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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
virology (0):
Recent article
virology
Journal of Virology (85)21 2011
Abstract
Persistent infections with human papillomavirus type 16 (HPV16), HPV18, or HPV31 are necessary for the development of cervical cancer, implying that HPVs have evolved immunoevasive mechanisms. Recent global transcriptome analyses indicated that these HPV types downregulate the consti...
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PMID: 21849431
PDF is available here.
PDF is available here.
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Abstract
We depleted the intestinal microbiota of mice with antibiotics before inoculation with poliovirus, an enteric virus. Antibiotic-treated mice were less susceptible to poliovirus disease and supported minimal viral replication in the intestine. Exposure to bacteria or their N-acetylglucosamine-contain...
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PMID: 21998395
PDF is available here.
PDF is available here.
Abstract
We found that MMTV, when ingested by newborn mice, stimulates a state of unresponsiveness toward viral antigens. This process required the intestinal microbiota, as antibiotic-treated mice or germ-free mice did not transmit infectious virus to their offspring. MMTV-bound bacterial lipopolysaccharide...
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PMID: 21998394
PDF is available here.
PDF is available here.
Abstract
New England Journal of Medicine (365)14 2011
Abstract
We enrolled neonates with HSV disease in two parallel, identical, double-blind, placebo-controlled studies. Neonates with central nervous system (CNS) involvement were enrolled in one study, and neonates with skin, eye, and mouth involvement only were enrolled in the other. After completing a regime...
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PMID: 21991950
PDF is available here.
PDF is available here.
Abstract
New England Journal of Medicine (365)12 2011
Abstract
We assessed RV5 coverage and diarrhea-associated health care use from July 2007 through June 2009 versus July 2001 through June 2006 in children under 5 years of age. We compared the rates of diarrhea-associated health care use in unvaccinated children in the period from January through June (when r...
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PMID: 21992123
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)11 2011
Abstract
We designed a noninferiority trial (noninferiority margin, -10.5%) to compare rates of sustained virologic response among patients receiving two treatment durations.
We enrolled patients with chronic infection with HCV genotype 1 who had not previously received treatment. All patient...
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PMID: 21916639
PDF is available here.
PDF is available here.
Abstract
We consistently observed that the PA gene of H1N1(pdm) results in increased polymerase activity, better replication in mice, and lower LD₅₀. Our findings suggest that monitoring of gene reassortment for the 2009 pandemic influenza and seasonal human viruses is also important, which would help to...
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PMID: 21849283
PDF is available here.
PDF is available here.
Biology Letters (7)4 2011
Abstract
We used spatially structured, experimental populations of the bacterium Pseudomonas fluorescens, cultured with or without the phage SBW25Ф2 under three levels of dispersal (none, localized or global), and quantified diversity in terms of evolved bacterial colony morphologies after approximately 100...
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PMID: 21325308
PDF is available here.
PDF is available here.
British Journal of Cancer (105)4 2011
Abstract
Chronic treatment of SLK cells with one of the five HIV-PIs alone or together resulted in increased resistance to doxorubicin. Co-treatment with one of the HIV-PIs in combination with doxorubicin resulted in a synergistic increase in resistance to doxorubicin, and the degree of resistance was found t...
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PMID: 21829205
PDF is available here.
PDF is available here.
Abstract
Orthotopic-liver-transplantation (OLT) in patients with Human-Immunodeficiency-Virus infection (HIV) and end-stage-liver-disease (ESDL) is rarely reported. The purpose of this study is to describe our institutional experience on OLT for HIV positive patients.
This is...
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PMID: 21813377
PDF is available here.
PDF is available here.
Abstract
We also studied progression of fibrosis in relation to rs12979860 C/T genotypes over two years.
82% of the patients were on HAART (74% without detectable HI viremia) and 67% were haemophiliacs, respectively. HCV genotype 1 was present in 62%. Cross-sectional median liver stiffness wa...
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PMID: 21813376
PDF is available here.
PDF is available here.
Abstract
We show here a study on the pathogenesis and the physiopathology of ROCV disease in the central nervous system of a Balb/C young adult mice experimental model. The animals were intraperitoneally infected by ROCV and followed from 0 to 9 days after infection, when all of them died. Nervous tissue sam...
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PMID: 21813860
PDF is available here.
PDF is available here.
Abstract
We describe KIR-associated amino-acid polymorphisms in the HIV-1 sequence of chronically infected individuals, on a population level. We show that these KIR-associated HIV-1 sequence polymorphisms can enhance the binding of inhibitory KIRs to HIV-1-infected CD4(+) T cells, and reduce the antiviral a...
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PMID: 21814282
PDF is available here.
PDF is available here.
Abstract
Nature Medicine (17)8 2011
Abstract
Virus Research (159)2 2011
Abstract
Audio, Transactions of the IRE Professional Group on (57 Suppl 1) 2011
Abstract
Access to antiretroviral therapy (ART) and routine laboratory monitoring are limited for HIV-1-infected children from sub-Saharan Africa. This trial conducted in Bobo-Dioulasso, Burkina Faso, aimed to describe the biological efficacy, tolerance, and adherence of the combination of di...
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PMID: 21857286
PDF is available here.
PDF is available here.
ISME Journal (5)7 2011
Abstract
We characterize previously undetected microbial metabolic capabilities concealed within the genomes of uncultured marine viral communities. A total of 34 microbial gene families were detected on 452 viral GOS scaffolds. The majority of auxiliary metabolic genes found on these scaffolds have never be...
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PMID: 21307954
PDF is available here.
PDF is available here.
Cancer Letters (305)2 2011
Abstract
We discuss the evidence suggesting a causal relationship between selected infectious agents and the pro-tumoral reprogramming of inflammatory cells, as well as its significance in tumor development. Finally, we discuss the implications of this phenomenon for both cancer prevention and therapy....
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PMID: 21093147
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)25 2011
Abstract
We assigned 1088 patients with HCV genotype 1 infection who had not received previous treatment for the infection to one of three groups: a group receiving telaprevir combined with peginterferon alfa-2a and ribavirin for 12 weeks (T12PR group), followed by peginterferon-ribavirin alone for 12 weeks...
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PMID: 21696307
PDF is available here.
PDF is available here.
Abstract
I and Subgroup Id. The 22 isolates could be further subdivided into 2 groups: Id1 (n = 20) and Id2 (n = 2). A marker (a non-conservative nucleotide substitution) for the Id1 SVCV group was identified. It was specifically found in all sequences of Id1 isolates when testing SVCV originating from diffe...
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PMID: 21848117
PDF is available here.
PDF is available here.
Abstract
We describe the development and validation of a rapid, sensitive and specific real-time reverse transcription quantitative PCR assay (RT-qPCR) that amplifies sequence from representative isolates of all VHSV genotypes (I, II, III and IV). The pan-specific VHSV RT-qPCR assay reliably detects 100 copi...
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PMID: 21848118
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
New England Journal of Medicine (364)22 2011
Abstract
We compared real-time PCR assays of liquid-saliva and dried-saliva specimens with rapid culture of saliva specimens obtained at birth.
A total of 177 of 34,989 infants (0.5%; 95% confidence interval [CI], 0.4 to 0.6) were positive for CMV, according to at least one of the three metho...
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PMID: 21631323
PDF is available here.
PDF is available here.
Abstract
We exposed bluegills Lepomis macrochirus to VHSV-IVb by intraperitoneal injection at six temperatures from 10 degrees C to 30 degrees C and followed the disease course by quantitative real-time reverse transcriptase polymerase chain reaction (qrt-RT-PCR). Mortality of injected fish was 90% at 10 deg...
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PMID: 21834331
PDF is available here.
PDF is available here.
Protein Journal (30)5 2011
Abstract
We utilized a proteomics strategy to characterize proteome-wide alterations between MP-treated MKN28 lines and their untreated counterparts. A total of 97 spots were positively identified as differentially expressed, and of these 62 proteins were up-regulated, whereas 35 proteins were down-regulated...
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PMID: 21574062
PDF is available here.
PDF is available here.
Abstract
We found that MNV infection can accelerate bacteria-induced inflammatory bowel disease (IBD) progression in Mdr1a(-/-) mice. The studies presented here examined whether MNV infection also affects the phenotype of a bacterially driven mouse model of inflammation-associated colon cancer in genetically...
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PMID: 21819691
PDF is available here.
PDF is available here.
PLoS Pathogens (7)6 2011
Abstract
We provide in-vivo data in macaques showing an increased percentage of α₄β₇ (high) CD4⁺ T cells in rectal mucosa, iliac lymph nodes and blood within 6 days of rectal exposure to live (n = 11), but not UV-treated (n = 8), HSV-2. We found that CD11c⁺ DCs are a major target of HSV-2 i...
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PMID: 21738472
PDF is available here.
PDF is available here.
Abstract
We characterized the F strain of herpes simplex virus-1 passaged in the presence of a natural carrageenan isolated from the red seaweed Gigartina skottbergii in view of the virulence for mice of isolated viral clones.
Viral clones (syn14-1 and syn17-2) showed a syncytial phenotype an...
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PMID: 22256337
PDF is available here.
PDF is available here.
Abstract
Abstract
We quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movem...
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PMID: 21614079
PDF is available here.
PDF is available here.
Abstract
Brain research (1389) 2011
Abstract
This study was carried out to investigate whether the congenital HCMV infection affect the induction and maintenance of LTP /DP. Rat models of Sprague-Dawley rats congenitally infected by HCMV were made. Field excitatory postsynaptic potentials (EPSPs) were recorded in the hippocampa...
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PMID: 21396925
PDF is available here.
PDF is available here.
Abstract
We observed decreased levels of mitochondrial proteins involved in oxidative phosphorylation and tricarboxylic acid cycle. Furthermore, deregulation of proteins of carbohydrate metabolism, the actin cytoskeleton, and extracellular matrix remodeling was observed. Proteomic observations were confirmed...
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PMID: 21417265
PDF is available here.
PDF is available here.
ISME Journal (5)5 2011
Abstract
We describe two complete ssDNA phage genomes that were reconstructed from a viral metagenome from 80 m depth at the Bermuda Atlantic Time-series Study (BATS) site in the northwestern Sargasso Sea and examine their spatial and temporal distributions. Both genomes (SARssφ1 and SARssφ2) exhibited s...
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PMID: 21124487
PDF is available here.
PDF is available here.
Abstract
Group B coxsackieviruses (CVB) and/or their components have been found in the blood and pancreas of patients with Type 1 diabetes (T1D). CVB infections lead to the activation of the innate and adaptive immune systems, which can result in the induction or aggravation of autoimmune pro...
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PMID: 21595602
PDF is available here.
PDF is available here.
Abstract
PURPOSE. Topical biphasic vesicle delivery system encapsulating interferon alpha (IFN α) was developed as an alternative to injections used to treat human papillomavirus (HPV) infections. METHODS. Biphasic lipid vesicles encapsulating increasing doses of IFN α (biphasic IFN α) wer...
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PMID: 21291377
PDF is available here.
PDF is available here.
Abstract
Measurement of human immunodeficiency virus(HIV) incidence among female sex workers in Rwanda is a key part of preparing for HIV prevention trials.
HIV-negative, nonpregnant female sex workers (N =397) were tested for HIV-1, sexually transmitted infections, and pregna...
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PMID: 22256340
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe in detail the PBMC-based assay, which is more laborious but in our opinion represents a closer approximation of the in vivo situation. As with all other in vitro assays the results of such measurements are only an indication of the antibody potency in vivo, and animal studies and ultimat...
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PMID: 19252841
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
The production of recombinant proteins usually involves the exploration of a wide variety of expression and purification methodologies in the pursuit of a strategy tailored to a particular protein. The methods applied are reliant on exploiting individual differences between expression systems or the...
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PMID: 18988024
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We detail a representative example of large-mammal siRNA use....
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PMID: 18369784
PDF is available here.
PDF is available here.
Abstract
Veterinary Microbiology (149)1-2 2011
Abstract
These results differ from what has been reported in in vitro studies, and indicate that different PBMC subpopulations may play different roles in EHV-1 viremia.
Copyright © 2010 Elsevier B.V. All rights reserved....
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PMID: 21093993
PDF is available here.
PDF is available here.
Abstract
Since herpes simplex virus type 2 (HSV-2) antibody tests have become commercially available, an increasing number of persons have learned that they have genital herpes through serologic testing. The course of natural history of HSV-2 in asymptomatic, seropositive persons is uncertain...
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PMID: 21486977
PDF is available here.
PDF is available here.
Annals of Internal Medicine (154)7 2011
Abstract
Abstract
The main objective of present research study was to evaluate the potential of lipid nanoparticles for active delivery of an antiretroviral drug to lymphatic tissues. Stavudine entrapped drug loaded solid lipid nanoparticles (SLNs) were prepared and characterized for a variety of phys...
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PMID: 21612153
PDF is available here.
PDF is available here.
FEBS Journal (278)8 2011
Abstract
We functionally characterized a stress-responsive group C MAPK gene (GhMPK2) from cotton. Northern blot analysis indicated that GhMPK2 was induced not only by signaling molecules, such as ethylene and methyl jasmonate, but also by methyl viologen-mediated oxidative stress. Transgenic tobacco (Nicoti...
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PMID: 21338470
PDF is available here.
PDF is available here.
Abstract
We investigated HCV-specific CD4+Th17 cells and their induction in OLT recipients with recurrence utilizing 51 HCV+ OLT recipients, 15 healthy controls and 9 HCV- OLT recipients. Frequency of HCV specific CD4+ Tcells secreting IFN-γ, IL-17 and IL-10 was analyzed by ELISpot. Serum cytokines and chem...
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PMID: 21446979
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We report that CD4+ T cell help in the form of IL-2 is required for IL-10 production by CTLs, but not for the induction of CTL effector cytokines. We show that IL-2 derived from CD4+ helper T cells cooperates with innate immune cell-derived IL-27 to amplify IL-10 production by CTLs through a Blimp-1...
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PMID: 21297642
PDF is available here.
PDF is available here.
Abstract
We use stem-loop real-time reverse transcription-polymerase chain reaction to quantify the expression changes of seven miRNAs and their target mRNAs in different tomato tissues during the pathogenic processes. Compared with mock-inoculated plants, the expression levels of investigated miRNAs and mRN...
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PMID: 21335334
PDF is available here.
PDF is available here.
The Lancet (377)9772 2011
Abstract
We provide an overview of the key causes, disease mechanisms of pathogenesis, and recommendations for treatment options including the evolving role of liver transplantation.
Copyright © 2011 Elsevier Ltd. All rights reserved....
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PMID: 21459211
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)13 2011
Abstract
We conducted a double-blind study in which previously untreated adults with HCV genotype 1 infection were randomly assigned to one of three groups. In all three groups, peginterferon alfa-2b and ribavirin were administered for 4 weeks (the lead-in period). Subsequently, group 1 (the control group) r...
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PMID: 21449783
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)13 2011
Abstract
We randomly assigned patients (in a 1:2:2 ratio) to one of three groups. In all three groups, peginterferon alfa-2b and ribavirin were administered for 4 weeks (the lead-in period). Subsequently, group 1 (control group) received placebo plus peginterferon-ribavirin for 44 weeks; group 2 received boc...
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PMID: 21449784
PDF is available here.
PDF is available here.
Abstract