice by cell transfer from interleukin-10 (IL-10)-/- mice. IL-10-/- cell-transferred mice showed weight loss, colon shortening and histological appe...
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PMID: 20969831
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
The successful replacement of large-scale cartilage defects or osteoarthritic lesions using tissue-engineering approaches will likely require composite biomaterial scaffolds that have biomimetic mechanical properties and can provide cell-instructive cues to control the growth and dif...
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PMID: 20857388
PDF is available here.
PDF is available here.
Abstract
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain. The gold-standard method for detecting synovitis...
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PMID: 20924410
PDF is available here.
PDF is available here.
Thoracic Surgery Clinics (20)4 2010
Abstract
Pectus carinatum or keel chest is a spectrum of progressive inborn anomalies of the anterior chest wall, named after the keel (carina) of ancient Roman ships. It defines a wide spectrum of inborn protrusion anomalies of the sternum and/or the adjacent costal cartilages. Pectus carina...
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PMID: 20974441
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)10 2010
Abstract
The promising potential of a RAD-16 self-assembly-peptide hydrogel as a scaffold for tissue-engineered cartilage was investigated. Within 3 weeks of in vitro culture, chondrocytes within the hydrogel produced a high amount of GAG and type-II collagen, which are the components of cart...
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PMID: 20552605
PDF is available here.
PDF is available here.
Abstract
Osteoarthritis (OA) is characterized by irreversible destruction of the articular cartilage. OA affects more than 100 million individuals worldwide and has a major impact on patients' quality of life. The lack of effective therapy that prevents, inhibits or reverses the progress of OA often leaves o...
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PMID: 20973646
PDF is available here.
PDF is available here.
Abstract
We show that BFP contains a population of stem cells that share a similar phenotype with ASCs from abdominal subcutaneous fat tissue, and are also able to differentiate into the chondrogenic, adipogenic, and osteogenic lineage. These results define BFP as a new, rich, and accessible source of ASCs f...
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PMID: 20078198
PDF is available here.
PDF is available here.
Abstract
Tissue engineering of human nasal septal chondrocytes offers the potential to create large quantities of autologous material for use in reconstructive surgery of the head and neck. Culture with recombinant human growth factors may improve the biochemical and biomechanical properties of engineered ti...
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PMID: 20178406
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
I summarized recent consensus in the pathogenesis of FGFR3 related chondrodysplasia....
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PMID: 20890030
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Journal of Surgical Research (163)2 2010
Abstract
Histological analysis demonstrated sulfated glycosaminoglycans and deposition of collagen type II in constructs from both groups. Constructs cultured in the bioreactor system prior in vivo implantation demonstrated higher levels of DNA, glycosaminoglycans, and hydroxyproline. An increase of 22% in t...
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PMID: 20538292
PDF is available here.
PDF is available here.
Abstract
Acute and chronic elbow pain is common, particularly in athletes. Although plain radiographs, ultrasound, and computed tomography all have a role to play in the investigation of elbow pain, magnetic resonance imaging (MRI) has emerged as the imaging modality of choice for diagnosis of soft tissue di...
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PMID: 20883896
PDF is available here.
PDF is available here.
Abstract
We describe the potential application of such PEG cryogels as scaffolds for cartilage tissue engineering. Three-dimensional macroporous cryogels were evaluated for chondrocyte growth and production of cartilage-specific extracellular matrix (ECM). Seeded primary bovine chondrocytes showed homogeneou...
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PMID: 20486791
PDF is available here.
PDF is available here.
Abstract
Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like articular cartilage. The objective was to engineer a collagen-...
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PMID: 20545556
PDF is available here.
PDF is available here.
Biomedical Materials (5)5 2010
Abstract
I (CS/COL-I) scaffolds for cartilage engineering. CS/COL-I scaffolds were fabricated through freeze-drying and cross-linked by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. SDSCs were isolated from synovium and cultured onto CS/COL-I scaffolds, constructs of which were incubated in serum-free chond...
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PMID: 20826911
PDF is available here.
PDF is available here.
Abstract
We have investigated the function of Dlx2 and Dlx5 by sustained misexpression in ovo. We find that RCAS-Dlx2- and RCAS-Dlx5-infected avian embryos exhibit very similar patterns of local, stereotypical changes in skeletal development in the upper jaw. The changes include ectopic dermal bone along the...
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PMID: 20883215
PDF is available here.
PDF is available here.
Abstract
Displacement and rotational data showed that rocking motion occurs throughout arytenoid abduction and most of the rotational component is attributable to pitch; greater pitch was associated with action of the lateral belly. Roll of the ventral arytenoid plane was principally associated with action o...
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PMID: 20807138
PDF is available here.
PDF is available here.
Abstract
To explore a novel approach, associated balancing surgical treatments of the first and second branchial arch syndrome and to supply an array of practical, efficacious, and relatively shorter course of treatments for clinics.
For microtia with severe ipsilateral facial dysplasia with the first and se...
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PMID: 20856036
PDF is available here.
PDF is available here.
Abstract
We evaluated the compressive mechanical properties and matrix deposition of maturing constructs over 56 days. Transcriptional differences between the two cell types were assessed on day 0 and 28 via microarray analysis and real-time polymerase chain reaction; differential deposition of matrix molecu...
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PMID: 20367254
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteocla...
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PMID: 20599900
PDF is available here.
PDF is available here.
Abstract
We analyzed the phenotypic alterations of human articular chondrocytes in this model on the broad molecular level. Freshly isolated chondrocytes were assembled as micromasses and maintained up to 6 weeks in medium containing human serum. Formation of cartilaginous extracellular matrix (ECM) was eval...
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PMID: 20433912
PDF is available here.
PDF is available here.
Abstract
For the superficial zone of surface-intact chondrocytes, bupivacaine with methylparaben caused a significantly higher percentage of chondrocyte death at 5 minutes (47.7%) than did bupivacaine (23.6%) or CCCM (25.4%). Bupivacaine (53.8%) and bupivacaine with methylparaben (62.5%) caused a significant...
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PMID: 20673085
PDF is available here.
PDF is available here.
Abstract
To evaluate cartilage and bone biomarkers and body composition in growing large-breed dogs consuming a diet designed for growth.
43 large-breed 2 month-old-puppies.
Dogs were randomly assigned to receive 1 of 2 foods until 18 months of age. Dogs were evaluated at 2, 5, 12, and 18 months of age via d...
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PMID: 20673093
PDF is available here.
PDF is available here.
Abstract
Compared with values in unaffected pigs, serum concentrations of C-propeptide of type II collagen (CPII) and cartilage oligomeric matrix protein were significantly increased and concentrations of carboxy-terminal telopeptide of type II collagen 3/4-length fragment (C2C) and pyridinoline cross-links...
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PMID: 20673095
PDF is available here.
PDF is available here.
Abstract
We suggest that chitin sponge scaffolds, apart from the demonstrated biomedical applications, are highly optimized structures for use as filtering systems, templates for biomineralization as well as metallization in order to produce catalysts.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20478334
PDF is available here.
PDF is available here.
Abstract
We aimed to analyse the immunohistochemical distribution of Lf in human embryonal and fetal bone and cartilaginous tissues at different gestational weeks in order to evaluate whether a role for this protein might be proposed also in human osteogenesis. Bone and cartilaginous specimens were taken at...
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PMID: 20443779
PDF is available here.
PDF is available here.
Abstract
We also obtained 16 normal ACL tibial insertions from cadavers. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) to detect apoptosis, proliferating cell nuclear antigen (PCNA) staining, and histological examination were performed. The percenta...
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PMID: 20175709
PDF is available here.
PDF is available here.
Bioactive collagen-grafted poly-L-lactic acid nanofibrous membrane for cartilage tissue engineering.
Abstract
Biodegradable nanofibrous membrane was prepared from poly-L-lactic acid by electrospinning and used as a scaffold for cartilage tissue engineering. Operating parameters during the electrospinning process were studied in terms of their influences on fiber diameter, membrane porosity a...
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PMID: 21125905
PDF is available here.
PDF is available here.
Haemophilia (16 Suppl 5) 2010
Abstract
SUMMARY: In spite of the fact that the diagnosis of haemophilia is essentially clinical and laboratory-based, imaging has become an important tool for the evaluation of complications, diagnostic confirmation and/or complementation and therapeutic follow-up in haemophilic arthropathy. Radiography rem...
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PMID: 20590865
PDF is available here.
PDF is available here.
Joint Bone Spine (77)4 2010
Abstract
Nature Reviews: Cancer (10)7 2010
Abstract
As a group, cartilage tumours are the most common primary bone lesions. They range from benign lesions, such as enchondromas and osteochondromas, to malignant chondrosarcoma. The benign lesions result from the deregulation of the hedgehog signalling pathway, which is involved in normal bone developm...
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PMID: 20535132
PDF is available here.
PDF is available here.
Abstract
This review attempts to show the bone community that there are many ways of being a 'bone', and that the range of mechanical properties of bone material is much greater than is conventionally thought to be the case. However the structure-function relationships have in many cases hardly moved beyond...
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PMID: 20416550
PDF is available here.
PDF is available here.
Dermatologic Surgery (36)7 2010
Abstract
Abstract
We assessed cartilage degeneration in estrogen receptor (ER)alpha null mice and examined the role of glucocorticoid receptor-interacting protein 1 (GRIP1) in the ERalpha-dependent transcription of a type II collagen gene (col2a1) with special reference to a crosstalk with the transforming growth fac...
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PMID: 20346402
PDF is available here.
PDF is available here.
Abstract
In the last few years, cartilage has been the preferred material for reconstruction of the tympanic membrane, particularly in the case of allergy, re-perforation, or total or subtotal perforation. The mechanical characteristics of cartilage offer the advantage of high resistance to retraction and re...
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PMID: 20219145
PDF is available here.
PDF is available here.
Abstract
We still observed the red fluorescence in the repair area. These findings suggest that the PLGA/NHA-MSCs composite may be potentially used for cartilage repair in clinical application. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010....
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PMID: 20166224
PDF is available here.
PDF is available here.
Abstract
We show that the bulk modulus of poly(glycerol sebacate) (PGS) can be changed by varying molar ratios during prepolymer synthesis and by varying curing time. We go on to show that PGS can be used to create 3D designed scaffolds via solid freeform fabrication methods with modulus values that fall wit...
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PMID: 20091702
PDF is available here.
PDF is available here.
Abstract
I and II clinical trials. Our objective was to determine the effect of adding AE-941 to chemoradiotherapy on overall survival of patients with unresectable stage III non-small cell lung cancer (NSCLC). METHODS A randomized, double-blinded, placebo-controlled, phase III clinical trial was designed to...
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PMID: 20505152
PDF is available here.
PDF is available here.
Abstract
We hypothesized that cells in the healthy tissue would deform less for given articular surface pressures than cells in the early OA tissue because of a loss of matrix integrity in early OA and the associated loss of structural integrity that is thought to protect chondrocytes. Chondrocyte dynamics w...
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PMID: 19933220
PDF is available here.
PDF is available here.