Abstract
We prospectively studied 16 patients with MVP and 9 healthy adult subjects using phase-contrast CMR and cine CMR to assess the PM velocity and excursion. LGE CMR was performed in 13 patients with MVP (81%). The peak PM systolic velocity and maximum PM excursion were significantly increased in those...
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PMID: 20599010
PDF is available here.
Abstract
We use laser diffraction in the analysis of the transversal deformation that the papillary muscle of the female and male Wistar rat may undergo when is subjected to different tension (tension range, 0-30 mN) in the longitudinal plane. Papillary muscles from the right ventricle were illuminated at no...
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PMID: 20577024
PDF is available here.
Abstract
We report a case of a papillary fibroelastoma in a 78-yr-old woman who had dyspnea and chest tightness. Echocardiography revealed a small lobulated mobile echogenic mass attached to the aortic valve, and CT demonstrated a lobulated soft tissue density mass with a thin stalk at the sinotubular juncti...
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PMID: 20436724
PDF is available here.
Abstract
Septal papillary muscles, similarly to other papillary muscles, are essential elements of the heart valvular system. Damage to their structure may lead to a considerable life risk. Of all the papillary muscles, the septal papillary muscles are characterized by the greatest topographical and morpholo...
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PMID: 20512760
PDF is available here.
Abstract
We report a case of a 1-month-old infant with multiple intracardiac rhabdomyomas. In contrast to the known natural history of rhabdomyomas to show postnatal regression, this patient showed marked tumor progression prior to initiation of tumor regression at 10 months of age. In the absence of pronoun...
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PMID: 20047026
PDF is available here.
Abstract
A 51-year-old previously asymptomatic man presented with complete heart block (CHB). During pacemaker implantation, fluoroscopy showed a peculiar pattern of cardiac calcification. Coronary angiography, performed to determine the origin of calcification, demonstrated an anomalous origin of the left c...
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PMID: 20165845
PDF is available here.
Abstract
A 72-year-old man presented with an acute myocardial infarction, he did not receive any reperfusion therapy because he presented as a non-ST elevation myocardial infarction (MI). A dobutamine stress echocardiography was done five days after. A partial rupture of the posterior papillary muscle occurr...
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PMID: 19467641
PDF is available here.
Abstract
Fourteen patients underwent repair with this technique. No deaths or major adverse events occurred. All patients underwent echocardiography at discharge, and again at six and 12 months after surgery. Thirteen patients had no residual insufficiency, and one patient had mild postoperative insufficienc...
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PMID: 20369512
PDF is available here.
Abstract
We describe a rare case of right coronary artery ostial obstruction by a 12 x 19 mm sized papillary fibroelastoma located in the sinus of Valsalva. The report underlies the importance of echocardiography in diagnosis and intraoperative treatment of this type of cardiac mass....
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PMID: 20486964
PDF is available here.
Abstract
Cardiac involvement is the main cause of morbidity and mortality in hypereosinophilic syndrome. In a patient with hypereosinophilia and a normal echocardiography, cardiac magnetic resonance imaging (CMR) helped confirm early cardiac involvement by demonstrating a typical pattern of left ventricular...
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PMID: 20049535
PDF is available here.
Abstract
A 63-year-old male presented with sudden onset chest pain and dyspnoea following a kick to the praecordium while gelding a horse. Transthoracic echocardiography showed evidence of flail tricuspid valve leaflets, severe tricuspid regurgitation and a widely patent foramen ovale with a right-to-left sh...
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PMID: 20666059
PDF is available here.
Abstract
We initiated an original papillary muscle head approximation procedure, commonly known as Sandwich plasty, for the treatment of ischemic mitral regurgitation (MR). In this study, we evaluated the appropriateness of this procedure for functional MR associated with aortic valve disease. Fifteen patien...
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PMID: 20145351
PDF is available here.
Abstract
We will discuss the current concepts of its pathophysiology, the benefits of revascularization, along with the surgical, and percutaneous therapeutic options....
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PMID: 20539099
PDF is available here.
Abstract
We report the case of an AMI complicated by the development of an abrupt cardiogenic shock due to the rupture of the head of the postero-medial papillary muscle with echocardiographic demonstration of severe mitral regurgitation due to flail posterior mitral valve leaflet. After initial stabilizatio...
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PMID: 20690097
PDF is available here.
Abstract
We report the cases of 2 patients who had malignant ventricular arrhythmias secondary to ischemic heart disease. The arrhythmias were treated intraoperatively by means of surgical ablation through a transmitral approach....
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PMID: 20548827
PDF is available here.
Abstract
The aim of this study was to make cellular-level measurements of the mechanical efficiency of mouse cardiac muscle and to use these measurements to determine (1) the work performed by a cross-bridge in one ATP-splitting cycle and (2) the fraction of the free energy available in metabolic substrates...
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PMID: 20824531
PDF is available here.
Abstract
Abnormality in the position of the papillary muscles changes continuously with the abnormality of the QRS axis. Understanding the electroanatomic relationships provides important insight into developmental relationships between the conduction system and the trabecular structures in primum AVSD patie...
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PMID: 20083068
PDF is available here.
Abstract
We report a case of a 59-year-old patient diagnosed with chagasic cardiomyopathy, who manifested sudden heart failure while hospitalized, evolving to death due to cardiogenic and septic shock. Anatomical-pathological studies revealed infarction of the papillary muscles together with histological cha...
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PMID: 20301988
PDF is available here.
Abstract
In cardiac papillary muscles, anandamide (1, 10, 100 nM) decreased AP duration in a concentration-dependent manner. Furthermore, 100 nM anandamide decreased AP amplitude, overshoot and Vmax in partially depolarized papillary muscles. These effects were abolished by AM251 (100 nM), a selective antago...
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PMID: 20050190
PDF is available here.
Abstract
111 Domestic Shorthair cats with idiopathic hypertrophic cardiomyopathy were reviewed retrospectively. Two-dimensional echocardiography was used to classify cases in 6 established phenotypes. Hypertrophy was diffuse in 61 % of cats and involved major portions of the ventricular septum and the left v...
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PMID: 19885798
PDF is available here.
Abstract
We presented a case of 64-year-old male with LVNC and with papillary muscle involvement....
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PMID: 20024858
PDF is available here.
Abstract
We observed a significant decrease on active tension, dT/dt(max), peak shortening and dL/dt(max) of -10.5+/-3.6%, -8.0+/-3.0%, -5.3+/-2.6% and -5.7+/-2.3%, respectively. There was no change on relaxation parameters, namely dT/dt(min) or dL/dt(min). Time to half relaxation was significantly decreased...
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PMID: 19524627
PDF is available here.
Mário Mateus Sugizaki,
André Soares Leopoldo,
Marina Politi Okoshi,
Alessandro Bruno,
Sandro José Conde,
Ana Paula Lima-Leopoldo,
Carlos Roberto Padovani,
Robson Francisco Carvalho,
André Ferreira do Nascimento,
Dijon Henrique Salomé de Campos,
Célia Regina Nogueira and
Antonio Carlos Cicogna
Abstract
We investigated the role of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) on myocardial performance in food-restricted rats. Male Wistar-Kyoto rats, 60 days old, were fed a control or restricted diet (daily energy intake reduced to 50% of the control) for 90 days. Expression of Serca2a, phospholamban...
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PMID: 19794517
PDF is available here.
Abstract
Of the 16 patients, 11 were diagnosed ARVC by MRI, 9 were by golden criteria. 9 ARVC patients were manifested by thinning of RV wall, dilatation of the RV (8 cases) trabecular hypertrophy and disarray (6 cases), fat signal intensity of right ventricular(RV)wall in DIRFSE,irregular insular pieces or...
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PMID: 19623124
PDF is available here.
Abstract
A case of acute severe mitral regurgitation with serious hemodynamic impairment in the setting of an inferior ST-elevation myocardial infarction is presented. Both transthoracic and transesophageal echocardiography demonstrated a posteriorly directed eccentric jet of severe mitral regurgitation with...
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PMID: 19618329
PDF is available here.
Abstract
As expected, the volume density of myocytes declined significantly (p<0.05) with aging. The length density of myocardial capillaries also declined with aging, but not significantly. The interstitial volume fraction of the papillary muscle tissue increased significantly (P<0.05) with age. The number...
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PMID: 19629291
PDF is available here.
Abstract
The major principal stretch during systole was significantly greater than that during diastole in the three PM positions. The major principal (radial) stretch was significantly greater in the taut PM position than in the normal and slack PM positions during diastole. However, there was no significan...
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PMID: 19455885
PDF is available here.
Abstract
BACKGROUND AND AIM OF THE STUDY: Functional mitral regurgitation (FMR) with leaflet tethering is a serious complication related to dilated cardiomyopathy. Although FMR with mitral leaflet tethering can be improved by secondary chordal cutting, the technique may compromise valvular-ventricular intera...
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PMID: 19455886
PDF is available here.
Abstract
� Carbachol (10��mol�L22121) evoked a positive inotropic response only in muscles from rats with heart failure approximating 36% of that elicited by 1��mol�L22121 isoproterenol (20���1.5% and 56���6.1% above basal respectively). Carbachol-evoked inotropic responses did not c...
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PMID: 19159405
PDF is available here.
Abstract
Our results demonstrate the specific localization of cardiotin in adult cardiomyocyte mitochondria and propose its use as an early marker for cardiomyocyte adaptive remodeling and dedifferentiation....
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PMID: 18402829
PDF is available here.
Abstract
Dominant direction of fibre orientation was absent in vertical and horizontal transmural slices, but was longitudinal in tangential slices. Control action potential duration (APD(90), 169.9 +/- 4 ms) and drug effects on this parameter were similar to papillary muscles. The L-type Ca-channel blocker...
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PMID: 19910693
PDF is available here.
Abstract
Papillary muscle rupture is an uncommon complication of myocardial infarction, with considerable operative and long-term mortality. However, survivors have good quality of life....
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PMID: 19399318
PDF is available here.
Abstract
One of the earliest hypotheses on the origin of the U wave was that these waves represent repolarisation of the papillary muscles and their neighboring structures. Various U-wave and TU-segment abnormalities have been described and ascribed to certain cardiac pathological conditions. In this case re...
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PMID: 19701539
PDF is available here.
Abstract
We report the case of a 2(1/2)year-old child, who sustained mitral valve insufficiency due to isolated rupture of the posterior mitral papillary muscle, which developed after a domestic accident....
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PMID: 19568400
PDF is available here.
Abstract
We present a case involving a hydatid cyst that was located in a cardiac papillary muscle and that caused mitral regurgitation in a 37-year-old woman. The cyst was removed by papillary muscle incision, and the mitral valve was repaired. The patient experienced an uneventful recovery....
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PMID: 20069089
PDF is available here.
Abstract
We report the case of a symptomatic 18-year-old patient, gene-positive for hypertrophic cardiomyopathy (HCM), who presented with symptomatic dynamic left ventricular outflow tract (LVOT) obstruction caused by an abnormally thickened papillary muscle in the absence of septal hypertrophy. This was con...
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PMID: 19131012
PDF is available here.
Abstract
We compared IL-6, IL-1beta and TNFalpha mRNA and protein, activated NF-kappaB and total oxidized proteins in skeletal and cardiac muscle 4 or 24 h after saline or LPS injection in mice receiving vitamin E or placebo for 3 days prior to the insult. Skeletal and cardiac IL-6 mRNA and protein were sign...
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PMID: 18586856
PDF is available here.
Abstract
These results suggest that the high [Mg(2+)](o)-induced increase in [Mg(2+)](i) could be coupled with the decrease in [Na(+)](i), which might involve activation of the reverse mode of Na(+)-Mg(2+) exchange, accompanied by activation of p38 MAP kinase and ERK2 in the guinea-pig heart....
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PMID: 18586857
PDF is available here.
Abstract
These results suggest that MA-2029 has sufficient cardiovascular safety although it inhibits multiple ion channels at supra-effective concentrations. On the other hand, cisapride, an effective IBS drug, showed clear hERG inhibition and APD prolongation at 100 ng/ml. Cisapride exhibited a narrow safe...
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PMID: 19043284
PDF is available here.
Abstract
An anatomical study of the tricuspid valve was performed in the hearts of 45 dogs using a method of dissection which preserves the integrity of the valve. Morphometrical criteria such as the width of the cusp base and larger depth of cusp and morphological criteria such as the number of tendinous co...
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PMID: 18798836
PDF is available here.
Abstract
We have proposed that hybrid logistic (HL) functions, calculated as the difference between two logistic functions, fit better the isovolumic LV pressure curves at any LV volume, heart rate, and infused calcium (Ca2+) concentration in coronary artery in the excised, cross-circulated canine heart, and...
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PMID: 19108490
PDF is available here.
Abstract
We describe a patient presenting with ventricular tachycardia and congestive heart failure. Magnetic resonance imaging revealed multiple delayed-enhanced areas in the left and right ventricles and papillary muscles....
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PMID: 17689728
PDF is available here.
Abstract
It has been well documented that matrine, a tetracyclo-quinolizindine alkaloid, possessed a positive inotropic effect. However, the underlying mechanisms at the cellular and ion channel levels have not been completely clarified. Therefore, the present study was designed to identify the cellular targ...
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PMID: 18981573
PDF is available here.
Abstract
At a transmitral pressure of 120 mmHg, anterolateral SC cutting increased the tension of the marginal chord from the anterolateral papillary muscle (from 0.10 +/- 0.02 to 0.29 +/- 0.11 N; p = 0.02), but not from the posteromedial papillary muscle. At a transmitral pressure of 120 mmHg, posteromedial...
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PMID: 19137793
PDF is available here.
Abstract
The patient recovered uneventfully. Interval echocardiography at one year showed a negligible outflow gradient, relief of SAM and mild residual MR. The patient currently is active, essentially asymptomatic, and not receiving any medical therapy. CONCLUSION: Previous approaches to HOCM have been limi...
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PMID: 19137796
PDF is available here.
Abstract
Acute dilatation of the heart with PPM displacement and mitral regurgitation were produced in this acute infarct model. Both hitching sutures shortened the distance from the free edge of the posterior leaflet to the PPM tip and reduced its displacement, with a resultant reduction in mitral regurgita...
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PMID: 19137792
PDF is available here.
M C Cerra,
M P Gallo,
T Angelone,
A M Quintieri,
E Pulerà,
E Filice,
B Guérold,
P Shooshtarizadeh,
R Levi,
R Ramella,
A Brero,
O Boero,
M H Metz-Boutigue,
B Tota and
G Alloatti
Abstract
Chromogranin A (CGA), produced by human and rat myocardium, generates several biologically active peptides processed at specific proteolytic cleavage sites. A highly conserved cleavage N-terminal site is the bond 64-65 that reproduces the native rat CGA sequence (rCGA1-64), corresponding to human N-...
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PMID: 18697842
PDF is available here.