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Metabolomics (0):
Recent article
Metabolomics
Hereditas (Beijing) (33)10 2011
Abstract
Filamentous fungi are used in a variety of industrial processes including the production of primary metabolites (e.g., organic acid, vitamins, and extracellular enzymes) and secondary metabolites (e.g., antibiotics, alkaloids, and gibberellins). Moreover, filamentous fungi have becom...
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PMID: 21993281
PDF is available here.
PDF is available here.
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Abstract
Type 2 diabetes mellitus (T2DM) and its attendant complications, such as diabetic nephropathy (DN), impose a significant societal and economic burden. The investigation of discovering potential biomarkers for T2DM and DN will facilitate the prediction and prevention of diabetes. Phos...
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PMID: 21872008
PDF is available here.
PDF is available here.
Abstract
We demonstrate that endogenous mesenchymal stem cells (MSCs) become activated during treatment with platinum analogs and secrete factors that protect tumor cells against a range of chemotherapeutics. Through a metabolomics approach, we identified two distinct platinum-induced polyunsaturated fatty a...
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PMID: 21907927
PDF is available here.
PDF is available here.
Abstract
We report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences...
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PMID: 21886157
PDF is available here.
PDF is available here.
Journal of Chromatography B (879)24 2011
Abstract
We investigated and compared the profiles of metabolites in nude mice with alcohol-induced liver injury or bearing a HCC xenograft (HCCX). Alcohol-induced liver injury was achieved by daily administration of grain liquor, and HCC xenografts were generated by subcutaneous inoculation of HepG2 cells i...
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PMID: 21763219
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of eight days of oral antibiotic exposure (penicillin and streptomycin sulfate) on gut microbial composition and host metabolic phenotype in male Han-Wistar rats (n = 6) compared to matched controls. Early recolonization was assessed in a third group exposed to antibiotic...
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PMID: 21591676
PDF is available here.
PDF is available here.
Cell Metabolism (14)2 2011
Abstract
The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains largely unknown. Here, stemness factor-mediated nuclear reprogramming reverted mitochondrial networks into cristae-poor structures. Metabolomic footprinting and fingerprinting distinguished der...
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PMID: 21803296
PDF is available here.
PDF is available here.
Abstract
We propose using the levels of the four metabolites for diagnosing NAFLD at various stages. Furthermore, the probability of developing NAFLD at a particular stage was assessed by multinomial logistic regression (MLR) based on the clinical results of the four serum metabolites....
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PMID: 21563774
PDF is available here.
PDF is available here.
Abstract
The most effective methods of analysis of organic compounds in biological fluids are coupled chromatographic techniques. Capillary gas chromatography/mass spectrometry (GC-MS) allows the most efficient separation, identification and quantification of volatile metabolites in biological fluids. Liquid...
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PMID: 21525822
PDF is available here.
PDF is available here.
Bioanalysis (3)10 2011
Abstract
The recent Montreux Symposium on LC-MS held in 2010 provided an insight into the key areas of present achievements and future developments in LC-MS. This domain is rapidly changing from a technology- to an application-driven enterprise. New demands for advanced options are coming fro...
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PMID: 21585298
PDF is available here.
PDF is available here.
FEMS Yeast Research (11)3 2011
Abstract
We investigate whether this gradual transition also occurs at the intracellular level by quantifying the intracellular metabolism of Saccharomyces cerevisiae, Saccharomyces bayanus, Saccharomyces exiguus, Kluyveromyces thermotolerans, Yarrowia lipolytica, Pichia angusta and Candida rugosa by (13)C-f...
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PMID: 21205161
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells. To mechanistically understand how these metabolites affect tumor cell behavior...
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PMID: 21512313
PDF is available here.
PDF is available here.
Abstract
Abstract
We used a metabolomics approach to generate unbiased small-molecule metabolic profiles in plasma that predict risk for CVD. Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an ind...
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PMID: 21475195
PDF is available here.
PDF is available here.
Abstract
We characterized the genomic, metabolic, and physiological divergence of several inbred rat strains--Brown Norway, Lewis, Wistar Kyoto, Fisher (F344)--frequently used as healthy controls in genetic studies of the cardiometabolic syndrome. Hierarchical clustering of (1)H NMR-based metabolic profiles...
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PMID: 21322573
PDF is available here.
PDF is available here.
Abstract
We characterized the genomic, metabolic, and physiological divergence of several inbred rat strains--Brown Norway, Lewis, Wistar Kyoto, Fisher (F344)--frequently used as healthy controls in genetic studies of the cardiometabolic syndrome. Hierarchical clustering of (1)H NMR-based metabolic profiles...
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PMID: 21322573
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We utilize a metabolomics approach that detects protein-metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts....
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PMID: 21283866
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits...
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PMID: 21258713
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits...
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PMID: 21258713
PDF is available here.
PDF is available here.
Abstract
We show that the biochemical pathways associated with tumour cell chemosensitivity to platinum-based drugs are highly coincident, i.e. they describe a consensus phenotype. Direct integration of metabolome and transcriptome data at the point of pathway analysis improved the detection of consensus pat...
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PMID: 21483477
PDF is available here.
PDF is available here.
Abstract
Nutrigenomics applications comprise transcript-, proteome- and metabolome-profiling techniques in which responses to diets or individual ingredients are assessed in biological samples. They may also include the characterization of heterogeneity in relevant genes that affect the biolo...
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PMID: 21280208
PDF is available here.
PDF is available here.
Abstract
We have shown that CD has a well-defined metabonomic signature. Here we address potential CD patients, defined as subjects who do not have, and have never had, a jejunal biopsy consistent with clear CD, and yet have immunological abnormalities similar to those found in celiac patients. Sixty-one ove...
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PMID: 21090607
PDF is available here.
PDF is available here.
Abstract
Metabonomics, also often referred to as "metabolomics" or "metabolic profiling," is the systematic profiling of metabolites in bio-fluids or tissues of organisms and their temporal changes. In the last decade, metabonomics has become increasingly popular in drug development, molecular medicine, and...
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PMID: 20972767
PDF is available here.
PDF is available here.
Abstract
We have developed a new approach called cellular metabolomics. This approach, developed in vitro, provides a panoramic view not only of the pathways involved in the metabolism of physiologic substrates of any normal or pathologic human or animal cell but also of the beneficial and adverse effects of...
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PMID: 20972755
PDF is available here.
PDF is available here.
Abstract
Clostridium acetobutylicum is an anaerobic bacterium which is known for its solvent-producing capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly efficient biofuel. For butanol production by C. acetobutylicum to be optimized and exploited on an industrial...
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PMID: 21247470
PDF is available here.
PDF is available here.
Abstract
These results reveal that PPARδ activation elicits a distinct metabolic and metabolomic profile in tumors that is in part related to PDK1 and AKT signaling....
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PMID: 21297860
PDF is available here.
PDF is available here.
Metabolic footprint analysis of recombinant Escherichia coli strains during fed-batch fermentations.
Abstract
Metabolic footprinting has become a valuable analytical approach for the characterization of phenotypes and the distinction of specific metabolic states resulting from environmental and/or genetic alterations. The metabolic impact of heterologous protein production in Escherichia col...
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PMID: 21152511
PDF is available here.
PDF is available here.
Abstract
A metabolomic method using reversed-phase liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was developed to obtain a systematic view of the development and progression of myocardial infarction (MI). By combining with partial least squares discriminant a...
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PMID: 21152560
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that individual cellular death pathways display characteristic phenotypes that allow them to be distinguished by the precise biochemical and metabolic responses that occur during stimulus-specific initiation. Using 832/13 and INS-1E rat insulinoma cells and isolated rat isle...
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PMID: 21829464
PDF is available here.
PDF is available here.
Abstract
We present a method for predicting the developmental stage of zebrafish embryos using novel metabolomic non-target fingerprints of "single-embryos". With this method, we observed the rate of development at different temperatures. Our results suggest that this method allows us to analyse the conditio...
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PMID: 21630594
PDF is available here.
PDF is available here.
Abstract
Epidemiological studies in man and with experimental animal models have shown that intrauterine growth restriction (IUGR) resulting in low birth weight is associated with higher risk of programming welfare diseases in later life. In the pig, severe IUGR occurs naturally and contribute substantially...
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PMID: 20814537
PDF is available here.
PDF is available here.
Abstract
Mice models are an important way to understand the relation between the fetus with cleft palate and changes of maternal biofluid. This paper aims to develop a metabonomics approach to analyze dexamethasone-induced cleft palate in pregnant C57BL/6J mice and to study the relationship between the chang...
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PMID: 20814536
PDF is available here.
PDF is available here.
Abstract
We found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced obesity. In this study, we applied (1)H NMR-based metabolomics with multivariate statistical analysis to compare the altered metabolic patterns detected in urine from high-fat diet (HFD) fed wild-type a...
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PMID: 21094140
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
Serum samples from kidney cancer patients and healthy controls were analyzed by both direct infusion mass spectrometry (DIMS) and liquid chromatography-mass spectrometry (LC-MS) with a high resolution ESI-Q-TOFMS. The classification and biomarker discovery capacities of the two methods were compared...
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PMID: 20856980
PDF is available here.
PDF is available here.
Abstract
We employed the use of hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) in a focused metabolomic study of sugar-nucleotides relevant to the biosynthesis of highly novel carbohydrate modifications on the flagellin of Campylobacter sp. We exploited the unique selectivity of t...
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PMID: 19882128
PDF is available here.
PDF is available here.
Abstract
These results collectively indicate that SHL injection has the potential to cause hemolytic anemia. Metabonomic analysis showed increases in serum lactate, choline and phosphocholine but a decrease in taurine in treated groups and these findings may underlie the toxicological mechanism of SHL inject...
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PMID: 20864460
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)8 2011
Abstract
Nuclear receptors (NRs) are a superfamily of ligand-regulated transcription factors that interact with coregulators and other transcription factors to direct tissue-specific programs of gene expression. Recent years have witnessed a rapid acceleration of the output of high-content data platforms in t...
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PMID: 21029773
PDF is available here.
PDF is available here.
Abstract
We will focus on the diagnostic approaches and new molecular diagnostics of primary hepatobiliary cancers and we will discuss how these new developments may impact the detection and management of these recalcitrant cancers....
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PMID: 20964609
PDF is available here.
PDF is available here.
Abstract
A major source of intestinal metabolites results from both host and microbial processing of dietary nutrients. (1)H NMR-based metabolic profiling of mouse feces was carried out over time in different microbiome mouse models, including conventional (n = 9), conventionalized (n = 10),...
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PMID: 20806900
PDF is available here.
PDF is available here.
Abstract
We discuss some of the great opportunities that molecular diagnostic tools have to offer both basic scientists and translational researchers for bench-to-bedside clinical application in transplantation medicine, with special focus on genomics and genome-wide association studies, epigenetics (DNA met...
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PMID: 20736923
PDF is available here.
PDF is available here.
Abstract
Metabolite profiling of Cheonggukjang inoculated with different Bacillus strains including Bacillus amyloliqueciens CH86-1, Bacillus licheniformis 58, and Bacillus licheniformis 67 during fermentation, was performed using gas chromatography-time of flight-mass spectrometry after derivatization, comb...
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PMID: 20834151
PDF is available here.
PDF is available here.
Abstract
Biotransformations of phenylpropanoids such as cinnamic acid, p-coumaric acid, caffeic acid, and ferulic acid were investigated with plant-cultured cells of Eucalyptus perriniana. The plant-cultured cells of E. perriniana converted cinnamic acid into cinnamic acid β-D-glucopyranosyl ester, p-coumar...
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PMID: 20834169
PDF is available here.
PDF is available here.
Abstract
We used a gas chromatography mass spectrometry approach and profiled small-molecule metabolites in serum and urine of 24 OS patients, 19 benign bone tumor patients, and 32 healthy controls, to determine whether there are significant alterations associated with carcinogenesis. The metabonomic results...
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PMID: 20690664
PDF is available here.
PDF is available here.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in most western countries. Current NAFLD diagnosis methods (e.g., liver biopsy analysis or imaging techniques) are poorly suited as tests for such a prevalent condition, from both a clinical and financial point...
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PMID: 20684516
PDF is available here.
PDF is available here.
Abstract
A fermented soybean paste known as doenjang is a traditional fermented food that is widely consumed in Korea. The quality of doenjang varies considerably by its basic ingredients, species of microflora, and fermentation process. The classification of predefined metabolites (e.g. amino acids, organic...
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PMID: 20572059
PDF is available here.
PDF is available here.
Analytical Biochemistry (404)1 2010
Abstract
In this investigation, a gas chromatography/mass spectrometry (GC/MS)-based metabolomic protocol for adherent cell cultures was developed using statistical design of experiments. Cell disruption, metabolite extraction, and the GC/MS settings were optimized aiming at a gentle, unbiased, sensitive, an...
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PMID: 20417172
PDF is available here.
PDF is available here.
Future Oncology (6)9 2010
Abstract
Metabolomics represents one of the new omics sciences and capitalizes on the unique presence and concentration of small molecules in tissues and body fluids to construct a 'fingerprint' that can be unique to the individual and, within that individual, unique to environmental influences, including he...
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PMID: 20919825
PDF is available here.
PDF is available here.
Abstract
We determined the variation of various proteins and metabolites by multiple analytical platforms. A total of 126 common proteins were assessed for biological variations between individuals by ESI-Orbitrap. A large spread in inter-individual variation was observed (relative standard deviations [RSDs]...
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PMID: 20811074
PDF is available here.
PDF is available here.
Abstract
A metabonomics approach, consisting of gas chromatography coupled to mass spectrometry (GC/MS) and a multivariate statistical technique, was developed to estimate the protective effects of Lonicera japonica extract (LJE) on acute liver injury. A high dose of dimethylnitrosamine (DMN) was used to ind...
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PMID: 20371156
PDF is available here.
PDF is available here.
Parasitology (137)9 2010
Abstract
Abstract
Natural products have been the source of many drugs used in modern therapeutics, and particularly in the case of anticancer drugs, more than 50 % originally came from natural products. Their importance as a source of leads for new drugs therefore cannot be underestimated. However, due to the painsta...
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PMID: 20486069
PDF is available here.
PDF is available here.
Abstract
Deeper insight into the mechanisms of radiation injury under accidental radiation conditions would be helpful in achieving better biodosimetry, decorporation strategies and improvement in prevention/post-irradiation management of radiation accident patients....
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PMID: 20673129
PDF is available here.
PDF is available here.
Molecular Cell (39)2 2010
Abstract
We demonstrate that mTORC1 activation is sufficient to stimulate specific metabolic pathways, including glycolysis, the oxidative arm of the pentose phosphate pathway, and de novo lipid biosynthesis. This is achieved through the activation of a transcriptional program affecting metabolic gene target...
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PMID: 20670887
PDF is available here.
PDF is available here.
Abstract
We argue that lipidomics will become an essential tool kit in cell and developmental biology, molecular medicine and nutrition....
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PMID: 20606693
PDF is available here.
PDF is available here.
Abstract
We characterize the integrated response of a rat host to the liver fluke Fasciola hepatica using a combination of (1)H nuclear magnetic resonance spectroscopic profiles (liver, kidney, intestine, brain, spleen, plasma, urine, feces) and multiplex cytokine markers of systemic inflammation. Multivaria...
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PMID: 20664642
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We report the application of isotopologue profiling for analyzing the metabolism of L. pneumophila. Cultures of Lp were supplied with [U-(13)C(3)]serine, [U-(13)C(6)]glucose, or [1,2-(13)C(2)]glucose. After growth, (13)C enrichments and isotopologue patterns of protein-derived amino acids and poly-3...
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PMID: 20442401
PDF is available here.
PDF is available here.
Abstract
We used a metabolomic approach in which we employed (1)H nuclear magnetic resonance spectroscopy to compare chemical structures of representatives from the two subgenera and to identify chemicals that consistently differ between them. We found that dichloromethane extracts of leaves from most specie...
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PMID: 20556637
PDF is available here.
PDF is available here.
Plant Physiology (153)3 2010
Abstract
Shotgun proteomics analysis allows hundreds of proteins to be identified and quantified from a single sample at relatively low cost. Extensive DNA sequence information is a prerequisite for shotgun proteomics, and it is ideal to have sequence for the organism being studied rather than from related s...
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PMID: 20431087
PDF is available here.
PDF is available here.
Pediatric Research (68)1 2010
Abstract
We conclude that metabolomics of VOCs in exhaled breath was possible in a reproducible way. This new technique was able to discriminate not only between CF patients and controls but also between CF patients with or without Pseudomonas colonization....
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PMID: 20351658
PDF is available here.
PDF is available here.
Analytical Biochemistry (401)2 2010
Abstract
We used complementary methods (e.g., gas chromatography and/or liquid chromatography coupled with mass spectrometry) to detect the highly chemically diverse groups of metabolites for a global insight into the intracellular metabolism of S. aureus.
Copyright (c) 2010 Elsevier Inc. All rights reserv...
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PMID: 20211591
PDF is available here.
PDF is available here.