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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genomics (4):
Recent article
Genomics
Abstract
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Abstract
We present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end librar...
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PMID: 21832995
PDF is available here.
PDF is available here.
Abstract
Journal of Biotechnology (155)1 2011
Abstract
Abstract
Funding injections by British Petroleum this summer are fueling studies in the Gulf Coast, raising hopes that the Deepwater Horizon oil spill might provide answers to long-standing questions on the nature of cellular toxicity. Rebecca Alvania investigates.
Copyright ...
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PMID: 21816268
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We review recent work with relatives of these species, motivated by a desire to understand the evolutionary and ecological context for morphological innovation. Unfortunately, despite a number of shining examples, progress in nonmodel systems has often been slow. The current revolution in DNA sequen...
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PMID: 21763609
PDF is available here.
PDF is available here.
Abstract
We screened 11 diverse strains for novel TTE families and coupled this nearly saturating screen with the sequencing and assembly of 14 phylogenetically diverse isolates from a broad collection of diseased host plants. TTE repertoires vary dramatically in size and content across all P. syringae clade...
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PMID: 21799664
PDF is available here.
PDF is available here.
Abstract
We sequenced the genomes of V. dahliae and V. albo-atrum and compared them to each other, and to the genome of Fusarium oxysporum, another fungal wilt pathogen. Our analyses identified a set of proteins that are shared among all three wilt pathogens, and present in few other fungal species. One of t...
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PMID: 21829347
PDF is available here.
PDF is available here.
Abstract
Abstract
Type 2 diabetes (T2D) and obesity represent major challenges for global public health. They are at the forefront of international efforts to identify the genetic variation contributing to complex disease susceptibility, and recent years have seen considerable success in identifying common risk-varian...
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PMID: 21647602
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)6 2011
Abstract
Rinsho Ketsueki (52)6 2011
[Acquired uniparental disomy and c-CBL mutation in myelodysplastic syndromes]. FAU - Sanada, Masashi
Abstract
Abstract
We bring this 'bottom-up' approach alongside the current NGS-driven genetic study of genetic variations and disease aetiology. We describe experimental and computational techniques for assessing genetic variants and their deleterious effects on protein structure and function....
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PMID: 21350909
PDF is available here.
PDF is available here.
Abstract
Morphological classification of Bagridae fishes is relatively difficult due to various kinds and similar shape, and the phyletic evolution is not very clear in some species. To provide basic data to the classification of Bagridae and Siluriformes fishes, the complete mitochondrial genome of Pelteobag...
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PMID: 21684869
PDF is available here.
PDF is available here.
Abstract
The past two decades have witnessed tremendous advances in noninvasive and postmortem neuroscientific techniques, advances that have made it possible, for the first time, to compare in detail the organization of the human brain to that of other primates. Studies comparing humans to c...
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PMID: 21599696
PDF is available here.
PDF is available here.
Abstract
We show how integrative genomics approaches can be used to characterize the role played by approximately a third of registered mouse miRNAs within the context of a liver gene regulatory network. Our analysis reveals that the transcript abundances of miRNAs are subject to regulatory control by many m...
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PMID: 21613979
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)20 2011
Abstract
Abstract
We first conducted a genome-wide linkage scan in 1,211 subjects from 100 Dominican families on five lipid quantitative traits: total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), and LDL-C/HDL-C ratio. We then investi...
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PMID: 21558551
PDF is available here.
PDF is available here.
Abstract
Childhood pilocytic astrocytoma is the most frequent brain tumor affecting children. Proteomics analysis is currently considered a powerful tool for global evaluation of protein expression and has been widely applied in the field of cancer research. In the present study, a series of...
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PMID: 21466243
PDF is available here.
PDF is available here.
Abstract
Prediction of high probability of survival from standard cancer treatments is fundamental for individualized cancer treatment strategies.
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PMID: 21558518
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
The discovery of novel target antigens for antibody-based immunotherapy is still a major challenge. Antibody phage display is one of the technologies that is widely applied for the identification of novel cell surface molecules on intact eukaryotic cells and many reports describe the isolation of ph...
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PMID: 19153691
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells. To mechanistically understand how these metabolites affect tumor cell behavior...
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PMID: 21512313
PDF is available here.
PDF is available here.
Abstract
médecine/sciences (27)4 2011
Abstract
Rat and mice are privileged tools for scientists. However, despite obvious advantages, such as a larger size, more faithful reproduction of human diseases, and utility for physiological and cognitive studies, rats have suffered from limited genetic technologies such as targeted mutagenesis. However,...
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PMID: 21524403
PDF is available here.
PDF is available here.
Abstract
Abstract
Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] (27)2 2011
Abstract
We compared the genome sequence of the 2 WUPyV isolates in Fuzhou, China to those documented in the GenBank database by using PHYLIP software version 3.65 and the neighbor-joining method. The 2 WUPyV strains in our study were clustered together. Strain FZTF was more closed to the reference strain B0...
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PMID: 21528542
PDF is available here.
PDF is available here.
Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] (27)2 2011
Abstract
Neuroinformatics (9)1 2011
Abstract
We report the development and implementation of an open access database (BTECH), a community resource for the deposition of a wide range of molecular data derived from brain tumor studies. This comprehensive database integrates multiple datasets, including transcript profiles, epigenomic CpG methyla...
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PMID: 21210251
PDF is available here.
PDF is available here.
Journal of Proteomics (74)3 2011
Abstract
We here proposes a Partial Least Squares Regression (PLSR)-based data integration strategy, which allows simultaneous analysis of proteomic data, gene expression data and classical clinical parameters. PLSR collapses multidimensional data into fewer relevant dimensions for data interpretation. PLSR...
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PMID: 21075225
PDF is available here.
PDF is available here.
Abstract
We demonstrate that machine learning of multiple CPIs can not only assess drug polypharmacology but can also efficiently identify novel bioactive scaffold-hopping compounds. Through a machine-learning technique that uses multiple CPIs, we have successfully identified novel lead compounds for two pha...
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PMID: 21364574
PDF is available here.
PDF is available here.
Abstract
We review progress in understanding the genomics as well as the structure and function of replicative enzymes achieved under the VIZIER program and the development of new disease control strategies....
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PMID: 21356244
PDF is available here.
PDF is available here.
Abstract
We undertook a quantitative study of PT modifications in prokaryotic genomes using a liquid chromatography-coupled tandem quadrupole mass spectrometry approach. The results revealed a diversity of unique PT sequence contexts and three discrete genomic frequencies in a wide range of bacteria. Metagen...
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PMID: 21285367
PDF is available here.
PDF is available here.
Abstract
We have conducted an in vitro cell-based small interfering RNA (siRNA) screen of 500 genes aimed at identifying genes whose loss of expression alters tumor cell response to oxaliplatin. The siRNA screen identified twenty-seven genes, which when silenced, significantly altered colon tumor cell line s...
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PMID: 21169384
PDF is available here.
PDF is available here.
Proteomics (11)4 2011
Abstract
The ability to sequence DNA rapidly, inexpensively and in a high-throughput fashion provides a unique opportunity to sequence whole genomes of a large number of species. The cataloging of protein-coding genes from these species, however, remains a non-trivial task with the majority o...
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PMID: 21246734
PDF is available here.
PDF is available here.
Abstract
Abstract
Multiple myeloma (MM) is the second most common hematological cancer. It is a very heterogeneous disease characterized by large genomic complexity, recurrent amplifications and/or deletions in the genome leading to different clinical manifestations and survival of patients. Thus, gen...
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PMID: 21923062
PDF is available here.
PDF is available here.
Abstract
We provided an integrated analysis of the genome-wide mRNA and miRNA expression profiles of three different genitourinary cancers: carcinomas of the bladder, kidney and testis.
Our results highlight the general or cancer-specific roles of several genes and miRNAs that may serve as ca...
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PMID: 21799901
PDF is available here.
PDF is available here.
Abstract
We propose a novel method for sRNA target prediction, termed sTarPicker, which was based on a two-step model for hybridization between an sRNA and an mRNA target. This method first selects stable duplexes after screening all possible duplexes between the sRNA and the potential mRNA target. Next, hyb...
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PMID: 21799937
PDF is available here.
PDF is available here.
Abstract
We determined the genomic distribution of Tup1 and Ssn6 by ChIP-chip. We found that most loci bound by Tup1-Ssn6 could not be explained by co-occupancy with a known recruiting cofactor and that deletion of individual known Tup1 recruiters did not significantly alter the Tup1 binding profile. These o...
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PMID: 21552514
PDF is available here.
PDF is available here.
Abstract
We quantified the conservation among birds and reptiles and across amniotes of long, conserved noncoding sequences (LCNS), which we define as sequences ≥500 bp in length and exhibiting ≥95% similarity between species. We found 4,294 LCNS shared between chicken and zebra finch and 574 LCNS shared...
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PMID: 21183607
PDF is available here.
PDF is available here.
Abstract
We introduce the concept of contagion in order to infer directionality at the edges, i.e., asymmetries in gene expression dependences of regulatory networks. Moreover, we present a bootstrap algorithm in order to test the contagion concept. This technique was applied in simulated data and, also, in...
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PMID: 20479499
PDF is available here.
PDF is available here.
Abstract
We have developed a very precise and high-throughput method to evaluate the sequence dependence of oligonucleotide labeling dyes using microarrays and have applied the method to Cy3 and Cy5. We used light-directed in-situ synthesis of terminally-labeled microarrays to determine the fluorescence inte...
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PMID: 21799789
PDF is available here.
PDF is available here.
Abstract
We analyzed the EGA-related transcriptome of rhesus-bovine iSCNT 8- to 16-cell embryos and dissected the reprogramming process in terms of embryonic gene activation, somatic gene silencing, and maternal RNA degradation. Compared with fibroblast donor cells, two thousand and seven genes were activate...
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PMID: 21799794
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe here two approaches, used by us for the study of breast cancer, both of which take the use of biobanks. One uses a cancer registry as a source of case information, which is then linked to a biobank on blood DNA. The biobank provides also samples from matched controls. After genotyping, c...
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PMID: 20949404
PDF is available here.
PDF is available here.
Nature Protocols (6)1 2011
Abstract
We developed a method called INTACT (isolation of nuclei tagged in specific cell types) that allows affinity-based isolation of nuclei from individual cell types of a tissue, thereby circumventing the problems associated with mechanical purification techniques. In this method nuclei are affinity-lab...
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PMID: 21212783
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Abstract
We present complete genome sequences for both taxa, with analyses involving other species of Streptococcus but focusing on adaptation in the SD species group. We found little evidence for enrichment in biochemical categories of genes carried by each SD strain, however, differences in the virulence g...
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PMID: 21282711
PDF is available here.
PDF is available here.
Public Health Genomics (14)4-5 2011
Abstract
So far health literacy has not been sufficiently discussed in the context of public health genomics. Primarily, not genomic but rather genome-based health information needs to be addressed taking into account genome-environment interactions and integrating all health determinants inc...
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PMID: 21734434
PDF is available here.
PDF is available here.
Abstract
We aimed to identify novel sRNAs and sORFs in Shigella, the principal etiologic agents of bacillary dysentery.
We identified 64 sRNAs in Shigella, which were experimentally validated in other bacteria based on sequence conservation. We employed computer-based and tiling array-based m...
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PMID: 21483688
PDF is available here.
PDF is available here.
Abstract
We used bioinformatic analysis of publicly available data in order to systematically identify the genes involved in resistance to cytotoxic effects of these two drugs in the NCI60 cell line panel. We used the pharmacological data available for all the NCI60 cell lines to classify simvastatin or lova...
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PMID: 21483694
PDF is available here.
PDF is available here.
Comptes Rendus Biologies (334)8-9 2011
Abstract
We report the early phase of yeast comparative genomics conducted by a group of seven French CNRS laboratories: the Génolevures Consortium. This first multispecies comparison of Hemiascomycetes (now called Saccharomycotina) opened the way to yeast evolutionary genomics. This analysis indicates that...
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PMID: 21819937
PDF is available here.
PDF is available here.
Comptes Rendus Biologies (334)8-9 2011
Abstract
DNA sequencing has revolutionized yeast taxonomy. Although initially rDNA sequences proved to be universal and convenient for assigning phylogenetic relationships, it was eventually supplanted by multigene analysis, which provided more discriminating and robust results. This led to a...
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PMID: 21819939
PDF is available here.
PDF is available here.
Comptes Rendus Biologies (334)8-9 2011
Abstract
We review recent progress in the exploration of the intraspecific diversity using large collections of yeast isolates. These recent large-scale polymorphism surveys have increased our understanding of the population structures as well as the evolutionary history of the species. In addition, these re...
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PMID: 21819942
PDF is available here.
PDF is available here.
Comptes Rendus Biologies (334)8-9 2011
Abstract
The steady-state mRNA level is the result of two opposing processes: transcription and degradation; both of which can provide important points to regulate gene expression. In the model organism yeast Saccharomyces cerevisiae, it is now possible to determine, at the genomic level, the...
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PMID: 21819946
PDF is available here.
PDF is available here.