Abstract
We identify in the mouse a subpopulation of the first (crescent-forming) field marked by endothelin receptor type A (Ednra) gene expression, which contributes to chamber myocardium through a unique type of cell behavior. Ednra-lacZ/EGFP-expressing cells arise in the ventrocaudal inflow region of the...
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PMID: 20929948
PDF is available here.
Abstract
The aim was to evaluate the role of the combination of olmesartan, an angiotensin II (Ang II) receptor blocker (ARB), with daunorubicin (DNR) in reducing cardiac toxicity in rats. DNR was administered at a dose of 3 mg/kg/day every other day for 12 days. Olmesartan was administered orally every day...
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PMID: 20815778
PDF is available here.
Abstract
I level above the normal range, and post-PCI increases in creatine kinase-MB and highly sensitive C-reactive protein were significantly higher in the control group than in the high-load group (all P<0.007). The post-PCI alanine aminotransferase levels in all four groups were significantly higher tha...
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PMID: 21076721
PDF is available here.
Abstract
We recently demonstrated that transfusion of anemic animals up to 100 g/L hemoglobin with fresh blood protects the heart from ischemic injuries following myocardial infarction. Erythropoietin has cardioprotective effects independent of its erythropoietic activity. The objective of this study was to...
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PMID: 20693887
PDF is available here.
Abstract
We have shown here that miR-21-null mice are normal and, in response to a variety of cardiac stresses, display cardiac hypertrophy, fibrosis, upregulation of stress-responsive cardiac genes, and loss of cardiac contractility comparable to wild-type littermates. Similarly, inhibition of miR-21 throug...
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PMID: 20978354
PDF is available here.
Abstract
A 37-year old patient was admitted with upper abdominal pain, vomiting and diarrhea. A 38-year-old patient was admitted for liver failure.
Case 1 was diagnosed with an AL amyloidosis due to deposition of the immunoglobulin light chain kappa in all tissues analyzed. In the bone marrow plasma cells we...
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PMID: 20979003
PDF is available here.
Abstract
Consumption of DHA has numerous beneficial effects, but little is known about these effects during the first few days of the DHA dietary intake. The main objectives of the present study were to determine the time course of DHA incorporation into phospholipids in different mouse tissues and the effec...
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PMID: 20487585
PDF is available here.
Abstract
These results suggest that the inhibition of contractile activity during IPost prevents cardiomyocyte oncosis and enhances cardioprotection through PI3K-dependent restoration of sarcolemmal dystrophin....
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PMID: 20877127
PDF is available here.
Abstract
Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress in patients with acute myocardial infarction (AMI).
The aim of this multi-center pilot study was to investigate the effect of `low-dose EPO'...
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PMID: 20834185
PDF is available here.
Nicolas Bousette,
Shaan Chugh,
Vincent Fong,
Ruth Isserlin,
Kyoung-Han Kim,
Allen Volchuk,
Peter H Backx,
Peter Liu,
Thomas Kislinger,
David H MacLennan,
Andrew Emili and
Anthony O Gramolini
Abstract
We deduced that delineating the proteomic profile of ventricular tissue from this model might identify novel, widely applicable therapeutic targets. Proteomic analysis was carried out by subjecting fractionated cardiac samples from CNA mice and their WT littermates to gel-free liquid chromatography...
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PMID: 20937869
PDF is available here.
Eric Larose,
Helena Tizon-Marcos,
Josep Rodés-Cabau,
Stéphane Rinfret,
Jean-Pierre Déry,
Can M Nguyen,
Onil Gleeton,
Jean-Rock Boudreault,
Louis Roy,
Bernard Noël,
Guy Proulx,
Jacques Rouleau,
Gérald Barbeau,
Robert De Larochellière and
Olivier F Bertrand
Abstract
We hypothesized that myocardial injury would be reduced in late STEMI by proximal embolic protection (PEP).
31 patients with first STEMI 12-24 hr after pain onset and TIMI 0-1 flow were treated with or without PEP (cohort design matched for age, gender, and infarct-related artery). Contrast-enhanced...
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PMID: 20506154
PDF is available here.
Abstract
Fetal hearts show a remarkable ability to develop under hypoxic conditions. The metabolic flexibility of fetal hearts allows sustained development under low oxygen conditions. In fact, hypoxia is critical for proper myocardial formation. Particularly, hypoxia inducible factor 1 (HIF-...
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PMID: 20712587
PDF is available here.
Abstract
Myocardial infarction (MI) results in the death of cardiomyocytes (CM), which causes scar formation and pathological remodeling of the heart. The delivery of healthy myocytes or bone marrow cells reduces pathological remodeling after MI, however, current cell injection methods have l...
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PMID: 20540095
PDF is available here.
Abstract
We report eight homologs of mical family genes in zebrafish and their expression profiles during embryonic development. Consistent with the findings in Drosophila and mammals, most zebrafish mical family genes display expression in neural and musculature systems. In addition, five mical homologs are...
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PMID: 21035094
PDF is available here.
Abstract
Our results showed that stromal cells with the immunophenotypical (vimentin, CD34) and ultrastructural features of telocytes were present in the mouse heart since early embryonic to adult life, as well as in primary cultures of neonatal mouse cardiac cells. These cells formed an extended network of...
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PMID: 20977627
PDF is available here.
Abstract
I bovine collagen supplemented with Matrigel™ (25% v/v) embedded with cardiomyocyte (CM)-enriched neonatal rat heart cells and assembled into a contractile, macroporous, sheet-like construct. Modules (without RAEC) cultured in 10% bovine serum (BS) were more contractile and responsive to external...
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PMID: 20504074
PDF is available here.
Abstract
To investigate the effects of granulocyto-colony stimulating factor (G-CSF) on the mobilization of endothelial progenitor cells (EPCs) in the rats with myocardial infarction (MI), to observe the density of neovascularization and the mRNA expressions of vascular endothelial growth factor (VEGF) and i...
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PMID: 21046814
PDF is available here.
Abstract
I B2 mRNA and collagen volume fraction (r = 0.757, P < 0.001).
Increased expression of MR and CYPIIB2 in the atria is one of the molecular mechanisms for the development of atrial interstitial fibrosis in patients with atrial fibrillation....
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PMID: 21125974
PDF is available here.
Abstract
I and III collagens form the natural framework of the heart, and decellularized heart tissue revealed a fine weave of three dimensionally arranged collagen fibers. To mimic this structure for the fabrication of a cardiac patch, a process has been devised to extract solid atelopeptide collagen from b...
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PMID: 19895207
PDF is available here.
Abstract
We have developed a new suspension induction method for myocardial differentiation of bone marrow-derived rat MSCs (rMSCs) in vitro on various extracellular matrix (ECM) proteins. Myocardial differentiation of rMSCs was induced with a conventional monolayer method and our suspension method. In our s...
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PMID: 20028217
PDF is available here.